BR112019014257A2 - método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina - Google Patents

método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina Download PDF

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BR112019014257A2
BR112019014257A2 BR112019014257-6A BR112019014257A BR112019014257A2 BR 112019014257 A2 BR112019014257 A2 BR 112019014257A2 BR 112019014257 A BR112019014257 A BR 112019014257A BR 112019014257 A2 BR112019014257 A2 BR 112019014257A2
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protein
gene
cells
hla
expression
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BR112019014257-6A
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Portuguese (pt)
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SCHREPFER Sonja
Deuse Tobias
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The Regents Of The University Of California
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2840/00—Vectors comprising a special translation-regulating system
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01021—Thymidine kinase (2.7.1.21)
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    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04001—Cytosine deaminase (3.5.4.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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BR112019014257-6A 2017-01-13 2018-01-14 método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina BR112019014257A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762445969P 2017-01-13 2017-01-13
US62/445,969 2017-01-13
PCT/US2018/013688 WO2018132783A1 (en) 2017-01-13 2018-01-14 Immunoengineered pluripotent cells

Publications (1)

Publication Number Publication Date
BR112019014257A2 true BR112019014257A2 (pt) 2020-04-28

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BR112019014257-6A BR112019014257A2 (pt) 2017-01-13 2018-01-14 método para gerar uma célula-tronco pluripotente hipoimunogênica, célula-tronco pluripotente hipoimunogênica humana, método para produzir uma célula pluripotente hipoimunogênica, e ss-2 microglobulina

Country Status (12)

