JP2020514361A5 - - Google Patents
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- JP2020514361A5 JP2020514361A5 JP2019550659A JP2019550659A JP2020514361A5 JP 2020514361 A5 JP2020514361 A5 JP 2020514361A5 JP 2019550659 A JP2019550659 A JP 2019550659A JP 2019550659 A JP2019550659 A JP 2019550659A JP 2020514361 A5 JP2020514361 A5 JP 2020514361A5
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- disease
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 22
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 7
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 7
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022200392A JP2023051962A (ja) | 2017-03-16 | 2022-12-15 | ９，１０，１１，１２－テトラヒドロ－８ｈ－［１，４］ジアゼピノ［５’，６’：４，５］チエノ［３，２－ｆ］キノリン－８－オン化合物およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762472027P | 2017-03-16 | 2017-03-16 | |
| US62/472,027 | 2017-03-16 | ||
| PCT/US2018/022548 WO2018170204A1 (en) | 2017-03-16 | 2018-03-15 | 9,10,11,12-tetrahydro-8h-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one compounds and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022200392A Division JP2023051962A (ja) | 2017-03-16 | 2022-12-15 | ９，１０，１１，１２－テトラヒドロ－８ｈ－［１，４］ジアゼピノ［５’，６’：４，５］チエノ［３，２－ｆ］キノリン－８－オン化合物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020514361A JP2020514361A (ja) | 2020-05-21 |
| JP2020514361A5 true JP2020514361A5 (enExample) | 2021-04-22 |
Family
ID=63522566
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019550659A Pending JP2020514361A (ja) | 2017-03-16 | 2018-03-15 | ９，１０，１１，１２−テトラヒドロ−８ｈ−［１，４］ジアゼピノ［５’，６’：４，５］チエノ［３，２−ｆ］キノリン−８−オン化合物およびその使用 |
| JP2022200392A Pending JP2023051962A (ja) | 2017-03-16 | 2022-12-15 | ９，１０，１１，１２－テトラヒドロ－８ｈ－［１，４］ジアゼピノ［５’，６’：４，５］チエノ［３，２－ｆ］キノリン－８－オン化合物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022200392A Pending JP2023051962A (ja) | 2017-03-16 | 2022-12-15 | ９，１０，１１，１２－テトラヒドロ－８ｈ－［１，４］ジアゼピノ［５’，６’：４，５］チエノ［３，２－ｆ］キノリン－８－オン化合物およびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11098057B2 (enExample) |
| EP (1) | EP3596084A4 (enExample) |
| JP (2) | JP2020514361A (enExample) |
| WO (1) | WO2018170204A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20210529T1 (hr) | 2014-09-17 | 2021-08-06 | Celgene Car Llc | Inhibitori za mk2 i njihove uporabe |
| WO2018170201A1 (en) * | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Deuterated analogs of mk2 inhibitors and uses thereof |
| AU2018236290B2 (en) | 2017-03-16 | 2022-06-02 | Bristol-Myers Squibb Company | MK2 inhibitors, synthesis thereof, and intermediates thereto |
| AU2018236286B2 (en) | 2017-03-16 | 2022-02-17 | Bristol-Myers Squibb Company | Forms and compositions of a MK2 inhibitor |
| JP2020514361A (ja) | 2017-03-16 | 2020-05-21 | セルジーン シーエーアール エルエルシー | ９，１０，１１，１２−テトラヒドロ−８ｈ−［１，４］ジアゼピノ［５’，６’：４，５］チエノ［３，２−ｆ］キノリン−８−オン化合物およびその使用 |
| EP3596083A4 (en) | 2017-03-16 | 2020-12-02 | Celgene CAR LLC | USEFUL HETERARYL COMPOUNDS AS MK2 INHIBITORS |
| KR20220041042A (ko) * | 2019-05-17 | 2022-03-31 | 셀젠 카르 엘엘씨 | Mk2-매개 장애를 치료하는 방법 |
| US12049470B2 (en) | 2021-02-01 | 2024-07-30 | Celgene Corporation | MK2 inhibitors, the synthesis thereof, and intermediates thereto |
| WO2023025298A1 (zh) * | 2021-08-27 | 2023-03-02 | 瑞石生物医药有限公司 | 喹啉并呋喃衍生物及其用途 |
| WO2024048697A1 (ja) * | 2022-08-31 | 2024-03-07 | 国立大学法人京都大学 | 化合物、小胞体ストレス抑制剤、医薬品、眼科用剤、点眼薬、組成物、化合物の製造方法 |
| CN115925718A (zh) * | 2022-12-27 | 2023-04-07 | 瑞石生物医药有限公司 | 一种四环内酰胺衍生物及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995026325A2 (en) | 1994-03-25 | 1995-10-05 | Isotechnika Inc. | Enhancement of the efficacy of drugs by deuteration |
| CA2510298A1 (en) | 2002-12-20 | 2004-07-15 | Pharmacia Corporation | Acyclic pyrazole compounds |
| US20060106020A1 (en) | 2004-04-28 | 2006-05-18 | Rodgers James D | Tetracyclic inhibitors of Janus kinases |
| CA2693904A1 (en) | 2007-07-16 | 2009-01-22 | Novartis Ag | Heterocyclic compounds useful as mk2 inhibitors |
| EP2201737A2 (en) * | 2007-10-20 | 2010-06-30 | Penango, Inc. | Methods and systems for indicating trustworthiness of secure communications |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| HK1210696A1 (en) * | 2012-07-11 | 2016-05-06 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| CA2908098A1 (en) | 2013-03-15 | 2014-09-25 | Celgene Avilomics Research, Inc. | Mk2 inhibitors and uses thereof |
| HRP20210529T1 (hr) * | 2014-09-17 | 2021-08-06 | Celgene Car Llc | Inhibitori za mk2 i njihove uporabe |
| AU2018236290B2 (en) * | 2017-03-16 | 2022-06-02 | Bristol-Myers Squibb Company | MK2 inhibitors, synthesis thereof, and intermediates thereto |
| AU2018236286B2 (en) | 2017-03-16 | 2022-02-17 | Bristol-Myers Squibb Company | Forms and compositions of a MK2 inhibitor |
| WO2018170201A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | Deuterated analogs of mk2 inhibitors and uses thereof |
| JP2020514361A (ja) | 2017-03-16 | 2020-05-21 | セルジーン シーエーアール エルエルシー | ９，１０，１１，１２−テトラヒドロ−８ｈ−［１，４］ジアゼピノ［５’，６’：４，５］チエノ［３，２−ｆ］キノリン−８−オン化合物およびその使用 |
| EP3596083A4 (en) * | 2017-03-16 | 2020-12-02 | Celgene CAR LLC | USEFUL HETERARYL COMPOUNDS AS MK2 INHIBITORS |
-
2018
- 2018-03-15 JP JP2019550659A patent/JP2020514361A/ja active Pending
- 2018-03-15 WO PCT/US2018/022548 patent/WO2018170204A1/en not_active Ceased
- 2018-03-15 EP EP18766809.0A patent/EP3596084A4/en not_active Withdrawn
- 2018-03-15 US US16/494,722 patent/US11098057B2/en active Active
-
2022
- 2022-12-15 JP JP2022200392A patent/JP2023051962A/ja active Pending
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