JP2020511471A5 - - Google Patents

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Publication number

JP2020511471A5

JP2020511471A5 JP2019551245A JP2019551245A JP2020511471A5 JP 2020511471 A5 JP2020511471 A5 JP 2020511471A5 JP 2019551245 A JP2019551245 A JP 2019551245A JP 2019551245 A JP2019551245 A JP 2019551245A JP 2020511471 A5 JP2020511471 A5 JP 2020511471A5

Authority

JP

Japan

Prior art keywords

alkyl

aryl

cycloalkyl

optionally substituted

benzyl

Prior art date

2017-12-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• 125000000217 alkyl group Chemical group 0.000 claims 63
• 125000003118 aryl group Chemical group 0.000 claims 17
• 125000001072 heteroaryl group Chemical group 0.000 claims 14
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 13
• 125000000753 cycloalkyl group Chemical group 0.000 claims 12
• 229910052739 hydrogen Inorganic materials 0.000 claims 12
• 229910052799 carbon Inorganic materials 0.000 claims 11
• 125000003107 substituted aryl group Chemical group 0.000 claims 11
• 125000003342 alkenyl group Chemical group 0.000 claims 9
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
• 125000000304 alkynyl group Chemical group 0.000 claims 8
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 8
• 150000001875 compounds Chemical class 0.000 claims 5
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
• 125000004104 aryloxy group Chemical group 0.000 claims 4
• 229910052736 halogen Inorganic materials 0.000 claims 4
• 125000001475 halogen functional group Chemical group 0.000 claims 4
• 150000002367 halogens Chemical class 0.000 claims 4
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
• 125000005553 heteroaryloxy group Chemical group 0.000 claims 4
• 150000002431 hydrogen Chemical class 0.000 claims 4
• 239000001257 hydrogen Substances 0.000 claims 4
• 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 3
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 3
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
• 125000004076 pyridyl group Chemical group 0.000 claims 3
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
• 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
• 125000003670 adamantan-2-yl group Chemical group [H]C1([H])C(C2([H])[H])([H])C([H])([H])C3([H])C([*])([H])C1([H])C([H])([H])C2([H])C3([H])[H] 0.000 claims 2
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
• NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims 2
• 125000006239 protecting group Chemical group 0.000 claims 2
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• -1 2,4,6-triisopropylbenzyl Chemical group 0.000 claims 1
• KLIDCXVFHGNTTM-UHFFFAOYSA-N 2,6-dimethoxyphenol Chemical group COC1=CC=CC(OC)=C1O KLIDCXVFHGNTTM-UHFFFAOYSA-N 0.000 claims 1
• 239000012359 Methanesulfonyl chloride Substances 0.000 claims 1
• 125000006193 alkinyl group Chemical group 0.000 claims 1
• 125000003710 aryl alkyl group Chemical group 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 125000000623 heterocyclic group Chemical group 0.000 claims 1
• QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 claims 1
• 125000003003 spiro group Chemical group 0.000 claims 1
• 230000002194 synthesizing effect Effects 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
• 0 *C(Nc(cccc1OCCP=C)c1P(*)(CO)=O)=O Chemical compound *C(Nc(cccc1OCCP=C)c1P(*)(CO)=O)=O 0.000 description 5