JP2018531929A5 - - Google Patents
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- JP2018531929A5 JP2018531929A5 JP2018515468A JP2018515468A JP2018531929A5 JP 2018531929 A5 JP2018531929 A5 JP 2018531929A5 JP 2018515468 A JP2018515468 A JP 2018515468A JP 2018515468 A JP2018515468 A JP 2018515468A JP 2018531929 A5 JP2018531929 A5 JP 2018531929A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- subject
- liver disease
- neuronal loss
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562233002P | 2015-09-25 | 2015-09-25 | |
| US62/233,002 | 2015-09-25 | ||
| PCT/US2016/053176 WO2017053613A1 (en) | 2015-09-25 | 2016-09-22 | Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531929A JP2018531929A (ja) | 2018-11-01 |
| JP2018531929A5 true JP2018531929A5 (https=) | 2019-11-07 |
| JP6989495B2 JP6989495B2 (ja) | 2022-01-05 |
Family
ID=58387333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515468A Active JP6989495B2 (ja) | 2015-09-25 | 2016-09-22 | Ｌ−オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる神経細胞喪失の治療および予防 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20200206174A1 (https=) |
| EP (1) | EP3352748A4 (https=) |
| JP (1) | JP6989495B2 (https=) |
| AU (1) | AU2016325556B2 (https=) |
| CA (1) | CA2998490A1 (https=) |
| HK (1) | HK1257679A1 (https=) |
| WO (1) | WO2017053613A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE035921T2 (en) | 2009-04-03 | 2018-05-28 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
| CN104434894A (zh) | 2009-06-08 | 2015-03-25 | Ucl商业有限公司 | 使用l-鸟氨酸苯乙酸盐治疗门静脉高压和恢复肝功能 |
| ES2769000T3 (es) | 2014-11-24 | 2020-06-24 | Ucl Business Ltd | Tratamiento de enfermedades asociadas con la activación de células estrelladas hepáticas utilizando terapias reductoras de amoníaco |
| CN108366983A (zh) * | 2015-11-13 | 2018-08-03 | 欧塞拉治疗有限公司 | L-鸟氨酸苯乙酸盐制剂 |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| MX2020001765A (es) | 2017-08-14 | 2020-07-29 | Axcella Health Inc | Composiciones de aminoacidos para el tratamiento de enfermedad hepatica. |
| WO2019226786A1 (en) * | 2018-05-22 | 2019-11-28 | Duke University | Compositions and methods for treating neurodegenerative disorders with rifaximin |
| CN112839643A (zh) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
| SG11202111509PA (en) * | 2019-05-09 | 2021-11-29 | Ocera Therapeutics Inc | Methods of assessing and treating hepatic encephalopathy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| CN1304723A (zh) * | 2001-01-16 | 2001-07-25 | 中山大学 | 含二氢呋喃环结构的丹参酮类化合物用于治疗肝性脑病的药物 |
| SI2153870T1 (sl) * | 2004-11-26 | 2014-05-30 | Ucl Business Plc | Sestavki, ki obsegajo ornitin in fenilacetat ali fenilbutirat, za zdravljenje hepatitične encefalopatije |
| HUE035921T2 (en) | 2009-04-03 | 2018-05-28 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
| CN104434894A (zh) * | 2009-06-08 | 2015-03-25 | Ucl商业有限公司 | 使用l-鸟氨酸苯乙酸盐治疗门静脉高压和恢复肝功能 |
-
2016
- 2016-09-22 HK HK19100043.6A patent/HK1257679A1/zh unknown
- 2016-09-22 WO PCT/US2016/053176 patent/WO2017053613A1/en not_active Ceased
- 2016-09-22 EP EP16849626.3A patent/EP3352748A4/en not_active Withdrawn
- 2016-09-22 US US15/751,442 patent/US20200206174A1/en not_active Abandoned
- 2016-09-22 JP JP2018515468A patent/JP6989495B2/ja active Active
- 2016-09-22 AU AU2016325556A patent/AU2016325556B2/en active Active
- 2016-09-22 CA CA2998490A patent/CA2998490A1/en not_active Abandoned
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