RU2765286C2 - Фармацевтические агенты, композиции и способы, относящиеся к ним - Google Patents

Фармацевтические агенты, композиции и способы, относящиеся к ним Download PDF

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Publication number
RU2765286C2
RU2765286C2 RU2019134865A RU2019134865A RU2765286C2 RU 2765286 C2 RU2765286 C2 RU 2765286C2 RU 2019134865 A RU2019134865 A RU 2019134865A RU 2019134865 A RU2019134865 A RU 2019134865A RU 2765286 C2 RU2765286 C2 RU 2765286C2
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Russia
Prior art keywords
compound
insulin
glucose
cells
mice
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RU2019134865A
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English (en)
Russian (ru)
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RU2019134865A3 (enExample
RU2019134865A (ru
Inventor
Цзы-Цзянь ЛАНЬ
Ронан Пауэр
Александрос ЯННИКУРИС
Тирупати Редди ЙЕРРАМРЕДДИ
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Оллтек, Инк.
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Publication of RU2019134865A publication Critical patent/RU2019134865A/ru
Publication of RU2019134865A3 publication Critical patent/RU2019134865A3/ru
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/167Purine radicals with ribosyl as the saccharide radical

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
RU2019134865A 2017-05-19 2018-05-01 Фармацевтические агенты, композиции и способы, относящиеся к ним RU2765286C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762508730P 2017-05-19 2017-05-19
US62/508,730 2017-05-19
PCT/US2018/030371 WO2018212980A1 (en) 2017-05-19 2018-05-01 Pharmaceutical agents, compositions, and methods relating thereto

Publications (3)

Publication Number Publication Date
RU2019134865A RU2019134865A (ru) 2021-06-21
RU2019134865A3 RU2019134865A3 (enExample) 2021-06-30
RU2765286C2 true RU2765286C2 (ru) 2022-01-28

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RU2019134865A RU2765286C2 (ru) 2017-05-19 2018-05-01 Фармацевтические агенты, композиции и способы, относящиеся к ним

Country Status (11)

Country Link
US (2) US11014954B2 (enExample)
EP (1) EP3624809A4 (enExample)
JP (1) JP7224303B2 (enExample)
CN (2) CN120647702A (enExample)
AU (1) AU2018269403B2 (enExample)
CA (1) CA3061893A1 (enExample)
NZ (1) NZ758538A (enExample)
RU (1) RU2765286C2 (enExample)
SA (1) SA519410561B1 (enExample)
SG (1) SG11201909932YA (enExample)
WO (1) WO2018212980A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ758538A (en) * 2017-05-19 2025-08-29 Alltech Inc Pharmaceutical agents, compositions, and methods relating thereto

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2298557C2 (ru) * 2001-08-08 2007-05-10 Си Ви Терапьютикс, Инк. Агонисты а3 рецепторов аденозина
EP3144001A1 (en) * 2015-09-15 2017-03-22 Alltech, Inc. Compositions of selenoorganic compounds and methods of use thereof
WO2017048253A1 (en) * 2014-03-14 2017-03-23 Alltech, Inc. Compositions of selenoorganic compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002305073A1 (en) * 2001-03-22 2002-10-08 Research Foundation Of The City University Of New York Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
EP1652519A1 (en) 2004-10-28 2006-05-03 Tamie Nasu Seleniferous composition for producing antioxidase in vivo
US20060198906A1 (en) 2005-03-07 2006-09-07 Sami Labs Limited Compositions and Method to Increase Serum Levels of HDL cholesterol and Lower the Risk of Cardiovascular Disease
US20070077238A1 (en) 2005-10-04 2007-04-05 Teo Alex Y Production of organic and inorganic selenium compounds by lactic acid bacteria
ES2358351T3 (es) 2005-10-13 2011-05-09 Cv Therapeutics, Inc. Agonistas del receptor de adenosina a1.
EP2192905A4 (en) 2007-08-29 2010-11-10 Adam Lubin METHOD FOR SELECTIVE THERAPY OF DISEASE
WO2013151975A1 (en) 2012-04-02 2013-10-10 Northeastern University Compositions and methods for the inhibition of methyltransferases
CN114533753A (zh) 2013-03-15 2022-05-27 全技术公司 含硒组合物及其治疗和预防与线粒体功能障碍有关的疾病或病症的应用
US20160090397A1 (en) 2014-09-30 2016-03-31 Northeastern University Se-Adenosyl-L-Selenohomocysteine Selenoxide As A Modulator Of Methyltransferase And Other Activities
NZ758538A (en) 2017-05-19 2025-08-29 Alltech Inc Pharmaceutical agents, compositions, and methods relating thereto

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2298557C2 (ru) * 2001-08-08 2007-05-10 Си Ви Терапьютикс, Инк. Агонисты а3 рецепторов аденозина
WO2017048253A1 (en) * 2014-03-14 2017-03-23 Alltech, Inc. Compositions of selenoorganic compounds and methods of use thereof
EP3144001A1 (en) * 2015-09-15 2017-03-22 Alltech, Inc. Compositions of selenoorganic compounds and methods of use thereof

Also Published As

Publication number Publication date
EP3624809A4 (en) 2021-03-03
RU2019134865A3 (enExample) 2021-06-30
JP2020520904A (ja) 2020-07-16
US11613552B2 (en) 2023-03-28
NZ758538A (en) 2025-08-29
AU2018269403B2 (en) 2025-03-27
JP7224303B2 (ja) 2023-02-17
BR112019022918A2 (pt) 2020-05-26
EP3624809A1 (en) 2020-03-25
CN110545822A (zh) 2019-12-06
SA519410561B1 (ar) 2024-03-06
RU2019134865A (ru) 2021-06-21
CN120647702A (zh) 2025-09-16
SG11201909932YA (en) 2019-11-28
CA3061893A1 (en) 2018-11-22
US20200123191A1 (en) 2020-04-23
WO2018212980A1 (en) 2018-11-22
US11014954B2 (en) 2021-05-25
US20210238216A1 (en) 2021-08-05
AU2018269403A1 (en) 2019-11-14

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