JP2020508317A5 - - Google Patents

Download PDF

Info

Publication number
JP2020508317A5
JP2020508317A5 JP2019545324A JP2019545324A JP2020508317A5 JP 2020508317 A5 JP2020508317 A5 JP 2020508317A5 JP 2019545324 A JP2019545324 A JP 2019545324A JP 2019545324 A JP2019545324 A JP 2019545324A JP 2020508317 A5 JP2020508317 A5 JP 2020508317A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
seq
antibody
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019545324A
Other languages
English (en)
Japanese (ja)
Other versions
JP7324710B2 (ja
JP2020508317A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/018747 external-priority patent/WO2018156494A1/en
Publication of JP2020508317A publication Critical patent/JP2020508317A/ja
Publication of JP2020508317A5 publication Critical patent/JP2020508317A5/ja
Priority to JP2022037781A priority Critical patent/JP7384949B2/ja
Application granted granted Critical
Publication of JP7324710B2 publication Critical patent/JP7324710B2/ja
Priority to JP2023190525A priority patent/JP7656012B2/ja
Priority to JP2025044340A priority patent/JP2025098103A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019545324A 2017-02-21 2018-02-20 肺癌の処置のための抗pd-1抗体 Active JP7324710B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022037781A JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体
JP2023190525A JP7656012B2 (ja) 2017-02-21 2023-11-08 肺癌の処置のための抗pd-1抗体
JP2025044340A JP2025098103A (ja) 2017-02-21 2025-03-19 肺癌の処置のための抗pd-1抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762461672P 2017-02-21 2017-02-21
US62/461,672 2017-02-21
US201762595190P 2017-12-06 2017-12-06
US62/595,190 2017-12-06
PCT/US2018/018747 WO2018156494A1 (en) 2017-02-21 2018-02-20 Anti-pd-1 antibodies for treatment of lung cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022037781A Division JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体

Publications (3)

Publication Number Publication Date
JP2020508317A JP2020508317A (ja) 2020-03-19
JP2020508317A5 true JP2020508317A5 (Direct) 2021-07-26
JP7324710B2 JP7324710B2 (ja) 2023-08-10

Family

ID=61628468

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2019545324A Active JP7324710B2 (ja) 2017-02-21 2018-02-20 肺癌の処置のための抗pd-1抗体
JP2022037781A Active JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体
JP2023190525A Active JP7656012B2 (ja) 2017-02-21 2023-11-08 肺癌の処置のための抗pd-1抗体
JP2025044340A Pending JP2025098103A (ja) 2017-02-21 2025-03-19 肺癌の処置のための抗pd-1抗体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2022037781A Active JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体
JP2023190525A Active JP7656012B2 (ja) 2017-02-21 2023-11-08 肺癌の処置のための抗pd-1抗体
JP2025044340A Pending JP2025098103A (ja) 2017-02-21 2025-03-19 肺癌の処置のための抗pd-1抗体

Country Status (12)

Country Link
US (3) US11292842B2 (Direct)
EP (1) EP3585812A1 (Direct)
JP (4) JP7324710B2 (Direct)
KR (2) KR20240011262A (Direct)
CN (2) CN110536905B (Direct)
AU (2) AU2018225102B2 (Direct)
CA (1) CA3054289A1 (Direct)
IL (3) IL321717A (Direct)
MA (1) MA47604A (Direct)
MX (2) MX2019009772A (Direct)
WO (1) WO2018156494A1 (Direct)
ZA (1) ZA201905051B (Direct)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
PL3334763T3 (pl) 2015-08-11 2024-12-02 WuXi Biologics Ireland Limited Nowe przeciwciała anty-pd-1
MX2019003683A (es) 2016-10-11 2019-08-22 Agenus Inc Anticuerpos anti gen 3 de activación linfocítica (lag 3 ) y métodos para usarlos.
KR20240011262A (ko) * 2017-02-21 2024-01-25 리제너론 파아마슈티컬스, 인크. 폐암의 치료를 위한 항-pd-1 항체
EP3700561A1 (en) * 2017-10-27 2020-09-02 Statens Serum Institut A polygene influenza vaccine
KR20210089146A (ko) 2018-09-19 2021-07-15 알파인 이뮨 사이언시즈, 인코포레이티드 변이체 cd80 단백질 및 관련 구축물의 방법 및 용도
HUE067601T2 (hu) 2018-11-14 2024-10-28 Regeneron Pharma PD-1 inhibitorok intraléziós beadása a bõrrák kezelésére
KR20210119451A (ko) * 2019-01-21 2021-10-05 사노피 진행성 단계의 고형 종양 암에 대한 치료용 rna
JP2022521800A (ja) * 2019-02-28 2022-04-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 皮膚がんを治療するためのpd-1阻害剤の投与
US12187792B2 (en) 2019-03-06 2025-01-07 Regeneron Pharmaceuticals, Inc. IL-4/IL-13 pathway inhibitors for enhanced efficacy in treating cancer
WO2021118321A1 (ko) * 2019-12-13 2021-06-17 삼성바이오에피스 주식회사 안정한 항-pd-1 항체 약제학적 제제
CN113244385A (zh) * 2020-02-07 2021-08-13 上海君实生物医药科技股份有限公司 抗pd-1抗体在治疗恶性肿瘤中的用途
AU2021233023A1 (en) 2020-03-13 2022-11-03 The Board Of Regents Of The University Of Texas System Sequential treatment of cancers using 6-thio-dg, checkpoint inhibitors and radiation therapy
CN119255817A (zh) * 2022-03-28 2025-01-03 齐鲁制药有限公司 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途
WO2024077069A1 (en) * 2022-10-05 2024-04-11 Chulalongkorn University Monoclonal antibodies against human programmed cell death protein 1 (pd-1)
WO2025030110A1 (en) * 2023-08-02 2025-02-06 Sensei Biotherapeutics, Inc. Cancer therapies targeting vista as monotherapy or in combination with anti-pd1 antibody to treat cancer
WO2025159618A1 (ko) 2024-01-24 2025-07-31 주식회사 엘지에너지솔루션 전극탭 용접장치 및 전극탭 용접방법
WO2025207705A1 (en) 2024-03-26 2025-10-02 Amgen Inc. Cancer treatments using mta-cooperative prmt5 inhibitors
WO2025213154A1 (en) 2024-04-05 2025-10-09 Amgen Inc. Gastrointestinal cancer treatments using mta-cooperative prmt5 inhibitors

