JP2020508695A - 安定な脂溶性活性成分組成物、マイクロカプセル及びその製造方法と応用 - Google Patents
安定な脂溶性活性成分組成物、マイクロカプセル及びその製造方法と応用 Download PDFInfo
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- JP2020508695A JP2020508695A JP2019560441A JP2019560441A JP2020508695A JP 2020508695 A JP2020508695 A JP 2020508695A JP 2019560441 A JP2019560441 A JP 2019560441A JP 2019560441 A JP2019560441 A JP 2019560441A JP 2020508695 A JP2020508695 A JP 2020508695A
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- fat
- active ingredient
- soluble active
- vitamin
- palmitate
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
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Abstract
Description
窒素ガス保護下で、ビタミンA結晶、ビタミンCパルミテート及びα−トコフェロールを75℃で溶融させ、ビタミンA溶融油に配合した。ビタミンA、ビタミンCパルミテート、α−トコフェロールの重量は、表1の要因設定表と表2の直交実験配置表に基づいて決定した。ビタミンA溶融油をサンプリングボトルに入れて、光から保護し、40℃で保管し、それぞれ0日、2日、4日、6日後にその含有量を測定した。
窒素ガス保護下で、ビタミンAパルミテート、ビタミンCパルミテート及びβ−トコフェロール混合物を、65℃で溶融して、タミンAパルミテート溶融油を配合した。ゼラチンとグルコースを65℃の水に溶解させ、ゼラチン及びグルコース水相溶液を配合した。高速のせん断条件の下で、ビタミンAパルミテート溶融油を上記水相溶液に注ぎ、乳化、脱気、均質化して安定的な乳化液を獲得した。ビタミンAパルミテート乳液をサンプリングボトルに入れて密封して、光から保護し、40℃で保管し、分それぞれ0週、1週、2週、3週後にその含有量を測定した。異なる抗酸化剤の配合比の乳液含量保有率データは、下記の表4の通りである。
窒素ガス保護下で、50kgのビタミンAアセテート結晶、0.5kgのビタミンCパルミテートと3.5kgの合成混合トコフェロールを85℃で溶融して、ビタミンAアセテート溶融油を配合した。75kgのゼラチンと50kgのグルコースを130kgの60℃の水に溶解して、49%のゼラチングルコース水相溶液を配合した。
窒素ガス保護下で、50kgのコエンザイムQ10結晶、0.5kgのビタミンCパルミテートと3kgの天然γ−トコフェロールを45℃で溶融して、コエンザイムQ10オイルを配合した。75kgのゼラチンと50kgのグルコースを130kgの70℃の水に溶解させ、49%のゼラチングルコース水相溶液を配合した。
Claims (10)
- 安定な脂溶性活性成分組成物であって、
前記脂溶性活性成分組成物は、トコフェロール、ビタミンCパルミテート及び脂溶性活性成分を含み、ここで、トコフェロールとビタミンCパルミテートの重量比は、2〜8:1であり、トコフェロール及びビタミンCパルミテートの組み合わせと脂溶性活性成分との重量比は、すべて7〜13:100である、前記脂溶性活性成分組成物。 - トコフェロールとビタミンCパルミテートとの重量比は、3〜7:1であることを特徴とする
請求項1に記載の脂溶性活性成分組成物。 - トコフェロールとビタミンCパルミテートとの重量比は、4〜6:1であることを特徴とする
請求項2に記載の脂溶性活性成分組成物。 - トコフェロール及びビタミンCパルミテートの組み合わせと脂溶性活性成分との重量比は、8〜12:100であることを特徴とする
請求項1に記載の脂溶性活性成分組成物。 - トコフェロール及びビタミンCパルミテートの組み合わせと脂溶性活性成分との重量比は、9〜11:100であることを特徴とする
請求項4に記載の脂溶性活性成分組成物。 - 前記脂溶性活性成分は、ビタミンA、ビタミンD、コエンザイムQ10(coenzyme Q10)、ビタミンK、カロチノイド(carotenoid)、多価不飽和脂肪酸またはこれのエステルから選択された少なくとも一つであることを特徴とする
請求項1〜5のいずれか一項に記載の脂溶性活性成分組成物。 - 脂溶性活性成分マイクロカプセルであって、
請求項1〜6のいずれか一項に記載の脂溶性活性成分組成物を含む、前記脂溶性活性成分マイクロカプセル。 - 食品、飲料、動物用飼料、化粧品または医薬品の製造における請求項1〜6のいずれか一項に記載の脂溶性活性成分組成物の応用。
- 請求項7に記載の脂溶性活性成分組成物を製造する方法であって、
窒素ガス保護下で、45〜85℃で脂溶性活性成分と抗酸化剤を一定の重量比で脂溶性活性成分溶融油の油相Aに配合することであって、ここで、前記抗酸化剤は、トコフェロール及びビタミンCパルミテートであり、前記脂溶性活性成分は、ビタミンA、ビタミンD、ビタミンK、コエンザイムQ10、カロチノイド、及び多価不飽和脂肪酸またはこれのエステルから選択された少なくとも一つであるステップ1)と、
窒素ガス保護下で、低分子充填剤としてのゼラチンまたは変性デンプンとグルコースまたは白砂糖を60〜70℃の水に溶解して、水相Bを獲得するステップ2)と、
窒素ガス保護下で、ステップ1)で獲得した油相Aとステップ2)で獲得した水相Bを、密閉条件下で、高せん断(high shear)によって乳化、脱気、均質化して乳化液を獲得するステップ3)と、及び
