JP2020517283A5 - - Google Patents
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- Publication number
- JP2020517283A5 JP2020517283A5 JP2019557794A JP2019557794A JP2020517283A5 JP 2020517283 A5 JP2020517283 A5 JP 2020517283A5 JP 2019557794 A JP2019557794 A JP 2019557794A JP 2019557794 A JP2019557794 A JP 2019557794A JP 2020517283 A5 JP2020517283 A5 JP 2020517283A5
- Authority
- JP
- Japan
- Prior art keywords
- tissue
- neural
- differentiation
- tissues
- pluripotent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000001519 tissue Anatomy 0.000 claims 36
- 230000001537 neural effect Effects 0.000 claims 16
- 238000000034 method Methods 0.000 claims 12
- 230000004069 differentiation Effects 0.000 claims 9
- 210000000944 nerve tissue Anatomy 0.000 claims 6
- 210000004129 prosencephalon Anatomy 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 210000001020 neural plate Anatomy 0.000 claims 2
- 230000008520 organization Effects 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 1
- 210000005155 neural progenitor cell Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17168051.5A EP3395942A1 (en) | 2017-04-25 | 2017-04-25 | Bi- or multi-differentiated organoid |
| EP17168051.5 | 2017-04-25 | ||
| PCT/EP2018/060559 WO2018197544A1 (en) | 2017-04-25 | 2018-04-25 | Bi- or multi-differentiated organoid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517283A JP2020517283A (ja) | 2020-06-18 |
| JP2020517283A5 true JP2020517283A5 (enExample) | 2021-04-30 |
| JP7248590B2 JP7248590B2 (ja) | 2023-03-29 |
Family
ID=58672346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019557794A Active JP7248590B2 (ja) | 2017-04-25 | 2018-04-25 | 二分化または多分化オルガノイド |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20210095260A1 (enExample) |
| EP (2) | EP3395942A1 (enExample) |
| JP (1) | JP7248590B2 (enExample) |
| KR (1) | KR102692498B1 (enExample) |
| CN (2) | CN110573609A (enExample) |
| AU (1) | AU2018260183B2 (enExample) |
| CA (1) | CA3061412A1 (enExample) |
| SG (1) | SG11201909470TA (enExample) |
| WO (1) | WO2018197544A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| EP3149156B1 (en) | 2014-05-28 | 2021-02-17 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| JP6804438B2 (ja) | 2014-10-17 | 2020-12-23 | チルドレンズ ホスピタル メディカル センター | 多能性幹細胞を使用するヒト小腸のｉｎ ｖｉｖｏモデル、並びにそれを作製、及び使用する方法 |
| EP4177335A1 (en) | 2016-05-05 | 2023-05-10 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
| EP3534976A4 (en) | 2016-11-04 | 2020-09-16 | Children's Hospital Medical Center | PATHOLOGICAL MODELS OF HEPATIC ORGANOIDS AND ASSOCIATED METHODS OF MANUFACTURE AND USE |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF |
| EP3609997A4 (en) | 2017-04-14 | 2021-03-03 | Children's Hospital Medical Center | COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES |
| EP3658666A4 (en) * | 2017-07-28 | 2021-04-28 | Memorial Sloan-Kettering Cancer Center | PRODUCTION OF A TOPOGRAPHICAL ORGANIZATION IN A THREE-DIMENSIONAL TISSUE CULTURE |
| EP3694603A4 (en) | 2017-10-10 | 2021-07-14 | Children's Hospital Medical Center | ESOPHAGUS TISSUE AND / OR ORGANOID COMPOSITIONS AND METHOD FOR MANUFACTURING THEREOF |
| AU2018379993A1 (en) * | 2017-12-04 | 2020-07-02 | Axosim, Inc. | Cell systems using spheroids and methods of making and using the same |
| US12379372B2 (en) | 2017-12-21 | 2025-08-05 | Children's Hospital Medical Center | Digitalized human organoids and methods of using same |
| KR102887406B1 (ko) | 2018-07-26 | 2025-11-19 | 칠드런즈 호스피탈 메디칼 센터 | 간-담도-췌장 조직 및 이를 제조하는 방법 |
| WO2020056158A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| WO2022010901A2 (en) * | 2020-07-06 | 2022-01-13 | President And Fellows Of Harvard College | Programmable organoids and methods of producing the same via orthogonal differentiation and bioprinting |
| JP7726489B2 (ja) * | 2021-01-15 | 2025-08-20 | 国立大学法人 東京大学 | 神経回路組織の神経活動の観察装置およびこれを用いた物質のスクリーニング方法 |
| DE102021132190A1 (de) * | 2021-12-07 | 2023-06-22 | Eberhard Karls Universität Tübingen, Körperschaft des öffentlichen Rechts | Biokompatible Strukturen zur Verbindung und Kultivierung von biologischem Material |
| HUP2200189A2 (hu) * | 2022-05-30 | 2023-12-28 | Biotalentum Tudasfejlesztoe Kft | Új, riportert stabilan expresszáló humán indukált pluripotens õssejt |
| EP4286513A1 (en) | 2022-06-03 | 2023-12-06 | IMBA-Institut für Molekulare Biotechnologie GmbH | Triple tissue culture fusion |
| CN116129193B (zh) * | 2023-02-27 | 2024-06-11 | 重庆大学附属肿瘤医院 | 一种类器官生长预测方法、系统及设备 |
| CN118530833B (zh) * | 2024-04-02 | 2024-11-29 | 武汉大学 | 一种同步共分化的多组织或多类器官模型及其构建方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
| DE10003521A1 (de) | 2000-01-27 | 2001-08-09 | Medigene Ag | Vorrichtung zum Herstellen eines dreidimensionalen Matrixkörpers, Multi-Well-Platte, Lösung zum Kultivieren von Säugerkardiomyocyten, Verfahren zum Kultivieren einer Zellkultur, Vorrichtung für die Messung isometrischer Kraftparameter von Zellkulturen sowie Verfahren zum meßbaren Verfolgen von Kontraktionen eines in eine Trägersubstanz eingelagerten Zellgewebes |
