JP2020522550A5 - - Google Patents
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- Publication number
- JP2020522550A5 JP2020522550A5 JP2019567650A JP2019567650A JP2020522550A5 JP 2020522550 A5 JP2020522550 A5 JP 2020522550A5 JP 2019567650 A JP2019567650 A JP 2019567650A JP 2019567650 A JP2019567650 A JP 2019567650A JP 2020522550 A5 JP2020522550 A5 JP 2020522550A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- compound according
- alkyl
- halo
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 27
- -1 Pyridine-4-yl Chemical group 0.000 claims 20
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 210000000845 cartilage Anatomy 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- DEOUZFWSQWEPGE-UHFFFAOYSA-N 2-methylheptanamide Chemical compound CCCCCC(C)C(N)=O DEOUZFWSQWEPGE-UHFFFAOYSA-N 0.000 claims 6
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 206010060820 Joint injury Diseases 0.000 claims 4
- 206010003246 arthritis Diseases 0.000 claims 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 210000001612 chondrocyte Anatomy 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims 1
- JNYLMODTPLSLIF-UHFFFAOYSA-N 6-(trifluoromethyl)pyridine-3-carboxylic acid Chemical group OC(=O)C1=CC=C(C(F)(F)F)N=C1 JNYLMODTPLSLIF-UHFFFAOYSA-N 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 229940000425 combination drug Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000004312 morpholin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC([H])(*)C1([H])[H] 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023021335A JP7432778B2 (ja) | 2017-06-09 | 2023-02-15 | 軟骨形成を誘導するための化合物及び組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762517394P | 2017-06-09 | 2017-06-09 | |
| US62/517,394 | 2017-06-09 | ||
| PCT/IB2018/054123 WO2018225009A1 (en) | 2017-06-09 | 2018-06-07 | Compounds and compositions for inducing chondrogenesis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023021335A Division JP7432778B2 (ja) | 2017-06-09 | 2023-02-15 | 軟骨形成を誘導するための化合物及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020522550A JP2020522550A (ja) | 2020-07-30 |
| JP2020522550A5 true JP2020522550A5 (https=) | 2021-07-26 |
| JP7229945B2 JP7229945B2 (ja) | 2023-02-28 |
Family
ID=62837959
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019567650A Active JP7229945B2 (ja) | 2017-06-09 | 2018-06-07 | 軟骨形成を誘導するための化合物及び組成物 |
| JP2023021335A Active JP7432778B2 (ja) | 2017-06-09 | 2023-02-15 | 軟骨形成を誘導するための化合物及び組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023021335A Active JP7432778B2 (ja) | 2017-06-09 | 2023-02-15 | 軟骨形成を誘導するための化合物及び組成物 |
Country Status (38)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY37759A (es) | 2017-06-09 | 2019-01-31 | Novartis Ag | Compuestos y composiciones para inducir condrogénesis |
| CN113015735B (zh) * | 2018-12-06 | 2024-06-21 | 诺华股份有限公司 | 用于诱导软骨发生以治疗关节损害的5-羟基-7-氧杂双环[2.2.1]庚烷-2-甲酰胺衍生物 |
| ES2965684T3 (es) | 2018-12-06 | 2024-04-16 | Novartis Ag | Derivados de 6-hidroxi-8-oxatriciclo[3.2.1.02,4]octano-2-carboxamida para inducir condrogénesis para el tratamiento del daño articular |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998030566A1 (en) * | 1997-01-06 | 1998-07-16 | Pfizer Inc. | Cyclic sulfone derivatives |
| ECSP982358A (es) | 1998-01-06 | 1998-12-22 | Derivados ciclicos de sulfona | |
| US6407250B1 (en) * | 2000-09-14 | 2002-06-18 | Allergan Sales, Inc. | Interphenylene 7-oxabicyclic [2.2.1] heptane oxazoles as prostaglandin F2a antagonists |
| US6369089B1 (en) | 2000-09-14 | 2002-04-09 | Allergan Sales, Inc. | Interheteroaryl 7-oxabicyclic [2.2.1]heptane oxazoles as prostaglandin F2α antagonists |
| CN1213050C (zh) | 2000-11-23 | 2005-08-03 | 拜尔公司 | 氧杂双环[2.2.1]庚烷衍生物，其制备方法和作为农药的用途 |
| US6653468B1 (en) | 2002-07-31 | 2003-11-25 | Isis Pharmaceuticals, Inc. | Universal support media for synthesis of oligomeric compounds |
| JP2005068052A (ja) | 2003-08-22 | 2005-03-17 | Mitsui Chemicals Inc | 新規なフラン誘導体及びその製造方法 |
| WO2006038112A1 (en) | 2004-10-01 | 2006-04-13 | Warner-Lambert Company Llc | Use of kinase inhibitors to promote neochondrogenesis |
| US7595327B2 (en) * | 2005-03-21 | 2009-09-29 | Wyeth | Beta-sulfonamide hydroxamic acid inhibitors of tace/matrix metalloproteinase |
