CN110691607A - 神经营养素用于治疗听力损失的用途 - Google Patents
神经营养素用于治疗听力损失的用途 Download PDFInfo
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0046—Ear
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17172659.9A EP3406259A1 (en) | 2017-05-24 | 2017-05-24 | Neurotrophins for use in the treatment of hearing loss |
| EP17172659.9 | 2017-05-24 | ||
| PCT/EP2018/063310 WO2018215414A1 (en) | 2017-05-24 | 2018-05-22 | Neurotrophins for use in the treatment of hearing loss |
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| CN110691607A true CN110691607A (zh) | 2020-01-14 |
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| CN201880033628.8A Pending CN110691607A (zh) | 2017-05-24 | 2018-05-22 | 神经营养素用于治疗听力损失的用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20200155647A1 (https=) |
| EP (2) | EP3406259A1 (https=) |
| JP (1) | JP2020520956A (https=) |
| KR (1) | KR20200011951A (https=) |
| CN (1) | CN110691607A (https=) |
| AU (1) | AU2018274589A1 (https=) |
| BR (1) | BR112019024504A2 (https=) |
| CA (1) | CA3062744A1 (https=) |
| IL (1) | IL270701A (https=) |
| RU (1) | RU2019137430A (https=) |
| WO (1) | WO2018215414A1 (https=) |
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| EP4093387A4 (en) * | 2020-01-24 | 2024-04-24 | Dompé farmaceutici S.p.A. | GROWTH FACTOR FORMULATION FOR A CONDITION ASSOCIATED WITH AN OTIC EVENT |
| WO2022221351A1 (en) * | 2021-04-13 | 2022-10-20 | Dompé Farmaceutici S.P.A. | Treatment of neuropathic corneal pain with ngf |
| PL4452267T3 (pl) * | 2021-12-23 | 2025-06-23 | Cilcare Dev | Pochodne 4-fenylo-tetrahydropirydyny do leczenia chorób słuchu |
| EP4316505A1 (en) * | 2022-08-05 | 2024-02-07 | Dompé farmaceutici S.p.a. | Intranasal administration of ngf for the treatment of sensorineural hearing loss |
| KR102851394B1 (ko) * | 2022-11-11 | 2025-09-04 | 단국대학교 천안캠퍼스 산학협력단 | 광반응성 하이드로젤을 이용한 분화유도인자 탑재 나노캡슐 |
| EP4501346A1 (en) * | 2023-08-04 | 2025-02-05 | Dompe' Farmaceutici S.P.A. | Method for the prevention of hearing loss induced by a platinum-based chemotherapy drug |
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| CN1181704A (zh) * | 1996-02-23 | 1998-05-13 | 安姆根有限公司 | 胶质细胞神经营养因子(gdnf)在治疗听觉疾病中的用途 |
| US6225282B1 (en) * | 1996-01-05 | 2001-05-01 | Genentech, Inc. | Treatment of hearing impairments |
| JP2002505671A (ja) * | 1997-06-13 | 2002-02-19 | ジェネンテック・インコーポレーテッド | 制御放出マイクロカプセル化ｎｇｆ製剤 |
| WO2003063543A2 (en) * | 2002-01-17 | 2003-07-31 | The Regents Of The University Of Michigan | Auditory nerve protection and re-growth |
| WO2009062149A1 (en) * | 2007-11-08 | 2009-05-14 | Creighton University | Methods for maintaining inner ear neurons |
| WO2017019907A1 (en) * | 2015-07-28 | 2017-02-02 | Otonomy, Inc. | Trkb or trkc agonist compositions and methods for the treatment of otic conditions |
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| ES2213861T3 (es) | 1998-10-09 | 2004-09-01 | Scil Proteins Gmbh | Procedimiento de obtencion de ngf-beta activa. |
| CN104203264B (zh) | 2011-12-19 | 2018-08-28 | 瓦克化学有限公司 | 新型proNGF突变体及其在生产β-NGF中的用途 |
| EP3328440A4 (en) * | 2015-07-28 | 2019-01-16 | Otonomy, Inc. | TREATMENT WITH REDUCED TRK-B AND TRK-C ANTAGONISTS |
-
2017
- 2017-05-24 EP EP17172659.9A patent/EP3406259A1/en not_active Withdrawn
-
2018
- 2018-05-22 KR KR1020197035948A patent/KR20200011951A/ko not_active Ceased
- 2018-05-22 WO PCT/EP2018/063310 patent/WO2018215414A1/en not_active Ceased
- 2018-05-22 US US16/615,201 patent/US20200155647A1/en not_active Abandoned
- 2018-05-22 CA CA3062744A patent/CA3062744A1/en active Pending
- 2018-05-22 CN CN201880033628.8A patent/CN110691607A/zh active Pending
- 2018-05-22 JP JP2019564510A patent/JP2020520956A/ja active Pending
- 2018-05-22 BR BR112019024504-9A patent/BR112019024504A2/pt not_active IP Right Cessation
- 2018-05-22 EP EP18725242.4A patent/EP3630159A1/en not_active Withdrawn
- 2018-05-22 RU RU2019137430A patent/RU2019137430A/ru unknown
- 2018-05-22 AU AU2018274589A patent/AU2018274589A1/en not_active Abandoned
-
2019
- 2019-11-17 IL IL270701A patent/IL270701A/en unknown
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| US6225282B1 (en) * | 1996-01-05 | 2001-05-01 | Genentech, Inc. | Treatment of hearing impairments |
| CN1181704A (zh) * | 1996-02-23 | 1998-05-13 | 安姆根有限公司 | 胶质细胞神经营养因子(gdnf)在治疗听觉疾病中的用途 |
| JP2002505671A (ja) * | 1997-06-13 | 2002-02-19 | ジェネンテック・インコーポレーテッド | 制御放出マイクロカプセル化ｎｇｆ製剤 |
| WO2003063543A2 (en) * | 2002-01-17 | 2003-07-31 | The Regents Of The University Of Michigan | Auditory nerve protection and re-growth |
| WO2009062149A1 (en) * | 2007-11-08 | 2009-05-14 | Creighton University | Methods for maintaining inner ear neurons |
| WO2017019907A1 (en) * | 2015-07-28 | 2017-02-02 | Otonomy, Inc. | Trkb or trkc agonist compositions and methods for the treatment of otic conditions |
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| IGOR KHALIN等: "Targeted delivery of brain-derived neurotrophic factor for the treatment of blindness and deafness", 《INT J NANOMEDICINE.》 * |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2018215414A1 (en) | 2018-11-29 |
| AU2018274589A1 (en) | 2019-11-28 |
| KR20200011951A (ko) | 2020-02-04 |
| RU2019137430A (ru) | 2021-06-24 |
| EP3630159A1 (en) | 2020-04-08 |
| IL270701A (en) | 2020-01-30 |
| CA3062744A1 (en) | 2018-11-29 |
| EP3406259A1 (en) | 2018-11-28 |
| JP2020520956A (ja) | 2020-07-16 |
| RU2019137430A3 (https=) | 2021-08-30 |
| BR112019024504A2 (pt) | 2020-06-23 |
| US20200155647A1 (en) | 2020-05-21 |
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