JP2020520904A5 - - Google Patents

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Publication number

JP2020520904A5

JP2020520904A5 JP2019563067A JP2019563067A JP2020520904A5 JP 2020520904 A5 JP2020520904 A5 JP 2020520904A5 JP 2019563067 A JP2019563067 A JP 2019563067A JP 2019563067 A JP2019563067 A JP 2019563067A JP 2020520904 A5 JP2020520904 A5 JP 2020520904A5

Authority

JP

Japan

Prior art keywords

compound according

formula

alkyl

compound

independently

Prior art date

2018-05-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 73
• 125000000217 alkyl group Chemical group 0.000 claims 26
• 239000008194 pharmaceutical composition Substances 0.000 claims 26
• 229910052736 halogen Inorganic materials 0.000 claims 25
• 150000002367 halogens Chemical class 0.000 claims 25
• 239000000651 prodrug Substances 0.000 claims 19
• 229940002612 prodrug Drugs 0.000 claims 19
• 150000003839 salts Chemical class 0.000 claims 19
• 125000000623 heterocyclic group Chemical group 0.000 claims 13
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 9
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• 102000004877 Insulin Human genes 0.000 claims 4
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• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
• 206010012601 diabetes mellitus Diseases 0.000 claims 4
• 229940125396 insulin Drugs 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
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• 125000003627 8 membered carbocyclic group Chemical group 0.000 claims 3
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• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
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• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
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• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 206010008616 Cholecystitis and cholelithiasis Diseases 0.000 claims 1
• 101150106966 FOXO1 gene Proteins 0.000 claims 1
• 102000018711 Facilitative Glucose Transport Proteins Human genes 0.000 claims 1
• 101150023900 G6PC1 gene Proteins 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 108091052347 Glucose transporter family Proteins 0.000 claims 1
• 201000005569 Gout Diseases 0.000 claims 1
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• 102000003746 Insulin Receptor Human genes 0.000 claims 1
• 108010001127 Insulin Receptor Proteins 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 101150029101 Pdk1 gene Proteins 0.000 claims 1
• 101150036454 Pdpk1 gene Proteins 0.000 claims 1
• 108091008611 Protein Kinase B Proteins 0.000 claims 1
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• 101150110386 SLC2A4 gene Proteins 0.000 claims 1
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• 101710107476 TBC1 domain family member 4 Proteins 0.000 claims 1
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• 201000001883 cholelithiasis Diseases 0.000 claims 1
• 235000012000 cholesterol Nutrition 0.000 claims 1
• 208000029078 coronary artery disease Diseases 0.000 claims 1
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• 239000008103 glucose Substances 0.000 claims 1
• 230000009229 glucose formation Effects 0.000 claims 1
• 210000003494 hepatocyte Anatomy 0.000 claims 1
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• 230000003451 hyperinsulinaemic effect Effects 0.000 claims 1
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• 208000017169 kidney disease Diseases 0.000 claims 1
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• 230000026731 phosphorylation Effects 0.000 claims 1
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• 102000004169 proteins and genes Human genes 0.000 claims 1
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