| WO2008008884A2 (en) | 2006-07-12 | 2008-01-17 | Cornell Research Foundation, Inc. | Inhibition of beta-amyloid peptide aggregation |
| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| US20100256385A1 (en) | 2009-04-02 | 2010-10-07 | Allergan, Inc. | Prostaglandin e receptor antagonists |
| AU2010273570B2 (en) | 2009-07-14 | 2014-07-03 | Novartis Ag | Mesenchymal stem cell differentiation |
| CN101628951B (zh) | 2009-08-12 | 2011-06-22 | 中国石油天然气股份有限公司 | 烯烃聚合用固体催化组分及其催化剂 |
| EP2651405A2 (en) | 2010-12-14 | 2013-10-23 | Electrophoretics Limited | Casein kinase 1 (ck1 ) inhibitors |
| WO2012129562A2 (en) | 2011-03-24 | 2012-09-27 | The Scripps Research Institute | Compounds and methods for inducing chondrogenesis |
| WO2012177856A2 (en) | 2011-06-21 | 2012-12-27 | Adispell, Inc. | Cognition modification |
| WO2013007765A1 (en) * | 2011-07-13 | 2013-01-17 | F. Hoffmann-La Roche Ag | Fused tricyclic compounds for use as inhibitors of janus kinases |
| ES2900815T3 (es) | 2013-03-15 | 2022-03-18 | Scripps Research Inst | Compuestos y métodos para inducir la condrogénesis |
| EP3143026B1 (en) * | 2014-05-13 | 2024-07-10 | Novartis AG | Compounds and compositions for inducing chondrogenesis |
| JP2016204316A (ja) | 2015-04-24 | 2016-12-08 | 日東電工株式会社 | 核酸固相合成用リンカー及び担体 |
| UY37759A (es) | 2017-06-09 | 2019-01-31 | Novartis Ag | Compuestos y composiciones para inducir condrogénesis |
-
2018
- 2018-06-05 UY UY0001037759A patent/UY37759A/es active IP Right Grant
- 2018-06-06 AR ARP180101514A patent/AR113227A1/es unknown
- 2018-06-07 IL IL300755A patent/IL300755A/en unknown
- 2018-06-07 HU HUE21178695A patent/HUE065194T2/hu unknown
- 2018-06-07 LT LTEP21178695.9T patent/LT3915994T/lt unknown
- 2018-06-07 PE PE2019002520A patent/PE20200403A1/es unknown
- 2018-06-07 MA MA57022A patent/MA57022B1/fr unknown
- 2018-06-07 SI SI201831061T patent/SI3915994T1/sl unknown
- 2018-06-07 MA MA050547A patent/MA50547A/fr unknown
- 2018-06-07 BR BR112019025866-3A patent/BR112019025866A2/pt not_active Application Discontinuation
- 2018-06-07 JO JOJO/P/2019/0282A patent/JOP20190282B1/ar active
- 2018-06-07 AU AU2018279306A patent/AU2018279306C1/en active Active
- 2018-06-07 HR HRP20240155TT patent/HRP20240155T1/hr unknown
- 2018-06-07 WO PCT/IB2018/054123 patent/WO2018225009A1/en not_active Ceased
- 2018-06-07 EP EP23203447.0A patent/EP4299123A3/en active Pending
- 2018-06-07 CN CN201880037287.1A patent/CN110719913B/zh active Active
- 2018-06-07 EA EA201992858A patent/EA201992858A1/ru unknown
- 2018-06-07 EP EP21178695.9A patent/EP3915994B9/en active Active
- 2018-06-07 CA CA3063985A patent/CA3063985A1/en active Pending
- 2018-06-07 US US16/620,407 patent/US11091499B2/en active Active
- 2018-06-07 CR CR20190551A patent/CR20190551A/es unknown
- 2018-06-07 KR KR1020207000290A patent/KR102656524B1/ko active Active
- 2018-06-07 CU CU2019000098A patent/CU24577B1/es unknown
- 2018-06-07 MY MYPI2019006646A patent/MY198288A/en unknown
- 2018-06-07 FI FIEP21178695.9T patent/FI3915994T3/fi active
- 2018-06-07 DK DK21178695.9T patent/DK3915994T3/da active
- 2018-06-07 RS RS20240179A patent/RS65161B1/sr unknown
- 2018-06-07 TW TW107119618A patent/TWI782036B/zh active
- 2018-06-07 EP EP18737718.9A patent/EP3634967A1/en not_active Withdrawn
- 2018-06-07 PL PL21178695.9T patent/PL3915994T3/pl unknown
- 2018-06-07 MX MX2019014757A patent/MX389169B/es unknown
- 2018-06-07 ES ES21178695T patent/ES2971319T3/es active Active
- 2018-06-07 PT PT211786959T patent/PT3915994T/pt unknown
- 2018-06-07 JP JP2019567650A patent/JP7229945B2/ja active Active
-
2019
- 2019-11-06 ZA ZA2019/07358A patent/ZA201907358B/en unknown
- 2019-12-03 IL IL271154A patent/IL271154B2/en unknown
- 2019-12-05 CO CONC2019/0013706A patent/CO2019013706A2/es unknown
- 2019-12-05 SA SA519410729A patent/SA519410729B1/ar unknown
- 2019-12-05 EC ECSENADI201986712A patent/ECSP19086712A/es unknown
- 2019-12-05 CL CL2019003564A patent/CL2019003564A1/es unknown
- 2019-12-05 DO DO2019000305A patent/DOP2019000305A/es unknown
- 2019-12-06 PH PH12019502764A patent/PH12019502764A1/en unknown
-
2021
- 2021-07-06 US US17/368,537 patent/US11753416B2/en active Active
-
2023
- 2023-02-15 JP JP2023021335A patent/JP7432778B2/ja active Active
- 2023-07-18 US US18/354,163 patent/US12209096B2/en active Active
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