JP2020520986A5 - - Google Patents
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- Publication number
- JP2020520986A5 JP2020520986A5 JP2019565425A JP2019565425A JP2020520986A5 JP 2020520986 A5 JP2020520986 A5 JP 2020520986A5 JP 2019565425 A JP2019565425 A JP 2019565425A JP 2019565425 A JP2019565425 A JP 2019565425A JP 2020520986 A5 JP2020520986 A5 JP 2020520986A5
- Authority
- JP
- Japan
- Prior art keywords
- drug composition
- substituted
- lung infection
- composition according
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229940079593 drug Drugs 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 20
- 208000032376 Lung infection Diseases 0.000 claims 11
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 230000001580 bacterial effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- -1 amino, substituted amino Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229960003085 meticillin Drugs 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000005309 thioalkoxy group Chemical group 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000033 alkoxyamino group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 claims 1
- 125000000266 alpha-aminoacyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229940112141 dry powder inhaler Drugs 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 125000004470 heterocyclooxy group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 229940071648 metered dose inhaler Drugs 0.000 claims 1
- 239000006199 nebulizer Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000005255 oxyaminoacyl group Chemical group 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 125000005296 thioaryloxy group Chemical group 0.000 claims 1
- 125000005404 thioheteroaryloxy group Chemical group 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 0 C*NC(C)(CC(OC(C1O)C(Oc(c(Oc(ccc(C(*)C(C(NC(C(*)=O)c2cc(O)c(*)c(O)c2-c2cc(C3NC(C4NC(C(CC(N)=O)NC(C(C(c(cc5)c6)O)NC(C(CC(C)C)NC)=O)=O)=O)=O)ccc2O)=O)NC3=O)c2)c2Cl)cc4c2)c2Oc5c6Cl)OC(CO)C1O)OC1C)C1O Chemical compound C*NC(C)(CC(OC(C1O)C(Oc(c(Oc(ccc(C(*)C(C(NC(C(*)=O)c2cc(O)c(*)c(O)c2-c2cc(C3NC(C4NC(C(CC(N)=O)NC(C(C(c(cc5)c6)O)NC(C(CC(C)C)NC)=O)=O)=O)=O)ccc2O)=O)NC3=O)c2)c2Cl)cc4c2)c2Oc5c6Cl)OC(CO)C1O)OC1C)C1O 0.000 description 2
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762509378P | 2017-05-22 | 2017-05-22 | |
| US62/509,378 | 2017-05-22 | ||
| US201762518280P | 2017-06-12 | 2017-06-12 | |
| US62/518,280 | 2017-06-12 | ||
| US201762560413P | 2017-09-19 | 2017-09-19 | |
| US62/560,413 | 2017-09-19 | ||
| PCT/US2018/033953 WO2018217800A1 (en) | 2017-05-22 | 2018-05-22 | Glycopeptide derivative compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020520986A JP2020520986A (ja) | 2020-07-16 |
| JP2020520986A5 true JP2020520986A5 (https=) | 2021-07-26 |
| JP7165146B2 JP7165146B2 (ja) | 2022-11-02 |
Family
ID=64395938
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565425A Active JP7165146B2 (ja) | 2017-05-22 | 2018-05-22 | グリコペプチド誘導体化合物およびそれらの使用 |
| JP2019565468A Active JP7210476B2 (ja) | 2017-05-22 | 2018-05-22 | リポ‐グリコペプチド可切断性誘導体及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019565468A Active JP7210476B2 (ja) | 2017-05-22 | 2018-05-22 | リポ‐グリコペプチド可切断性誘導体及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11071769B2 (https=) |
| EP (2) | EP3634464A4 (https=) |
| JP (2) | JP7165146B2 (https=) |
| KR (2) | KR102661786B1 (https=) |
| CN (2) | CN110996984A (https=) |
| AU (2) | AU2018271873B2 (https=) |
| BR (2) | BR112019024472A2 (https=) |
| GB (2) | GB2577419B (https=) |
| IL (2) | IL270685B (https=) |
| NZ (1) | NZ758836A (https=) |
| WO (2) | WO2018217808A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5548121B2 (ja) | 2007-05-14 | 2014-07-16 | リサーチ ファウンデーション オブ ステイト ユニバーシティ オブ ニューヨーク | バイオフィルム中の細菌細胞における生理学的分散応答の誘導 |