Country Link
US (2) US20190376045A1 (OSRAM)
EP (1) EP3568464A1 (OSRAM)
JP (3) JP2020505025A (OSRAM)
KR (2) KR20190103373A (OSRAM)
CN (1) CN110177869A (OSRAM)
AU (2) AU2018207649B2 (OSRAM)
BR (1) BR112019014257A2 (OSRAM)
CA (1) CA3049766A1 (OSRAM)
EA (1) EA201991692A1 (OSRAM)
IL (1) IL267616A (OSRAM)
MX (1) MX2019008413A (OSRAM)
WO (1) WO2018132783A1 (OSRAM)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015360502A1 (en) 2014-12-10 2017-06-29 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
JP2018515139A (ja) 2015-05-08 2018-06-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 万能ドナー幹細胞および関連する方法
SG10202109655VA (en) 2015-12-04 2021-10-28 Novartis Ag Compositions and methods for immunooncology
EA201991692A1 (ru) * 2017-01-13 2019-12-30 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Иммуносконструированные плюрипотентные клетки
EP3601528A4 (en) * 2017-03-20 2021-05-05 Washington University CELLS AND METHODS OF USE AND PRODUCTION OF THEM
JP2020513832A (ja) 2017-03-22 2020-05-21 ノバルティス アーゲー 免疫腫瘍学のための組成物および方法
GB2588249B (en) 2017-06-12 2023-01-04 Sinai Health Sys Allograft tolerance without the need for systemic immune suppression
US11866726B2 (en) 2017-07-14 2024-01-09 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
CA3106022A1 (en) * 2018-07-17 2020-01-23 The Regents Of The University Of California Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells
BR112021000637A2 (pt) * 2018-07-17 2021-04-13 The Regents Of The University Of California Célula cardíaca hipoimune isolada, método para tratar um paciente que sofre de uma afecção ou doença cardíaca, método para produzir uma população de células cardíacas hipoimunes, célula endotelial hipoimune isolada, método para tratar um paciente que sofre de uma afecção ou doença vascular, método para produzir uma população de células endoteliais hipoimunes, neurônio dopaminérgico hipoimune isolado, método para tratar um paciente que sofre de uma doença ou afecção neurodegenerativa, método para produzir uma população de neurônios dopaminérgicos hipoimunes, célula de ilhota pancreática hipoimune isolada, método para tratar um paciente que sofre de diabetes, método para produzir uma população de células de ilhota pancreática hipoimunes, célula de epitélio pigmentado da retina (rpe) hipoimune isolada, método para tratar um paciente que sofre de uma afecção ocular, e método para produzir uma população de células de epitélio pigmentado da retina (rpe) hipoimunes
US12378572B2 (en) 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
WO2020067993A1 (en) * 2018-09-26 2020-04-02 National University Of Singapore Engineered human mesenchymal stromal cells with low immunogenicity, methods and kits of generating the same
UY38427A (es) * 2018-10-26 2020-05-29 Novartis Ag Métodos y composiciones para terapia con células oculares
CN111424016A (zh) * 2019-01-09 2020-07-17 复旦大学 降低细胞免疫原性的诱导型多能干细胞系及建立方法
BR112021016178A2 (pt) * 2019-02-15 2021-11-03 Harvard College Células-tronco doadoras universais e métodos relacionados
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
JP2022532174A (ja) 2019-05-10 2022-07-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 修飾多能性細胞
EP3990627A4 (en) 2019-06-26 2023-07-19 The Regents of The University of California SIRP-ALPHA SILENCED NATURAL KILLER CELLS (NK)
TW202115245A (zh) * 2019-06-27 2021-04-16 丹麥商諾佛 儂迪克股份有限公司 安全免疫隱形細胞
EP4022037A1 (en) 2019-07-10 2022-07-06 Helmuth Heinrich Kunz Methods for deriving autologous and hypoimmunogenic hair follicle containing sheets in vitro
EP4007596A1 (en) * 2019-08-01 2022-06-08 Sana Biotechnology, Inc. Dux4 expressing cells and uses thereof
EP4017508A1 (en) 2019-08-23 2022-06-29 Sana Biotechnology, Inc. Cd24 expressing cells and uses thereof
US11118196B2 (en) 2019-09-05 2021-09-14 Crispr Therapeutics Ag Universal donor cells
WO2021044377A1 (en) 2019-09-05 2021-03-11 Crispr Therapeutics Ag Universal donor cells
US20230081117A1 (en) * 2019-09-09 2023-03-16 Scribe Therapeutics Inc. Compositions and methods for use in immunotherapy
WO2021055985A1 (en) * 2019-09-22 2021-03-25 Cellerant Therapeutics, Inc. Ipsc-derived, hypoimmunogenic, myeloid progenitor cells
JP2022551975A (ja) * 2019-10-15 2022-12-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｆｃ封鎖を介する移植細胞保護
EP4090743A1 (en) * 2020-01-13 2022-11-23 Sana Biotechnology, Inc. Modification of blood type antigens
US20230058557A1 (en) * 2020-01-15 2023-02-23 The Regents Of The University Of California Transplanted cell protection via inhibition of polymorphonuclear cells
BR112022014118A2 (pt) * 2020-01-17 2022-09-27 Sana Biotechnology Inc Interruptores de segurança para regulação da expressão gênica
JP2023520997A (ja) * 2020-03-25 2023-05-23 サナ バイオテクノロジー，インコーポレイテッド 神経学的障害及び神経学的病態の処置のための低免疫原性神経細胞
EP4132544A4 (en) * 2020-04-06 2024-10-23 Rxcell Inc. HYPOIMMUNOGENIC CELLS AND METHODS AND COMPOSITIONS FOR THEIR PRODUCTION
CA3176416A1 (en) * 2020-04-21 2021-10-28 Modassir CHOUDHRY Cellular vaccine platform and methods of use
JP2023525579A (ja) * 2020-05-15 2023-06-16 アールエックスセル インコーポレーテッド 低免疫原性の細胞および免疫応答におけるそれらの使用
EP4196568A1 (en) 2020-08-13 2023-06-21 Sana Biotechnology, Inc. Methods of treating sensitized patients with hypoimmunogenic cells, and associated methods and compositions
CN112342196A (zh) * 2020-08-18 2021-02-09 未来智人再生医学研究院(广州)有限公司 一种免疫兼容可逆的通用型多能干细胞及其应用
WO2022076928A1 (en) * 2020-10-09 2022-04-14 Sana Biotechnology, Inc. METHODS FOR TRIGGERING SAFETY KILLING MECHANISMS USING A CD47-SIRPα BLOCKADE AGENT
