JP2020508691A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020508691A5 JP2020508691A5 JP2019548419A JP2019548419A JP2020508691A5 JP 2020508691 A5 JP2020508691 A5 JP 2020508691A5 JP 2019548419 A JP2019548419 A JP 2019548419A JP 2019548419 A JP2019548419 A JP 2019548419A JP 2020508691 A5 JP2020508691 A5 JP 2020508691A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- soluble
- fusion protein
- protein complex
- 15rαsu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims description 75
- 102000037865 fusion proteins Human genes 0.000 claims description 75
- 108090000623 proteins and genes Proteins 0.000 claims description 70
- 102000004169 proteins and genes Human genes 0.000 claims description 70
- 108090000172 Interleukin-15 Proteins 0.000 claims description 44
- 102000003812 Interleukin-15 Human genes 0.000 claims description 44
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 229920001184 polypeptide Polymers 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 108060003951 Immunoglobulin Proteins 0.000 claims description 14
- 239000012634 fragment Substances 0.000 claims description 14
- 102000018358 immunoglobulin Human genes 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 108010017535 Interleukin-15 Receptors Proteins 0.000 claims description 7
- 102000004556 Interleukin-15 Receptors Human genes 0.000 claims description 7
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 208000035473 Communicable disease Diseases 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 208000035269 cancer or benign tumor Diseases 0.000 claims description 4
- 230000004927 fusion Effects 0.000 claims description 3
- 102000037982 Immune checkpoint proteins Human genes 0.000 claims description 2
- 108091008036 Immune checkpoint proteins Proteins 0.000 claims description 2
- 230000011664 signaling Effects 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000000710 homodimer Substances 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 230000007928 solubilization Effects 0.000 claims 1
- 238000005063 solubilization Methods 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 description 45
- 238000000034 method Methods 0.000 description 20
- 210000004027 cell Anatomy 0.000 description 18
- 210000002865 immune cell Anatomy 0.000 description 17
- 108040003610 interleukin-12 receptor activity proteins Proteins 0.000 description 8
- 108040002014 interleukin-18 receptor activity proteins Proteins 0.000 description 8
- 102000008625 interleukin-18 receptor activity proteins Human genes 0.000 description 8
- 108040002039 interleukin-15 receptor activity proteins Proteins 0.000 description 7
- 102000008616 interleukin-15 receptor activity proteins Human genes 0.000 description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 description 5
- 230000035772 mutation Effects 0.000 description 5
- 150000007523 nucleic acids Chemical group 0.000 description 5
- 102220311640 rs1382779104 Human genes 0.000 description 5
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 108010053727 Interleukin-15 Receptor alpha Subunit Proteins 0.000 description 4
- 230000003213 activating effect Effects 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 230000019491 signal transduction Effects 0.000 description 4
- 239000004471 Glycine Substances 0.000 description 3
- 230000000975 bioactive effect Effects 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 230000006918 subunit interaction Effects 0.000 description 3
- 102000009109 Fc receptors Human genes 0.000 description 2
- 108010087819 Fc receptors Proteins 0.000 description 2
- 108091006020 Fc-tagged proteins Proteins 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
- 206010060862 Prostate cancer Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 230000005714 functional activity Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 201000005202 lung cancer Diseases 0.000 description 2
- 208000020816 lung neoplasm Diseases 0.000 description 2
- 210000000822 natural killer cell Anatomy 0.000 description 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 2
