CN110520536B - 用于穿过维管结构的基因转移的方法和组合物 - Google Patents

用于穿过维管结构的基因转移的方法和组合物 Download PDF

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Publication number
CN110520536B
CN110520536B CN201880025093.XA CN201880025093A CN110520536B CN 110520536 B CN110520536 B CN 110520536B CN 201880025093 A CN201880025093 A CN 201880025093A CN 110520536 B CN110520536 B CN 110520536B
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aav
amino acid
seq
viral vector
capsid
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CN110520536A (zh
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阿拉温德·阿索卡恩
吉里达尔·莫里达尔安
布莱克·奥尔布赖特
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University of North Carolina at Chapel Hill
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors

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CN201880025093.XA 2017-02-15 2018-02-15 用于穿过维管结构的基因转移的方法和组合物 Expired - Fee Related CN110520536B (zh)

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US201762459286P 2017-02-15 2017-02-15
US62/459,286 2017-02-15
PCT/US2018/018381 WO2018152333A1 (en) 2017-02-15 2018-02-15 Methods and compositions for gene transfer across the vasculature

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US (2) US11905312B2 (enExample)
EP (1) EP3583220A4 (enExample)
JP (2) JP7291397B2 (enExample)
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CN (2) CN110520536B (enExample)
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EA038695B1 (ru) 2021-10-06
IL268534B2 (en) 2024-10-01
IL268534A (en) 2019-09-26
WO2018152333A9 (en) 2019-01-24
KR20190117571A (ko) 2019-10-16
US20190367562A1 (en) 2019-12-05
US11905312B2 (en) 2024-02-20
JP2023052541A (ja) 2023-04-11
EP3583220A1 (en) 2019-12-25
CA3052829A1 (en) 2018-08-23
CN118978574A (zh) 2024-11-19
IL268534B1 (en) 2024-06-01
JP7291397B2 (ja) 2023-06-15
AU2018221738B2 (en) 2024-06-27
JP2020505936A (ja) 2020-02-27
EP3583220A4 (en) 2021-07-07
JP7574508B2 (ja) 2024-10-29
WO2018152333A1 (en) 2018-08-23
SG11201907298WA (en) 2019-09-27
BR112019016769A2 (pt) 2020-05-26
US20240209031A1 (en) 2024-06-27
CN110520536A (zh) 2019-11-29
IL312788A (en) 2024-07-01
MX2019009720A (es) 2019-10-07
AU2018221738A1 (en) 2019-08-22
EA201991911A1 (ru) 2020-02-20

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