MX2019011986A - Regiones constantes de igm humana modificadas para la modulacion de la funcion efectora de la citolisis dependiente de complemento referencia cruzada a solicitudes relacionadas. - Google Patents
Regiones constantes de igm humana modificadas para la modulacion de la funcion efectora de la citolisis dependiente de complemento referencia cruzada a solicitudes relacionadas.Info
- Publication number
- MX2019011986A MX2019011986A MX2019011986A MX2019011986A MX2019011986A MX 2019011986 A MX2019011986 A MX 2019011986A MX 2019011986 A MX2019011986 A MX 2019011986A MX 2019011986 A MX2019011986 A MX 2019011986A MX 2019011986 A MX2019011986 A MX 2019011986A
- Authority
- MX
- Mexico
- Prior art keywords
- human igm
- constant regions
- dependent
- cytolysis
- modulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Prostheses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762483087P | 2017-04-07 | 2017-04-07 | |
| PCT/US2018/026474 WO2018187702A2 (en) | 2017-04-07 | 2018-04-06 | Modified human igm constant regions for modulation of complement-dependent cytolysis effector function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019011986A true MX2019011986A (es) | 2019-11-07 |
Family
ID=63713537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019011986A MX2019011986A (es) | 2017-04-07 | 2018-04-06 | Regiones constantes de igm humana modificadas para la modulacion de la funcion efectora de la citolisis dependiente de complemento referencia cruzada a solicitudes relacionadas. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11401337B2 (https=) |
| EP (1) | EP3607091A4 (https=) |
| JP (3) | JP2020512820A (https=) |
| KR (1) | KR102696143B1 (https=) |
| CN (1) | CN110536900B (https=) |
| AU (1) | AU2018248336B2 (https=) |
| CA (1) | CA3055790A1 (https=) |
| IL (1) | IL268901B2 (https=) |
| MX (1) | MX2019011986A (https=) |
| SG (1) | SG11201908051RA (https=) |
| WO (1) | WO2018187702A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017512208A (ja) | 2014-02-10 | 2017-05-18 | アイジーエム バイオサイエンス， インコーポレイテッド | ＩｇＡ多重特異性結合分子 |
| IL292311A (en) | 2014-04-03 | 2022-06-01 | Igm Biosciences Inc | J-chain qualified |
| PT3247728T (pt) | 2015-01-20 | 2020-07-16 | Igm Biosciences Inc | Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas |
| KR102357312B1 (ko) | 2015-03-04 | 2022-02-03 | 아이쥐엠 바이오사이언스 인코포레이티드 | Ｃｄ20 결합 분자 및 그의 용도 |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| WO2016168758A1 (en) | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| EP3824903A1 (en) | 2015-09-30 | 2021-05-26 | IGM Biosciences Inc. | Binding molecules with modified j-chain |
| JP6979971B2 (ja) | 2016-05-09 | 2021-12-15 | アイジーエム バイオサイエンシズ インコーポレイテッド | 抗ｐｄ−ｌ１抗体 |
| US11401337B2 (en) * | 2017-04-07 | 2022-08-02 | Igm Biosciences, Inc. | Modified human IgM constant regions for modulation of complement-dependent cytolysis effector function |
| CN111787951B (zh) | 2018-03-01 | 2025-06-17 | Igm生物科学股份有限公司 | 影响IgM血清半衰期的IgM Fc和J链突变 |
| KR20210083260A (ko) * | 2018-10-23 | 2021-07-06 | 아이쥐엠 바이오사이언스 인코포레이티드 | 다가 IgM- 및 IgA-Fc 기반 결합 분자 |
