JP2020505936A5 - - Google Patents
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- Publication number
- JP2020505936A5 JP2020505936A5 JP2019542561A JP2019542561A JP2020505936A5 JP 2020505936 A5 JP2020505936 A5 JP 2020505936A5 JP 2019542561 A JP2019542561 A JP 2019542561A JP 2019542561 A JP2019542561 A JP 2019542561A JP 2020505936 A5 JP2020505936 A5 JP 2020505936A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- capsid protein
- aav capsid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023007075A JP7574508B2 (ja) | 2017-02-15 | 2023-01-20 | 血管系を通過する遺伝子移入の方法および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762459286P | 2017-02-15 | 2017-02-15 | |
| US62/459,286 | 2017-02-15 | ||
| PCT/US2018/018381 WO2018152333A1 (en) | 2017-02-15 | 2018-02-15 | Methods and compositions for gene transfer across the vasculature |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023007075A Division JP7574508B2 (ja) | 2017-02-15 | 2023-01-20 | 血管系を通過する遺伝子移入の方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505936A JP2020505936A (ja) | 2020-02-27 |
| JP2020505936A5 true JP2020505936A5 (enExample) | 2021-03-04 |
| JP7291397B2 JP7291397B2 (ja) | 2023-06-15 |
Family
ID=63169716
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019542561A Active JP7291397B2 (ja) | 2017-02-15 | 2018-02-15 | 血管系を通過する遺伝子移入の方法および組成物 |
| JP2023007075A Active JP7574508B2 (ja) | 2017-02-15 | 2023-01-20 | 血管系を通過する遺伝子移入の方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023007075A Active JP7574508B2 (ja) | 2017-02-15 | 2023-01-20 | 血管系を通過する遺伝子移入の方法および組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11905312B2 (enExample) |
| EP (1) | EP3583220A4 (enExample) |
| JP (2) | JP7291397B2 (enExample) |
| KR (1) | KR20190117571A (enExample) |
| CN (2) | CN118978574A (enExample) |
| AU (1) | AU2018221738B2 (enExample) |
| BR (1) | BR112019016769A2 (enExample) |
| CA (1) | CA3052829A1 (enExample) |
| EA (1) | EA038695B1 (enExample) |
| IL (2) | IL268534B2 (enExample) |
| MX (1) | MX2019009720A (enExample) |
| SG (1) | SG11201907298WA (enExample) |
| WO (1) | WO2018152333A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
| ES2865487T3 (es) | 2015-09-28 | 2021-10-15 | Univ North Carolina Chapel Hill | Métodos y composiciones para vectores virales que evaden los anticuerpos |
| AU2018320849A1 (en) * | 2017-08-25 | 2020-03-05 | Ovid Therapeutics Inc. | Recombinant adeno-associated vectors |
| AU2018338728B2 (en) | 2017-09-29 | 2025-01-02 | Centre National De La Recherche Scientifique (Cnrs) | Rescue of central and peripheral neurological phenotype of Friedreich's Ataxia by intravenous delivery |
| AU2019247748A1 (en) | 2018-04-03 | 2020-10-08 | Ginkgo Bioworks, Inc. | Antibody-evading virus vectors |
| MX2020010465A (es) | 2018-04-03 | 2021-01-08 | Vectores de virus para direccionamiento a tejidos oftalmicos. | |
| EP3774852A1 (en) | 2018-04-03 | 2021-02-17 | Stridebio, Inc. | Antibody-evading virus vectors |
| CA3100006A1 (en) | 2018-05-11 | 2019-11-14 | Massachusetts Eye And Ear Infirmary | Altering tissue tropism of adeno-associated viruses |
| WO2020014471A1 (en) | 2018-07-11 | 2020-01-16 | The Brigham And Women's Hospital, Inc. | Methods and compositions for delivery of agents across the blood-brain barrier |
| CN113966399A (zh) | 2018-09-26 | 2022-01-21 | 加州理工学院 | 用于靶向基因疗法的腺相关病毒组合物 |
| EP3856762A1 (en) | 2018-09-28 | 2021-08-04 | Voyager Therapeutics, Inc. | Frataxin expression constructs having engineered promoters and methods of use thereof |
| WO2020160508A1 (en) * | 2019-01-31 | 2020-08-06 | Oregon Health & Science University | Methods for using transcription-dependent directed evolution of aav capsids |
