JP2020520895A - デクルシン誘導体を有効成分として含有する老化関連疾患の予防または治療用薬学組成物 - Google Patents
デクルシン誘導体を有効成分として含有する老化関連疾患の予防または治療用薬学組成物 Download PDFInfo
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- A61K31/33—Heterocyclic compounds
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Landscapes
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (8)
- 下記化学式1または化学式2で表される化合物またはその薬学的に許容可能な塩:
- 下記化学式1または化学式2で表される化合物またはその薬学的に許容可能な塩を含む老化関連疾患の予防または治療用薬学組成物:
- 前記化学式1で表される化合物またはその薬学的に許容可能な塩は、(7S)−(+)−8,8−ジメチル−7−(3−フェニル−アリルオキシ)−7,8−ジヒドロ−6H−ピラノ[3,2−g]クロメン−2−オン;SLC−D011)であり、前記化学式2で表される化合物またはその薬学的に許容可能な塩は、(7S)−(+)−(E)−2−(ピリジン−3−イル)エテニルカルバミン酸,8,8−ジメチル−2−オキソ−6,7−ジヒドロ−2H,8H−ピラノ[3,2−g]クロメン−7−イル−エステル;JH010)であることを特徴とする請求項2に記載の老化関連疾患の予防または治療用薬学組成物。
- 前記老化関連疾患は、早老症であることを特徴とする請求項2に記載の老化関連疾患の予防または治療用薬学組成物。
- 前記早老症は、ウェルナー症候群及びハッチンソン・ギルフォード症侯群からなる群から選択されることを特徴とする請求項4に記載の老化関連疾患の予防または治療用薬学組成物。
- 前記化学式1または化学式2で表される化合物及びその薬学的に許容可能な塩は、プロジェリンとラミンAとの結合を抑制することを特徴とする請求項2に記載の老化関連疾患の予防または治療用薬学組成物。
- 下記化学式1または化学式2で表される化合物またはその薬学的に許容可能な塩を含むしわの予防または改善用化粧料組成物:
- 前記化学式1または化学式2で表される化合物及びその薬学的に許容可能な塩は、ケラチン細胞及び線維芽細胞でコラーゲン生成を向上させることを特徴とする請求項7に記載のしわの予防または改善用化粧料組成物。
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KR20170052787 | 2017-04-25 | ||
KR10-2017-0052787 | 2017-04-25 | ||
KR1020180045593A KR102070328B1 (ko) | 2017-04-25 | 2018-04-19 | 데커신 유도체를 유효성분으로 함유하는 노화 관련 질환 예방 또는 치료용 약학조성물 |
KR10-2018-0045593 | 2018-04-19 | ||
PCT/KR2018/004812 WO2018199633A1 (ko) | 2017-04-25 | 2018-04-25 | 데커신 유도체를 유효성분으로 함유하는 노화 관련 질환 예방 또는 치료용 약학조성물 |
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US (1) | US11008332B2 (ja) |
EP (1) | EP3617211A4 (ja) |
JP (1) | JP6826674B2 (ja) |
KR (1) | KR102070328B1 (ja) |
CN (1) | CN110573514B (ja) |
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US11008332B2 (en) | 2021-05-18 |
CN110573514B (zh) | 2022-01-04 |
US20200048274A1 (en) | 2020-02-13 |
JP6826674B2 (ja) | 2021-02-03 |
EP3617211A1 (en) | 2020-03-04 |
EP3617211A4 (en) | 2021-01-27 |
CN110573514A (zh) | 2019-12-13 |
KR20180119490A (ko) | 2018-11-02 |
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