JP2020517703A5 - - Google Patents
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- Publication number
- JP2020517703A5 JP2020517703A5 JP2019558411A JP2019558411A JP2020517703A5 JP 2020517703 A5 JP2020517703 A5 JP 2020517703A5 JP 2019558411 A JP2019558411 A JP 2019558411A JP 2019558411 A JP2019558411 A JP 2019558411A JP 2020517703 A5 JP2020517703 A5 JP 2020517703A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- composition according
- free amino
- composition
- isoleucine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 16
- 229940024606 amino acid Drugs 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 12
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 10
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 7
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 7
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 7
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 7
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 7
- 229960000310 isoleucine Drugs 0.000 claims 7
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 7
- 229960003136 leucine Drugs 0.000 claims 7
- 229960004295 valine Drugs 0.000 claims 7
- 239000004474 valine Substances 0.000 claims 7
- 239000004475 Arginine Substances 0.000 claims 6
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 6
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 6
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 6
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 6
- 239000004472 Lysine Substances 0.000 claims 6
- 229960004308 acetylcysteine Drugs 0.000 claims 6
- 229960003121 arginine Drugs 0.000 claims 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 6
- 229960002743 glutamine Drugs 0.000 claims 6
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 6
- 229960003646 lysine Drugs 0.000 claims 6
- 239000004471 Glycine Substances 0.000 claims 4
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 4
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 4
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 4
- 239000000796 flavoring agent Substances 0.000 claims 4
- 235000013355 food flavoring agent Nutrition 0.000 claims 4
- 229960002449 glycine Drugs 0.000 claims 4
- 229930182817 methionine Natural products 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 229960002429 proline Drugs 0.000 claims 4
- 230000009529 traumatic brain injury Effects 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000003086 colorant Substances 0.000 claims 2
- -1 compressors Substances 0.000 claims 2
- 239000007884 disintegrant Substances 0.000 claims 2
- 239000006185 dispersion Substances 0.000 claims 2
- 235000003599 food sweetener Nutrition 0.000 claims 2
- 239000000314 lubricant Substances 0.000 claims 2
- 229960004452 methionine Drugs 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000003765 sweetening agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762491796P | 2017-04-28 | 2017-04-28 | |
| US62/491,796 | 2017-04-28 | ||
| PCT/US2018/029908 WO2018201024A1 (en) | 2017-04-28 | 2018-04-27 | Amino acid compositions and their use for the treatment of traumatic brain injury |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020517703A JP2020517703A (ja) | 2020-06-18 |
| JP2020517703A5 true JP2020517703A5 (https=) | 2021-06-17 |
Family
ID=62165694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558411A Pending JP2020517703A (ja) | 2017-04-28 | 2018-04-27 | アミノ酸組成物及び外傷性脳損傷の治療のためのそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11617731B2 (https=) |
| EP (1) | EP3615018A1 (https=) |
| JP (1) | JP2020517703A (https=) |
| CN (1) | CN110678172A (https=) |
| WO (1) | WO2018201024A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| WO2018201024A1 (en) | 2017-04-28 | 2018-11-01 | Axcella Health Inc. | Amino acid compositions and their use for the treatment of traumatic brain injury |
| IT201700087359A1 (it) | 2017-07-28 | 2019-01-28 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale |
| MX2020001765A (es) | 2017-08-14 | 2020-07-29 | Axcella Health Inc | Composiciones de aminoacidos para el tratamiento de enfermedad hepatica. |
| JP2021529735A (ja) | 2018-06-20 | 2021-11-04 | アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． | アミノ酸組成物の製造方法 |
| CU20200106A7 (es) | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| CN112839643A (zh) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
| IT201800006725A1 (it) | 2018-06-27 | 2019-12-27 | Composizioni comprendenti aminoacidi per l'uso nella prevenzione e nel trattamento di malattie epatiche | |
| IT201900002109A1 (it) * | 2019-02-13 | 2020-08-13 | Professional Dietetics Spa | Composizioni comprendenti amminoacidi per l'uso nel trattamento di lesioni del sistema nervoso centrale |