| KR20210148101A (ko) | 2019-02-04 | 2021-12-07 | 프리라인 테라퓨틱스 리미티드 | 폴리뉴클레오티드 |
| AR118465A1 (es) | 2019-03-21 | 2021-10-06 | Stridebio Inc | Vectores de virus adenoasociados recombinantes |
| TW202102526A (zh) * | 2019-04-04 | 2021-01-16 | 美商銳進科斯生物股份有限公司 | 重組腺相關病毒及其用途 |
| WO2020219868A1 (en) * | 2019-04-24 | 2020-10-29 | Regenxbio Inc. | Fully-human post-translationally modified antibody therapeutics |
| WO2021030764A1 (en) * | 2019-08-14 | 2021-02-18 | University Of Florida Research Foundation, Incorporated | Aav capsid variants for gene therapy |
| CA3153972A1 (en) * | 2019-09-09 | 2021-03-18 | Massachusetts Eye And Ear Infirmary | Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav |
| JP2022551739A (ja) | 2019-10-17 | 2022-12-13 | ストライドバイオ，インコーポレイテッド | ニーマン・ピック病ｃ型の治療のためのアデノ随伴ウイルスベクター |
| US12611436B2 (en) | 2019-10-17 | 2026-04-28 | Sarepta Therapeutics, Inc. | AAV transfer cassette |
| WO2021087007A1 (en) * | 2019-10-28 | 2021-05-06 | University Of Florida Research Foundation, Incorporated | Gene therapy vectors |
| KR20220116459A (ko) * | 2019-11-22 | 2022-08-23 | 더 칠드런스 호스피탈 오브 필라델피아 | 아데노(adeno)-관련 바이러스 벡터 변이체 |
| CN115279400B (zh) | 2020-01-10 | 2026-04-28 | 布里格姆妇女医院 | 用于跨血脑屏障递送免疫治疗剂以治疗脑癌的方法和组合物 |
| WO2021163357A2 (en) | 2020-02-13 | 2021-08-19 | Tenaya Therapeutics, Inc. | Gene therapy vectors for treating heart disease |
| EP4103214B1 (en) | 2020-02-13 | 2026-04-29 | Tenaya Therapeutics, Inc. | Gene therapy vectors for treating heart disease |
| BR112022016965A2 (pt) * | 2020-02-25 | 2022-12-06 | Childrens Medical Res Institute | Polipeptídeos e vetores de capsídeo do vírus adenoassociado |
| CA3177869A1 (en) * | 2020-05-05 | 2021-11-11 | Duke University | Cross-species compatible adeno-associated virus compositions and methods of use thereof |
| AU2021328475A1 (en) | 2020-08-19 | 2023-03-16 | Sarepta Therapeutics, Inc. | Adeno-associated virus vectors for treatment of Rett syndrome |
| WO2022076750A2 (en) * | 2020-10-07 | 2022-04-14 | Regenxbio Inc. | Recombinant adeno-associated viruses for cns or muscle delivery |
| KR20230082613A (ko) * | 2020-10-07 | 2023-06-08 | 리젠엑스바이오 인크. | Cns 또는 근육 전달을 위한 재조합 아데노-연관 바이러스 |
| WO2022150634A2 (en) * | 2021-01-08 | 2022-07-14 | Massachusetts Eye And Ear Infirmary | Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav |
| EP4277524A4 (en) * | 2021-01-13 | 2025-06-04 | Duke University | Compositions for and methods of improving fluid flux in the brain |
| KR20240032971A (ko) | 2021-07-08 | 2024-03-12 | 테나야 테라퓨틱스, 인코포레이티드 | 유전자 요법을 위한 최적화된 발현 카세트 |
| WO2023288184A2 (en) * | 2021-07-14 | 2023-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for treating chronic pain and for retrograde transduction of neurons |
| CN113563430B (zh) * | 2021-07-30 | 2022-05-31 | 上海信致医药科技有限公司 | 用于治疗眼部疾病的基因递送系统及其应用 |
| CN113480615B (zh) * | 2021-07-30 | 2022-05-31 | 上海信致医药科技有限公司 | 高视网膜亲和性的新型腺相关病毒衣壳蛋白及其应用 |
| CR20240137A (es) * | 2021-08-20 | 2024-07-29 | Biocad Joint Stock Co | Método para obtener una cápside de virus adenoasociado modificada |
| AR126839A1 (es) * | 2021-08-20 | 2023-11-22 | Llc «Anabion» | Proteína de la cápside vp1 modificada aislada del virus adeno-asociado de serotipo 9 (aav9), cápside y vector basado en esta |
| US20240352077A1 (en) * | 2021-08-25 | 2024-10-24 | Children's Medical Research Institute | Modified aav capsids and vectors |
| US20240425549A1 (en) * | 2021-08-25 | 2024-12-26 | Children's Medical Research Institute | Modified aav capsid polypeptides and vectors |
| WO2023060272A2 (en) * | 2021-10-07 | 2023-04-13 | Regenxbio Inc. | Recombinant adeno-associated viruses for cns tropic delivery |
| CN114516901B (zh) * | 2022-03-11 | 2023-01-17 | 上海勉亦生物科技有限公司 | 一种神经系统高亲和性的aav载体及其应用 |
