JP2020515280A5 - - Google Patents
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- JP2020515280A5 JP2020515280A5 JP2019554692A JP2019554692A JP2020515280A5 JP 2020515280 A5 JP2020515280 A5 JP 2020515280A5 JP 2019554692 A JP2019554692 A JP 2019554692A JP 2019554692 A JP2019554692 A JP 2019554692A JP 2020515280 A5 JP2020515280 A5 JP 2020515280A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- amino acid
- nanostructure
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001184 polypeptide Polymers 0.000 claims 70
- 102000004196 processed proteins & peptides Human genes 0.000 claims 70
- 108090000765 processed proteins & peptides Proteins 0.000 claims 70
- 239000002086 nanomaterial Substances 0.000 claims 25
- 125000003275 alpha amino acid group Chemical group 0.000 claims 20
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 17
- 108020001507 fusion proteins Proteins 0.000 claims 13
- 102000037865 fusion proteins Human genes 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 11
- 241000711902 Pneumovirus Species 0.000 claims 9
- 230000002163 immunogen Effects 0.000 claims 7
- 230000000712 assembly Effects 0.000 claims 5
- 238000000429 assembly Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 230000003472 neutralizing effect Effects 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 3
- 238000003259 recombinant expression Methods 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000351643 Metapneumovirus Species 0.000 claims 1
- 208000004692 Pneumovirus Infections Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 229960000789 guanidine hydrochloride Drugs 0.000 claims 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000005829 trimerization reaction Methods 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022167524A JP7541701B2 (ja) | 2017-04-04 | 2022-10-19 | パラミクソウイルスおよび／またはニューモウイルスのｆタンパク質を表示する自己アセンブリするタンパク質ナノ構造およびその使用 |
| JP2024132065A JP2024160321A (ja) | 2017-04-04 | 2024-08-08 | パラミクソウイルスおよび／またはニューモウイルスのｆタンパク質を表示する自己アセンブリするタンパク質ナノ構造およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762481331P | 2017-04-04 | 2017-04-04 | |
| US62/481,331 | 2017-04-04 | ||
| PCT/US2018/025880 WO2018187325A1 (en) | 2017-04-04 | 2018-04-03 | Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus f proteins and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022167524A Division JP7541701B2 (ja) | 2017-04-04 | 2022-10-19 | パラミクソウイルスおよび／またはニューモウイルスのｆタンパク質を表示する自己アセンブリするタンパク質ナノ構造およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515280A JP2020515280A (ja) | 2020-05-28 |
| JP2020515280A5 true JP2020515280A5 (enExample) | 2021-05-06 |
| JP7168938B2 JP7168938B2 (ja) | 2022-11-10 |
Family
ID=62116943
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019554692A Active JP7168938B2 (ja) | 2017-04-04 | 2018-04-03 | パラミクソウイルスおよび／またはニューモウイルスのｆタンパク質を表示する自己アセンブリするタンパク質ナノ構造およびその使用 |
| JP2022167524A Active JP7541701B2 (ja) | 2017-04-04 | 2022-10-19 | パラミクソウイルスおよび／またはニューモウイルスのｆタンパク質を表示する自己アセンブリするタンパク質ナノ構造およびその使用 |
