AU2018290983B2 - Methods of treating heart failure with cardiac sarcomere activators - Google Patents

Methods of treating heart failure with cardiac sarcomere activators Download PDF

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Publication number
AU2018290983B2
AU2018290983B2 AU2018290983A AU2018290983A AU2018290983B2 AU 2018290983 B2 AU2018290983 B2 AU 2018290983B2 AU 2018290983 A AU2018290983 A AU 2018290983A AU 2018290983 A AU2018290983 A AU 2018290983A AU 2018290983 B2 AU2018290983 B2 AU 2018290983B2
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dose
subject
csa
plasma concentration
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AU2018290983A1 (en
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Narimon HONARPOUR
Fady Malik
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Amgen Inc
Cytokinetics Inc
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Amgen Inc
Cytokinetics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2018290983A 2017-06-30 2018-06-29 Methods of treating heart failure with cardiac sarcomere activators Active AU2018290983B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2024200991A AU2024200991B2 (en) 2017-06-30 2024-02-15 Methods of treating heart failure with cardiac sarcomere activators

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762527983P 2017-06-30 2017-06-30
US62/527,983 2017-06-30
PCT/US2018/040181 WO2019006235A1 (en) 2017-06-30 2018-06-29 METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS

Related Child Applications (1)

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AU2024200991A Division AU2024200991B2 (en) 2017-06-30 2024-02-15 Methods of treating heart failure with cardiac sarcomere activators

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AU2018290983A1 AU2018290983A1 (en) 2020-01-23
AU2018290983B2 true AU2018290983B2 (en) 2023-11-23

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MX2022000498A (es) 2019-07-17 2022-02-03 Cytokinetics Inc Polimorfos de (r)-n-(5-(5-isopropil-1,2,4-oxadiazol-3-il)-2,3-dihi dro-1h-inden-1-il) -2-metil-2h- tetrazol-5-carboxamida.
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JP7832128B2 (ja) * 2020-06-15 2026-03-17 マイオカーディア，インク 心房機能不全の治療
CN116710139A (zh) * 2020-11-12 2023-09-05 安进股份有限公司 通过施用奥美卡替莫卡必尔治疗心力衰竭的方法
IL302850A (en) * 2020-11-12 2023-07-01 Amgen Inc Methods of treating heart failure by administering OMECAMTIV MECARBIL
AU2022232919A1 (en) 2021-03-10 2023-10-19 Amgen Inc. Synthesis of omecamtiv mecarbil
WO2023164452A2 (en) * 2022-02-22 2023-08-31 Yale University Methods of treating, ameliorating, or preventing heart failure, and methods of promoting heart muscle growth
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WO2024081611A1 (en) * 2022-10-11 2024-04-18 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
JP7858148B1 (ja) 2023-03-27 2026-05-13 エッジワイズ セラピューティクス， インコーポレイテッド キナゾリンジオン化合物およびその使用
KR20250174911A (ko) 2023-03-27 2025-12-15 엣지와이즈 테라퓨틱스, 인크. 퀴놀리논 아미드 화합물 및 이의 용도
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators
WO2026050494A1 (en) 2024-08-29 2026-03-05 Cytokinetics, Incorporated Omecamtiv mecarbil for use in treating heart failure by activating cardiac sarcomere

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MD3645002T2 (ro) 2025-04-30
CN110996953A (zh) 2020-04-10
MA49508B1 (fr) 2024-12-31
US11931358B2 (en) 2024-03-19
CA3068588A1 (en) 2019-01-03
HUE069805T2 (hu) 2025-04-28
FI3645002T3 (fi) 2025-01-29
US20230149394A1 (en) 2023-05-18
MX2020000190A (es) 2020-07-22
MA49508A (fr) 2020-05-06
US20230355615A1 (en) 2023-11-09
RS66581B1 (sr) 2025-04-30
PT3645002T (pt) 2025-01-24
EP3645002B1 (en) 2024-10-30
ES3008457T3 (en) 2025-03-24
AU2018290983A1 (en) 2020-01-23
BR112019028046A2 (pt) 2020-07-07
DK3645002T3 (da) 2024-12-16
US11576910B2 (en) 2023-02-14
LT3645002T (lt) 2025-02-10
SMT202500067T1 (it) 2025-03-12
EP3645002A1 (en) 2020-05-06
EP4512470A3 (en) 2025-04-23
JP2020526483A (ja) 2020-08-31
AU2024200991A1 (en) 2024-03-07
SI3645002T1 (sl) 2025-03-31
US12295952B2 (en) 2025-05-13
US20250255862A1 (en) 2025-08-14
EP4512470A2 (en) 2025-02-26
US20200155547A1 (en) 2020-05-21
WO2019006235A1 (en) 2019-01-03
MX2022015115A (es) 2023-01-18
AU2024200991B2 (en) 2025-04-10
JP2025165979A (ja) 2025-11-05
HRP20241729T1 (hr) 2025-03-14
PL3645002T3 (pl) 2025-03-24
JP2023088944A (ja) 2023-06-27

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