JP2020520917A - 頸部ジストニアの治療方法 - Google Patents

頸部ジストニアの治療方法 Download PDF

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Publication number
JP2020520917A
JP2020520917A JP2019563463A JP2019563463A JP2020520917A JP 2020520917 A JP2020520917 A JP 2020520917A JP 2019563463 A JP2019563463 A JP 2019563463A JP 2019563463 A JP2019563463 A JP 2019563463A JP 2020520917 A JP2020520917 A JP 2020520917A
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Japan
Prior art keywords
botulinum toxin
gly
positively charged
composition
duration
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Pending
Application number
JP2019563463A
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English (en)
Japanese (ja)
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JP2020520917A5 (enExample
Inventor
カーティス エル． リュエッグ
カーティス エル． リュエッグ
ジェイコブ エム． ウォー
ジェイコブ エム． ウォー
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Revance Therapeuticals Inc
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Revance Therapeuticals Inc
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Application filed by Revance Therapeuticals Inc filed Critical Revance Therapeuticals Inc
Publication of JP2020520917A publication Critical patent/JP2020520917A/ja
Publication of JP2020520917A5 publication Critical patent/JP2020520917A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2019563463A 2017-05-18 2018-05-18 頸部ジストニアの治療方法 Pending JP2020520917A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762508324P 2017-05-18 2017-05-18
US62/508,324 2017-05-18
PCT/US2018/033397 WO2018213710A1 (en) 2017-05-18 2018-05-18 Methods of treatment for cervical dystonia

Publications (2)

Publication Number Publication Date
JP2020520917A true JP2020520917A (ja) 2020-07-16
JP2020520917A5 JP2020520917A5 (enExample) 2021-07-26

Family

ID=64274745

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019563463A Pending JP2020520917A (ja) 2017-05-18 2018-05-18 頸部ジストニアの治療方法

Country Status (13)

Country Link
US (3) US20200179498A1 (enExample)
EP (1) EP3624819A4 (enExample)
JP (1) JP2020520917A (enExample)
KR (2) KR20250037595A (enExample)
CN (1) CN110996979A (enExample)
AU (2) AU2018270092B2 (enExample)
BR (1) BR112019024082A2 (enExample)
CA (1) CA3064070A1 (enExample)
CO (1) CO2019014212A2 (enExample)
MX (1) MX2019013716A (enExample)
PH (1) PH12019502578A1 (enExample)
RU (1) RU2019141383A (enExample)
WO (1) WO2018213710A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20181869T1 (hr) * 2009-10-21 2019-01-11 Revance Therapeutics, Inc. Metode i sustavi za pročišćavanje nekompleksiranog botulinskog neurotoksina
EP3675900A4 (en) 2017-08-28 2021-05-05 Revance Therapeutics, Inc. Transmucosal botulinum toxin compositions, kits, and methods for treating bladder disorders
WO2022081736A1 (en) * 2020-10-13 2022-04-21 Revance Therapeutics, Inc. Methods for treating cervical dystonia
CA3209156A1 (en) * 2021-02-21 2022-08-25 Revance Therapeutics, Inc. Methods of and compositions for treatment of upper limb spasticity
WO2025059665A1 (en) 2023-09-15 2025-03-20 Revance Therapeutics, Inc. Serial treatment with botulinum toxin for cervical dystonia

