JP2020514361A - 9,10,11,12−テトラヒドロ−8h−[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2−f]キノリン−8−オン化合物およびその使用 - Google Patents
9,10,11,12−テトラヒドロ−8h−[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2−f]キノリン−8−オン化合物およびその使用 Download PDFInfo
- Publication number
- JP2020514361A JP2020514361A JP2019550659A JP2019550659A JP2020514361A JP 2020514361 A JP2020514361 A JP 2020514361A JP 2019550659 A JP2019550659 A JP 2019550659A JP 2019550659 A JP2019550659 A JP 2019550659A JP 2020514361 A JP2020514361 A JP 2020514361A
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- Japan
- Prior art keywords
- compound
- aliphatic
- nitrogen
- optionally substituted
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PYOQIOLRFIRRSO-NSHDSACASA-N CCOCc(c(Oc(cc1)nc(cc2)c1c1c2[s]c2c1NC[C@H](C)NC2=O)n1)cnc1Cl Chemical compound CCOCc(c(Oc(cc1)nc(cc2)c1c1c2[s]c2c1NC[C@H](C)NC2=O)n1)cnc1Cl PYOQIOLRFIRRSO-NSHDSACASA-N 0.000 description 1
- 0 Cc1cc(*)ccc1* Chemical compound Cc1cc(*)ccc1* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11024—Mitogen-activated protein kinase (2.7.11.24), i.e. MAPK or MAPK2 or c-Jun N-terminal kinase
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022200392A JP2023051962A (ja) | 2017-03-16 | 2022-12-15 | 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762472027P | 2017-03-16 | 2017-03-16 | |
| US62/472,027 | 2017-03-16 | ||
| PCT/US2018/022548 WO2018170204A1 (en) | 2017-03-16 | 2018-03-15 | 9,10,11,12-tetrahydro-8h-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one compounds and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022200392A Division JP2023051962A (ja) | 2017-03-16 | 2022-12-15 | 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020514361A true JP2020514361A (ja) | 2020-05-21 |
| JP2020514361A5 JP2020514361A5 (enExample) | 2021-04-22 |
Family
ID=63522566
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019550659A Pending JP2020514361A (ja) | 2017-03-16 | 2018-03-15 | 9,10,11,12−テトラヒドロ−8h−[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2−f]キノリン−8−オン化合物およびその使用 |
| JP2022200392A Pending JP2023051962A (ja) | 2017-03-16 | 2022-12-15 | 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022200392A Pending JP2023051962A (ja) | 2017-03-16 | 2022-12-15 | 9,10,11,12-テトラヒドロ-8h-[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2-f]キノリン-8-オン化合物およびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11098057B2 (enExample) |
| EP (1) | EP3596084A4 (enExample) |
| JP (2) | JP2020514361A (enExample) |
| WO (1) | WO2018170204A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020511468A (ja) * | 2017-03-16 | 2020-04-16 | セルジーン シーエーアール エルエルシー | Mk2阻害剤の重水素化アナログおよびその使用 |
| JP2020512315A (ja) * | 2017-03-16 | 2020-04-23 | セルジーン シーエーアール エルエルシー | Mk2阻害剤として有用なヘテロアリール化合物 |
| WO2024048697A1 (ja) * | 2022-08-31 | 2024-03-07 | 国立大学法人京都大学 | 化合物、小胞体ストレス抑制剤、医薬品、眼科用剤、点眼薬、組成物、化合物の製造方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20210529T1 (hr) | 2014-09-17 | 2021-08-06 | Celgene Car Llc | Inhibitori za mk2 i njihove uporabe |
| AU2018236290B2 (en) | 2017-03-16 | 2022-06-02 | Bristol-Myers Squibb Company | MK2 inhibitors, synthesis thereof, and intermediates thereto |
| AU2018236286B2 (en) | 2017-03-16 | 2022-02-17 | Bristol-Myers Squibb Company | Forms and compositions of a MK2 inhibitor |
| JP2020514361A (ja) | 2017-03-16 | 2020-05-21 | セルジーン シーエーアール エルエルシー | 9,10,11,12−テトラヒドロ−8h−[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2−f]キノリン−8−オン化合物およびその使用 |
| KR20220041042A (ko) * | 2019-05-17 | 2022-03-31 | 셀젠 카르 엘엘씨 | Mk2-매개 장애를 치료하는 방법 |
| US12049470B2 (en) | 2021-02-01 | 2024-07-30 | Celgene Corporation | MK2 inhibitors, the synthesis thereof, and intermediates thereto |
| WO2023025298A1 (zh) * | 2021-08-27 | 2023-03-02 | 瑞石生物医药有限公司 | 喹啉并呋喃衍生物及其用途 |
| CN115925718A (zh) * | 2022-12-27 | 2023-04-07 | 瑞石生物医药有限公司 | 一种四环内酰胺衍生物及其用途 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016044463A2 (en) * | 2014-09-17 | 2016-03-24 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