| MX2022001934A (es) | 2019-08-15 | 2022-03-11 | Igm Biosciences Inc | Moleculas de union multimericas inmunoestimuladoras. |
| WO2021034646A1 (en) * | 2019-08-17 | 2021-02-25 | Igm Biosciences, Inc. | Multimeric bispecific anti-cd123 binding molecules and uses thereof |
| CN114616031A (zh) * | 2019-09-19 | 2022-06-10 | Igm生物科学股份有限公司 | 对靶标密度高的细胞的选择性增强的多聚体抗体 |
| BR112022021392A2 (pt) | 2020-04-22 | 2022-12-06 | Igm Biosciences Inc | Moléculas de ligação multiméricas de agonista de pd-1 |
| JP2024508709A (ja) * | 2021-02-17 | 2024-02-28 | アイジーエム バイオサイエンシズ インコーポレイテッド | 抗ｃｄ１２３結合分子及びその使用法 |
| GEAP202416592A (en) * | 2022-02-03 | 2024-11-11 | Igm Biosciences Inc | Anti-cd38 binding molecules and uses thereof |
| WO2023196995A1 (en) | 2022-04-07 | 2023-10-12 | Repertoire Immune Medicines, Inc. | T cell receptor multimers and uses thereof |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5256771A (en) | 1990-04-03 | 1993-10-26 | Miles Inc. | Heat treatment of IgM-containing immunoglobulins to eliminate non-specific complement activation |
| AU2003217912A1 (en) * | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| US20050014932A1 (en) | 2003-05-15 | 2005-01-20 | Iogenetics, Llc | Targeted biocides |
| US20150071948A1 (en) * | 2003-09-26 | 2015-03-12 | Gregory Alan Lazar | Novel immunoglobulin variants |
| BRPI0417266B8 (pt) * | 2003-12-25 | 2021-05-25 | Kyowa Hakko Kirin Co Ltd | anticorpo monoclonal, seu uso e composição farmacêutica |
| CN101098889A (zh) | 2004-11-05 | 2008-01-02 | 盘林京有限公司 | 抗体导致的细胞膜损伤 |
| CA2780221A1 (en) | 2009-11-04 | 2011-05-12 | Fabrus Llc | Methods for affinity maturation-based antibody optimization |
| JP6205363B2 (ja) * | 2011-09-26 | 2017-09-27 | ジェイエヌ バイオサイエンシーズ エルエルシー | ハイブリッド定常領域 |
| TWI606064B (zh) | 2012-02-08 | 2017-11-21 | Ｉｇｍ生物科技公司 | 細胞死亡誘導分子（ｃｄｉｍ）結合蛋白類及彼等之用途 |
| JP6721505B2 (ja) | 2013-09-05 | 2020-07-15 | アイジーエム バイオサイエンシズ インコーポレイテッド | 定常領域が修飾された（ｃｏｎｓｔａｎｔ ｃｈａｉｎ ｍｏｄｉｆｉｅｄ）二重特異性五価及び六価Ｉｇ−Ｍ抗体 |
| US9416496B2 (en) * | 2013-10-16 | 2016-08-16 | Georgia-Pacific Consumer Products Lp | Method for reducing the bulk and increasing the density of a tissue product |
| JP2017512208A (ja) | 2014-02-10 | 2017-05-18 | アイジーエム バイオサイエンス， インコーポレイテッド | ＩｇＡ多重特異性結合分子 |
| TW201536801A (zh) | 2014-02-25 | 2015-10-01 | Fujirebio Kk | 改質單體ＩｇＭ |
| IL292311A (en) | 2014-04-03 | 2022-06-01 | Igm Biosciences Inc | J-chain qualified |
| PT3247728T (pt) | 2015-01-20 | 2020-07-16 | Igm Biosciences Inc | Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas |
| KR102357312B1 (ko) | 2015-03-04 | 2022-02-03 | 아이쥐엠 바이오사이언스 인코포레이티드 | Ｃｄ20 결합 분자 및 그의 용도 |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| WO2016168758A1 (en) | 2015-04-17 | 2016-10-20 | Igm Biosciences, Inc. | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
| EP3352760B1 (en) * | 2015-09-21 | 2026-03-11 | Aptevo Research and Development LLC | Cd3 binding polypeptides |
| EP3824903A1 (en) | 2015-09-30 | 2021-05-26 | IGM Biosciences Inc. | Binding molecules with modified j-chain |
| EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| CN105441455B (zh) * | 2015-10-21 | 2020-08-28 | 重庆金迈博生物科技有限公司 | 一种嵌合核酸分子及其在人源化抗体制备中的应用 |
| JP6979971B2 (ja) | 2016-05-09 | 2021-12-15 | アイジーエム バイオサイエンシズ インコーポレイテッド | 抗ｐｄ−ｌ１抗体 |
| JP2019530640A (ja) | 2016-07-20 | 2019-10-24 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多量体ｏｘ４０結合分子及びその使用 |
| EP3496536A4 (en) | 2016-07-20 | 2020-02-12 | IGM Biosciences, Inc. | MULTIMERE CD40-BINDING MOLECULES AND USES THEREOF |
| EP3487298A4 (en) | 2016-07-20 | 2020-03-11 | IGM Biosciences, Inc. | MULTIMERE CD137 / 4-1BB-BINDING MOLECULES AND USES THEREOF |
| AU2017300647A1 (en) | 2016-07-20 | 2019-02-07 | Igm Biosciences, Inc. | Multimeric GITR binding molecules and uses thereof |
| US11401337B2 (en) * | 2017-04-07 | 2022-08-02 | Igm Biosciences, Inc. | Modified human IgM constant regions for modulation of complement-dependent cytolysis effector function |
| AU2019224136A1 (en) | 2018-02-26 | 2020-09-10 | Igm Biosciences, Inc. | Use of a multimeric anti-DR5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
| CN111787951B (zh) | 2018-03-01 | 2025-06-17 | Igm生物科学股份有限公司 | 影响IgM血清半衰期的IgM Fc和J链突变 |
| KR20210083260A (ko) | 2018-10-23 | 2021-07-06 | 아이쥐엠 바이오사이언스 인코포레이티드 | 다가 IgM- 및 IgA-Fc 기반 결합 분자 |
-
2018
- 2018-04-06 US US16/500,292 patent/US11401337B2/en active Active
- 2018-04-06 IL IL268901A patent/IL268901B2/en unknown
- 2018-04-06 EP EP18781914.9A patent/EP3607091A4/en active Pending
- 2018-04-06 MX MX2019011986A patent/MX2019011986A/es unknown
- 2018-04-06 CN CN201880022469.1A patent/CN110536900B/zh active Active
- 2018-04-06 WO PCT/US2018/026474 patent/WO2018187702A2/en not_active Ceased
- 2018-04-06 AU AU2018248336A patent/AU2018248336B2/en active Active
- 2018-04-06 KR KR1020197030684A patent/KR102696143B1/ko active Active
- 2018-04-06 SG SG11201908051RA patent/SG11201908051RA/en unknown
- 2018-04-06 CA CA3055790A patent/CA3055790A1/en active Pending
- 2018-04-06 JP JP2019554816A patent/JP2020512820A/ja not_active Withdrawn
-
2022
- 2022-06-10 US US17/806,339 patent/US20220340676A1/en not_active Abandoned
-
2023
- 2023-04-07 JP JP2023062508A patent/JP2023085503A/ja active Pending
-
2024
- 2024-10-07 JP JP2024175523A patent/JP2024177479A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023085503A (ja) | 2023-06-20 |
| AU2018248336B2 (en) | 2024-10-03 |
| US20210147567A1 (en) | 2021-05-20 |
| CN110536900B (zh) | 2024-06-11 |
| US11401337B2 (en) | 2022-08-02 |
| IL268901B1 (en) | 2025-07-01 |
| IL268901A (en) | 2019-10-31 |
| SG11201908051RA (en) | 2019-09-27 |
| JP2020512820A (ja) | 2020-04-30 |
| KR20190137821A (ko) | 2019-12-11 |
| US20220340676A1 (en) | 2022-10-27 |
| JP2024177479A (ja) | 2024-12-19 |
| CA3055790A1 (en) | 2018-10-11 |
| AU2018248336A1 (en) | 2019-09-26 |
| EP3607091A2 (en) | 2020-02-12 |
| EP3607091A4 (en) | 2021-01-20 |
| WO2018187702A2 (en) | 2018-10-11 |
| KR102696143B1 (ko) | 2024-08-21 |
| IL268901B2 (en) | 2025-11-01 |
| CN110536900A (zh) | 2019-12-03 |
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