JP2020519742A5 - - Google Patents
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- Publication number
- JP2020519742A5 JP2020519742A5 JP2019563248A JP2019563248A JP2020519742A5 JP 2020519742 A5 JP2020519742 A5 JP 2020519742A5 JP 2019563248 A JP2019563248 A JP 2019563248A JP 2019563248 A JP2019563248 A JP 2019563248A JP 2020519742 A5 JP2020519742 A5 JP 2020519742A5
- Authority
- JP
- Japan
- Prior art keywords
- dextran sulfate
- pharmaceutically acceptable
- acceptable salt
- use according
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 27
- 229960000633 dextran sulfate Drugs 0.000 claims 24
- 206010030348 Open-Angle Glaucoma Diseases 0.000 claims 5
- 208000010412 Glaucoma Diseases 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 4
- 229920002307 Dextran Polymers 0.000 claims 3
- 206010030043 Ocular hypertension Diseases 0.000 claims 3
- 229960002086 dextran Drugs 0.000 claims 3
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 229910021653 sulphate ion Inorganic materials 0.000 claims 3
- 238000005481 NMR spectroscopy Methods 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- 230000004410 intraocular pressure Effects 0.000 claims 2
- 201000006366 primary open angle glaucoma Diseases 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 210000004126 nerve fiber Anatomy 0.000 claims 1
- 230000004493 normal intraocular pressure Effects 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 210000003994 retinal ganglion cell Anatomy 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1750615 | 2017-05-17 | ||
| SE1750615-5 | 2017-05-17 | ||
| US201762555848P | 2017-09-08 | 2017-09-08 | |
| US62/555,848 | 2017-09-08 | ||
| PCT/SE2018/050506 WO2018212708A1 (en) | 2017-05-17 | 2018-05-16 | Treatment of glaucoma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020519742A JP2020519742A (ja) | 2020-07-02 |
| JP2020519742A5 true JP2020519742A5 (https=) | 2020-08-13 |
| JP6817466B2 JP6817466B2 (ja) | 2021-01-20 |
Family
ID=62245395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563248A Active JP6817466B2 (ja) | 2017-05-17 | 2018-05-16 | 緑内障の治療 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11291684B2 (https=) |
| EP (1) | EP3532072B1 (https=) |
| JP (1) | JP6817466B2 (https=) |
| KR (1) | KR102331421B1 (https=) |
| CN (1) | CN110621320B (https=) |
| CA (1) | CA3063851C (https=) |
| DK (1) | DK3532072T3 (https=) |
| ES (1) | ES2777836T3 (https=) |
| IL (1) | IL270362B (https=) |
| PL (1) | PL3532072T3 (https=) |
| PT (1) | PT3532072T (https=) |
| RU (1) | RU2759998C2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3074987A1 (en) * | 2017-09-08 | 2019-03-14 | Tx Medic Ab | New use of dextran sulfate |
| GB202008919D0 (en) * | 2020-06-11 | 2020-07-29 | Univ Birmingham | Polysaccharide conpositions and therapeutic gels |
| CN115531417B (zh) * | 2022-11-14 | 2024-04-09 | 青岛海尔生物科技有限公司 | ITGA6阳性iPSC源小梁网类细胞在制备治疗高眼压疾病药物中的应用及筛选方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4238482A (en) * | 1978-09-29 | 1980-12-09 | Peyman Gholam A | Intraocular infusion irrigation solution and method |
| DE3705669A1 (de) | 1987-02-21 | 1988-09-01 | Thomae Gmbh Dr K | Verwendung von dextransulfat zur herstellung eines arzneimittels zur behandlung und prophylaxe von gefaessverengungen und gefaessverschluessen |
| JPH02223525A (ja) * | 1988-11-16 | 1990-09-05 | Takeda Chem Ind Ltd | 血管新生阻害剤 |
| US5135920A (en) * | 1988-11-16 | 1992-08-04 | Takeda Chemical Industries, Ltd. | Angiostatic agents |
| US5227372A (en) | 1990-03-07 | 1993-07-13 | Children's Medical Center Corporation | Method for retaining ophthalmological agents in ocular tissues |
| CA2020199C (en) | 1990-06-29 | 2002-08-20 | Daniel Bar-Shalom | Uses of sulphated sugars |
| US5605938A (en) | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
| CA2331620A1 (en) | 1998-05-11 | 1999-11-18 | The Endowment For Research In Human Biology, Inc. | Use of neomycin for treating angiogenesis-related diseases |
| GB9917092D0 (en) | 1999-07-22 | 1999-09-22 | Ml Lab Plc | Treatment of angiogenesis-dependent conditions |
| WO2005110438A2 (en) | 2004-04-15 | 2005-11-24 | Massachusetts Institute Of Technology | Methods and products related to the intracellular delivery of polysaccharides |
| SE0401182D0 (sv) | 2004-05-05 | 2004-05-05 | Q Med Ab | Novel use of a viscoelastic composition |
| US20060154894A1 (en) | 2004-09-15 | 2006-07-13 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
| WO2007002139A2 (en) | 2005-06-22 | 2007-01-04 | The Trustees Of The University Of Pennsylvania | Neuroprotection of retinal ganglion cells |
| US20140186339A1 (en) * | 2006-10-27 | 2014-07-03 | Lpath, Inc. | Compositions and methods for treating ocular diseases and conditions |
| US20130273096A1 (en) | 2011-10-05 | 2013-10-17 | Bruce A. Daniels | Therapeutic Sulfated Polysaccharides, Compositions Thereof, and Methods for Treating Patients |
| EP3142684A4 (en) * | 2014-05-12 | 2018-05-23 | Purdue Research Foundation | Selectin and icam/vcam peptide ligand conjugates |
| WO2015190989A1 (en) | 2014-06-12 | 2015-12-17 | Tx Medic Ab | The use of dextran sulfate having an average molecular weight below 10000 da for inducing angiogenisis in a subject |
| SE538503C2 (en) | 2014-11-11 | 2016-08-16 | Tx Medic Ab | New dextran sulfate |
| SE539575C2 (en) * | 2015-07-30 | 2017-10-17 | Tx Medic Ab | Dextran sulfate for use in treating, inhibiting or preventing cardiac fibrosis |
| CN107137421A (zh) | 2017-05-25 | 2017-09-08 | 青岛市中心医院 | 硫酸葡聚糖在制备抑制角膜血管新生药物中的应用 |
-
2018
- 2018-05-16 ES ES18727467T patent/ES2777836T3/es active Active
- 2018-05-16 US US16/614,279 patent/US11291684B2/en active Active
- 2018-05-16 CN CN201880031854.2A patent/CN110621320B/zh active Active
- 2018-05-16 EP EP18727467.5A patent/EP3532072B1/en active Active
- 2018-05-16 KR KR1020197033872A patent/KR102331421B1/ko active Active
- 2018-05-16 PT PT187274675T patent/PT3532072T/pt unknown
- 2018-05-16 RU RU2019136633A patent/RU2759998C2/ru active
- 2018-05-16 CA CA3063851A patent/CA3063851C/en active Active
- 2018-05-16 JP JP2019563248A patent/JP6817466B2/ja active Active
- 2018-05-16 DK DK18727467.5T patent/DK3532072T3/da active
- 2018-05-16 PL PL18727467T patent/PL3532072T3/pl unknown
-
2019
- 2019-10-31 IL IL270362A patent/IL270362B/en active IP Right Grant
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