JP2020505025A - 免疫工学的な改変をした多能性細胞 - Google Patents
免疫工学的な改変をした多能性細胞 Download PDFInfo
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- JP2020505025A JP2020505025A JP2019538202A JP2019538202A JP2020505025A JP 2020505025 A JP2020505025 A JP 2020505025A JP 2019538202 A JP2019538202 A JP 2019538202A JP 2019538202 A JP2019538202 A JP 2019538202A JP 2020505025 A JP2020505025 A JP 2020505025A
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
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- C12N2510/00—Genetically modified cells
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/005—Vectors comprising a special translation-regulating system cell cycle specific
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- C12N2840/00—Vectors comprising a special translation-regulating system
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01021—Thymidine kinase (2.7.1.21)
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- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04001—Cytosine deaminase (3.5.4.1)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Pharmacology & Pharmacy (AREA)
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- Physics & Mathematics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Gynecology & Obstetrics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022208126A JP2023052079A (ja) | 2017-01-13 | 2022-12-26 | 免疫工学的な改変をした多能性細胞 |
| JP2025003516A JP2025069169A (ja) | 2017-01-13 | 2025-01-09 | 免疫工学的な改変をした多能性細胞 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762445969P | 2017-01-13 | 2017-01-13 | |
| US62/445,969 | 2017-01-13 | ||
| PCT/US2018/013688 WO2018132783A1 (en) | 2017-01-13 | 2018-01-14 | Immunoengineered pluripotent cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022208126A Division JP2023052079A (ja) | 2017-01-13 | 2022-12-26 | 免疫工学的な改変をした多能性細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020505025A true JP2020505025A (ja) | 2020-02-20 |
| JP2020505025A5 JP2020505025A5 (OSRAM) | 2021-02-25 |
Family
ID=61148505
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538202A Pending JP2020505025A (ja) | 2017-01-13 | 2018-01-14 | 免疫工学的な改変をした多能性細胞 |
| JP2022208126A Pending JP2023052079A (ja) | 2017-01-13 | 2022-12-26 | 免疫工学的な改変をした多能性細胞 |
| JP2025003516A Pending JP2025069169A (ja) | 2017-01-13 | 2025-01-09 | 免疫工学的な改変をした多能性細胞 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022208126A Pending JP2023052079A (ja) | 2017-01-13 | 2022-12-26 | 免疫工学的な改変をした多能性細胞 |
| JP2025003516A Pending JP2025069169A (ja) | 2017-01-13 | 2025-01-09 | 免疫工学的な改変をした多能性細胞 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20190376045A1 (OSRAM) |
| EP (1) | EP3568464A1 (OSRAM) |
| JP (3) | JP2020505025A (OSRAM) |
| KR (2) | KR20190103373A (OSRAM) |
| CN (1) | CN110177869A (OSRAM) |
| AU (2) | AU2018207649B2 (OSRAM) |
| BR (1) | BR112019014257A2 (OSRAM) |
| CA (1) | CA3049766A1 (OSRAM) |
| EA (1) | EA201991692A1 (OSRAM) |
| IL (1) | IL267616A (OSRAM) |
| MX (1) | MX2019008413A (OSRAM) |
| WO (1) | WO2018132783A1 (OSRAM) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022191216A1 (ja) * | 2021-03-09 | 2022-09-15 | 国立研究開発法人理化学研究所 | 低免疫原性網膜色素上皮細胞の製造方法 |
| JP2023052079A (ja) * | 2017-01-13 | 2023-04-11 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 免疫工学的な改変をした多能性細胞 |
| JP2023520997A (ja) * | 2020-03-25 | 2023-05-23 | サナ バイオテクノロジー,インコーポレイテッド | 神経学的障害及び神経学的病態の処置のための低免疫原性神経細胞 |
| JP2023521157A (ja) * | 2020-04-06 | 2023-05-23 | アールエックスセル インコーポレーテッド | 低免疫原性の細胞ならびにそれらの産生のための方法および組成物 |
| JP2023545056A (ja) * | 2020-10-09 | 2023-10-26 | サナ バイオテクノロジー,インコーポレイテッド | CD47-SIRPα封鎖剤を使用して安全殺傷機構を誘発する方法 |
| JP2023552441A (ja) * | 2020-12-07 | 2023-12-15 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | SIRP-αエンゲージャーによる自然免疫細胞のサイレンシング |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015360502A1 (en) | 2014-12-10 | 2017-06-29 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| JP2018515139A (ja) | 2015-05-08 | 2018-06-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 万能ドナー幹細胞および関連する方法 |
| SG10202109655VA (en) | 2015-12-04 | 2021-10-28 | Novartis Ag | Compositions and methods for immunooncology |
| EP3601528A4 (en) * | 2017-03-20 | 2021-05-05 | Washington University | CELLS AND METHODS OF USE AND PRODUCTION OF THEM |
| JP2020513832A (ja) | 2017-03-22 | 2020-05-21 | ノバルティス アーゲー | 免疫腫瘍学のための組成物および方法 |
| GB2588249B (en) | 2017-06-12 | 2023-01-04 | Sinai Health Sys | Allograft tolerance without the need for systemic immune suppression |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| CA3106022A1 (en) * | 2018-07-17 | 2020-01-23 | The Regents Of The University Of California | Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells |
