JP2020516314A5 - - Google Patents
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- Publication number
- JP2020516314A5 JP2020516314A5 JP2020504454A JP2020504454A JP2020516314A5 JP 2020516314 A5 JP2020516314 A5 JP 2020516314A5 JP 2020504454 A JP2020504454 A JP 2020504454A JP 2020504454 A JP2020504454 A JP 2020504454A JP 2020516314 A5 JP2020516314 A5 JP 2020516314A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- polypeptide
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 60
- 125000003275 alpha amino acid group Chemical group 0.000 claims 30
- 229920001184 polypeptide Polymers 0.000 claims 26
- 102000004196 processed proteins & peptides Human genes 0.000 claims 26
- 238000000034 method Methods 0.000 claims 15
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 13
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 239000007787 solid Substances 0.000 claims 10
- 239000000758 substrate Substances 0.000 claims 10
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 8
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 8
- 241000700605 Viruses Species 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 7
- 150000004676 glycans Chemical class 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- 239000002105 nanoparticle Substances 0.000 claims 6
- 239000002071 nanotube Substances 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 6
- 239000005017 polysaccharide Substances 0.000 claims 6
- 229920001282 polysaccharide Polymers 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- -1 small molecule organic compound Chemical class 0.000 claims 6
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 5
- 239000013598 vector Substances 0.000 claims 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
- 239000004471 Glycine Substances 0.000 claims 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 4
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 4
- 239000004474 valine Substances 0.000 claims 4
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 3
- 102000003960 Ligases Human genes 0.000 claims 3
- 108090000364 Ligases Proteins 0.000 claims 3
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 230000001268 conjugating effect Effects 0.000 claims 3
- 235000013922 glutamic acid Nutrition 0.000 claims 3
- 239000004220 glutamic acid Substances 0.000 claims 3
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Chemical group OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 229940024606 amino acid Drugs 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1705750.6 | 2017-04-10 | ||
| GBGB1705750.6A GB201705750D0 (en) | 2017-04-10 | 2017-04-10 | Peptide ligase and use therof |
| PCT/GB2018/050943 WO2018189517A1 (en) | 2017-04-10 | 2018-04-10 | Peptide ligase and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020516314A JP2020516314A (ja) | 2020-06-11 |
| JP2020516314A5 true JP2020516314A5 (https=) | 2021-05-20 |
| JP7075678B2 JP7075678B2 (ja) | 2022-05-26 |
Family
ID=58744859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020504454A Active JP7075678B2 (ja) | 2017-04-10 | 2018-04-10 | ペプチドリガーゼ及びその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10889622B2 (https=) |
| EP (1) | EP3610005B1 (https=) |
| JP (1) | JP7075678B2 (https=) |
| KR (1) | KR102669378B1 (https=) |
| CN (2) | CN110582566B (https=) |
| AU (1) | AU2018251237B2 (https=) |
| BR (1) | BR112019021009A2 (https=) |
| CA (1) | CA3059132A1 (https=) |
| DK (1) | DK3610005T3 (https=) |
| ES (1) | ES2900612T3 (https=) |
| GB (1) | GB201705750D0 (https=) |
| WO (1) | WO2018189517A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3774926A1 (en) | 2018-04-05 | 2021-02-17 | Bio-Rad ABD Serotec GmbH | Display systems for proteins of interest |
| CN112638411B (zh) | 2018-05-04 | 2025-03-04 | 斯拜生物技术有限公司 | 疫苗组合物 |
| GB201819850D0 (en) | 2018-12-05 | 2019-01-23 | Univ Oxford Innovation Ltd | Polypeptide and its use in affinity purification |
| GB201903479D0 (en) | 2019-03-14 | 2019-05-01 | Univ Oxford Innovation Ltd | Polypeptide with enchanced rate of spontaneous isopeptide bond formation with it's peptide tag partner and uses thereof |
| EP3942079A1 (en) | 2019-03-18 | 2022-01-26 | Bio-Rad ABD Serotec GmbH | Protection of spytag-containing periplasmic fusion proteins from protease tsp and ompt degradation |
| GB201915905D0 (en) | 2019-11-01 | 2019-12-18 | Spybiotech Ltd | Viruses with modified capsid proteins |
