BR112019028046A2 - métodos de tratamento da insuficiência cardíaca com ativadores de sarcômeros cardíacos - Google Patents

métodos de tratamento da insuficiência cardíaca com ativadores de sarcômeros cardíacos Download PDF

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Publication number
BR112019028046A2
BR112019028046A2 BR112019028046-4A BR112019028046A BR112019028046A2 BR 112019028046 A2 BR112019028046 A2 BR 112019028046A2 BR 112019028046 A BR112019028046 A BR 112019028046A BR 112019028046 A2 BR112019028046 A2 BR 112019028046A2
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BR
Brazil
Prior art keywords
subject
dose
asc
initial
fact
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BR112019028046-4A
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English (en)
Portuguese (pt)
Inventor
Narimon Honarpour
Malik Fady
Original Assignee
Amgen Inc.
Cytokinetics, Inc.
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Application filed by Amgen Inc., Cytokinetics, Inc. filed Critical Amgen Inc.
Publication of BR112019028046A2 publication Critical patent/BR112019028046A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112019028046-4A 2017-06-30 2018-06-29 métodos de tratamento da insuficiência cardíaca com ativadores de sarcômeros cardíacos BR112019028046A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762527983P 2017-06-30 2017-06-30
US62/527,983 2017-06-30
PCT/US2018/040181 WO2019006235A1 (en) 2017-06-30 2018-06-29 METHODS OF TREATING CARDIAC INSUFFICIENCY WITH CARDIAC SARCOMER ACTIVATORS

Publications (1)

Publication Number Publication Date
BR112019028046A2 true BR112019028046A2 (pt) 2020-07-07

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Family Applications (1)

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BR112019028046-4A BR112019028046A2 (pt) 2017-06-30 2018-06-29 métodos de tratamento da insuficiência cardíaca com ativadores de sarcômeros cardíacos

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US (4) US11576910B2 (cg-RX-API-DMAC10.html)
EP (2) EP4512470A3 (cg-RX-API-DMAC10.html)
JP (3) JP2020526483A (cg-RX-API-DMAC10.html)
CN (1) CN110996953A (cg-RX-API-DMAC10.html)
AU (2) AU2018290983B2 (cg-RX-API-DMAC10.html)
BR (1) BR112019028046A2 (cg-RX-API-DMAC10.html)
CA (1) CA3068588A1 (cg-RX-API-DMAC10.html)
DK (1) DK3645002T3 (cg-RX-API-DMAC10.html)
ES (1) ES3008457T3 (cg-RX-API-DMAC10.html)
FI (1) FI3645002T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20241729T1 (cg-RX-API-DMAC10.html)
HU (1) HUE069805T2 (cg-RX-API-DMAC10.html)
LT (1) LT3645002T (cg-RX-API-DMAC10.html)
MA (1) MA49508B1 (cg-RX-API-DMAC10.html)
MD (1) MD3645002T2 (cg-RX-API-DMAC10.html)
MX (2) MX2020000190A (cg-RX-API-DMAC10.html)
PL (1) PL3645002T3 (cg-RX-API-DMAC10.html)
PT (1) PT3645002T (cg-RX-API-DMAC10.html)
RS (1) RS66581B1 (cg-RX-API-DMAC10.html)
SI (1) SI3645002T1 (cg-RX-API-DMAC10.html)
SM (1) SMT202500067T1 (cg-RX-API-DMAC10.html)
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KR20250174911A (ko) 2023-03-27 2025-12-15 엣지와이즈 테라퓨틱스, 인크. 퀴놀리논 아미드 화합물 및 이의 용도
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Also Published As

Publication number Publication date
MD3645002T2 (ro) 2025-04-30
CN110996953A (zh) 2020-04-10
MA49508B1 (fr) 2024-12-31
US11931358B2 (en) 2024-03-19
CA3068588A1 (en) 2019-01-03
HUE069805T2 (hu) 2025-04-28
FI3645002T3 (fi) 2025-01-29
US20230149394A1 (en) 2023-05-18
MX2020000190A (es) 2020-07-22
MA49508A (fr) 2020-05-06
US20230355615A1 (en) 2023-11-09
RS66581B1 (sr) 2025-04-30
PT3645002T (pt) 2025-01-24
EP3645002B1 (en) 2024-10-30
ES3008457T3 (en) 2025-03-24
AU2018290983A1 (en) 2020-01-23
DK3645002T3 (da) 2024-12-16
US11576910B2 (en) 2023-02-14
LT3645002T (lt) 2025-02-10
SMT202500067T1 (it) 2025-03-12
EP3645002A1 (en) 2020-05-06
EP4512470A3 (en) 2025-04-23
JP2020526483A (ja) 2020-08-31
AU2024200991A1 (en) 2024-03-07
SI3645002T1 (sl) 2025-03-31
US12295952B2 (en) 2025-05-13
US20250255862A1 (en) 2025-08-14
EP4512470A2 (en) 2025-02-26
US20200155547A1 (en) 2020-05-21
WO2019006235A1 (en) 2019-01-03
AU2018290983B2 (en) 2023-11-23
MX2022015115A (es) 2023-01-18
AU2024200991B2 (en) 2025-04-10
JP2025165979A (ja) 2025-11-05
HRP20241729T1 (hr) 2025-03-14
PL3645002T3 (pl) 2025-03-24
JP2023088944A (ja) 2023-06-27

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI N? 10196/2001, QUE MODIFICOU A LEI N? 9279/96, A CONCESS?O DA PATENTE EST? CONDICIONADA ? ANU?NCIA PR?VIA DA ANVISA. CONSIDERANDO A APROVA??O DOS TERMOS DO PARECER N? 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL N? 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVID?NCIAS CAB?VEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]