JP2020533971A5 - - Google Patents
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- Publication number
- JP2020533971A5 JP2020533971A5 JP2020511477A JP2020511477A JP2020533971A5 JP 2020533971 A5 JP2020533971 A5 JP 2020533971A5 JP 2020511477 A JP2020511477 A JP 2020511477A JP 2020511477 A JP2020511477 A JP 2020511477A JP 2020533971 A5 JP2020533971 A5 JP 2020533971A5
- Authority
- JP
- Japan
- Prior art keywords
- fusion protein
- cells
- soluble
- protein complex
- soluble fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762551218P | 2017-08-28 | 2017-08-28 | |
| US62/551,218 | 2017-08-28 | ||
| PCT/US2018/048365 WO2019046313A1 (en) | 2017-08-28 | 2018-08-28 | IL-15 BASED FUSIONS WITH IL-7 AND IL-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020533971A JP2020533971A (ja) | 2020-11-26 |
| JP2020533971A5 true JP2020533971A5 (https=) | 2021-10-07 |
Family
ID=65526059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511477A Withdrawn JP2020533971A (ja) | 2017-08-28 | 2018-08-28 | Ｉｌ−１５をベースとするｉｌ−７及びｉｌ−２１への融合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US11161890B2 (https=) |
| EP (1) | EP3676289B1 (https=) |
| JP (1) | JP2020533971A (https=) |
| KR (1) | KR20200090742A (https=) |
| CN (1) | CN111655716B (https=) |
| AU (1) | AU2018323455B2 (https=) |
| CA (1) | CA3074635A1 (https=) |
| WO (1) | WO2019046313A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2160401T3 (da) * | 2007-05-11 | 2014-10-20 | Altor Bioscience Corp | Fusionsmolekyler og il-15-varianter |
| EP3572502B1 (en) * | 2017-01-20 | 2023-01-11 | Kyoto University | Method for producing cd8alpha +beta + cytotoxic t cells |
| CN117986384A (zh) | 2017-03-06 | 2024-05-07 | 艾尔特生物科技公司 | 与il-12和il-18的基于il-15的融合物 |
| EP3676289B1 (en) | 2017-08-28 | 2026-03-04 | Altor BioScience, LLC | Il-15-based fusions to il-7 and il-21 |
| WO2020037120A1 (en) * | 2018-08-16 | 2020-02-20 | Nantbio, Inc. | Il7-il15 txm compositions and methods |
| US11518792B2 (en) | 2018-08-30 | 2022-12-06 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| US11401324B2 (en) | 2018-08-30 | 2022-08-02 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| CA3109361A1 (en) | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Single-chain and multi-chain chimeric polypeptides and uses thereof |
| GB201818816D0 (en) * | 2018-11-19 | 2019-01-02 | Synpromics Ltd | Regulatory nucleic acid sequences |
| CN111825770B (zh) * | 2019-04-16 | 2023-06-09 | 成都医学院 | 长效白介素21-Fc融合蛋白及其用途 |
| CN120924491A (zh) | 2019-06-21 | 2025-11-11 | 免疫生物公司 | 多链嵌合多肽和其用途 |
| GB201909144D0 (en) | 2019-06-25 | 2019-08-07 | Autolus Ltd | Culture medium |
| AU2019456283B2 (en) * | 2019-07-08 | 2023-06-08 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| WO2021041886A1 (en) * | 2019-08-29 | 2021-03-04 | Nantbio, Inc. | Modified n-810 and methods therefor |
| AU2020406083A1 (en) | 2019-12-17 | 2022-06-16 | Boehringer Ingelheim International Gmbh | Bifunctional molecules comprising an IL-7 variant |
| WO2021163299A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Chromatography resin and uses thereof |
| AU2021220870A1 (en) | 2020-02-11 | 2022-08-04 | Immunitybio, Inc. | Methods of treating age-related and inflammatory diseases |
| CA3169243A1 (en) | 2020-02-11 | 2021-08-19 | HCW Biologics, Inc. | Methods of activating regulatory t cells |
| CN115836087A (zh) | 2020-04-29 | 2023-03-21 | Hcw生物科技公司 | 抗cd26蛋白及其用途 |
| WO2021247003A1 (en) * | 2020-06-01 | 2021-12-09 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| JP2023527869A (ja) * | 2020-06-01 | 2023-06-30 | エイチシーダブリュー バイオロジックス インコーポレイテッド | 加齢関連障害の治療法 |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| GB202008957D0 (en) | 2020-06-12 | 2020-07-29 | Autolus Ltd | Culture medium |