| US12298314B2 (en) | 2020-10-09 | 2025-05-13 | 10X Genomics, Inc. | Methods and compositions for analyzing target binding of molecules |
| WO2022076914A1 (en) | 2020-10-09 | 2022-04-14 | 10X Genomics, Inc. | Methods and compositions for profiling immune repertoire |
| GB202019817D0 (en) | 2020-12-15 | 2021-01-27 | Univ Oxford Innovation Ltd | Ligand-binding polypeptides and uses thereof |
| CN112877347B (zh) * | 2021-01-28 | 2023-02-17 | 华南理工大学 | 一种多酶复合体及其构建方法和应用 |
| GB202104104D0 (en) | 2021-03-24 | 2021-05-05 | Liliumx Ltd | Platform and method |
| GB202104999D0 (en) * | 2021-04-08 | 2021-05-26 | Univ Oxford Innovation Ltd | Polypeptides that interact with peptide tags at loops or termini and uses thereof |
| US20240240203A1 (en) | 2021-05-04 | 2024-07-18 | SpyBiotech Limited | Adenoviral vectors and vaccines thereof |
| GB202106361D0 (en) | 2021-05-04 | 2021-06-16 | Spybiotech Ltd | Viral vectored vaccines |
| GB202117283D0 (en) | 2021-11-30 | 2022-01-12 | Univ Oxford Innovation Ltd | Switchable polypeptide and its use for gentle affinity purification |
| US12043862B2 (en) | 2021-12-28 | 2024-07-23 | Encodia, Inc. | High-throughput serotyping and antibody profiling assays |
| JP2025534309A (ja) | 2022-09-28 | 2025-10-15 | ヴァリンク セラピューティクス リミテッド | 多価タンパク質およびスクリーニング法 |
| GB202306808D0 (en) | 2023-05-09 | 2023-06-21 | Univ Oxford Innovation Ltd | Method for detecting interactions |
| GB202313175D0 (en) | 2023-08-30 | 2023-10-11 | Univ Oxford Innovation Ltd | A bivalent polypeptide scaffold and uses thereof |
| TW202528546A (zh) | 2023-09-07 | 2025-07-16 | 美商再生元醫藥公司 | 經共價表面修飾之腺相關病毒的生產及純化 |
| WO2025083285A1 (en) | 2023-10-20 | 2025-04-24 | Norwegian University Of Science And Technology (Ntnu) | Methods and products for use in genome-wide chromatin profiling |
| TW202540433A (zh) | 2023-11-21 | 2025-10-16 | 美商再生元醫藥公司 | 藉由活體外接合產生共價表面修飾之腺相關病毒及共價表面修飾的腺相關病毒之純化 |
| GB202317925D0 (en) | 2023-11-23 | 2024-01-10 | Spybiotech Ltd | Vaccines |
| WO2025250838A1 (en) * | 2024-05-31 | 2025-12-04 | University Of Washington | Boolean logic-gated protein presentation via autonomously compiled molecular topology |
| WO2026050618A1 (en) | 2024-08-29 | 2026-03-05 | Regeneron Pharmaceuticals, Inc. | Polynucleotide constructs and cell lines for recombinant aav production |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE414775T1 (de) * | 1997-05-16 | 2008-12-15 | Novozymes Inc | Polypeptide mit prolyldipeptidylaminopeptidase- aktivität und dafür kodierende nukleinsäuren |
| GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| CN103897045A (zh) | 2009-01-12 | 2014-07-02 | 诺华股份有限公司 | 抗革兰氏阳性细菌疫苗中的Cna_B结构域 |
| GB201002362D0 (en) * | 2010-02-11 | 2010-03-31 | Isis Innovation | Peptide tag systems that spontaneously form an irreversible link to protein partners via isopeptide bonds |
| WO2013124473A1 (en) * | 2012-02-24 | 2013-08-29 | Novartis Ag | Pilus proteins and compositions |
| WO2015185592A2 (en) * | 2014-06-03 | 2015-12-10 | Dsm Ip Assets B.V. | Proline-specific endoprotease and use thereof |
| DK3152304T3 (da) * | 2014-06-03 | 2019-10-14 | Dsm Ip Assets Bv | Prolinspecifik endoprotease og anvendelse deraf |
| WO2016112921A1 (en) | 2015-01-15 | 2016-07-21 | University Of Copenhagen | Virus-like particle with efficient epitope display |
| GB201509782D0 (en) * | 2015-06-05 | 2015-07-22 | Isis Innovation | Methods and products for fusion protein synthesis |
-
2017
- 2017-04-10 GB GBGB1705750.6A patent/GB201705750D0/en not_active Ceased
-
2018
- 2018-04-10 AU AU2018251237A patent/AU2018251237B2/en active Active
- 2018-04-10 KR KR1020197030655A patent/KR102669378B1/ko active Active
- 2018-04-10 DK DK18719246.3T patent/DK3610005T3/da active
- 2018-04-10 CN CN201880024247.3A patent/CN110582566B/zh active Active
- 2018-04-10 CN CN202410483896.7A patent/CN118389457A/zh active Pending
- 2018-04-10 WO PCT/GB2018/050943 patent/WO2018189517A1/en not_active Ceased
- 2018-04-10 ES ES18719246T patent/ES2900612T3/es active Active
- 2018-04-10 BR BR112019021009A patent/BR112019021009A2/pt unknown
- 2018-04-10 EP EP18719246.3A patent/EP3610005B1/en active Active
- 2018-04-10 US US16/603,850 patent/US10889622B2/en active Active
- 2018-04-10 JP JP2020504454A patent/JP7075678B2/ja active Active
- 2018-04-10 CA CA3059132A patent/CA3059132A1/en active Pending
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