| IL270685B (en) | 2017-05-22 | 2022-09-01 | Insmed Inc | Cleavable derivatives of lipoglycopeptide and their uses |
| NL2023883B1 (en) * | 2019-09-24 | 2021-04-26 | Univ Leiden | Antibiotic compounds |
| US11793808B2 (en) | 2021-02-22 | 2023-10-24 | Mannkind Corp. | Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them |
| WO2023094994A1 (en) * | 2021-11-24 | 2023-06-01 | Cumberland Pharmaceuticals Inc | Methods for the prevention or treatment of anthrax infection |
| CN121270649A (zh) * | 2024-07-03 | 2026-01-06 | 烟台新药创制山东省实验室 | 一类万古霉素衍生物、其制备方法、药物组合物和用途 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4639433A (en) | 1985-08-14 | 1987-01-27 | Eli Lilly And Company | Glycopeptide derivatives |
| PT86457B (pt) * | 1986-12-30 | 1990-11-20 | Smithkline Beecham Corp | Processo para a preparacao de glicopeptidos glicosilados e de composicoes que os contem |
| IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| PT101450B (pt) | 1994-02-02 | 1999-11-30 | Hovione Produtos Farmaceuticos | Novo dispositivo para inalacao |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| AU5719798A (en) | 1996-12-31 | 1998-07-31 | Inhale Therapeutic Systems, Inc. | Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes |
| WO1999016420A1 (en) | 1997-09-29 | 1999-04-08 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in nebulizers |
| AU756693B2 (en) | 1997-09-29 | 2003-01-23 | Novartis Ag | Stabilized bioactive preparations and methods of use |
| US6518242B1 (en) * | 1998-02-20 | 2003-02-11 | Theravance, Inc. | Derivatives of glycopeptide antibacterial agents |
| US6288234B1 (en) * | 1998-06-08 | 2001-09-11 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
| UA73924C2 (en) | 1998-10-09 | 2005-10-17 | Nektar Therapeutics | Device for delivering active agent formulation to lungs of human patient |
| PT1140993E (pt) | 1998-12-23 | 2003-10-31 | Theravance Inc | Derivados de glicopeptidos e composicoes farmaceuticas contendo os mesmos |
| MXPA01012246A (es) | 1999-05-28 | 2002-08-12 | Inhale Therapeutic Syst | Aparato y metodo para distribuir una cantidad medida de medicamento en aerosol. |
| US6606992B1 (en) | 1999-06-30 | 2003-08-19 | Nektar Therapeutics | Systems and methods for aerosolizing pharmaceutical formulations |
| US6586008B1 (en) | 1999-08-25 | 2003-07-01 | Advanced Inhalation Research, Inc. | Use of simple amino acids to form porous particles during spray drying |
| AU2001238020A1 (en) | 2000-02-04 | 2001-08-14 | Advanced Medicine, Inc. | Glycopeptide derivatives having antibiotic activity |
| CA2399640A1 (en) | 2000-02-11 | 2001-08-16 | Eli Lilly And Company | Selective n-acylation of a82846 glycopeptide analogs |
| PT1280520E (pt) | 2000-05-10 | 2014-12-16 | Novartis Ag | Pós à base de fosfolípidos para administração de fármacos |
| UA75083C2 (uk) * | 2000-06-22 | 2006-03-15 | Тераванс, Інк. | Похідні глікопептидфосфонатів |
| TWI312785B (en) * | 2001-08-24 | 2009-08-01 | Theravance Inc | Process for preparing vancomycin derivatives |
| WO2004044222A2 (en) | 2002-11-12 | 2004-05-27 | Enzon Pharmaceuticals, Inc. | Polymeric prodrugs of vancomycin |
| JP2006528704A (ja) * | 2003-05-27 | 2006-12-21 | セラヴァンス インコーポレーテッド | グリコペプチド抗細菌剤と組み合わせたポリエンマクロライド抗真菌剤の使用 |
| TWI342312B (en) * | 2003-10-22 | 2011-05-21 | Theravance Inc | Hydrochloride salts of a glycopeptide phosphonate derivative |
| US20070185015A1 (en) * | 2005-02-28 | 2007-08-09 | Chiron Corporation and North China Pharmaceutical Corporation | Semi-synthetic desmethyl-vancomycin-based glycopeptides with antibiotic activity |
| US7632918B2 (en) * | 2005-02-28 | 2009-12-15 | Novartis Vaccines And Diagnostics, Inc. | Semi-synthetic glycopeptides with antibiotic activity |
| MX2010003263A (es) | 2007-09-25 | 2010-06-02 | Novartis Ag | Tratamiento de trastornos pulmonares con medicamentos aerosolizados tales como vancomicina. |
