CN114209065A - 一种维生素d2微囊粉及其制备方法 - Google Patents
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Abstract
本发明涉及维生素D2微囊制备技术领域。维生素D2微囊制备是将维生素D2微囊溶解到植物油中，通过变性淀粉及抗氧化剂进行乳化，采用喷雾干燥，利用淀粉包埋，形成微囊产品。该产品特点通过乳化形成微囊，具有很高的稳定和水溶性的特性，可添加于奶粉、米粉，软饮料及钙制剂中补充维生素D2。
Description
技术领域
本发明涉及维生素D2衍生物技术领域，更具体地说是一种维生素D2微囊粉及其制备方法。
背景技术
维生素D2是人和动物维持正常生命活动与健康所必须的微量有机化合物之一，药品、食品和饲料中都可以适量添加维生素D2来满足人或动物有规律地从外界摄取。维生素D2是在植物中发现的维生素D2的主要天然形式。(参见中国专利95118188.2)。而维生素根据其溶解度分为两类即脂溶性维生素(A、D、E、K)等，或水溶性维生素(B1、B2、B6)，叶酸、烟酸及维生素C)等。[见《药物化学》第15章，一、维生素的分类(中央电大农医部王淑霞)]。由于维生素D2不溶于水而溶于脂肪及脂溶剂，因此在食物中常与脂质共存，在肠道吸收时也与脂质的吸收密切相关，当人或动物对脂质的吸收不良时，脂溶性维生素D2的吸收会减少，从而引起相应的缺乏症。在医学上维生素D2的主要适应症包含三个方面:一、用于维生素D缺乏症的预防与治疗。如:绝对素食者、肠外营养病人、胰腺功能不全伴吸收不良综合症、肝胆疾病(肝功能损害、肝硬化、阻塞性黄疸)、小肠疾病(脂性腹泻、局限性肠道炎、长期腹泻)，胃切除等。二、用于慢性低钙血症、低磷血症、佝偻病及伴有慢性肾功能不全的骨软化症、家族性低磷血症及甲状旁腺功能低下(术后，特发性或假性甲状旁腺功能低下)的治疗。三、用于治疗急、慢性及潜在手术后手足抽搐症及特发性手足抽搐症，而动物维生素D2的缺乏症的特征表现为:维生素D2不足时，即使钙、磷充足，动物也不能很好的利用，钙，磷、镁在骨骼中的沉积会下降；幼龄动物的成骨作用发生障碍，出现佝偻病和软骨症，牙齿发育不良，生长受阻；成年动物发生骨质疏松症，易骨折，关节变形；母畜孕期维生素D2过度缺乏会造成新生幼仔先天畸形，母畜本身也会受到损害；家禽缺乏维生素D2可降低产蛋量和孵化率，蛋壳薄而易脆裂。因此在现代机械化人工大量饲养动物的条件下更需补充维生素D2。大多数情况下补充维生素D2的方式服用相关的衍生物进行补充，但维生素D2属于脂溶性维生素，无法直接服用，从而选择制成微囊粉，微囊粉可以直接服用或可添加于奶粉、米粉、软饮料及钙制剂中用于补充维生素D2。目前的微囊粉生产工艺及配方不能够充分解决生素D2属于脂溶性维生素，无法直接服用的问题，并且添加于奶粉、米粉、软饮料及钙制剂等中不能使维生素D2充分被人体吸收，从而造成一定量维生素D2的浪费，使得下游生产线成本的增加，产品稳定性降低。
发明内容
针对现有技术中上述的不足，本发明的目的在于提供一种维生素D2微囊粉及其制备方法；本发明能够有效的提高微囊的稳定性与水溶性，同时保证微囊与其它产品的互溶性。
为了达到上述目的，本发明采用的解决方案是：一种维生素D2微囊粉，由下列重量份原料制备而成，包括维生素D2油900～1100g、变性淀粉8500～8600g、白砂糖14500～14600g、抗坏血酸棕榈酸脂48～49g和生育酚242～243g。
一种维生素D2微囊粉制备方法，包括以下步骤：
a、按上述比例取维生素D2置于容器中，加入植物油使维生素D2溶解于；
b、待维生素D2完全溶解后，加入包合物以及抗坏血酸棕榈酸脂抗氧化剂进行乳化；
c、完全乳化后采用喷雾制粒干燥，再利用淀粉和抗结剂二氧化硅包埋；
d、筛分，得维生素D2微囊粉产品。
优选的，所述步骤c中干燥温度为110-130℃。
优选的，所述步骤a中的植物油可选用葵花油、花生油、菜籽油。
优选的，所述步骤b中的包合物为乙基纤维素或蔗糖或变性淀粉，使用时选择其中的一种或者两种。