| JP2016518316A (ja) * | 2013-03-15 | 2016-06-23 | セルジーン アビロミクス リサーチ, インコーポレイテッド | Mk2阻害剤およびそれらの使用 |
| JP2020510063A (ja) * | 2017-03-16 | 2020-04-02 | セルジーン シーエーアール エルエルシー | Mk2阻害剤、その合成、およびそれに至るまでの中間体 |
| JP2020511468A (ja) * | 2017-03-16 | 2020-04-16 | セルジーン シーエーアール エルエルシー | Mk2阻害剤の重水素化アナログおよびその使用 |
| JP2020512315A (ja) * | 2017-03-16 | 2020-04-23 | セルジーン シーエーアール エルエルシー | Mk2阻害剤として有用なヘテロアリール化合物 |
| JP2020514360A (ja) * | 2017-03-16 | 2020-05-21 | セルジーン シーエーアール エルエルシー | Mk2阻害剤の形態および組成物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995026325A2 (en) | 1994-03-25 | 1995-10-05 | Isotechnika Inc. | Enhancement of the efficacy of drugs by deuteration |
| CA2510298A1 (en) | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Acyclic pyrazole compounds |
| US20060106020A1 (en) | 2004-04-28 | 2006-05-18 | Rodgers James D | Tetracyclic inhibitors of Janus kinases |
| CA2693904A1 (en) | 2007-07-16 | 2009-01-22 | Novartis Ag | Heterocyclic compounds useful as mk2 inhibitors |
| EP2201737A2 (en) * | 2007-10-20 | 2010-06-30 | Penango, Inc. | Methods and systems for indicating trustworthiness of secure communications |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| HK1210696A1 (en) * | 2012-07-11 | 2016-05-06 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| JP2020514361A (ja) | 2017-03-16 | 2020-05-21 | セルジーン シーエーアール エルエルシー | 9,10,11,12−テトラヒドロ−8h−[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2−f]キノリン−8−オン化合物およびその使用 |
-
2018
- 2018-03-15 JP JP2019550659A patent/JP2020514361A/ja active Pending
- 2018-03-15 WO PCT/US2018/022548 patent/WO2018170204A1/en not_active Ceased
- 2018-03-15 EP EP18766809.0A patent/EP3596084A4/en not_active Withdrawn
- 2018-03-15 US US16/494,722 patent/US11098057B2/en active Active
-
2022
- 2022-12-15 JP JP2022200392A patent/JP2023051962A/ja active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016518316A (ja) * | 2013-03-15 | 2016-06-23 | セルジーン アビロミクス リサーチ, インコーポレイテッド | Mk2阻害剤およびそれらの使用 |
| WO2016044463A2 (en) * | 2014-09-17 | 2016-03-24 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
| JP2020510063A (ja) * | 2017-03-16 | 2020-04-02 | セルジーン シーエーアール エルエルシー | Mk2阻害剤、その合成、およびそれに至るまでの中間体 |
| JP2020511468A (ja) * | 2017-03-16 | 2020-04-16 | セルジーン シーエーアール エルエルシー | Mk2阻害剤の重水素化アナログおよびその使用 |
| JP2020512315A (ja) * | 2017-03-16 | 2020-04-23 | セルジーン シーエーアール エルエルシー | Mk2阻害剤として有用なヘテロアリール化合物 |
| JP2020514360A (ja) * | 2017-03-16 | 2020-05-21 | セルジーン シーエーアール エルエルシー | Mk2阻害剤の形態および組成物 |
Non-Patent Citations (3)
| Title |
|---|
| ANDERSON,D.R. ET AL.: "Benzothiophene inhibitors of MK2. Part 1: Structure-activity relationships, assessments of selectivi", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 16, JPN6021048482, 2009, pages 4878 - 4881, XP026419100, ISSN: 0004657111 * |
| ANDERSON,D.R. ET AL.: "Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 16, JPN6021048487, 2009, pages 4882 - 4884, XP026419101, ISSN: 0004657113 * |
| MARIO FIORE ET AL.: "Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Che", J. MED. CHEM., vol. 59, no. 8, JPN6021048484, 26 October 2015 (2015-10-26), pages 3609 - 3634, XP055306184, ISSN: 0004657112, DOI: 10.1021/acs.jmedchem.5b01457 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020511468A (ja) * | 2017-03-16 | 2020-04-16 | セルジーン シーエーアール エルエルシー | Mk2阻害剤の重水素化アナログおよびその使用 |
| JP2020512315A (ja) * | 2017-03-16 | 2020-04-23 | セルジーン シーエーアール エルエルシー | Mk2阻害剤として有用なヘテロアリール化合物 |
| JP7200120B2 (ja) | 2017-03-16 | 2023-01-06 | セルジーン シーエーアール エルエルシー | Mk2阻害剤として有用なヘテロアリール化合物 |
| WO2024048697A1 (ja) * | 2022-08-31 | 2024-03-07 | 国立大学法人京都大学 | 化合物、小胞体ストレス抑制剤、医薬品、眼科用剤、点眼薬、組成物、化合物の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3596084A4 (en) | 2020-12-23 |
| EP3596084A1 (en) | 2020-01-22 |
| JP2023051962A (ja) | 2023-04-11 |
| WO2018170204A1 (en) | 2018-09-20 |
| US11098057B2 (en) | 2021-08-24 |
| US20200102327A1 (en) | 2020-04-02 |
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