| JP5855829B2 (ja) * | 2007-10-23 | 2016-02-09 | インスメッド， インコーポレイテッド | リポソーム化バンコマイシン製剤 |
| CA2710602A1 (en) * | 2007-12-26 | 2009-07-09 | Lead Therapeutics, Inc. | Novel semi-synthetic glycopeptides as antibacterial agents |
| WO2010048340A2 (en) * | 2008-10-24 | 2010-04-29 | Lead Therapeutics, Inc. | Novel semi-synthetic glycopeptides as antibacterial agents |
| GB2465863A (en) * | 2008-12-05 | 2010-06-09 | Lead Therapeutics Inc | Semi-synthetic heptapeptidic glycopeptides for the treatment of bacterial infections |
| US20120058198A1 (en) * | 2009-03-26 | 2012-03-08 | Pulmatrix, Inc. | Methods for treating and preventing pneumonia and ventilator-associated tracheobronchitis |
| US9682061B2 (en) * | 2009-04-28 | 2017-06-20 | The Medicines Company | Methods of treating bacterial infections using oritavancin |
| US9572774B2 (en) * | 2011-05-19 | 2017-02-21 | Savara Inc. | Dry powder vancomycin compositions and associated methods |
| JP6012716B2 (ja) | 2011-05-19 | 2016-10-25 | サヴァラ，インク． | 乾燥粉末バンコマイシン組成物および関連する方法 |
| WO2013022763A1 (en) | 2011-08-05 | 2013-02-14 | The Scripps Research Institute | Glycopeptide antibiotic analogs effective against vancomycin-resistant bacterial strains |
| PL2852391T3 (pl) * | 2012-05-21 | 2022-04-11 | Insmed Incorporated | Układy do leczenia infekcji płuc |
| US10124066B2 (en) * | 2012-11-29 | 2018-11-13 | Insmed Incorporated | Stabilized vancomycin formulations |
| GB201402267D0 (en) * | 2014-02-10 | 2014-03-26 | Cambridge Entpr Ltd | Antibacterial agents |
| CN105085636B (zh) * | 2014-05-19 | 2020-05-01 | 中国医学科学院药物研究所 | 一类万古霉素衍生物、其制备方法及其在抗菌方面的应用 |
| CA2954653C (en) | 2014-07-10 | 2023-01-24 | The Scripps Research Institute | N-(hydrophobe-substituted)vancosaminyl [.psi.[c(=nh)nh]tpg4]vancomycin and [.psi.[ch2nh]tpg4]vancomycin |
| CN107325159A (zh) | 2016-04-29 | 2017-11-07 | 中国科学院上海药物研究所 | 一类万古霉素衍生物、其制备方法、药物组合物和用途 |
| WO2018008197A1 (ja) | 2016-07-07 | 2018-01-11 | 日東電工株式会社 | 反射層および蛍光体層付光半導体素子 |
| AU2017348434B2 (en) | 2016-10-31 | 2021-10-07 | The Scripps Research Institute | Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability |
| IL270685B (en) * | 2017-05-22 | 2022-09-01 | Insmed Inc | Cleavable derivatives of lipoglycopeptide and their uses |
-
2018
- 2018-05-22 IL IL270685A patent/IL270685B/en unknown
- 2018-05-22 BR BR112019024472-7A patent/BR112019024472A2/pt not_active Application Discontinuation
- 2018-05-22 CN CN201880048300.3A patent/CN110996984A/zh active Pending
- 2018-05-22 AU AU2018271873A patent/AU2018271873B2/en active Active
- 2018-05-22 EP EP18805177.5A patent/EP3634464A4/en active Pending
- 2018-05-22 GB GB1917675.9A patent/GB2577419B/en active Active
- 2018-05-22 IL IL270686A patent/IL270686B/en unknown
- 2018-05-22 KR KR1020197035481A patent/KR102661786B1/ko active Active
- 2018-05-22 EP EP18805750.9A patent/EP3630154A4/en active Pending
- 2018-05-22 WO PCT/US2018/033963 patent/WO2018217808A1/en not_active Ceased
- 2018-05-22 NZ NZ758836A patent/NZ758836A/en unknown
- 2018-05-22 KR KR1020197035485A patent/KR102661790B1/ko active Active
- 2018-05-22 US US16/615,214 patent/US11071769B2/en not_active Expired - Fee Related
- 2018-05-22 US US16/615,232 patent/US20200368312A1/en not_active Abandoned
- 2018-05-22 JP JP2019565425A patent/JP7165146B2/ja active Active
- 2018-05-22 WO PCT/US2018/033953 patent/WO2018217800A1/en not_active Ceased
- 2018-05-22 CN CN201880047233.3A patent/CN110891590B/zh active Active
- 2018-05-22 BR BR112019024549A patent/BR112019024549A2/pt not_active Application Discontinuation
- 2018-05-22 JP JP2019565468A patent/JP7210476B2/ja active Active
- 2018-05-22 GB GB1917677.5A patent/GB2577420B/en active Active
- 2018-05-22 AU AU2018273887A patent/AU2018273887B2/en active Active
-
2021
- 2021-06-10 US US17/344,322 patent/US11857597B2/en active Active
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