JP7069202B2 - 新規キラルジヒドロベンゾアザホスホール配位子及びその合成 - Google Patents
新規キラルジヒドロベンゾアザホスホール配位子及びその合成 Download PDFInfo
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- JP7069202B2 JP7069202B2 JP2019551245A JP2019551245A JP7069202B2 JP 7069202 B2 JP7069202 B2 JP 7069202B2 JP 2019551245 A JP2019551245 A JP 2019551245A JP 2019551245 A JP2019551245 A JP 2019551245A JP 7069202 B2 JP7069202 B2 JP 7069202B2
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- alkyl
- optionally substituted
- aryl
- cycloalkyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65844—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a five-membered ring which may be condensed with another ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0073—Rhodium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/65811—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having four or more phosphorus atoms as ring hetero atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662430375P | 2016-12-06 | 2016-12-06 | |
| US62/430,375 | 2016-12-06 | ||
| PCT/US2017/064582 WO2018106621A1 (en) | 2016-12-06 | 2017-12-05 | Novel chiral dihydrobenzoazaphosphole ligands and synthesis thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511471A JP2020511471A (ja) | 2020-04-16 |
| JP2020511471A5 JP2020511471A5 (https=) | 2021-01-21 |
| JP7069202B2 true JP7069202B2 (ja) | 2022-05-17 |
Family
ID=60703225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551245A Active JP7069202B2 (ja) | 2016-12-06 | 2017-12-05 | 新規キラルジヒドロベンゾアザホスホール配位子及びその合成 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10196413B2 (https=) |
| EP (1) | EP3551639B1 (https=) |
| JP (1) | JP7069202B2 (https=) |
| WO (1) | WO2018106621A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109096338B (zh) * | 2018-09-10 | 2020-05-12 | 中国科学院上海有机化学研究所 | 苯并氮杂磷杂茂膦氧配体及含其络合物、制备方法和应用 |
| CN114315894B (zh) * | 2021-12-09 | 2023-05-26 | 同济大学 | 手性α-芳基磷酸酯、手性α-芳基膦化合物及其合成 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013510154A (ja) | 2009-11-05 | 2013-03-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規キラルリンリガンド |
| JP2013523813A (ja) | 2010-04-05 | 2013-06-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | クロスカップリング反応におけるモノリン配位子及びそれらの使用 |
| CN104558038A (zh) | 2013-10-23 | 2015-04-29 | 中国科学院上海有机化学研究所 | 一种取代的2,3-二氢苯并[d][1,3]氧杂磷杂茂配体的制备方法 |
| JP2016523972A (ja) | 2013-07-10 | 2016-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なキラル窒素−リン配位子及びアルケン類の不斉水素化のためのその使用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7169953B2 (en) | 2001-11-09 | 2007-01-30 | The Penn State Research Foundation | P-chiral phospholanes and phosphocyclic compounds and their use in asymmetric catalytic reactions |
| RU2335342C2 (ru) | 2004-03-12 | 2008-10-10 | Уорнер-Ламберт Компани Ллс | C1-симметричные бисфосфиновые лиганды и их применение в асимметрическом синтезе прегабалина |
-
2017
- 2017-12-05 EP EP17817612.9A patent/EP3551639B1/en active Active
- 2017-12-05 WO PCT/US2017/064582 patent/WO2018106621A1/en not_active Ceased
- 2017-12-05 JP JP2019551245A patent/JP7069202B2/ja active Active
- 2017-12-05 US US15/831,419 patent/US10196413B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013510154A (ja) | 2009-11-05 | 2013-03-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規キラルリンリガンド |
| JP2013523813A (ja) | 2010-04-05 | 2013-06-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | クロスカップリング反応におけるモノリン配位子及びそれらの使用 |
| JP2016523972A (ja) | 2013-07-10 | 2016-08-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規なキラル窒素−リン配位子及びアルケン類の不斉水素化のためのその使用 |
| CN104558038A (zh) | 2013-10-23 | 2015-04-29 | 中国科学院上海有机化学研究所 | 一种取代的2,3-二氢苯并[d][1,3]氧杂磷杂茂配体的制备方法 |
Non-Patent Citations (11)
| Title |
|---|
| Aluri, Bhaskar Reddy 他，Bulky N-Substituted 1,3-Benzazaphospholes: Access via Pd-Catalyzed C-N and C-P Cross Coupling, Lithiation, and Conversion to Novel P=C-PtBu2 Hybrid Ligands，Inorganic Chemistry，2008年，47(15)，6900-6912 |
| AMANDA D WORTHY ET AL，Regioselective Hydroformylation of Sulfonamides using a Scaffolding Ligand，ORGANIC LETTERS，2009年，vol. 11, no. 13，2764 - 2767 |
| BHASKAR R ALURI ET AL，Sterically and Polarity-Controlled Reactions of tBuLi with P=CH-NR Heterocycles: Novel Heterocyclic P- and P,O-Ligands and Preliminary Tests in Transition-Metal Catalysis，CHEMISTRY - A EUROPEAN JOURNAL，2008年，vol. 14, no. 14，4328 - 4335 |
| BHASKAR R ALURI ET AL，π-Excess Aromatic σ2P Ligands: Formation of a Heterocyclic 1,2-Diphosphine by the Addition of tBuLi and Subsequent Inverse Addition of the Product at the P=C Bonds of Two Molecules of 1-Neopentyl-1,3-benzazaphosphole，HETEROATOM CHEMISTRY，2015年，26(6)，426-435 |
| CANDICE L. JOE ET AL，Enantioselective Hydroformylation of Aniline Derivatives，JOURNAL OF ORGANIC CHEMISTRY，2011年，vol. 76, no. 18，7590 - 7596 |
| Ghalib, Mohammed 他，Benzazaphospholine-2-carboxylic acids: Synthesis, structure and properties of heterocyclic phosphanyl amino acids，Polyhedron，2014年，77，10-16 |
| Ghalib, Mohammed 他，Enantiomerically Pure N Chirally Substituted 1,3-Benzazaphospholes Synthesis, Reactivity toward tBuLi, and Conversion to Functionalized Benzazaphospholes and Catalytically Useful Dihydrobenzazaphospholes，Organometallics，2014年，33(3)，804-816 |
| Heinicke, Joachim 他，Ambident Reactivity of P=CH-N-Heterocycles: Lithiation and Substitution Sites，Phosphorus, Sulfur and Silicon and the Related Elements，2011年，186(4)，683-687 |
| Issleib, Kurt; Bruenner, H. U.; Oehme, H.，Benzazaphospholine，Organometallics in Chemical Synthesis ，1971年，1(2)，161-8 |
| MOHAMMED GHALIB ET AL，Solvent-controlled lithiation of P=C-N-heterocycles: Synthesis of mono- and bis(trimethylsilyl)-tert-butyl-dihydrobenzazaphospholes - A new type of highly bulky and basic phosphine ligands，JOURNAL OF ORGANOMETALLIC CHEMISTRY，2014年，763-764，44-51 |
| THOMAS E LIGHTBURN ET AL，Catalytic Scaffolding Ligands: An Efficient Strategy for Directing Reactions，JOURNAL OF THE AMERICAN CHEMICAL SOCIETY，2008年，vol. 130, no. 29，9210 - 9211 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3551639A1 (en) | 2019-10-16 |
| JP2020511471A (ja) | 2020-04-16 |
| WO2018106621A1 (en) | 2018-06-14 |
| EP3551639B1 (en) | 2023-08-23 |
| US10196413B2 (en) | 2019-02-05 |
| US20180155377A1 (en) | 2018-06-07 |
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