JP2020520956A5 - - Google Patents

Info

Publication number

JP2020520956A5

JP2020520956A5 JP2019564510A JP2019564510A JP2020520956A5 JP 2020520956 A5 JP2020520956 A5 JP 2020520956A5 JP 2019564510 A JP2019564510 A JP 2019564510A JP 2019564510 A JP2019564510 A JP 2019564510A JP 2020520956 A5 JP2020520956 A5 JP 2020520956A5

Authority

JP

Japan

Prior art keywords

composition according

ngf

neurotrophin

composition

item

Prior art date

2018-05-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108010025020 Nerve Growth Factor Proteins 0.000 claims description 17
• 102000007072 Nerve Growth Factors Human genes 0.000 claims description 7
• 206010011878 Deafness Diseases 0.000 claims description 5
• 239000000203 mixture Substances 0.000 claims 20
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
• 231100000888 hearing loss Toxicity 0.000 claims 4
• 230000010370 hearing loss Effects 0.000 claims 4
• 208000016354 hearing loss disease Diseases 0.000 claims 4
• 239000010419 fine particle Substances 0.000 claims 3
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
• 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 2
• 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 2
• 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 229940077737 brain-derived neurotrophic factor Drugs 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 229920002674 hyaluronan Polymers 0.000 claims 2
• 229960003160 hyaluronic acid Drugs 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
• 239000000725 suspension Substances 0.000 claims 2
• VHRSUDSXCMQTMA-PJHHCJLFSA-N 6alpha-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims 1
• 108090000742 Neurotrophin 3 Proteins 0.000 claims 1
• 102100029268 Neurotrophin-3 Human genes 0.000 claims 1
• 102000003683 Neurotrophin-4 Human genes 0.000 claims 1
• 108090000099 Neurotrophin-4 Proteins 0.000 claims 1
• 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 1
• 206010061373 Sudden Hearing Loss Diseases 0.000 claims 1
• 229920001577 copolymer Polymers 0.000 claims 1
• 229960003957 dexamethasone Drugs 0.000 claims 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
• 239000002360 explosive Substances 0.000 claims 1
• 229960004584 methylprednisolone Drugs 0.000 claims 1
• 229940032018 neurotrophin 3 Drugs 0.000 claims 1
• 229940097998 neurotrophin 4 Drugs 0.000 claims 1
• JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims 1
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
• 229960005205 prednisolone Drugs 0.000 claims 1
• OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
• 150000003431 steroids Chemical group 0.000 claims 1
• 238000010171 animal model Methods 0.000 description 2
• 208000003098 Ganglion Cysts Diseases 0.000 description 1
• 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 description 1
• 208000005400 Synovial Cyst Diseases 0.000 description 1
• 210000003477 cochlea Anatomy 0.000 description 1
• 210000003027 ear inner Anatomy 0.000 description 1
• 239000000835 fiber Substances 0.000 description 1
• 238000010353 genetic engineering Methods 0.000 description 1
• 102000046917 human NGF Human genes 0.000 description 1
• 230000000877 morphologic effect Effects 0.000 description 1
• 210000002569 neuron Anatomy 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 230000001766 physiological effect Effects 0.000 description 1
• 102000004169 proteins and genes Human genes 0.000 description 1
• 108090000623 proteins and genes Proteins 0.000 description 1
• 230000008929 regeneration Effects 0.000 description 1
• 238000011069 regeneration method Methods 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1