| BR112021000637A2 (pt) * | 2018-07-17 | 2021-04-13 | The Regents Of The University Of California | Célula cardíaca hipoimune isolada, método para tratar um paciente que sofre de uma afecção ou doença cardíaca, método para produzir uma população de células cardíacas hipoimunes, célula endotelial hipoimune isolada, método para tratar um paciente que sofre de uma afecção ou doença vascular, método para produzir uma população de células endoteliais hipoimunes, neurônio dopaminérgico hipoimune isolado, método para tratar um paciente que sofre de uma doença ou afecção neurodegenerativa, método para produzir uma população de neurônios dopaminérgicos hipoimunes, célula de ilhota pancreática hipoimune isolada, método para tratar um paciente que sofre de diabetes, método para produzir uma população de células de ilhota pancreática hipoimunes, célula de epitélio pigmentado da retina (rpe) hipoimune isolada, método para tratar um paciente que sofre de uma afecção ocular, e método para produzir uma população de células de epitélio pigmentado da retina (rpe) hipoimunes |
| US12378572B2 (en) | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| WO2020067993A1 (en) * | 2018-09-26 | 2020-04-02 | National University Of Singapore | Engineered human mesenchymal stromal cells with low immunogenicity, methods and kits of generating the same |
| UY38427A (es) * | 2018-10-26 | 2020-05-29 | Novartis Ag | Métodos y composiciones para terapia con células oculares |
| CN111424016A (zh) * | 2019-01-09 | 2020-07-17 | 复旦大学 | 降低细胞免疫原性的诱导型多能干细胞系及建立方法 |
| BR112021016178A2 (pt) * | 2019-02-15 | 2021-11-03 | Harvard College | Células-tronco doadoras universais e métodos relacionados |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| JP2022532174A (ja) | 2019-05-10 | 2022-07-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 修飾多能性細胞 |
| EP3990627A4 (en) | 2019-06-26 | 2023-07-19 | The Regents of The University of California | SIRP-ALPHA SILENCED NATURAL KILLER CELLS (NK) |
| TW202115245A (zh) * | 2019-06-27 | 2021-04-16 | 丹麥商諾佛 儂迪克股份有限公司 | 安全免疫隱形細胞 |
| EP4022037A1 (en) | 2019-07-10 | 2022-07-06 | Helmuth Heinrich Kunz | Methods for deriving autologous and hypoimmunogenic hair follicle containing sheets in vitro |
| EP4007596A1 (en) * | 2019-08-01 | 2022-06-08 | Sana Biotechnology, Inc. | Dux4 expressing cells and uses thereof |
| EP4017508A1 (en) | 2019-08-23 | 2022-06-29 | Sana Biotechnology, Inc. | Cd24 expressing cells and uses thereof |
| US11118196B2 (en) | 2019-09-05 | 2021-09-14 | Crispr Therapeutics Ag | Universal donor cells |
| WO2021044377A1 (en) | 2019-09-05 | 2021-03-11 | Crispr Therapeutics Ag | Universal donor cells |
| US20230081117A1 (en) * | 2019-09-09 | 2023-03-16 | Scribe Therapeutics Inc. | Compositions and methods for use in immunotherapy |
| WO2021055985A1 (en) * | 2019-09-22 | 2021-03-25 | Cellerant Therapeutics, Inc. | Ipsc-derived, hypoimmunogenic, myeloid progenitor cells |
| JP2022551975A (ja) * | 2019-10-15 | 2022-12-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Fc封鎖を介する移植細胞保護 |
| EP4090743A1 (en) * | 2020-01-13 | 2022-11-23 | Sana Biotechnology, Inc. | Modification of blood type antigens |
| US20230058557A1 (en) * | 2020-01-15 | 2023-02-23 | The Regents Of The University Of California | Transplanted cell protection via inhibition of polymorphonuclear cells |
| BR112022014118A2 (pt) * | 2020-01-17 | 2022-09-27 | Sana Biotechnology Inc | Interruptores de segurança para regulação da expressão gênica |
| CA3176416A1 (en) * | 2020-04-21 | 2021-10-28 | Modassir CHOUDHRY | Cellular vaccine platform and methods of use |
| JP2023525579A (ja) * | 2020-05-15 | 2023-06-16 | アールエックスセル インコーポレーテッド | 低免疫原性の細胞および免疫応答におけるそれらの使用 |
| EP4196568A1 (en) | 2020-08-13 | 2023-06-21 | Sana Biotechnology, Inc. | Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions |
| CN112342196A (zh) * | 2020-08-18 | 2021-02-09 | 未来智人再生医学研究院(广州)有限公司 | 一种免疫兼容可逆的通用型多能干细胞及其应用 |
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| US11459372B2 (en) | 2020-11-30 | 2022-10-04 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| CN114107211B (zh) * | 2020-12-04 | 2025-09-30 | 未来智人再生医学研究院(广州)有限公司 | 一种多能干细胞及其衍生物 |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
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| AU2018207649A1 (en) | 2019-07-11 |
| AU2024256086A1 (en) | 2024-11-28 |
| KR20190103373A (ko) | 2019-09-04 |
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