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
PT1210428E (pt) 1999-08-23 2015-07-21 Genetics Inst Llc Pd-1, um recetor para b7-4 e suas utilizações
US7794710B2 (en) 2001-04-20 2010-09-14 Mayo Foundation For Medical Education And Research Methods of enhancing T cell responsiveness
CA2508660C (en) 2002-12-23 2013-08-20 Wyeth Antibodies against pd-1 and uses therefor
US7563869B2 (en) 2003-01-23 2009-07-21 Ono Pharmaceutical Co., Ltd. Substance specific to human PD-1
AU2006230099B2 (en) 2005-03-25 2012-04-19 Gitr, Inc. GITR binding molecules and uses therefor
KR101498834B1 (ko) 2005-05-09 2015-03-05 오노 야꾸힝 고교 가부시키가이샤 예정 사멸 인자 1(pd-1)에 대한 인간 모노클로날 항체, 및 항-pd-1 항체를 단독 사용하거나 기타 면역 요법제와 병용한 암 치료 방법
HRP20080053A2 (hr) 2005-07-01 2009-08-31 Medarex Ljudska monoklonska protutijela na ligand 1 za programiranu smrt stanice (pd-l1)
CN104945508B (zh) 2007-06-18 2019-02-22 默沙东有限责任公司 针对人程序性死亡受体pd-1的抗体
CN101801413A (zh) 2007-07-12 2010-08-11 托勒克斯股份有限公司 采用gitr结合分子的联合疗法
AU2007358569B2 (en) 2007-09-07 2014-09-04 Ablynx N.V. Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
JP5798919B2 (ja) 2008-08-25 2015-10-21 アンプリミューン、インコーポレーテッドAmplimmune, Inc. Pd−1アンタゴニストの組成物および使用方法
CA3120172A1 (en) 2008-12-09 2010-07-08 Genentech, Inc. Anti-pd-l1 antibodies and their use to enhance t-cell function
PL3023438T3 (pl) 2009-09-03 2020-07-27 Merck Sharp & Dohme Corp. Przeciwciała anty-gitr
HUE037159T2 (hu) 2009-11-24 2018-08-28 Medimmune Ltd Targetált kötõdõ ágensek B7-H1 ellen
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
WO2011159877A2 (en) 2010-06-18 2011-12-22 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
JP6240600B2 (ja) 2011-07-24 2017-11-29 キュアテク リミテッド ヒト化免疫モノクローナル抗体の変異体
TWI835048B (zh) 2011-08-01 2024-03-11 美商建南德克公司 利用pd-1軸結合拮抗劑及mek抑制劑治療癌症之方法
EP3511343A1 (en) 2012-05-04 2019-07-17 Dana Farber Cancer Institute, Inc. Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use
US9889982B2 (en) 2012-07-23 2018-02-13 Silgan Dispensing Systems Corporation Aerosol actuators, devices, and methods of making and using the same
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
WO2015030929A1 (en) 2013-08-30 2015-03-05 Ebay, Inc. Keyword bid optimization for text ads
US10241115B2 (en) 2013-12-10 2019-03-26 Merck Sharp & Dohme Corp. Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue
SG10201809385RA (en) 2013-12-17 2018-11-29 Genentech Inc Anti-cd3 antibodies and methods of use
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗pd-l1之人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
CA2949121A1 (en) 2014-05-15 2015-11-19 Bristol-Myers Squibb Company Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
WO2015184099A1 (en) 2014-05-28 2015-12-03 4-Antibody Ag Anti-gitr antibodies and methods of use thereof
SG10201810507WA (en) 2014-06-06 2018-12-28 Bristol Myers Squibb Co Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
US10092645B2 (en) 2014-06-17 2018-10-09 Medimmune Limited Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy
LT3157956T (lt) 2014-06-19 2020-05-11 Regeneron Pharmaceuticals, Inc. Nepriklausantys žmonėms gyvūnai, turintys humanizuotą užprogramuotos ląstelių žūties 1 geną
WO2016089873A1 (en) * 2014-12-02 2016-06-09 Celgene Corporation Combination therapies
DK3254110T3 (da) 2015-02-03 2020-05-18 Ventana Med Syst Inc Histokemisk test til vurdering af ekspression af programmeret død-ligand 1 (pd-l1)
SG11201707383PA (en) 2015-03-13 2017-10-30 Cytomx Therapeutics Inc Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
SG10201912035YA (en) * 2015-04-17 2020-02-27 Bristol Myers Squibb Co Compositions comprising a combination of an anti-pd-1 antibody and another antibody
IL295002A (en) * 2015-05-12 2022-09-01 Genentech Inc Therapeutic and diagnostic methods for cancer containing a pd–l1 binding antagonist
US20180155429A1 (en) * 2015-05-28 2018-06-07 Bristol-Myers Squibb Company Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody
WO2017144681A1 (en) 2016-02-25 2017-08-31 Cell Medica Switzerland Ag Binding members to pd-l1
MY191926A (en) 2016-12-01 2022-07-18 Regeneron Pharma Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
KR20240011262A (ko) * 2017-02-21 2024-01-25 리제너론 파아마슈티컬스, 인크. 폐암의 치료를 위한 항-pd-1 항체
US11603407B2 (en) 2017-04-06 2023-03-14 Regeneron Pharmaceuticals, Inc. Stable antibody formulation
AU2023356866A1 (en) * 2022-10-03 2025-04-17 Regeneron Pharmaceuticals, Inc. Methods of treating cancer with bispecific egfr x cd28 antibodies alone or in combination with anti-pd-1 antibodies

