JP2020512820A - 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトＩｇＭ定常領域 - Google Patents

補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトＩｇＭ定常領域 Download PDF

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JP2020512820A
JP2020512820A JP2019554816A JP2019554816A JP2020512820A JP 2020512820 A JP2020512820 A JP 2020512820A JP 2019554816 A JP2019554816 A JP 2019554816A JP 2019554816 A JP2019554816 A JP 2019554816A JP 2020512820 A JP2020512820 A JP 2020512820A
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human igm
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constant region
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antibody
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ラメッシュ バリガ
ラメッシュ バリガ
ディーン エング
ディーン エング
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アイジーエム バイオサイエンシズ インコーポレイテッド
アイジーエム バイオサイエンシズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

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  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019554816A 2017-04-07 2018-04-06 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトＩｇＭ定常領域 Withdrawn JP2020512820A (ja)

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JP2023062508A JP2023085503A (ja) 2017-04-07 2023-04-07 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトＩｇＭ定常領域
JP2024175523A JP2024177479A (ja) 2017-04-07 2024-10-07 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトＩｇＭ定常領域

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US201762483087P 2017-04-07 2017-04-07
US62/483,087 2017-04-07
PCT/US2018/026474 WO2018187702A2 (en) 2017-04-07 2018-04-06 Modified human igm constant regions for modulation of complement-dependent cytolysis effector function

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JP2023062508A Pending JP2023085503A (ja) 2017-04-07 2023-04-07 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトＩｇＭ定常領域
JP2024175523A Pending JP2024177479A (ja) 2017-04-07 2024-10-07 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトＩｇＭ定常領域

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JP2024175523A Pending JP2024177479A (ja) 2017-04-07 2024-10-07 補体依存性細胞溶解のエフェクター機能の調節のための修飾されたヒトＩｇＭ定常領域

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US (2) US11401337B2 (https=)
EP (1) EP3607091A4 (https=)
JP (3) JP2020512820A (https=)
KR (1) KR102696143B1 (https=)
CN (1) CN110536900B (https=)
AU (1) AU2018248336B2 (https=)
CA (1) CA3055790A1 (https=)
IL (1) IL268901B2 (https=)
MX (1) MX2019011986A (https=)
SG (1) SG11201908051RA (https=)
WO (1) WO2018187702A2 (https=)

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KR20210083260A (ko) * 2018-10-23 2021-07-06 아이쥐엠 바이오사이언스 인코포레이티드 다가 IgM- 및 IgA-Fc 기반 결합 분자
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JP2023085503A (ja) 2023-06-20
AU2018248336B2 (en) 2024-10-03
US20210147567A1 (en) 2021-05-20
CN110536900B (zh) 2024-06-11
MX2019011986A (es) 2019-11-07
US11401337B2 (en) 2022-08-02
IL268901B1 (en) 2025-07-01
IL268901A (en) 2019-10-31
SG11201908051RA (en) 2019-09-27
KR20190137821A (ko) 2019-12-11
US20220340676A1 (en) 2022-10-27
JP2024177479A (ja) 2024-12-19
CA3055790A1 (en) 2018-10-11
AU2018248336A1 (en) 2019-09-26
EP3607091A2 (en) 2020-02-12
EP3607091A4 (en) 2021-01-20
WO2018187702A2 (en) 2018-10-11
KR102696143B1 (ko) 2024-08-21
IL268901B2 (en) 2025-11-01
CN110536900A (zh) 2019-12-03

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