JP2020505017A5 - - Google Patents
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- JP2020505017A5 JP2020505017A5 JP2019536981A JP2019536981A JP2020505017A5 JP 2020505017 A5 JP2020505017 A5 JP 2020505017A5 JP 2019536981 A JP2019536981 A JP 2019536981A JP 2019536981 A JP2019536981 A JP 2019536981A JP 2020505017 A5 JP2020505017 A5 JP 2020505017A5
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- 239000002773 nucleotide Substances 0.000 claims description 16
- 125000003729 nucleotide group Chemical group 0.000 claims description 16
- 239000013604 expression vector Substances 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000012258 culturing Methods 0.000 claims description 4
- 230000014509 gene expression Effects 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 description 2
- 238000003259 recombinant expression Methods 0.000 description 2
- 238000011426 transformation method Methods 0.000 description 2
- 230000009452 underexpressoin Effects 0.000 description 2
- 241000699802 Cricetulus griseus Species 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 230000009465 prokaryotic expression Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710054783.5 | 2017-01-24 | ||
| CN201710054783.5A CN108341871A (zh) | 2017-01-24 | 2017-01-24 | 抗pd-1单克隆抗体及其制备方法和应用 |
| PCT/CN2018/073575 WO2018137576A1 (zh) | 2017-01-24 | 2018-01-22 | 抗pd-1单克隆抗体及其制备方法和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505017A JP2020505017A (ja) | 2020-02-20 |
| JP2020505017A5 true JP2020505017A5 (cg-RX-API-DMAC7.html) | 2020-11-19 |
| JP7098629B2 JP7098629B2 (ja) | 2022-07-11 |
Family
ID=62962821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019536981A Active JP7098629B2 (ja) | 2017-01-24 | 2018-01-22 | 抗ｐｄ－１モノクローナル抗体、その製造方法及び用途 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11254746B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3575322B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7098629B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN108341871A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018137576A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111196856A (zh) * | 2018-11-19 | 2020-05-26 | 三生国健药业（上海）股份有限公司 | 抗her2/pd1双特异性抗体 |
| CN111196855B (zh) * | 2018-11-19 | 2022-11-15 | 三生国健药业（上海）股份有限公司 | 抗egfr/pd-1双特异性抗体 |
| CN111518206B (zh) | 2019-02-01 | 2022-03-29 | 长春金赛药业有限责任公司 | 人源化抗Aβ单克隆抗体及其应用 |
| CN109748965A (zh) * | 2019-03-13 | 2019-05-14 | 安徽安科生物工程（集团）股份有限公司 | 全人源pd-l1单克隆抗体及其制备方法和应用 |
| CN109929037B (zh) * | 2019-04-01 | 2023-03-17 | 华博生物医药技术（上海）有限公司 | 针对程序性死亡配体的结合物及其应用 |
| CN110563849B (zh) * | 2019-08-09 | 2022-09-09 | 安徽瀚海博兴生物技术有限公司 | 一种抗vegf-抗pd1双特异性抗体 |
| EP4056592A4 (en) * | 2019-11-08 | 2024-03-20 | Jiangsu Simcere Pharmaceutical Co., Ltd. | ANTIBODY AGAINST HUMAN PROGRAMMED CELL DEATH LIGAND 1 (PD-L1) AND USE THEREOF |
| CN113563473A (zh) | 2020-04-29 | 2021-10-29 | 三生国健药业（上海）股份有限公司 | 四价双特异性抗体、其制备方法和用途 |
| WO2021226984A1 (zh) * | 2020-05-15 | 2021-11-18 | 三生国健药业（上海）股份有限公司 | 一种抗pd-1和pd-l1的四价双特异性抗体 |
| MX2022014974A (es) * | 2020-05-26 | 2023-01-11 | Boehringer Ingelheim Int | Anticuerpos anti-pd-1. |
| CN113754767A (zh) * | 2020-06-03 | 2021-12-07 | 上海恒润达生生物科技股份有限公司 | 抗人pd-1抗体及其用途 |
| CN111647624A (zh) * | 2020-06-10 | 2020-09-11 | 成都和同易创生物科技有限公司 | Tsab人源单克隆抗体重组载体、重组抗体及其制备方法 |
| CN113797330A (zh) * | 2020-06-11 | 2021-12-17 | 三生国健药业（上海）股份有限公司 | 一种抗pd-1单克隆抗体液体制剂 |
| CN114761434B (zh) * | 2020-09-30 | 2023-06-27 | 苏州沙砾生物科技有限公司 | Pd-1抗体及其制备方法与应用 |
| CN116782937A (zh) * | 2020-12-10 | 2023-09-19 | 优特力克斯有限公司 | 抗pd-1抗体及其用途 |
| CN114316047B (zh) * | 2021-01-14 | 2023-12-22 | 东大生物技术(苏州)有限公司 | 一组pd-1单克隆抗体及其医药用途 |
| CN113980129B (zh) * | 2021-01-15 | 2023-07-28 | 东大生物技术(苏州)有限公司 | 一组il-11单克隆抗体及其医药用途 |
