JP2020524184A - キトサン−プルロニック複合体、及びこれを含むナノ運搬体 - Google Patents
キトサン−プルロニック複合体、及びこれを含むナノ運搬体 Download PDFInfo
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
Description
(PEO)a−(PPO)b−(PEO)a
Claims (18)
- プルロニック高分子の両末端にキトサンが置換された、キトサン−プルロニック複合体。
- 前記プルロニック高分子は、下記化学式1で表される、請求項1に記載のキトサン−プルロニック複合体 。
(化1)
(PEO)a−(PPO)b−(PEO)a
(前記PEOはポリエチレンオキシド、前記PPOはポリプロピレンオキシドであり、前記a及びbはそれぞれ独立に1乃至300の整数である。) - 前記キトサンの分子量は、3乃至760kDaである、請求項1に記載のキトサン−プルロニック複合体 。
- 請求項1のキトサン−プルロニック複合体を含む、ナノ運搬体。
- 前記ナノ運搬体は、プルロニック高分子をさらに含む、請求項4に記載のナノ運搬体。
- 前記キトサン−プルロニック複合体と前記プルロニック高分子は、
総重量100重量%に対して、前記キトサン−プルロニック複合体は10重量%以上100重量%以下であり、前記プルロニック高分子は0重量%以上90重量%以下で混合された、請求項5に記載のナノ運搬体。 - 前記キトサン−プルロニック複合体における、キトサンの分子量が3乃至760kDaである、請求項4又は5に記載のナノ運搬体。
- 前記ナノ運搬体は、大きさが500nm以下である、請求項4又は5に記載のナノ運搬体。
- 前記ナノ運搬体は、表面電荷が0乃至50mVである、請求項4又は5に記載のナノ運搬体。
- 前記ナノ運搬体は肌透過率の低い薬物又は活性成分を運搬する、請求項4に記載のナノ運搬体。
- 前記ナノ運搬体は、肌透過率の低い薬物又は活性成分のローディング(loading)効率が90%以上である、請求項10に記載のナノ運搬体。
- 前記肌透過率の低い薬物又は活性成分は、化粧品、医薬品、医薬外品、又は美容用品に使用される機能性の物質である、請求項10に記載のナノ運搬体。
- 前記ナノ運搬体は、化粧品、医薬品、医薬外品、又は美容用品に用いられる、 請求項4に記載のナノ運搬体。
- 前記ナノ運搬体は、経皮透過用、経口投与用、又は侵襲用である、請求項4に記載のナノ運搬体。
- 前記ナノ運搬体は、肌透過率の低い薬品又は活性成分を含有する薬物複合体に用いられる、請求項4に記載のナノ運搬体。
- (a)プルロニック高分子とキトサンとを混合し、プルロニック高分子の末端にキトサンが置換された複合体を製造する段階と、
(b)前記複合体を溶媒下でプルロニック高分子と混合して混合物を製造する段階と、
(c)前記混合物を蒸留水に滴下する段階と、
(d)前記混合物が滴下した蒸留水を攪拌する段階と、を含むナノ運搬体の製造方法。 - 前記(a)段階で、3乃至760kDaの分子量のキトサンを混合する、請求項16に記載のナノ運搬体の製造方法。
- 前記(b)段階で、
前記複合体と前記プルロニック高分子は、総重量100重量%に対して、前記キトサン−プルロニック複合体は10乃至100重量%であり、前記プルロニック高分子は、0乃至90重量%で混合される、請求項16に記載のナノ運搬体の製造方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020170078481A KR102009240B1 (ko) | 2017-06-21 | 2017-06-21 | 키토산-플루로닉 복합체 및 이를 포함하는 나노운반체 |
KR10-2017-0078481 | 2017-06-21 | ||
PCT/KR2018/006706 WO2018236090A2 (ko) | 2017-06-21 | 2018-06-14 | 키토산-플루로닉 복합체 및 이를 포함하는 나노운반체 |
Publications (3)
Publication Number | Publication Date |
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JP2020524184A true JP2020524184A (ja) | 2020-08-13 |
JP6918276B2 JP6918276B2 (ja) | 2021-08-11 |
JP6918276B6 JP6918276B6 (ja) | 2021-10-20 |
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Application Number | Title | Priority Date | Filing Date |
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JP2020520410A Active JP6918276B6 (ja) | 2017-06-21 | 2018-06-14 | キトサン−プルロニック複合体、及びこれを含むナノ運搬体 |
Country Status (6)
Country | Link |
---|---|
US (1) | US11471534B2 (ja) |
EP (1) | EP3643300B1 (ja) |
JP (1) | JP6918276B6 (ja) |
KR (1) | KR102009240B1 (ja) |
CN (1) | CN110799177B (ja) |