| WO2023201277A1 (en) * | 2022-04-14 | 2023-10-19 | Regenxbio Inc. | Recombinant adeno-associated viruses for cns tropic delivery |
| WO2024054864A1 (en) | 2022-09-06 | 2024-03-14 | Tenaya Therapeutics, Inc. | Cardioprotective heart disease therapies |
| KR102855674B1 (ko) * | 2022-10-06 | 2025-09-08 | 주식회사 글루진테라퓨틱스 | 폐 기관지 특이적 유전자 전달이 가능한 아데노부속바이러스 벡터 |
| WO2024215655A1 (en) | 2023-04-10 | 2024-10-17 | Tenaya Therapeutics, Inc. | Cardioprotective bag3 therapies |
| WO2024215653A1 (en) | 2023-04-10 | 2024-10-17 | Tenaya Therapeutics, Inc. | Guide rnas, vectors, and virions for targeting mutations in the pln gene |
| WO2025015388A1 (en) * | 2023-07-20 | 2025-01-23 | Children's Medical Research Institute | Modified cardiotropic aav capsid polypeptides and vectors |
| KR102868933B1 (ko) * | 2023-11-08 | 2025-10-14 | 주식회사 글루진테라퓨틱스 | 성상세포 특이적 유전자 전달이 가능한 아데노부속바이러스 벡터 |
| WO2025121957A1 (ko) * | 2023-12-06 | 2025-06-12 | 주식회사 글루진테라퓨틱스 | 뇌 성상교세포 특이적 유전자 전달이 가능한 아데노부속바이러스 변이체와 이의 응용 |
| WO2025147741A1 (en) * | 2024-01-11 | 2025-07-17 | Children's Medical Research Institute | Aav capsids and vectors for transduction of cells |
| CN119405806A (zh) * | 2024-10-25 | 2025-02-11 | 南通大学 | 小肌营养蛋白域含2抑制剂在制备促进神经生长药物中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU780231B2 (en) * | 1998-11-10 | 2005-03-10 | University Of North Carolina At Chapel Hill, The | Virus vectors and methods of making and administering the same |
| DE19933288A1 (de) | 1999-07-15 | 2001-01-18 | Medigene Ag | Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung |
| SI1496944T1 (sl) * | 2002-05-01 | 2009-02-28 | Univ Florida | Izboljšani sistemi ekspresije RAAV za genetsko modifikacijo specifičnih kapsidnih proteinov |
| WO2010093784A2 (en) * | 2009-02-11 | 2010-08-19 | The University Of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| HK1202434A1 (en) * | 2011-11-22 | 2015-10-02 | The Children's Hospital Of Philadelphia | Virus vectors for highly efficient transgene delivery |
| EP2900686B1 (en) * | 2012-09-28 | 2020-06-10 | The University of North Carolina At Chapel Hill | Aav vectors targeted to oligodendrocytes |
| EP3151866B1 (en) * | 2014-06-09 | 2023-03-08 | Voyager Therapeutics, Inc. | Chimeric capsids |
| WO2017015102A1 (en) * | 2015-07-17 | 2017-01-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for achieving high levels of transduction in human liver cells |
-
2018
- 2018-02-15 US US16/485,094 patent/US11905312B2/en active Active
- 2018-02-15 EA EA201991911A patent/EA038695B1/ru unknown
- 2018-02-15 WO PCT/US2018/018381 patent/WO2018152333A1/en not_active Ceased
- 2018-02-15 IL IL268534A patent/IL268534B2/en unknown
- 2018-02-15 EP EP18754551.2A patent/EP3583220A4/en not_active Withdrawn
- 2018-02-15 SG SG11201907298WA patent/SG11201907298WA/en unknown
- 2018-02-15 BR BR112019016769-2A patent/BR112019016769A2/pt not_active Application Discontinuation
- 2018-02-15 CA CA3052829A patent/CA3052829A1/en active Pending
- 2018-02-15 JP JP2019542561A patent/JP7291397B2/ja active Active
- 2018-02-15 IL IL312788A patent/IL312788A/en unknown
- 2018-02-15 CN CN202410828011.2A patent/CN118978574A/zh active Pending
- 2018-02-15 CN CN201880025093.XA patent/CN110520536B/zh not_active Expired - Fee Related
- 2018-02-15 MX MX2019009720A patent/MX2019009720A/es unknown
- 2018-02-15 AU AU2018221738A patent/AU2018221738B2/en not_active Ceased
- 2018-02-15 KR KR1020197025393A patent/KR20190117571A/ko active Pending
-
2023
- 2023-01-20 JP JP2023007075A patent/JP7574508B2/ja active Active
-
2024
- 2024-01-10 US US18/409,304 patent/US20240209031A1/en active Pending
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