JP2020506722A - 目的分子を産生するための遺伝的に最適化された微生物 - Google Patents

目的分子を産生するための遺伝的に最適化された微生物 Download PDF

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JP2020506722A
JP2020506722A JP2019561348A JP2019561348A JP2020506722A JP 2020506722 A JP2020506722 A JP 2020506722A JP 2019561348 A JP2019561348 A JP 2019561348A JP 2019561348 A JP2019561348 A JP 2019561348A JP 2020506722 A JP2020506722 A JP 2020506722A
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microorganism
genetically modified
molecule
interest
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JP2020506722A5 (enExample
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ボワザール、セドリック
モラン、ニコラ
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Enobraq
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01001—Transketolase (2.2.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01002—Transaldolase (2.2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01019—Phosphoribulokinase (2.7.1.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01039—Ribulose-bisphosphate carboxylase (4.1.1.39)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2019561348A 2017-01-27 2018-01-26 目的分子を産生するための遺伝的に最適化された微生物 Pending JP2020506722A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1750696 2017-01-27
FR1750696A FR3062395B1 (fr) 2017-01-27 2017-01-27 Microorganisme genetiquement optimise pour la production de molecules d'interet
PCT/EP2018/052004 WO2018138288A1 (fr) 2017-01-27 2018-01-26 Microorganisme génétiquement optimisé pour la production de molécules d'intérêt

Publications (2)

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JP2020506722A true JP2020506722A (ja) 2020-03-05
JP2020506722A5 JP2020506722A5 (enExample) 2021-02-12

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JP2019561348A Pending JP2020506722A (ja) 2017-01-27 2018-01-26 目的分子を産生するための遺伝的に最適化された微生物

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Country Link
US (1) US20190359988A1 (enExample)
EP (1) EP3574082A1 (enExample)
JP (1) JP2020506722A (enExample)
KR (1) KR20190114982A (enExample)
CN (1) CN110475851A (enExample)
BR (1) BR112019015411A2 (enExample)
FR (1) FR3062395B1 (enExample)
WO (1) WO2018138288A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014219510A1 (en) * 2013-02-22 2015-08-27 Technische Universiteit Delft Recombinant micro-organism for use in method with increased product yield
US11767521B2 (en) * 2020-02-21 2023-09-26 The Regents Of The University Of California Genetically modified bacterial cells and methods useful for producing indigoidine
CN118956840A (zh) * 2021-04-19 2024-11-15 武汉合生科技有限公司 获得α-法尼烯以及β-法尼烯的重组微生物及其构建方法
CN115259391B (zh) * 2022-08-26 2023-10-10 辽宁中森生物科技有限公司 一种污水处理用多元菌藻组合物、复合剂及其应用
CN117210446A (zh) * 2023-03-21 2023-12-12 北京蓝晶微生物科技有限公司 一种重建卡尔文循环提高异养微生物代谢产物产量的方法
CN117721054B (zh) * 2023-12-12 2025-01-28 四川大学 一种提高乳酸菌在盐胁迫下生物膜产量的方法
CN119709580A (zh) * 2025-03-04 2025-03-28 诸城市浩天药业有限公司 一种高效生产d-泛酸的工程菌株及其构建方法与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG2014012520A (en) * 2011-07-12 2014-06-27 Scientist Of Fortune Sa Recombinant microorganism for the production of useful metabolites
FR3016371B1 (fr) * 2014-01-16 2018-02-02 Institut National De La Recherche Agronomique Levures modifiees pour utiliser le dioxyde de carbone

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MARY A. TICHI & F. ROBERT TABITA: "Metabolic Signals That Lead to Control of cbb Gene Expression in Rhodobacter capsulatus", JOURNAL OF BACTERIOLOGY, vol. 184, no. 7, JPN6021044782, 2002, pages 1905 - 1915, ISSN: 0004798489 *
PENG-FEI XIA ET AL.: "Recycling Carbon Dioxide during Xylose Fermentation by Engineered Saccharomyces cerevisiae", ACS SYNTHETIC BIOLOGY, vol. 6, no. 2, JPN6021044783, 17 October 2016 (2016-10-17), pages 276 - 283, XP055405751, ISSN: 0004798490, DOI: 10.1021/acssynbio.6b00167 *
XIN QI ET AL.: "Heterologous xylose isomerase pathway and evolutionary engineering improve xylose utilization in Sac", FRONTIERS IN MICROBIOLOGY, vol. 6, JPN6021044784, 2015, pages 1165, ISSN: 0004798491 *

Also Published As

Publication number Publication date
KR20190114982A (ko) 2019-10-10
CN110475851A (zh) 2019-11-19
FR3062395B1 (fr) 2021-04-16
BR112019015411A2 (pt) 2020-05-26
US20190359988A1 (en) 2019-11-28
EP3574082A1 (fr) 2019-12-04
WO2018138288A1 (fr) 2018-08-02
FR3062395A1 (fr) 2018-08-03

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