GB2619410A (en) * 2020-10-20 2023-12-06 Replay Holdings Inc Methods and compositions for cellular therapy
CN114525255A (zh) * 2020-10-30 2022-05-24 未来智人再生医学研究院(广州)有限公司 一种表达il-11的多能干细胞衍生物及其应用
CN114457021A (zh) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 一种表达cd47抗体的多能干细胞及其衍生物与应用
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
KR20230118887A (ko) 2020-12-03 2023-08-14 센츄리 쎄라퓨틱스 인코포레이티드 유전자 조작 세포 및 이의 용도
CN114107211B (zh) * 2020-12-04 2025-09-30 未来智人再生医学研究院(广州)有限公司 一种多能干细胞及其衍生物
CN116829698A (zh) * 2020-12-07 2023-09-29 加利福尼亚大学董事会 通过SIRP-α衔接体的先天免疫细胞沉默
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
WO2022144856A1 (en) 2020-12-31 2022-07-07 Crispr Therapeutics Ag Universal donor cells
JP2024501971A (ja) 2020-12-31 2024-01-17 サナ バイオテクノロジー，インコーポレイテッド Ｃａｒ－ｔ活性を調節するための方法及び組成物
US20220296572A1 (en) 2021-03-03 2022-09-22 Sana Biotechnology, Inc. Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions
EP4306634A4 (en) * 2021-03-09 2025-03-26 Riken METHOD FOR PRODUCING HYPOIMMUNOGENIC RETINAL PIGMENT EPITHELIAL CELLS
EP4313087A4 (en) * 2021-03-30 2025-03-19 The Regents of the University of California PROTECTION OF TRANSPLANTED CELLS VIA MODIFIED FC RECEPTORS
CN117597439A (zh) * 2021-05-24 2024-02-23 桑格摩生物治疗股份有限公司 Ciita靶向锌指核酸酶
JP2024521619A (ja) 2021-05-27 2024-06-04 サナ バイオテクノロジー，インコーポレイテッド 操作されたｈｌａ－ｅまたはｈｌａ－ｇを含む低免疫原性細胞
KR20240046319A (ko) 2021-07-14 2024-04-08 사나 바이오테크놀로지, 인크. 저면역원성 세포에서의 y 염색체-연결 항원의 변경된 발현
WO2023008918A1 (ko) * 2021-07-28 2023-02-02 의료법인 성광의료재단 B2m 유전자의 발현이 저해된 유전적으로 조작된 줄기세포 및 이의 이용방법
EP4384188A1 (en) 2021-08-11 2024-06-19 Sana Biotechnology, Inc. Inducible systems for altering gene expression in hypoimmunogenic cells
AU2022325955A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
AU2022325231A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
WO2023019229A1 (en) 2021-08-11 2023-02-16 Sana Biotechnology, Inc. Genetically modified primary cells for allogeneic cell therapy
EP4384544A1 (en) 2021-08-11 2024-06-19 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
CN117904109A (zh) * 2021-08-27 2024-04-19 浙江大学 一种超级增强子核心序列调控b2m基因表达的效果及应用
US20250313861A1 (en) 2021-10-22 2025-10-09 Sana Biotechnology, Inc. Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods
EP4452285A1 (en) 2021-12-23 2024-10-30 Sana Biotechnology, Inc. Chimeric antigen receptor (car) t cells for treating autoimmune disease and associated methods
US20250302953A1 (en) 2022-02-14 2025-10-02 Sana Biotechnology, Inc. Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
CA3244101A1 (en) 2022-02-17 2023-08-24 Sana Biotechnology, Inc. MODIFIED CD47 PROTEINS AND THEIR USES
WO2023173123A1 (en) 2022-03-11 2023-09-14 Sana Biotechnology, Inc. Genetically modified cells and compositions and uses thereof
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
CN114958768B (zh) * 2022-06-02 2023-03-24 健颐生物科技发展(山东)有限公司 Fgf10旁分泌通用型人成纤维细胞制剂的制备方法
CN117343962A (zh) * 2022-06-29 2024-01-05 中国科学院上海营养与健康研究所 免疫兼容型人多能干细胞、其制备方法及应用
EP4547825A1 (en) 2022-07-01 2025-05-07 Novo Nordisk A/S Enhancing neuronal differentiation of ventral midbrain neural progenitor cells
CN117384851B (zh) * 2022-07-11 2025-11-21 士泽生物医药（苏州）有限公司 一种表达faslg的通用型细胞及其制备方法
CN117431217A (zh) * 2022-07-12 2024-01-23 上海驯鹿生物技术有限公司 表达靶向cd5的嵌合抗原受体(car)的细胞及其应用
GB202211117D0 (en) * 2022-07-29 2022-09-14 Replay Holdings Llc Compositions and methods for non-immunogenecity
GB202212144D0 (en) * 2022-08-19 2022-10-05 Resolution Therapeutics Ltd Cells for therapy
WO2024097311A2 (en) 2022-11-02 2024-05-10 Sana Biotechnology, Inc. Hypoimmunogenic mail cells, methods of making and methods of using same
WO2024107420A1 (en) * 2022-11-15 2024-05-23 The Board Of Trustees Of The Leland Stanford Junior University Hypoallogenic-immunogenic pluripotent stem cells as anti-cancer vaccine
CN118207165A (zh) * 2022-12-07 2024-06-18 士泽生物医药（苏州）有限公司 一种表达stc1的通用型细胞及其制备方法
CN118147077B (zh) * 2022-12-07 2025-09-26 士泽生物医药（苏州）有限公司 一种表达gsn的通用型细胞及其制备方法
GB202218755D0 (en) * 2022-12-13 2023-01-25 Replay Holdings Llc Compositions and methods for non-immunogenicity
CN118207166A (zh) * 2022-12-16 2024-06-18 士泽生物医药（苏州）有限公司 一种通用型细胞及其制备方法
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
CN118497129A (zh) * 2023-02-16 2024-08-16 士泽生物医药（苏州）有限公司 通用型细胞及其制备方法
WO2024229302A1 (en) 2023-05-03 2024-11-07 Sana Biotechnology, Inc. Methods of dosing and administration of engineered islet cells
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
WO2025003393A1 (en) 2023-06-30 2025-01-02 Novo Nordisk A/S Enhancing neuronal differentiation of neural progenitor cells
KR102740042B1 (ko) * 2023-07-12 2024-12-06 ㈜바이오솔빅스 인간 전분화능 줄기세포로 유래된 심장 오가노이드 제조방법, 효능 및 독성 평가 기술
WO2025043172A1 (en) 2023-08-23 2025-02-27 Sana Biotechnology, Inc. Modified cd47 proteins and their uses
WO2025054202A1 (en) 2023-09-05 2025-03-13 Sana Biotechnology, Inc. Method of screening a sample comprising a transgene with a unique barcode
CN119351338A (zh) * 2023-09-15 2025-01-24 士泽生物医药（苏州）有限公司 一种表达cd300ld的低免疫原性细胞及其制备方法
WO2025096757A1 (en) 2023-11-01 2025-05-08 Sana Biotechnology, Inc. Hypoimmunogenic cd22-targeted car t cells for the treatment of relapsed and/or refractory b cell lymphomas
WO2025151838A1 (en) 2024-01-12 2025-07-17 Sana Biotechnology, Inc. Safety switches to control in vitro and in vivo proliferation of cell therapy products
WO2025230941A1 (en) 2024-04-30 2025-11-06 Satellite Biosciences, Inc. Hypoimmunogenic cell mixtures and methods of use thereof
WO2025230947A1 (en) 2024-04-30 2025-11-06 Satellite Biosciences, Inc. Engineered hepatocytes for secreting polypeptides