| IT202000000442A1 (it) | 2020-01-13 | 2021-07-13 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nella prevenzione e nel trattamento di effetti collaterali della chemioterapia |
| US20220218640A1 (en) * | 2021-01-14 | 2022-07-14 | Rob Dickerman | Amino acid delivery system |
| WO2023009444A1 (en) | 2021-07-26 | 2023-02-02 | Axcella Health Inc. | Amino acid compositions and methods for use in the treatment of post-acute sequelae of covid-19 |
| CN119235838A (zh) * | 2024-11-04 | 2025-01-03 | 苏州市立医院 | 一种hmb在制备改善创伤性脑损伤药物中的应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4438144A (en) | 1980-07-31 | 1984-03-20 | Blackburn George L | Amino acid preparation and therapy for treatment of stress and injury |
| WO1997025883A1 (de) * | 1996-01-17 | 1997-07-24 | Friedrich Kisters | Aminosäuren-präparat zur haarwuchsförderung |
| CA2439293A1 (en) * | 2001-03-05 | 2002-09-12 | Stephen P. Ernest | Enteral formulation |
| JP2004123564A (ja) * | 2002-09-30 | 2004-04-22 | Inst Of Physical & Chemical Res | 中枢機能改善用アミノ酸組成物 |
| US20050107338A1 (en) | 2003-11-17 | 2005-05-19 | Seidman Michael D. | Nutritional supplement enhancing mitochondrial function |
| JP4815752B2 (ja) * | 2004-04-01 | 2011-11-16 | 味の素株式会社 | アミノ酸含有飲食品 |
| WO2006102451A2 (en) | 2005-03-21 | 2006-09-28 | Abbott Laboratories | Amino acid composition for improving glucose tolerance |
| US20070286909A1 (en) * | 2006-06-07 | 2007-12-13 | Daniel S. Smith | Amino acid compositions |
| GB0624879D0 (en) | 2006-12-14 | 2007-01-24 | Shs Int Ltd | Treatment of pervasive development disorders |
| JP2009106217A (ja) * | 2007-10-31 | 2009-05-21 | Ajinomoto Co Inc | 増粘剤とアミノ酸を含有する食品組成物 |
| JPWO2010050168A1 (ja) * | 2008-10-27 | 2012-03-29 | 味の素株式会社 | バリン、イソロイシン、ロイシン固溶体およびその製造方法 |
| WO2012047800A1 (en) * | 2010-10-06 | 2012-04-12 | Abbott Laboratories | Methods for increasing muscle glucose uptake and decreasing muscle recovery time using amino acid blend |
| ES2893825T3 (es) | 2011-02-04 | 2022-02-10 | Hough Ear Inst | Métodos de tratamiento de lesiones cerebrales |
| US20130090356A1 (en) | 2011-06-24 | 2013-04-11 | Jon D. Kaiser | Compositions and methods for treatment of neuropsychological deficits |
| EP2580967A1 (en) | 2011-10-11 | 2013-04-17 | Nestec S.A. | Accelerating muscle recovery after immobilization-induced muscle atrophy |
| US9101580B2 (en) * | 2012-12-18 | 2015-08-11 | Matthew Bennett | Compositions and methods for treating traumatic brain injury |
| ES2844199T3 (es) * | 2013-04-16 | 2021-07-21 | Childrens Hospital Philadelphia | Composiciones y métodos para el tratamiento de lesiones cerebrales |
| US20180125926A1 (en) | 2013-09-25 | 2018-05-10 | Axcella Health Inc. | Compositions and Formulations and Methods of Production and Use Thereof |
| RU2016110800A (ru) | 2013-09-25 | 2017-10-30 | Пронутриа Биосайенсис, Инк. | Составы и композиции для поддержания и увеличения мышечной массы, силы и результативности, и способы их производства и использования |
| US20180133185A1 (en) | 2016-11-11 | 2018-05-17 | The Children's Hospital Of Philadelphia | Compositions and Methods for the Improvement of Memory |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| JOP20190147A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض واضطرابات العضلات |
| WO2018201024A1 (en) | 2017-04-28 | 2018-11-01 | Axcella Health Inc. | Amino acid compositions and their use for the treatment of traumatic brain injury |
| JP7370960B2 (ja) | 2017-08-14 | 2023-10-30 | アクセラ・ヘルス・インコーポレイテッド | 神経細胞損傷の治療のためのアミノ酸組成物 |
| MX2020001765A (es) | 2017-08-14 | 2020-07-29 | Axcella Health Inc | Composiciones de aminoacidos para el tratamiento de enfermedad hepatica. |
| JP2021529735A (ja) | 2018-06-20 | 2021-11-04 | アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． | アミノ酸組成物の製造方法 |
| CU20200106A7 (es) | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| WO2019246221A1 (en) | 2018-06-20 | 2019-12-26 | Axcella Health Inc. | Compositions and methods for the treatment of liver diseases and disorders |
| CN112839643A (zh) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
| MX2020013731A (es) | 2018-06-20 | 2021-02-26 | Axcella Health Inc | Composiciones para terapia y salud que contienen aminoacidos con sabor amargo. |
-
2018
- 2018-04-27 WO PCT/US2018/029908 patent/WO2018201024A1/en not_active Ceased
- 2018-04-27 EP EP18724718.4A patent/EP3615018A1/en not_active Withdrawn
- 2018-04-27 JP JP2019558411A patent/JP2020517703A/ja active Pending
- 2018-04-27 US US16/608,349 patent/US11617731B2/en active Active
- 2018-04-27 CN CN201880035067.5A patent/CN110678172A/zh active Pending
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