Similar Documents

Publication Publication Date Title
JP2020508317A5 (Direct)
IL321717A (en) Anti-PD-1 antibodies for the treatment of lung cancer
KR102333658B1 (ko) 비-소세포 폐암을 치료하기 위한 항-b7-h1 및 항-ctla-4 항체
JP2022078265A5 (Direct)
JP2022050618A5 (Direct)
JP2019515008A5 (Direct)
IL318482A (en) Pd-1 inhibitor for use in a method of treating skin cancer
JP2016520082A5 (Direct)
CN111132696B (zh) Pd-1抗体和表观遗传调节剂联合在制备治疗肿瘤的药物中的用途
FI3810281T3 (fi) Menetelmiä syövän hoitamiseksi bispesifisillä anti-CD3XMUC16-vasta-aineilla ja anti-PD-1-vasta-aineilla
JP7491220B2 (ja) 免疫チェックポイント阻害薬およびfolfirinox療法との併用によるがん治療
EP3347054A1 (en) Dosing regimens for anti-tf-antibody drug-conjugates
CN108350080A (zh) 用于癌症的联合疗法
WO2017205216A1 (en) Combination of pembrolizumab and abemaciclib for the treatment of cancer
CN109663130B (zh) Pd-1抗体和mek抑制剂联合在制备治疗肿瘤的药物中的用途
JPWO2020232019A5 (Direct)
JPWO2020223702A5 (Direct)
CN118871128A (zh) 抗tim-3抗体与抗pd-l1抗体的药物组合
WO2024026019A1 (en) Methods for treating chronic myelomonocytic leukemia with anti-ilt3 antibodies
Hwang et al. Emerging egfr-targeted therapy in head and neck cancer: A review
TWI814752B (zh) 免疫治療劑、核苷類抗代謝物和鉑類聯合在製備治療腫瘤的藥物中的用途
KR20200105825A (ko) 삼중 음성 유방암의 치료를 위한 pd-1 항체 및 아파티닙의 조합 치료의 용도
WO2024041652A1 (en) Methods of cancer treatment
CN119607196A (zh) 抗lag-3抗体与抗pd-1抗体的应用
NZ781933A (en) Combination of pd-1 inhibitors and lag-3 inhibitors for enhanced efficacy in treating cancer