- 230000014621 translational initiation Effects 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
- 208000003950 B-cell lymphoma Diseases 0.000 description 1
- 208000012526 B-cell neoplasm Diseases 0.000 description 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 108010069112 Complement System Proteins Proteins 0.000 description 1
- 102000000989 Complement System Proteins Human genes 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 206010062878 Gastrooesophageal cancer Diseases 0.000 description 1
- 208000017604 Hodgkin disease Diseases 0.000 description 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
- 208000034578 Multiple myelomas Diseases 0.000 description 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 108700022034 Opsonin Proteins Proteins 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 description 1
- 206010042971 T-cell lymphoma Diseases 0.000 description 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
- 230000024203 complement activation Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 201000006974 gastroesophageal cancer Diseases 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 201000010536 head and neck cancer Diseases 0.000 description 1
- 208000014829 head and neck neoplasm Diseases 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 239000000833 heterodimer Substances 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 201000005962 mycosis fungoides Diseases 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 206010038038 rectal cancer Diseases 0.000 description 1
- 201000001275 rectum cancer Diseases 0.000 description 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 102000035025 signaling receptors Human genes 0.000 description 1
- 108091005475 signaling receptors Proteins 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 210000003741 urothelium Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022194613A JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762467623P | 2017-03-06 | 2017-03-06 | |
| US62/467,623 | 2017-03-06 | ||
| PCT/US2018/021220 WO2018165208A1 (en) | 2017-03-06 | 2018-03-06 | Il-15-based fusions to il-12 and il-18 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022194613A Division JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508691A JP2020508691A (ja) | 2020-03-26 |
| JP2020508691A5 true JP2020508691A5 (https=) | 2021-04-15 |
| JP7191030B2 JP7191030B2 (ja) | 2022-12-16 |
Family
ID=63448011
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548419A Active JP7191030B2 (ja) | 2017-03-06 | 2018-03-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2022194613A Pending JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A Active JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022194613A Pending JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A Active JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US11129883B2 (https=) |
| EP (1) | EP3592778A4 (https=) |
| JP (3) | JP7191030B2 (https=) |
| KR (4) | KR102867975B1 (https=) |
| CN (2) | CN117986384A (https=) |
| AU (1) | AU2018231170B2 (https=) |
| CA (2) | CA3216726C (https=) |
| WO (1) | WO2018165208A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2160401T3 (da) * | 2007-05-11 | 2014-10-20 | Altor Bioscience Corp | Fusionsmolekyler og il-15-varianter |
| CN117986384A (zh) | 2017-03-06 | 2024-05-07 | 艾尔特生物科技公司 | 与il-12和il-18的基于il-15的融合物 |
| CN113061577A (zh) * | 2017-09-05 | 2021-07-02 | 四川新生命干细胞科技股份有限公司 | 一种高纯度nk细胞的分离培养方法 |
| CN111315395A (zh) | 2017-09-06 | 2020-06-19 | 耶鲁大学 | 白细胞介素-18变体和使用方法 |
| JP2021516052A (ja) * | 2018-03-01 | 2021-07-01 | フンダシオン パラ ラ インベスティガシオン ビオメディカ デル オスピタル グレゴリオ マラニョン | 胸腺組織に由来する制御性ｔ細胞を入手する方法および免疫系障害における細胞免疫療法としての前記細胞の使用 |
| WO2020023713A1 (en) * | 2018-07-26 | 2020-01-30 | Nantbio, Inc. | Tri-cytokine txm compositions and methods |
| US11518792B2 (en) | 2018-08-30 | 2022-12-06 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| US11401324B2 (en) | 2018-08-30 | 2022-08-02 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| CA3109361A1 (en) | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Single-chain and multi-chain chimeric polypeptides and uses thereof |
