JP2020507578A5 - - Google Patents
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- JP2020507578A5 JP2020507578A5 JP2019543277A JP2019543277A JP2020507578A5 JP 2020507578 A5 JP2020507578 A5 JP 2020507578A5 JP 2019543277 A JP2019543277 A JP 2019543277A JP 2019543277 A JP2019543277 A JP 2019543277A JP 2020507578 A5 JP2020507578 A5 JP 2020507578A5
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- JP
- Japan
- Prior art keywords
- seq
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- chain variable
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 101001062768 Homo sapiens Coagulation factor XI Proteins 0.000 claims 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 2
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 2
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 2
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710073984.XA CN108409863B (zh) | 2017-02-10 | 2017-02-10 | 抗凝血因子xi抗体 |
| CN201710073984.X | 2017-02-10 | ||
| PCT/CN2017/119856 WO2018145533A1 (zh) | 2017-02-10 | 2017-12-29 | 抗凝血因子xi抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020507578A JP2020507578A (ja) | 2020-03-12 |
| JP2020507578A5 true JP2020507578A5 (enExample) | 2021-02-12 |
| JP7271430B2 JP7271430B2 (ja) | 2023-05-11 |
Family
ID=63107934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019543277A Active JP7271430B2 (ja) | 2017-02-10 | 2017-12-29 | 抗ｘｉ因子抗体 |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP3581587B1 (enExample) |
| JP (1) | JP7271430B2 (enExample) |
| KR (1) | KR102690437B1 (enExample) |
| CN (1) | CN108409863B (enExample) |
| AU (2) | AU2017397778B2 (enExample) |
| BR (1) | BR112019016300A2 (enExample) |
| CA (1) | CA3054322A1 (enExample) |
| MX (1) | MX2019009500A (enExample) |
| WO (1) | WO2018145533A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020029179A1 (en) * | 2018-08-09 | 2020-02-13 | Shanghai Benemae Pharmaceutical Corporation | Anti-factor xi antibodies |
| US11958911B2 (en) | 2017-02-10 | 2024-04-16 | Shanghai Benemae Pharmaceutical | Anti-coagulation factor XI antibody |
| CN110878123B (zh) * | 2018-09-05 | 2022-08-23 | 华瑞同康生物技术（深圳）有限公司 | 一种抗tk1原核重组单链抗体及制备方法 |
| EP3914624A4 (en) * | 2019-01-21 | 2022-10-19 | Aronora, Inc. | NOVEL HUMANIZED ANTIBODIES AGAINST FACTOR XI HAVING ANTI-THROMBOTIC AND ANTI-INFLAMMATORY EFFECTS AND ASSOCIATED USES |
| CN113474374B (zh) * | 2019-04-16 | 2025-05-02 | 四川科伦博泰生物医药股份有限公司 | 抗FXI/FXIa抗体及其用途 |
| CN110423278B (zh) | 2019-08-08 | 2020-07-17 | 上海博槿生物科技有限公司 | 一种抗凝血因子XI活化形式因子XIa的抗体及其制备方法和应用 |
| CN110498839A (zh) * | 2019-09-19 | 2019-11-26 | 河南省农业科学院 | 氟罗沙星单链抗体关键多肽序列及应用 |
| JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
| TWI882142B (zh) * | 2020-07-02 | 2025-05-01 | 大陸商北京拓界生物醫藥科技有限公司 | 抗FXI/FXIa抗體、其抗原結合片段及醫藥用途 |
| CN116589588B (zh) * | 2023-04-14 | 2023-12-22 | 北京基科晟斯医药科技有限公司 | 结合凝血因子x的抗体 |
| WO2025130748A1 (zh) * | 2023-12-22 | 2025-06-26 | 四川科伦博泰生物医药股份有限公司 | 一种抗凝血因子XI/XIa抗体制剂 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2981754B2 (ja) * | 1990-02-02 | 1999-11-22 | 第一化学薬品株式会社 | 血液凝固第▲ｘ▼▲ｉｉｉ▼因子に対するモノクロナール抗体 |
| KR100925348B1 (ko) * | 2001-06-12 | 2009-11-09 | 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 인간형 항-혈액 응고 인자 ⅷ 항체 |
| DE10205520A1 (de) * | 2002-02-08 | 2003-08-14 | Aventis Behring Gmbh | Inhibitorischer, monoklonaler Antikörper gegen die den Blutgerinnungsfaktor VII aktivierende Protease |
| AU2008326348B2 (en) | 2007-11-21 | 2014-01-30 | Oregon Health & Science University | Anti-factor XI monoclonal antibodies and methods of use thereof |
| AU2009335643B2 (en) * | 2008-12-18 | 2014-05-29 | Oregon Health & Science University | Anti-fXI antibodies and methods of use |
| SI2847228T1 (sl) * | 2012-05-10 | 2018-11-30 | Bayer Pharma Aktiengesellschaft | Protitelesa zmožna vezave na faktor koagulacije XI in/ali njeno aktivirano obliko faktor XIa in njihove uporabe |
| JOP20200312A1 (ar) * | 2015-06-26 | 2017-06-16 | Novartis Ag | الأجسام المضادة للعامل xi وطرق الاستخدام |
| EP3325010B1 (en) * | 2015-07-23 | 2023-06-21 | The Regents of The University of California | Antibodies to coagulation factor xia and uses thereof |
-
2017
- 2017-02-10 CN CN201710073984.XA patent/CN108409863B/zh active Active
- 2017-12-29 CA CA3054322A patent/CA3054322A1/en active Pending
- 2017-12-29 MX MX2019009500A patent/MX2019009500A/es unknown
- 2017-12-29 AU AU2017397778A patent/AU2017397778B2/en active Active
- 2017-12-29 BR BR112019016300-0A patent/BR112019016300A2/pt unknown
- 2017-12-29 JP JP2019543277A patent/JP7271430B2/ja active Active
- 2017-12-29 EP EP17895532.4A patent/EP3581587B1/en active Active
- 2017-12-29 WO PCT/CN2017/119856 patent/WO2018145533A1/zh not_active Ceased
- 2017-12-29 KR KR1020197025752A patent/KR102690437B1/ko active Active
-
2025
- 2025-05-08 AU AU2025203303A patent/AU2025203303A1/en active Pending
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