ステップ3)で獲得した前記乳化液をスプレー造粒した後、流動乾燥して、脂溶性活性成分マイクロカプセルを獲得するステップ4)とを含む、脂溶性活性成分組成物を製造する方法。 - ステップ4)で獲得した脂溶性活性成分マイクロカプセルを架橋させて、撥水型脂溶性活性成分マイクロカプセルを獲得することを特徴とする
請求項9に記載の脂溶性活性成分組成物を製造する方法。
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KR20230047243A (ko) | 2021-09-30 | 2023-04-07 | 고려자연식품(주) | 지용성 성분을 함유한 마이크로캡슐의 제조방법, 이의 제조방법에 따라 제조된 마이크로캡슐 및 이를 포함하는 젤리 |
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CN114588067A (zh) * | 2022-03-18 | 2022-06-07 | 上海世领制药有限公司 | 羟基频哪酮视黄酸酯高油促渗传递体、制备方法及其应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001058945A (ja) * | 1999-07-06 | 2001-03-06 | F Hoffmann La Roche Ag | 炭水化物マトリックス中に脂溶性物質を含む組成物 |
CN1850062A (zh) * | 2006-02-24 | 2006-10-25 | 无锡杰西医药科技有限公司 | 适用于干眼病的脂肪酸眼用纳米制剂 |
JP2009505809A (ja) * | 2005-07-04 | 2009-02-12 | ビーエーエスエフ ソシエタス・ヨーロピア | 乳化剤系、そのエマルジョンおよびその使用 |
JP2009512657A (ja) * | 2005-10-21 | 2009-03-26 | ディーエスエム アイピー アセッツ ビー.ブイ. | 高い生体利用効率を有する脂溶性活性成分の新規な処方物 |
JP2012139175A (ja) * | 2010-12-29 | 2012-07-26 | Riken Vitamin Co Ltd | フライ用油脂組成物 |
EP2862447A1 (en) * | 2013-10-16 | 2015-04-22 | Idcaps | Multilayer microcapsules containing an oxidizable active, and a process for preparing the same |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2189697B1 (es) * | 2001-12-28 | 2005-02-01 | Antibioticos, S.A.U. | Procedimiento para obtener nuevas formulaciones a base de luteina. |
CN102362864B (zh) * | 2011-10-26 | 2013-03-13 | 浙江新维普添加剂有限公司 | 提高维生素a或维生素d3微胶囊流散性和堆密度的方法 |
CN102550817B (zh) * | 2011-12-31 | 2013-11-20 | 厦门金达威集团股份有限公司 | 一种功能型油脂微胶囊及其制备方法 |
CN102525923B (zh) * | 2012-02-16 | 2014-09-10 | 中国农业大学 | 类胡萝卜素乳液及微胶囊的制备方法 |
-
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001058945A (ja) * | 1999-07-06 | 2001-03-06 | F Hoffmann La Roche Ag | 炭水化物マトリックス中に脂溶性物質を含む組成物 |
JP2009505809A (ja) * | 2005-07-04 | 2009-02-12 | ビーエーエスエフ ソシエタス・ヨーロピア | 乳化剤系、そのエマルジョンおよびその使用 |
JP2009512657A (ja) * | 2005-10-21 | 2009-03-26 | ディーエスエム アイピー アセッツ ビー.ブイ. | 高い生体利用効率を有する脂溶性活性成分の新規な処方物 |
CN1850062A (zh) * | 2006-02-24 | 2006-10-25 | 无锡杰西医药科技有限公司 | 适用于干眼病的脂肪酸眼用纳米制剂 |
JP2012139175A (ja) * | 2010-12-29 | 2012-07-26 | Riken Vitamin Co Ltd | フライ用油脂組成物 |
EP2862447A1 (en) * | 2013-10-16 | 2015-04-22 | Idcaps | Multilayer microcapsules containing an oxidizable active, and a process for preparing the same |
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KR102571958B1 (ko) | 2023-08-29 |
BR112019014985A2 (pt) | 2020-04-07 |
BR112019014985B1 (pt) | 2023-03-28 |
AU2018208993A1 (en) | 2019-09-05 |
AU2018208993B2 (en) | 2021-07-08 |
SG11201906708WA (en) | 2019-08-27 |
MX2019008650A (es) | 2020-01-30 |
CN108324699A (zh) | 2018-07-27 |
BR112019014985A8 (pt) | 2023-03-14 |
CA3051023A1 (en) | 2018-07-26 |
KR20200015884A (ko) | 2020-02-13 |
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