| CN113150154B (zh) * | 2021-04-15 | 2022-05-10 | 博奥信生物技术（南京）有限公司 | 抗人pdl1单克隆抗体及其用途 |
| CN115536749A (zh) | 2021-06-29 | 2022-12-30 | 三生国健药业（上海）股份有限公司 | 三特异性抗体、其制备方法和用途 |
| CN114539406B (zh) * | 2021-12-31 | 2023-04-14 | 浙江大学 | 一种全人源抗PD-1的单克隆抗体No.8-3及其应用 |
| CN114539407B (zh) * | 2021-12-31 | 2023-04-18 | 浙江大学 | 一种全人源抗PD-1的单克隆抗体No.1-10及其应用 |
| CN119698432A (zh) * | 2022-06-01 | 2025-03-25 | 希恩克罗姆恩股份有限公司 | 经由肿瘤细胞裂解和肿瘤内施用免疫治疗成分组合来治疗癌症的方法 |
| CN115925947B (zh) * | 2022-09-27 | 2023-08-22 | 上海百英生物科技股份有限公司 | 一种亲和力成熟方法及抗人pd-l1单域抗体的亲和力成熟 |
| CN115951055B (zh) * | 2022-12-13 | 2024-10-15 | 湖南湘医投蕙尧生命科技有限公司 | 一种癌症相关蛋白及其抗体和应用 |
| WO2025128264A1 (en) * | 2023-12-15 | 2025-06-19 | Pharmaessentia Corporation | Anti-pd-1 monoclonal antibody and methods of use thereof |
| CN120518767B (zh) * | 2025-05-30 | 2025-11-11 | 中国人民解放军军事科学院军事医学研究院 | 一种pd-1单克隆抗体及其应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1896582A4 (en) | 2005-05-09 | 2009-04-08 | Ono Pharmaceutical Co | HUMAN MONOCLONAL ANTIBODIES AGAINST PROGRAMMED CELL DEATH 1 (PD-1) AND METHOD FOR CREATING TREATMENT WITH ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS |
| WO2008156712A1 (en) | 2007-06-18 | 2008-12-24 | N. V. Organon | Antibodies to human programmed death receptor pd-1 |
| WO2009114335A2 (en) * | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| WO2010029435A1 (en) * | 2008-09-12 | 2010-03-18 | Isis Innovation Limited | Pd-1 specific antibodies and uses thereof |
| WO2013169693A1 (en) | 2012-05-09 | 2013-11-14 | Bristol-Myers Squibb Company | Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody |
| JP6563906B2 (ja) * | 2013-05-31 | 2019-08-21 | ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｐｄ−１に結合する抗原結合蛋白質 |
| CN104250302B (zh) | 2013-06-26 | 2017-11-14 | 上海君实生物医药科技股份有限公司 | 抗pd‑1抗体及其应用 |
| EA034666B1 (ru) | 2013-09-13 | 2020-03-04 | Бейджин Свитзерланд Гмбх | Антитело против pd-1 и его применение для лечения рака или вирусной инфекции и фрагмент антитела |
| HUE046249T2 (hu) | 2013-12-12 | 2020-02-28 | Shanghai hengrui pharmaceutical co ltd | PD-1 antitest, antigén-kötõ fragmense, és gyógyászati alkalmazása |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| BR122020025583B1 (pt) | 2014-07-22 | 2023-12-05 | Cb Therapeutics, Inc | Anticorpo isolado ou fragmento do mesmo que liga a pd-1, uso deste, composição, polinucleotídeo isolado e vetor de expressão |
| CN105330740B (zh) | 2014-07-30 | 2018-08-17 | 珠海市丽珠单抗生物技术有限公司 | 抗pd-1抗体及其应用 |
| CN105622753B (zh) * | 2014-11-04 | 2019-04-09 | 博生吉医药科技(苏州)有限公司 | 一种pd-1单克隆抗体及其应用 |
| CN105061597B (zh) * | 2015-06-09 | 2016-04-27 | 北京东方百泰生物科技有限公司 | 一种抗pd-1的单克隆抗体及其获得方法 |
| WO2017011580A2 (en) * | 2015-07-13 | 2017-01-19 | Cytomx Therapeutics, Inc. | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
| CN106336460B (zh) * | 2015-07-15 | 2021-02-12 | 杭州贝颐药业有限公司 | 抗人pd-1蛋白抗体及其编码基因和应用 |
| ES2898958T3 (es) * | 2015-07-30 | 2022-03-09 | Macrogenics Inc | Moléculas de unión a PD-1 y LAG-3 y métodos de uso de las mismas |
| BR112018006547A2 (pt) | 2015-09-29 | 2018-12-11 | Asia Biotech Pte. Ltd | anticorpos de pd-1 e usos dos mesmos |
| CN106008714B (zh) | 2016-05-24 | 2019-03-15 | 瑞阳(苏州)生物科技有限公司 | 抗人pd-1人源化单克隆抗体及其应用 |
-
2017
- 2017-01-24 CN CN201710054783.5A patent/CN108341871A/zh active Pending
-
2018
- 2018-01-22 US US16/480,014 patent/US11254746B2/en active Active
- 2018-01-22 EP EP18745412.9A patent/EP3575322B1/en active Active
- 2018-01-22 JP JP2019536981A patent/JP7098629B2/ja active Active
- 2018-01-22 CN CN201880007287.7A patent/CN110225928B/zh active Active
- 2018-01-22 WO PCT/CN2018/073575 patent/WO2018137576A1/zh not_active Ceased
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