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012514003A (ja) * 2008-12-31 2012-06-21 ルバンス セラピュティックス インク． 注射用ボツリヌス毒素製剤
JP2012531442A (ja) * 2009-06-25 2012-12-10 ルバンス セラピュティックス インク． アルブミン非含有ボツリヌス毒素製剤
JP2013503165A (ja) * 2009-08-26 2013-01-31 アラーガン、インコーポレイテッド 修飾クロストリジウム毒素を使用して慢性神経原性炎症を治療する方法
JP2014520892A (ja) * 2011-07-20 2014-08-25 アラーガン、インコーポレイテッド 脂肪沈着物を処置するための方法におけるボツリヌス毒素の使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8557256B2 (en) * 1993-12-28 2013-10-15 Allergan, Inc. Treatment for cervical dystonia with the neurotoxic component of a botulinum toxin
TW574036B (en) * 1998-09-11 2004-02-01 Elan Pharm Inc Stable liquid compositions of botulinum toxin
PT2985039T (pt) * 2004-03-03 2018-11-09 Revance Therapeutics Inc Aplicação tópica e administração transdérmica de toxinas botulínicas
ES2641068T3 (es) * 2011-01-07 2017-11-07 Revance Therapeutics, Inc. Composición tópica que comprende una toxina botulínica y un colorante
SG10202004337WA (en) 2015-10-29 2020-06-29 Revance Therapeutics Inc Injectable botulinum toxin formulations and methods of use thereof having long duration of therapeutic or cosmetic effect
AU2018359962A1 (en) * 2017-11-03 2020-05-28 Revance Therapeutics, Inc. Botulinum toxin formulations and methods of use thereof in plantar fasciitis with extended duration of effect
WO2019113133A1 (en) * 2017-12-04 2019-06-13 Revance Therapeutics, Inc. Injectable botulinum toxin formulations and methods of use thereof having high response rate and long effect duration
RU2741221C1 (ru) 2020-04-30 2021-01-22 Федеральное государственное автономное образовательное учреждение высшего образования "Крымский федеральный университет имени В.И. Вернадского" (ФГАОУ ВО "КФУ им. В.И. Вернадского") Способ комплексной реабилитации двигательной функции верхней конечности у больных детским церебральным параличом

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012514003A (ja) * 2008-12-31 2012-06-21 ルバンス セラピュティックス インク． 注射用ボツリヌス毒素製剤
JP2012531442A (ja) * 2009-06-25 2012-12-10 ルバンス セラピュティックス インク． アルブミン非含有ボツリヌス毒素製剤
JP2013503165A (ja) * 2009-08-26 2013-01-31 アラーガン、インコーポレイテッド 修飾クロストリジウム毒素を使用して慢性神経原性炎症を治療する方法
JP2014520892A (ja) * 2011-07-20 2014-08-25 アラーガン、インコーポレイテッド 脂肪沈着物を処置するための方法におけるボツリヌス毒素の使用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOSEPH JANKOVIC, MD: "Treatment of Cervical Dystonia With Botulinum Toxin", MOVEMENT DISORDERS, vol. Vol.19, Suppl.8, JPN6022022245, 2004, pages 109 - 115, ISSN: 0004960710 *
目崎高広: "ボツリヌス治療", 神経治療, vol. 33, no. 5, JPN6022022247, 2016, pages 153, ISSN: 0004790891 *

Also Published As

Publication number Publication date
KR20250037595A (ko) 2025-03-17
PH12019502578A1 (en) 2020-07-20
RU2019141383A3 (enExample) 2022-01-19
CN110996979A (zh) 2020-04-10
EP3624819A4 (en) 2021-03-24
BR112019024082A2 (pt) 2020-06-16
US20220096610A1 (en) 2022-03-31
US12257293B2 (en) 2025-03-25
US20250319168A1 (en) 2025-10-16
KR20200006587A (ko) 2020-01-20
KR102777928B1 (ko) 2025-03-10
AU2025205532A1 (en) 2025-08-07
MX2019013716A (es) 2020-10-12
AU2018270092B2 (en) 2025-04-17
WO2018213710A1 (en) 2018-11-22
EP3624819A1 (en) 2020-03-25
CA3064070A1 (en) 2018-11-22
US20200179498A1 (en) 2020-06-11
CO2019014212A2 (es) 2020-01-17
RU2019141383A (ru) 2021-06-18
AU2018270092A1 (en) 2019-12-19
NZ759612A (en) 2024-01-26

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