| EP4232071A4 (en) | 2020-10-23 | 2024-08-28 | Asher Biotherapeutics, Inc. | FUSIONS WITH CD8 ANTIGEN-BINDING MOLECULES TO MODULATE IMMUNE CELL FUNCTION |
| AU2022275666A1 (en) | 2021-05-19 | 2023-12-07 | Asher Biotherapeutics, Inc. | Il-21 polypeptides and targeted constructs |
| US12180492B2 (en) | 2021-06-09 | 2024-12-31 | Immunitybio, Inc. | Methods and systems for producing a protein of interest in a plant |
| EP4362969A4 (en) * | 2021-06-30 | 2025-05-07 | The Regents of University of California | CHANGE IN CYTOKINE SPECIFICITY BY BINDING VALENCE |
| CN113549158B (zh) * | 2021-07-19 | 2022-10-21 | 广州百暨基因科技有限公司 | 包含突变型il15以及嵌合抗原受体的融合蛋白 |
| WO2023201311A1 (en) | 2022-04-13 | 2023-10-19 | HCW Biologics, Inc. | Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder |
| JP2025515470A (ja) * | 2022-04-27 | 2025-05-15 | アシャ バイオセラピューティクス，インク． | サイトカイン融合タンパク質とｃｄ８抗原結合分子の併用 |
| EP4572781A2 (en) * | 2022-08-16 | 2025-06-25 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Synergistic interactions for improved cancer treatment |
| KR20250160456A (ko) * | 2023-03-23 | 2025-11-13 | 길리애드 사이언시즈, 인코포레이티드 | Tnf 슈퍼패밀리 멤버 면역사이토카인 및 이의 용도 |
| CN117186243B (zh) * | 2023-07-26 | 2025-08-19 | 四川三优康生物技术有限公司 | 猪白细胞介素15，21和23共表达生物制剂材料及应用 |
| WO2025064822A2 (en) * | 2023-09-20 | 2025-03-27 | Factor Bioscience Inc. | Cells and methods for engineering cells with persistent transgene expression |
| CN117050178B (zh) * | 2023-10-13 | 2024-01-12 | 北京百普赛斯生物科技股份有限公司 | 特异性检测il-7的抗体及应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8507A (en) | 1851-11-11 | petess | ||
| US222A (en) | 1837-06-10 | Truss for the retention and radical cure qe hernia | ||
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| WO1994004689A1 (en) | 1992-08-14 | 1994-03-03 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant toxin with increased half-life |
| US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5534592A (en) | 1995-09-22 | 1996-07-09 | The Goodyear Tire & Rubber Company | High performance blend for tire treads |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| US8772451B2 (en) | 2003-11-10 | 2014-07-08 | Altor Bioscience Corporation | Soluble TCR molecules and methods of use |
| DK2160401T3 (da) * | 2007-05-11 | 2014-10-20 | Altor Bioscience Corp | Fusionsmolekyler og il-15-varianter |
| US9931386B2 (en) * | 2008-06-16 | 2018-04-03 | Atsuo Ochi | Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of antigen-specific immunity |
| CN107880136B (zh) * | 2010-09-21 | 2021-11-12 | 阿尔托生物科学有限公司 | 多聚体il-15可溶性融合分子与其制造与使用方法 |
| AU2016333873A1 (en) | 2015-10-06 | 2018-05-17 | The Wistar Institute Of Anatomy And Biology | Methods and compositions for treatment of metastatic and refractory cancers and tumors |
| CN118562016A (zh) | 2016-10-21 | 2024-08-30 | 艾尔特生物科技公司 | 基于多聚体il-15的分子 |
| EP3676289B1 (en) | 2017-08-28 | 2026-03-04 | Altor BioScience, LLC | Il-15-based fusions to il-7 and il-21 |
-
2018
- 2018-08-28 EP EP18851494.7A patent/EP3676289B1/en active Active
- 2018-08-28 AU AU2018323455A patent/AU2018323455B2/en active Active
- 2018-08-28 US US16/114,870 patent/US11161890B2/en active Active
- 2018-08-28 CN CN201880070462.7A patent/CN111655716B/zh active Active
- 2018-08-28 WO PCT/US2018/048365 patent/WO2019046313A1/en not_active Ceased
- 2018-08-28 KR KR1020207009046A patent/KR20200090742A/ko not_active Ceased
- 2018-08-28 CA CA3074635A patent/CA3074635A1/en not_active Abandoned
- 2018-08-28 JP JP2020511477A patent/JP2020533971A/ja not_active Withdrawn
-
2021
- 2021-10-18 US US17/504,100 patent/US11965007B2/en active Active
-
2023
- 2023-09-21 US US18/472,053 patent/US12410224B2/en active Active
-
2024
- 2024-07-17 US US18/775,868 patent/US20240368237A1/en active Pending
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