| US12098177B2 (en) * | 2018-09-07 | 2024-09-24 | Nantbio, Inc. | Targeted IL-12 treatments and methods to stimulate haNK and NK92mi cells |
| CN120924491A (zh) | 2019-06-21 | 2025-11-11 | 免疫生物公司 | 多链嵌合多肽和其用途 |
| CA3117134A1 (en) * | 2019-07-08 | 2021-01-14 | Nantkwest, Inc. | Ciml nk cells and methods therefor |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| AU2019456283B2 (en) | 2019-07-08 | 2023-06-08 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| US20210008107A1 (en) * | 2019-07-08 | 2021-01-14 | Nantkwest, Inc. | CIML NK cells and Methods Therefor |
| WO2021044439A1 (en) * | 2019-09-08 | 2021-03-11 | Immunoadaptive Cell Therapy Pvt Ltd. | Inducible cytokine signals & methods for immunotherapy |
| RU2753282C2 (ru) * | 2019-09-19 | 2021-08-12 | Закрытое Акционерное Общество "Биокад" | ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ |
| CN115916233A (zh) * | 2019-10-03 | 2023-04-04 | Xencor股份有限公司 | 靶向IL-12异源二聚体Fc融合蛋白 |
| WO2021097227A1 (en) * | 2019-11-14 | 2021-05-20 | Altor Bioscience, Llc | Il-15 fusion protein enhanced adoptive cell therapeutics |
| KR102400884B1 (ko) * | 2019-11-15 | 2022-05-23 | 주식회사 제넥신 | 변형된 인터루킨-7 및 인터루킨-2를 포함하는 융합단백질 및 이의 용도 |
| CA3169243A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| AU2021220870A1 (en) | 2020-02-11 | 2022-08-04 | Immunitybio, Inc. | Methods of treating age-related and inflammatory diseases |
| WO2021163299A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Chromatography resin and uses thereof |
| CN115836087A (zh) | 2020-04-29 | 2023-03-21 | Hcw生物科技公司 | 抗cd26蛋白及其用途 |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| GB202102049D0 (en) * | 2021-02-13 | 2021-03-31 | Psioxus Therapeutics Ltd | Viruses |
| CA3211456A1 (en) * | 2021-03-03 | 2022-09-09 | Immunitybio, Inc. | Highly potent m-cenk cells and methods |
| US12180492B2 (en) | 2021-06-09 | 2024-12-31 | Immunitybio, Inc. | Methods and systems for producing a protein of interest in a plant |
| CN114853899B (zh) * | 2021-11-02 | 2024-05-28 | 北京华奥玄德生物医药科技有限公司 | 一种il-12和il-18变体的融合蛋白及其制备方法和用途 |
| WO2023201311A1 (en) | 2022-04-13 | 2023-10-19 | HCW Biologics, Inc. | Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder |
| EP4572781A2 (en) * | 2022-08-16 | 2025-06-25 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Synergistic interactions for improved cancer treatment |
| CN121152797A (zh) * | 2023-03-31 | 2025-12-16 | 免疫生物公司 | Il-12/il-18超级因子 |
| IL325267A (en) * | 2023-06-14 | 2026-02-01 | Fuse Biotherapeutics Inc | Single-cytokine and multi-cytokine fusion proteins and their uses |
| AU2024352706A1 (en) * | 2023-09-28 | 2026-04-02 | Prokarium Limited | Interleukin 18 variants |
| WO2025184052A1 (en) * | 2024-02-26 | 2025-09-04 | Allegheny Singer Research Institute | Interleukin 2 and interleukin 12 fusion proteins and methods of using |
| US20260027155A1 (en) | 2024-07-23 | 2026-01-29 | Immunitybio, Inc. | Compositions and methods related to potent cytotoxic m-cenk cells from cd3/cd14-depleted apheresis products |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| WO1994004689A1 (en) | 1992-08-14 | 1994-03-03 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant toxin with increased half-life |
| US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US5891680A (en) * | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5534592A (en) | 1995-09-22 | 1996-07-09 | The Goodyear Tire & Rubber Company | High performance blend for tire treads |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| WO2004060291A2 (en) | 2002-12-31 | 2004-07-22 | Schering Corporation | Uses of mammalian cytokine; related reagents |
| DE602004031341D1 (de) | 2003-07-21 | 2011-03-24 | Transgene Sa | Multifunktionelle cytokine |
| US8772451B2 (en) | 2003-11-10 | 2014-07-08 | Altor Bioscience Corporation | Soluble TCR molecules and methods of use |
| DK2160401T3 (da) | 2007-05-11 | 2014-10-20 | Altor Bioscience Corp | Fusionsmolekyler og il-15-varianter |
| CN105131127B (zh) * | 2007-05-30 | 2018-09-07 | 浦项工科大学校产学协力团 | 免疫球蛋白融合蛋白 |
