JP2020509043A5 - - Google Patents

Info

Publication number

JP2020509043A5

JP2020509043A5 JP2019547448A JP2019547448A JP2020509043A5 JP 2020509043 A5 JP2020509043 A5 JP 2020509043A5 JP 2019547448 A JP2019547448 A JP 2019547448A JP 2019547448 A JP2019547448 A JP 2019547448A JP 2020509043 A5 JP2020509043 A5 JP 2020509043A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

dementia

composition according

group

alkyl

Prior art date

2018-02-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 15
• 206010012289 Dementia Diseases 0.000 claims 11
• 150000001875 compounds Chemical class 0.000 claims 10
• 150000003839 salts Chemical class 0.000 claims 5
• 239000012453 solvate Substances 0.000 claims 5
• -1 2 -thiomorpholinyl group Chemical group 0.000 claims 4
• 229910052799 carbon Inorganic materials 0.000 claims 4
• 229910052736 halogen Inorganic materials 0.000 claims 3
• 150000002367 halogens Chemical class 0.000 claims 3
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 3
• 125000001041 indolyl group Chemical group 0.000 claims 3
• 230000002427 irreversible effect Effects 0.000 claims 3
• 125000004312 morpholin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC([H])(*)C1([H])[H] 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 229940122041 Cholinesterase inhibitor Drugs 0.000 claims 1
• 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
• 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
• 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
• 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
• 208000031886 HIV Infections Diseases 0.000 claims 1
• 208000023105 Huntington disease Diseases 0.000 claims 1
• HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
• 201000004810 Vascular dementia Diseases 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 230000001713 cholinergic effect Effects 0.000 claims 1
• 239000000544 cholinesterase inhibitor Substances 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003825 glutamate receptor antagonist Substances 0.000 claims 1
• 230000003902 lesion Effects 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
• 229910052760 oxygen Inorganic materials 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 125000003386 piperidinyl group Chemical group 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 210000004129 prosencephalon Anatomy 0.000 claims 1
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
• 125000003107 substituted aryl group Chemical group 0.000 claims 1
• 229910052717 sulfur Inorganic materials 0.000 claims 1
• 0 *C(*)*1c(cccc2)c2C(C(*)=O)=C1* Chemical compound *C(*)*1c(cccc2)c2C(C(*)=O)=C1* 0.000 description 2