JP2020516659A5 - - Google Patents
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- Publication number
- JP2020516659A5 JP2020516659A5 JP2019555961A JP2019555961A JP2020516659A5 JP 2020516659 A5 JP2020516659 A5 JP 2020516659A5 JP 2019555961 A JP2019555961 A JP 2019555961A JP 2019555961 A JP2019555961 A JP 2019555961A JP 2020516659 A5 JP2020516659 A5 JP 2020516659A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- pharmaceutically acceptable
- case
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *[n]1ncc(Nc2nc(-c3cc(CN(*)CC[C@]4NC(C5=CC=CC=CC=CC=CC5)=O)c4cc3)ccn2)c1 Chemical compound *[n]1ncc(Nc2nc(-c3cc(CN(*)CC[C@]4NC(C5=CC=CC=CC=CC=CC5)=O)c4cc3)ccn2)c1 0.000 description 3
- BRFXPABSZCKBGA-LWUPDDLQSA-N CC(C)(C)N(/C=C(/C(N[C@H](CCN(C1)C2COC2)c(cc2)c1cc2-c1ccnc(Nc2c[n](C)nc2)n1)=O)\N)N Chemical compound CC(C)(C)N(/C=C(/C(N[C@H](CCN(C1)C2COC2)c(cc2)c1cc2-c1ccnc(Nc2c[n](C)nc2)n1)=O)\N)N BRFXPABSZCKBGA-LWUPDDLQSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022148866A JP7581294B2 (ja) | 2017-04-14 | 2022-09-20 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
| JP2024190472A JP7778206B2 (ja) | 2017-04-14 | 2024-10-30 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762485745P | 2017-04-14 | 2017-04-14 | |
| US62/485,745 | 2017-04-14 | ||
| PCT/US2018/027415 WO2018191577A1 (en) | 2017-04-14 | 2018-04-13 | Benzoazepine analogs as inhibiting agents for bruton's tyrosine kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022148866A Division JP7581294B2 (ja) | 2017-04-14 | 2022-09-20 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020516659A JP2020516659A (ja) | 2020-06-11 |
| JP2020516659A5 true JP2020516659A5 (https=) | 2021-05-27 |
| JP7145874B2 JP7145874B2 (ja) | 2022-10-03 |
Family
ID=62092333
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019555961A Active JP7145874B2 (ja) | 2017-04-14 | 2018-04-13 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
| JP2022148866A Active JP7581294B2 (ja) | 2017-04-14 | 2022-09-20 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
| JP2024190472A Active JP7778206B2 (ja) | 2017-04-14 | 2024-10-30 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022148866A Active JP7581294B2 (ja) | 2017-04-14 | 2022-09-20 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
| JP2024190472A Active JP7778206B2 (ja) | 2017-04-14 | 2024-10-30 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
Country Status (36)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3080103B9 (en) | 2013-12-11 | 2018-09-19 | Biogen MA Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| JP7145874B2 (ja) | 2017-04-14 | 2022-10-03 | バイオジェン・エムエイ・インコーポレイテッド | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
| EP3866926A1 (en) * | 2018-10-15 | 2021-08-25 | Biogen MA Inc. | Crystalline polymorphs of bruton's tyrosine kinase inhibitors |
| WO2020232330A1 (en) * | 2019-05-15 | 2020-11-19 | Biogen Ma Inc. | Inhibiting agents for bruton's tyrosine kinase |
| US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| US20240216330A1 (en) * | 2021-04-02 | 2024-07-04 | Biogen Ma Inc. | Combination treatment methods of multiple sclerosis |
| EP4429770A1 (en) | 2021-11-10 | 2024-09-18 | Biogen MA Inc. | Btk inhibitors |
| AU2022424178A1 (en) | 2021-12-30 | 2024-07-11 | Beone Medicines I Gmbh | Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use |
| JP7805983B2 (ja) | 2022-03-22 | 2026-01-26 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
| WO2024245577A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor |
| WO2024245578A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| EP2125819B1 (en) | 2007-03-21 | 2014-10-22 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases |
| BRPI0817503B8 (pt) | 2007-10-05 | 2021-05-25 | Sstarbio Pte Ltd | derivados de purina substituídos por pirimidina, composição farmacêutica compreendendo ditos compostos e uso dos mesmos para a prevenção ou tratamento de uma condição proliferativa |
| US20110009421A1 (en) | 2008-02-27 | 2011-01-13 | Takeda Pharmaceutical Company Limited | Compound having 6-membered aromatic ring |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| TWI546290B (zh) | 2008-06-27 | 2016-08-21 | 賽基艾維洛米斯研究股份有限公司 | 雜芳基化合物及其用途 |
| PT2473049T (pt) * | 2009-09-04 | 2019-03-04 | Sunesis Pharmaceuticals Inc | Inibidores de tirosina quinase de bruton |
| US8334292B1 (en) | 2010-06-14 | 2012-12-18 | Cystic Fibrosis Foundation Therapeutics, Inc. | Pyrimidine compounds and methods of making and using same |
| BR112014001255B1 (pt) | 2011-07-19 | 2019-07-02 | Merck Sharp & Dohme B.V. | Composto, uso de um composto, combinação, composição farmacêutica, e, sal farmaceuticamente aceitável de um composto |