WO (1) | WO2018236090A2 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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KR102292747B1 (ko) * | 2019-11-22 | 2021-08-25 | 한국세라믹기술원 | 생리활성물질 전달용 키토산으로 코팅된 온도민감성 나노스펀지 플랫폼 및 이의 용도 |
KR102630383B1 (ko) * | 2022-04-12 | 2024-01-29 | (주)심플스틱 | 피부 도포 시 인체 피부 온도에 반응하여 인공 막을 형성하는 바이오 필름 제조방법 및 그 제조방법으로 제조된 피부 도포 시 인체 피부 온도에 반응하여 인공 막을 형성하는 바이오 필름 |
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Publication number | Priority date | Publication date | Assignee | Title |
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US8486528B2 (en) * | 2008-01-22 | 2013-07-16 | Gwangju Institute Of Science And Technology | Temperature-sensitive nano-carriers |
US20100016450A1 (en) * | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
KR101228106B1 (ko) * | 2010-01-21 | 2013-02-01 | 광주과학기술원 | 피부투과도, 세포유입 및 종양전달성이 증가된 나노운반체 |
KR101327555B1 (ko) | 2011-03-11 | 2013-11-08 | 서울대학교산학협력단 | 모공을 통해 피부를 투과하는 경피 전달용 펩타이드 |
JP5805882B2 (ja) * | 2011-11-21 | 2015-11-10 | イノ セラピー インコーポレイテッド | カテコール基が結合したキトサンまたはポリアミン及び末端にチオール基が結合したポロキサマーを含むヒドロゲル及びこれの製造方法及びこれを利用した止血剤 |
KR101740895B1 (ko) | 2012-07-25 | 2017-05-29 | 광주과학기술원 | 뇌조직에 특이적으로 전달 가능한 뇌조직 표적화 펩티드와 키토산이 결합된 플루로닉 고분자를 포함하는 뇌표적 나노전달체 |
KR101607398B1 (ko) | 2014-10-22 | 2016-03-29 | 동국대학교 산학협력단 | 이중 약물 방출 기능을 가진 온도감응성 플루로닉-키토산올리고당-카토제닌 나노 복합체 |
-
2017
- 2017-06-21 KR KR1020170078481A patent/KR102009240B1/ko active IP Right Grant
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- 2018-06-14 JP JP2020520410A patent/JP6918276B6/ja active Active
- 2018-06-14 EP EP18820311.1A patent/EP3643300B1/en active Active
- 2018-06-14 US US16/624,994 patent/US11471534B2/en active Active
- 2018-06-14 CN CN201880041759.0A patent/CN110799177B/zh active Active
- 2018-06-14 WO PCT/KR2018/006706 patent/WO2018236090A2/ko unknown
Also Published As
Publication number | Publication date |
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JP6918276B6 (ja) | 2021-10-20 |
CN110799177A (zh) | 2020-02-14 |
US11471534B2 (en) | 2022-10-18 |
EP3643300A2 (en) | 2020-04-29 |
KR102009240B1 (ko) | 2019-08-09 |
EP3643300C0 (en) | 2023-09-06 |
WO2018236090A3 (ko) | 2019-03-28 |
CN110799177B (zh) | 2022-06-17 |
KR20180138357A (ko) | 2018-12-31 |
WO2018236090A2 (ko) | 2018-12-27 |
EP3643300B1 (en) | 2023-09-06 |
JP6918276B2 (ja) | 2021-08-11 |
US20200222542A1 (en) | 2020-07-16 |
EP3643300A4 (en) | 2020-12-16 |
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