| US9931386B2 (en) * | 2008-06-16 | 2018-04-03 | Atsuo Ochi | Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of antigen-specific immunity |
| US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
| CN107880136B (zh) * | 2010-09-21 | 2021-11-12 | 阿尔托生物科学有限公司 | 多聚体il-15可溶性融合分子与其制造与使用方法 |
| CA3101783C (en) * | 2011-10-11 | 2023-01-31 | Universitat Zurich Prorektorat Mnw | Combination medicament comprising il-12 and an agent for blockade of t-cell inhibitory molecules for tumour therapy |
| CA3151221C (en) | 2014-06-30 | 2026-01-13 | Altor Bioscience Corporation | Il-15-based molecules and methods of use thereof |
| CN118562016A (zh) * | 2016-10-21 | 2024-08-30 | 艾尔特生物科技公司 | 基于多聚体il-15的分子 |
| CN117986384A (zh) | 2017-03-06 | 2024-05-07 | 艾尔特生物科技公司 | 与il-12和il-18的基于il-15的融合物 |
| US20190048055A1 (en) | 2017-03-31 | 2019-02-14 | Altor Bioscience Corporation | Alt-803 in combination with anti-cd38 antibody for cancer therapies |
| EP3676289B1 (en) | 2017-08-28 | 2026-03-04 | Altor BioScience, LLC | Il-15-based fusions to il-7 and il-21 |
| TW202003011A (zh) | 2018-03-26 | 2020-01-16 | 美商艾爾特生物科技責任有限公司 | 抗ＰＤＬ１、ＩＬ－１５及ＴＧＦ－β受體組合分子 |
-
2018
- 2018-03-06 CN CN202311813891.8A patent/CN117986384A/zh active Pending
- 2018-03-06 CN CN201880016721.8A patent/CN110785435B/zh active Active
- 2018-03-06 JP JP2019548419A patent/JP7191030B2/ja active Active
- 2018-03-06 EP EP18764359.8A patent/EP3592778A4/en active Pending
- 2018-03-06 CA CA3216726A patent/CA3216726C/en active Active
- 2018-03-06 WO PCT/US2018/021220 patent/WO2018165208A1/en not_active Ceased
- 2018-03-06 KR KR1020247039400A patent/KR102867975B1/ko active Active
- 2018-03-06 US US15/913,837 patent/US11129883B2/en active Active
- 2018-03-06 KR KR1020257032318A patent/KR20250150164A/ko active Pending
- 2018-03-06 CA CA3055318A patent/CA3055318C/en active Active
- 2018-03-06 KR KR1020197029313A patent/KR102625293B1/ko active Active
- 2018-03-06 AU AU2018231170A patent/AU2018231170B2/en active Active
- 2018-03-06 KR KR1020237042270A patent/KR102739572B1/ko active Active
-
2021
- 2021-09-27 US US17/486,683 patent/US11571470B2/en active Active
-
2022
- 2022-08-19 US US17/820,980 patent/US11612645B2/en active Active
- 2022-12-06 JP JP2022194613A patent/JP2023027174A/ja active Pending
-
2023
- 2023-02-13 US US18/168,428 patent/US11872272B2/en active Active
- 2023-12-01 US US18/526,598 patent/US11975059B2/en active Active
-
2024
- 2024-03-20 US US18/611,464 patent/US20240252609A1/en not_active Abandoned
- 2024-05-21 JP JP2024082540A patent/JP7720950B2/ja active Active
- 2024-09-25 US US18/896,286 patent/US12233116B2/en active Active
-
2025
- 2025-01-15 US US19/021,639 patent/US20250152686A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020508691A5 (https=) | ||
| CN112534052B (zh) | 全新il-21前药及使用方法 | |
| CN112654636A (zh) | 可活化白介素12多肽及其使用方法 | |
| JP7121496B2 (ja) | 癌治療で使用するためのペグ化インターロイキン－１０ | |
| CN106459219B (zh) | 白细胞介素15蛋白复合物及其用途 | |
| CN102906112B (zh) | Trail r2-特异性多聚体支架 | |
| JP2025041812A5 (https=) | ||
| JP7423607B2 (ja) | インターロイキン ２突然変異タンパク質およびｉ型インターフェロンで構成される融合タンパク質 | |
| AU2020353235A1 (en) | Cytokine prodrugs and dual-prodrugs | |
| JP2021521822A5 (https=) | ||
| JP2020533971A5 (https=) | ||
| JP2003507012A5 (https=) | ||
| JP7356726B2 (ja) | タンパク性ヘテロ二量体及びその使用 | |
| EP4284819A1 (en) | Chimeric molecules comprising an il-10 or tgf-beta agonist polypeptide | |
| EA012622B1 (ru) | Биспецифичные гибридные антитела с увеличенным периодом полувыведения из сыворотки | |
| EA011992B1 (ru) | Гибридный белок антитела l19 к фибронектину ed-b и интерлейкина 12 | |
| CA2935599A1 (en) | Il-15 heterodimeric protein and uses thereof | |
| JP2019528683A (ja) | 多量体ｇｉｔｒ結合分子及びその使用 | |
| EP4019536A1 (en) | Immunocytokine, preparation for same, and uses thereof | |
| JPWO2021189139A5 (https=) | ||
| JP2004508828A (ja) | 標的−特異的プロドラッグとしての使用のための抗体サイトカイン−サイトカインインヒビター（セレクトカイン）からの融合タンパク質 | |
| JP2008535475A5 (https=) | ||
| TW201841944A (zh) | 4-1bbl變異體及包含其之融合蛋白 | |
| WO2019096026A1 (zh) | 抗il-17抗体/tnfr ecd融合蛋白及其用途 | |
| JP2008521426A5 (https=) |