| TWI648274B (zh) * | 2013-02-15 | 2019-01-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類 （二） |
| WO2014130856A2 (en) | 2013-02-21 | 2014-08-28 | Wayne Rothbaum | Treatment of skeletal-related disorders |
| BR112016008632A8 (pt) | 2013-10-21 | 2020-03-17 | Merck Patent Gmbh | compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica |
| EP3080103B9 (en) | 2013-12-11 | 2018-09-19 | Biogen MA Inc. | Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology |
| ES2907622T3 (es) * | 2014-10-06 | 2022-04-25 | Merck Patent Gmbh | Compuestos de heteroarilo como inhibidores de BTK y usos de estos |
| JP7145874B2 (ja) | 2017-04-14 | 2022-10-03 | バイオジェン・エムエイ・インコーポレイテッド | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
-
2018
- 2018-04-13 JP JP2019555961A patent/JP7145874B2/ja active Active
- 2018-04-13 KR KR1020237040706A patent/KR102862996B1/ko active Active
- 2018-04-13 IL IL294175A patent/IL294175B2/en unknown
- 2018-04-13 PE PE2024000228A patent/PE20240930A1/es unknown
- 2018-04-13 MD MDE20200193T patent/MD3609886T2/ro unknown
- 2018-04-13 FI FIEP18721632.0T patent/FI3609886T3/fi active
- 2018-04-13 RS RS20240419A patent/RS65386B1/sr unknown
- 2018-04-13 CR CR20190517A patent/CR20190517A/es unknown
- 2018-04-13 EP EP23187919.8A patent/EP4249071A3/en active Pending
- 2018-04-13 US US15/952,505 patent/US10227341B2/en active Active
- 2018-04-13 IL IL316713A patent/IL316713A/en unknown
- 2018-04-13 TW TW107112785A patent/TWI790227B/zh active
- 2018-04-13 SG SG11201909224Q patent/SG11201909224QA/en unknown
- 2018-04-13 PT PT187216320T patent/PT3609886T/pt unknown
- 2018-04-13 UA UAA201911128A patent/UA127347C2/uk unknown
- 2018-04-13 DK DK18721632.0T patent/DK3609886T3/da active
- 2018-04-13 EA EA201992354A patent/EA201992354A1/ru unknown
- 2018-04-13 KR KR1020197032715A patent/KR102607900B1/ko active Active
- 2018-04-13 CA CA3058774A patent/CA3058774A1/en active Pending
- 2018-04-13 JO JOJO/P/2019/0233A patent/JOP20190233B1/ar active
- 2018-04-13 PL PL18721632.0T patent/PL3609886T3/pl unknown
- 2018-04-13 HU HUE18721632A patent/HUE066253T2/hu unknown
- 2018-04-13 ES ES18721632T patent/ES2975769T3/es active Active
- 2018-04-13 SI SI201831083T patent/SI3609886T1/sl unknown
- 2018-04-13 WO PCT/US2018/027415 patent/WO2018191577A1/en not_active Ceased
- 2018-04-13 TW TW111149550A patent/TWI846229B/zh active
- 2018-04-13 CN CN201880031744.6A patent/CN110621670B/zh active Active
- 2018-04-13 KR KR1020257031163A patent/KR20250140646A/ko active Pending
- 2018-04-13 EP EP18721632.0A patent/EP3609886B1/en active Active
- 2018-04-13 HR HRP20240361TT patent/HRP20240361T1/hr unknown
- 2018-04-13 AU AU2018253209A patent/AU2018253209B2/en active Active
- 2018-04-13 AR ARP180100935A patent/AR111594A1/es not_active Application Discontinuation
- 2018-04-13 IL IL269933A patent/IL269933B/en unknown
- 2018-04-13 CN CN202311088635.7A patent/CN117567453A/zh active Pending
- 2018-04-13 SM SM20240166T patent/SMT202400166T1/it unknown
- 2018-04-13 MA MA50013A patent/MA50013B1/fr unknown
- 2018-04-13 PE PE2019002016A patent/PE20200740A1/es unknown
- 2018-04-13 LT LTEPPCT/US2018/027415T patent/LT3609886T/lt unknown
- 2018-08-27 US US16/113,455 patent/US10189829B2/en active Active
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2019
- 2019-04-13 CR CR20230539A patent/CR20230539A/es unknown
- 2019-08-07 US US16/534,540 patent/US10961237B2/en active Active
- 2019-10-10 SA SA519410292A patent/SA519410292B1/ar unknown
- 2019-10-11 CL CL2019002900A patent/CL2019002900A1/es unknown
- 2019-10-11 MX MX2023000812A patent/MX2023000812A/es unknown
- 2019-10-14 PH PH12019502334A patent/PH12019502334A1/en unknown
- 2019-11-12 CO CONC2019/0012571A patent/CO2019012571A2/es unknown
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2021
- 2021-02-24 US US17/183,702 patent/US11427577B2/en active Active
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2022
- 2022-07-22 US US17/871,157 patent/US11858926B2/en active Active
- 2022-08-18 AU AU2022218560A patent/AU2022218560B2/en active Active
- 2022-09-20 JP JP2022148866A patent/JP7581294B2/ja active Active
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2023
- 2023-06-12 ZA ZA2023/06172A patent/ZA202306172B/en unknown
- 2023-06-15 AR ARP230101541A patent/AR129632A2/es unknown
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2024
- 2024-06-20 AU AU2024204241A patent/AU2024204241A1/en active Pending
- 2024-10-30 JP JP2024190472A patent/JP7778206B2/ja active Active
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