本发明的有益效果是：本发明将产品通过乳化形成微囊，使得微囊具有很高的稳定和水溶性的特性，可添加于奶粉、米粉，软饮料及钙制剂中使维生素D2利用更加充分，又因为该工艺有效的提高了微囊的稳定性和水溶性，使其够更好与奶粉、米粉，软饮料及钙制剂充分的互溶，提高了维生素D2的利用率，有效的降低了下游生产线的成本，同时保证下游产品的稳定性。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚，下面将对本发明实施例中的技术方案进行清楚、完整地描述。实施例中未注明具体条件者，按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者，均为可以通过市售购买获得的常规产品。
下面结合具体的实施方式来对本发明的技术方案做进一步的限定，但要求保护的范围不仅局限于所作的描述。
本发明提供一种技术方案：一种维生素D2微囊粉，由下列重量份原料制备而成，包括维生素D2油1000g、变性淀粉8500g、白砂糖14500g、抗坏血酸棕榈酸脂48g和生育酚242g。
一种维生素D2微囊粉制备方法，包括以下步骤：
a、按上述比例取维生素D2置于容器中，加入植物油使维生素D2溶解于；
b、待维生素D2完全溶解后，加入包合物以及抗坏血酸棕榈酸脂抗氧化剂进行乳化；
c、完全乳化后采用喷雾制粒干燥，再利用淀粉和抗结剂二氧化硅包埋；
d、筛分，得维生素D2微囊粉产品。
优选的，所述步骤c中干燥温度为120℃。
优选的，所述步骤a中的植物油可选用葵花油、花生油、菜籽油。
优选的，所述步骤b中的包合物为乙基纤维素或蔗糖或变性淀粉，使用时选择其中的一种或者两种。
本发明将产品通过乳化形成微囊，使得微囊具有很高的稳定和水溶性的特性，可添加于奶粉、米粉，软饮料及钙制剂中使维生素D2利用更加充分，又因为该工艺有效的提高了微囊的稳定性和水溶性，使其够更好与奶粉、米粉，软饮料及钙制剂充分的互溶，提高了维生素D2的利用率，有效的降低了下游生产线的成本，同时保证下游产品的稳定性。
以上所述仅为本发明的优选实施例而已，并不用于限制本发明，对于本领域的技术人员来说，本发明可以有各种更改和变化。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (5)
1.一种维生素D2微囊粉，其特征在于：由下列重量份原料制备而成，包括维生素D2油900～1100g、变性淀粉8500～8600g、白砂糖14500～14600g、抗坏血酸棕榈酸酯48～49g和生育酚242～243g。
2.如权利要求1所述的一种维生素D2微囊粉制备方法，其特征在于：包括以下步骤：
a、按上述比例取维生素D2置于容器中，加入植物油使维生素D2溶解于；
b、待维生素D2完全溶解后，加入包合物以及抗坏血酸棕榈酸酯抗氧化剂进行乳化；
c、完全乳化后采用喷雾制粒干燥，再利用淀粉和抗结剂二氧化硅包埋；
d、筛分，得维生素D2微囊粉产品。
3.根据权利要求2所述的维生素D2微囊粉制备方法，其特征在于：所述步骤c中干燥温度为110-130℃。
4.根据权利要求2所述的维生素D2微囊粉制备方法，其特征在于：所述步骤a中的植物油可选用葵花油、花生油、菜籽油。
5.根据权利要求2所述的维生素D2微囊粉制备方法，其特征在于：所述步骤b中的包合物为乙基纤维素或蔗糖或变性淀粉，使用时选择其中的一种或者两种。
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| CN111494408A (zh) * | 2020-04-28 | 2020-08-07 | 广东润源中天生物科技有限公司 | 一种钙维生素d3片及其生产方法 |
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| CN108324699A (zh) * | 2017-01-20 | 2018-07-27 | 浙江医药股份有限公司新昌制药厂 | 稳定的脂溶性活性成分组合物、微囊及其制备方法和应用 |
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