| ATE438708T1 (de) | 2001-11-15 | 2009-08-15 | Childrens Medical Center | Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon |
| US20060263336A1 (en) | 2003-03-24 | 2006-11-23 | Caplan Arnold I | Cell targeting methods and compositions |
| WO2009023246A2 (en) | 2007-08-14 | 2009-02-19 | Wake Forest University Health Sciences | Pluripotent adult stem cells |
| EP2028268A1 (en) * | 2007-08-20 | 2009-02-25 | Université Libre De Bruxelles | Generation of neuronal cells from pluripotent stem cells |
| US20110143433A1 (en) | 2008-03-17 | 2011-06-16 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
| WO2011055855A1 (en) * | 2009-11-05 | 2011-05-12 | Riken | A method for differentiation induction in cultured stem cells |
| WO2012013936A1 (en) * | 2010-07-30 | 2012-02-02 | Cambridge Enterprise Limited | Corticogenesis of human pluripotent cells |
| JP6470687B2 (ja) * | 2012-09-03 | 2019-02-13 | ノヴォ ノルディスク アー／エス | 小分子を用いた多能性幹細胞からの膵臓内胚葉の作製 |
| EP2743345A1 (en) | 2012-12-13 | 2014-06-18 | IMBA-Institut für Molekulare Biotechnologie GmbH | Three dimensional heterogeneously differentiated tissue culture |
| KR101381798B1 (ko) * | 2013-02-27 | 2014-04-07 | 씨제이제일제당 (주) | 신규 박테리오파지 및 이를 포함하는 항균 조성물 |
| US9677085B2 (en) * | 2013-03-18 | 2017-06-13 | Massachusetts Institute Of Technology | Engineering a heterogeneous tissue from pluripotent stem cells |
| EP3498824A1 (en) * | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
| US10794802B2 (en) * | 2013-09-20 | 2020-10-06 | California Institute Of Technology | Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high resolution intact circuit mapping and phenotyping |
| WO2015069736A1 (en) * | 2013-11-08 | 2015-05-14 | The Mclean Hospital Corporation | METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS |
| MY188836A (en) * | 2013-11-22 | 2022-01-07 | Sumitomo Chemical Co | Method for manufacturing telencephalon or progenitor tissue thereof |
| US10081792B2 (en) * | 2014-12-31 | 2018-09-25 | Wisconsin Alumni Research Foundation | Derivation of human microglia from pluripotent stem cells |
| JP6807853B2 (ja) * | 2015-03-03 | 2021-01-06 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 機能的ヒト組織の作製方法 |
| US10087417B2 (en) * | 2015-04-22 | 2018-10-02 | William J. Freed | Three-dimensional model of human cortex |
| US10081791B2 (en) * | 2015-05-07 | 2018-09-25 | William J. Freed | Modeling connections between dopaminergic neurons and the cerebral cortex |
| LU92845B1 (en) * | 2015-10-08 | 2017-05-02 | Univ Du Luxembourg Campus Belval | Means and methods for generating midbrain organoids |
| WO2017083705A1 (en) * | 2015-11-13 | 2017-05-18 | The Johns Hopkins University | Cell culture system and method of use thereof |
| WO2017117547A1 (en) * | 2015-12-31 | 2017-07-06 | President And Fellows Of Harvard College | Methods for generating neural tissue and uses thereof |
| SG11201807487WA (en) * | 2016-03-14 | 2018-09-27 | Agency Science Tech & Res | Generation of midbrain-specific organoids from human pluripotent stem cells |
| FR3058892B1 (fr) * | 2016-11-23 | 2021-04-09 | Univ Bordeaux | Unite de tissu neural et utilisation d'une telle unite pour l'implantation dans le systeme nerveux d'un mammifere |
| US10676715B2 (en) * | 2017-03-28 | 2020-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Assembly of functionally integrated human forebrain spheroids and methods of use thereof |
| US20200017606A1 (en) * | 2017-03-29 | 2020-01-16 | Eastman Chemical Company | Regioselectively substituted cellulose esters |
| GB201900930D0 (en) * | 2019-01-23 | 2019-03-13 | Res & Innovation Uk | Choroid plexus organoids and methods for productions thereof |
| EP3976796A4 (en) * | 2019-06-03 | 2023-05-03 | The Regents of the University of California | PIFITHRIN ANALOGS AND METHODS OF TREATMENT OF RETT SYNDROME |
-
2017
- 2017-04-25 EP EP17168051.5A patent/EP3395942A1/en not_active Withdrawn
-
2018
- 2018-04-25 KR KR1020197034778A patent/KR102692498B1/ko active Active
- 2018-04-25 WO PCT/EP2018/060559 patent/WO2018197544A1/en not_active Ceased
- 2018-04-25 CN CN201880027801.3A patent/CN110573609A/zh active Pending
- 2018-04-25 SG SG11201909470T patent/SG11201909470TA/en unknown
- 2018-04-25 AU AU2018260183A patent/AU2018260183B2/en active Active
- 2018-04-25 CA CA3061412A patent/CA3061412A1/en active Pending
- 2018-04-25 CN CN202411042018.8A patent/CN119101651A/zh active Pending
- 2018-04-25 EP EP18720229.6A patent/EP3615661A1/en active Pending
- 2018-04-25 US US16/608,719 patent/US20210095260A1/en active Pending
- 2018-04-25 JP JP2019557794A patent/JP7248590B2/ja active Active
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