| JP2024132065A Pending JP2024160321A (ja) | 2017-04-04 | 2024-08-08 | パラミクソウイルスおよび／またはニューモウイルスのｆタンパク質を表示する自己アセンブリするタンパク質ナノ構造およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022167524A Active JP7541701B2 (ja) | 2017-04-04 | 2022-10-19 | パラミクソウイルスおよび／またはニューモウイルスのｆタンパク質を表示する自己アセンブリするタンパク質ナノ構造およびその使用 |
| JP2024132065A Pending JP2024160321A (ja) | 2017-04-04 | 2024-08-08 | パラミクソウイルスおよび／またはニューモウイルスのｆタンパク質を表示する自己アセンブリするタンパク質ナノ構造およびその使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US11192926B2 (enExample) |
| EP (2) | EP4559869A3 (enExample) |
| JP (3) | JP7168938B2 (enExample) |
| KR (2) | KR20240161683A (enExample) |
| CN (3) | CN110603262A (enExample) |
| AU (3) | AU2018249533C1 (enExample) |
| BR (1) | BR112019020661A2 (enExample) |
| CA (1) | CA3058794A1 (enExample) |
| DK (1) | DK3606942T3 (enExample) |
| ES (1) | ES3040563T3 (enExample) |
| FI (1) | FI3606942T3 (enExample) |
| HR (1) | HRP20251060T1 (enExample) |
| IL (2) | IL322023A (enExample) |
| LT (1) | LT3606942T (enExample) |
| MX (2) | MX2019011869A (enExample) |
| PH (1) | PH12019502276A1 (enExample) |
| PL (1) | PL3606942T3 (enExample) |
| PT (1) | PT3606942T (enExample) |
| RS (1) | RS67190B1 (enExample) |
| SG (1) | SG11201908999QA (enExample) |
| SI (1) | SI3606942T1 (enExample) |
| SM (1) | SMT202500317T1 (enExample) |
| WO (1) | WO2018187325A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9630994B2 (en) * | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| LT3606942T (lt) | 2017-04-04 | 2025-10-10 | Savaiminės sąrankos baltymų nanostruktūros, eksponuojančios paramiksoviruso ir (arba) pneumoviruso f baltymus ir jų naudojimas | |
| US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
| AU2019228551B2 (en) | 2018-02-28 | 2025-07-24 | University Of Washington | Self-assembling nanostructure vaccines |
| CN113423718A (zh) | 2019-02-08 | 2021-09-21 | 美国政府(由卫生和人类服务部的部长所代表) | 基于纳米颗粒的流感病毒疫苗及其用途 |
| US20220306697A1 (en) * | 2019-09-04 | 2022-09-29 | University Of Washington | Self-Assembling Protein Nanostructures Displaying Paramyxovirus and/or Pneumovirus F Proteins and Their Use |
| CN110878128A (zh) * | 2019-11-04 | 2020-03-13 | 中国疾病预防控制中心病毒病预防控制所 | 一种人呼吸道合胞病毒粘膜疫苗及其制备方法和应用 |
| EP4096683A4 (en) * | 2020-01-30 | 2024-04-10 | ModernaTX, Inc. | IMMUNIZATION COMPOSITIONS FOR RESPIRATORY VIRUSES |
| US20240277831A1 (en) * | 2020-02-14 | 2024-08-22 | University Of Washington | Polypeptides, compositions, and their use to treat or limit development of an infection |
| WO2021163481A1 (en) * | 2020-02-14 | 2021-08-19 | University Of Washington | Polypeptides and their use |
| KR20230038465A (ko) * | 2020-06-09 | 2023-03-20 | 아이코사백스, 인크. | 2성분 바이러스 유사 입자를 조립하는 방법 |
| CN116194460A (zh) * | 2020-06-09 | 2023-05-30 | Icosavax股份有限公司 | 制备病毒样颗粒的方法 |
| IL320367A (en) | 2020-10-09 | 2025-06-01 | Univ Texas | Prefusion-stabilized hmpv f proteins |
| CN111991556B (zh) * | 2020-10-29 | 2021-03-02 | 中山大学 | SARS-CoV-2 RBD共轭纳米颗粒疫苗 |
| WO2022103967A1 (en) | 2020-11-13 | 2022-05-19 | Icosavax, Inc. | Protein-based nanoparticle vaccine for metapneumovirus |
| CN112778404B (zh) * | 2021-01-28 | 2022-11-29 | 中山大学 | 一种含EB病毒gHgL蛋白的自组装纳米颗粒及其制备方法与应用 |
| EP4384535A4 (en) * | 2021-08-10 | 2025-06-25 | Icosavax, Inc. | Virus-like particle vaccine for respiratory syncytial virus |