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8724885D0 (en) 1987-10-23 1987-11-25 Binns M M Fowlpox virus promotors
DE19539493A1 (de) 1995-10-24 1997-04-30 Thomae Gmbh Dr K Starker homologer Promotor aus Hamster
US20040053836A1 (en) * 2002-04-22 2004-03-18 Philipp Mayer-Kuckuk Method for modulating the production of a selected protein in vivo
CA2753338A1 (en) 2008-09-22 2010-03-25 Rxi Pharmaceuticals Corporation Neutral nanotransporters
AU2010254811B2 (en) * 2009-06-05 2015-02-19 FUJIFILM Cellular Dynamics, Inc. Reprogramming T cells and hematopoietic cells
US9089520B2 (en) 2010-05-21 2015-07-28 Baylor College Of Medicine Methods for inducing selective apoptosis
AU2013249820C1 (en) * 2012-04-17 2018-10-25 University Of Washington Through Its Center For Commercialization HLA Class II Deficient Cells, HLA Class I Deficient Cells Capable of Expressing HLA Class II Proteins, and Uses Thereof
AU2015226960A1 (en) * 2014-03-07 2016-09-15 Bellicum Pharmaceuticals, Inc. Caspase polypeptides having modified activity and uses thereof
CN106459918A (zh) * 2014-04-24 2017-02-22 得克萨斯州大学系统董事会 施加诱导多能干细胞产生过继细胞疗法产品
AU2016231061B2 (en) * 2015-03-11 2020-11-26 Cellectis Methods for engineering allogeneic T cell to increase their persistence and/or engraftment into patients
JP2018515139A (ja) * 2015-05-08 2018-06-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 万能ドナー幹細胞および関連する方法
ES2953925T3 (es) * 2015-11-04 2023-11-17 Fate Therapeutics Inc Ingeniería genómica de células pluripotentes
EA201991692A1 (ru) * 2017-01-13 2019-12-30 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Иммуносконструированные плюрипотентные клетки
JP2022532174A (ja) * 2019-05-10 2022-07-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 修飾多能性細胞

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