| WO2023225562A1 (en) | 2022-05-17 | 2023-11-23 | Icosavax, Inc. | Multivalent vaccine for paramyxoviruses and uses thereof |
| JP2025539418A (ja) * | 2022-11-29 | 2025-12-05 | ザ スクリプス リサーチ インスティテュート | 新規ナノ粒子足場を含有するワクチン |
| WO2024131862A1 (zh) * | 2022-12-22 | 2024-06-27 | 北京吉诺卫生物科技有限公司 | 一种rsv疫苗及其制备方法与应用 |
| CN118108812B (zh) * | 2023-05-04 | 2025-04-15 | 国药中生生物技术研究院有限公司 | Rsv f蛋白的突变体 |
| TW202519273A (zh) * | 2023-07-18 | 2025-05-16 | 瑞典商阿斯特捷利康公司 | Rsv疫苗 |
| CN119930762A (zh) * | 2023-11-03 | 2025-05-06 | 广东蓝玉生物科技有限公司 | 非洲猪瘟病毒ep153r蛋白的免疫原性组合物及其应用 |
| WO2025093041A1 (zh) * | 2023-11-03 | 2025-05-08 | 广东蓝玉生物科技有限公司 | 非洲猪瘟病毒CD2v蛋白的免疫原性组合物及其应用 |
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-
2018
- 2018-04-03 LT LTEPPCT/US2018/025880T patent/LT3606942T/lt unknown
- 2018-04-03 RS RS20250807A patent/RS67190B1/sr unknown
- 2018-04-03 IL IL322023A patent/IL322023A/en unknown
- 2018-04-03 CN CN201880023734.8A patent/CN110603262A/zh active Pending
- 2018-04-03 EP EP25152898.0A patent/EP4559869A3/en active Pending
- 2018-04-03 SM SM20250317T patent/SMT202500317T1/it unknown
- 2018-04-03 CN CN202310044111.1A patent/CN115779077A/zh active Pending
- 2018-04-03 KR KR1020247035024A patent/KR20240161683A/ko active Pending
- 2018-04-03 SI SI201831259T patent/SI3606942T1/sl unknown
- 2018-04-03 SG SG11201908999Q patent/SG11201908999QA/en unknown
- 2018-04-03 JP JP2019554692A patent/JP7168938B2/ja active Active
- 2018-04-03 EP EP18723094.1A patent/EP3606942B1/en active Active
- 2018-04-03 US US16/500,331 patent/US11192926B2/en active Active
- 2018-04-03 MX MX2019011869A patent/MX2019011869A/es unknown
- 2018-04-03 AU AU2018249533A patent/AU2018249533C1/en active Active
- 2018-04-03 CN CN202310044118.3A patent/CN115947873A/zh active Pending
- 2018-04-03 PL PL18723094.1T patent/PL3606942T3/pl unknown
- 2018-04-03 HR HRP20251060TT patent/HRP20251060T1/hr unknown
- 2018-04-03 DK DK18723094.1T patent/DK3606942T3/da active
- 2018-04-03 BR BR112019020661-2A patent/BR112019020661A2/pt unknown
- 2018-04-03 PT PT187230941T patent/PT3606942T/pt unknown
- 2018-04-03 KR KR1020197029815A patent/KR102774312B1/ko active Active
- 2018-04-03 CA CA3058794A patent/CA3058794A1/en active Pending
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- 2018-04-03 FI FIEP18723094.1T patent/FI3606942T3/fi active
- 2018-04-03 WO PCT/US2018/025880 patent/WO2018187325A1/en not_active Ceased
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2019
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- 2019-10-02 MX MX2023004704A patent/MX2023004704A/es unknown
- 2019-10-02 PH PH12019502276A patent/PH12019502276A1/en unknown
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2021
- 2021-11-10 US US17/523,174 patent/US11732011B2/en active Active
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2022
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2023
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2024
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2025
- 2025-03-12 US US19/077,674 patent/US20250263445A1/en active Pending
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