JP2020504746A5 - - Google Patents
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- Publication number
- JP2020504746A5 JP2020504746A5 JP2019534680A JP2019534680A JP2020504746A5 JP 2020504746 A5 JP2020504746 A5 JP 2020504746A5 JP 2019534680 A JP2019534680 A JP 2019534680A JP 2019534680 A JP2019534680 A JP 2019534680A JP 2020504746 A5 JP2020504746 A5 JP 2020504746A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- migraine
- symptoms
- composition
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000019695 Migraine disease Diseases 0.000 claims description 39
- 206010027599 migraine Diseases 0.000 claims description 39
- 208000024891 symptom Diseases 0.000 claims description 31
- 150000001875 compounds Chemical class 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 24
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 claims description 8
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 8
- 159000000000 sodium salts Chemical class 0.000 claims description 8
- 206010028813 Nausea Diseases 0.000 claims description 6
- 230000037396 body weight Effects 0.000 claims description 6
- 159000000007 calcium salts Chemical class 0.000 claims description 6
- 230000008693 nausea Effects 0.000 claims description 6
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 6
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- 159000000003 magnesium salts Chemical class 0.000 claims description 4
- 230000002503 metabolic effect Effects 0.000 claims description 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 4
- 239000002243 precursor Substances 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 206010019233 Headaches Diseases 0.000 claims description 3
- 230000000069 prophylactic effect Effects 0.000 claims description 3
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- 208000017667 Chronic Disease Diseases 0.000 claims description 2
- 206010061818 Disease progression Diseases 0.000 claims description 2
- 206010013887 Dysarthria Diseases 0.000 claims description 2
- 206010015958 Eye pain Diseases 0.000 claims description 2
- 206010016059 Facial pain Diseases 0.000 claims description 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical class NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 206010026749 Mania Diseases 0.000 claims description 2
- 206010027940 Mood altered Diseases 0.000 claims description 2
- 206010027951 Mood swings Diseases 0.000 claims description 2
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical class CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 2
- 206010060860 Neurological symptom Diseases 0.000 claims description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 2
- 206010072731 White matter lesion Diseases 0.000 claims description 2
- QYPPJABKJHAVHS-UHFFFAOYSA-P agmatinium(2+) Chemical class NC(=[NH2+])NCCCC[NH3+] QYPPJABKJHAVHS-UHFFFAOYSA-P 0.000 claims description 2
- 229940024606 amino acid Drugs 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 2
- 235000013361 beverage Nutrition 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 229960004203 carnitine Drugs 0.000 claims description 2
- 230000001149 cognitive effect Effects 0.000 claims description 2
- 229940000425 combination drug Drugs 0.000 claims description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical class NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims description 2
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 230000006735 deficit Effects 0.000 claims description 2
- 230000005750 disease progression Effects 0.000 claims description 2
- 239000001087 glyceryl triacetate Substances 0.000 claims description 2
- 235000013773 glyceryl triacetate Nutrition 0.000 claims description 2
- 125000000487 histidyl group Chemical class [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims description 2
- 235000003642 hunger Nutrition 0.000 claims description 2
- 230000001771 impaired effect Effects 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- 150000002576 ketones Chemical class 0.000 claims description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000035945 sensitivity Effects 0.000 claims description 2
- 230000001953 sensory effect Effects 0.000 claims description 2
- 230000035922 thirst Effects 0.000 claims description 2
- 229960002622 triacetin Drugs 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 13
- WHBMMWSBFZVSSR-GSVOUGTGSA-M (R)-3-hydroxybutyrate Chemical compound C[C@@H](O)CC([O-])=O WHBMMWSBFZVSSR-GSVOUGTGSA-M 0.000 claims 1
- IGUZJYCAXLYZEE-UHFFFAOYSA-N 3,4,5-trihydroxypentan-2-one Chemical compound CC(=O)C(O)C(O)CO IGUZJYCAXLYZEE-UHFFFAOYSA-N 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- -1 Acetoacetyl glycerol Chemical compound 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022130419A JP2022166218A (ja) | 2016-12-21 | 2022-08-18 | 片頭痛の予防および治療 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16206018 | 2016-12-21 | ||
| EP16206018.0 | 2016-12-21 | ||
| EP17154258 | 2017-02-01 | ||
| EP17154258.2 | 2017-02-01 | ||
| PCT/EP2017/083880 WO2018115158A1 (en) | 2016-12-21 | 2017-12-20 | Migraine prevention and treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022130419A Division JP2022166218A (ja) | 2016-12-21 | 2022-08-18 | 片頭痛の予防および治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504746A JP2020504746A (ja) | 2020-02-13 |
| JP2020504746A5 true JP2020504746A5 (https=) | 2021-02-04 |
| JP7514457B2 JP7514457B2 (ja) | 2024-07-11 |
Family
ID=61005774
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019534680A Active JP7514457B2 (ja) | 2016-12-21 | 2017-12-20 | 片頭痛の予防および治療 |
| JP2022130419A Pending JP2022166218A (ja) | 2016-12-21 | 2022-08-18 | 片頭痛の予防および治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022130419A Pending JP2022166218A (ja) | 2016-12-21 | 2022-08-18 | 片頭痛の予防および治療 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11166928B2 (https=) |
| EP (2) | EP4245368A3 (https=) |
| JP (2) | JP7514457B2 (https=) |
| KR (1) | KR102610870B1 (https=) |
| CN (1) | CN110087642B (https=) |
| AU (2) | AU2017384625B2 (https=) |
| CA (1) | CA3046415A1 (https=) |
| DK (1) | DK3558280T3 (https=) |
| ES (1) | ES2948609T3 (https=) |
| FI (1) | FI3558280T3 (https=) |
| HR (1) | HRP20230851T1 (https=) |
| HU (1) | HUE062536T2 (https=) |
| LT (1) | LT3558280T (https=) |
| PL (1) | PL3558280T3 (https=) |
| RU (1) | RU2753057C9 (https=) |
| SI (1) | SI3558280T1 (https=) |
| WO (1) | WO2018115158A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180057846A1 (en) | 2016-08-30 | 2018-03-01 | KetoneAid Inc. | Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy |
| FI3558280T3 (fi) * | 2016-12-21 | 2023-07-13 | Univ Kinderspital Beider Basel | Migreenin ennaltaehkäisy ja hoito |
| US20180177753A1 (en) | 2016-12-23 | 2018-06-28 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for migraine symptom management |
| US11760963B2 (en) | 2017-08-23 | 2023-09-19 | KetoneAid Inc. | Ketogenic beer and alcoholic beverage mixture containing non-racemic ethyl 3-hydroxybutyrate and/or 1,3 butanediol |
| AU2020246928B2 (en) * | 2019-03-22 | 2025-05-15 | Société des Produits Nestlé S.A. | Methods using administration of medium chain triglycerides (MCT) prior to a meal to increase ketone production from the MCTs |
| AU2020274805A1 (en) | 2019-05-10 | 2021-10-28 | Ketoswiss Ag | Ketone bodies enclosed in microbeads |
| EP3956282A1 (de) * | 2019-06-12 | 2022-02-23 | IOI Oleo GmbH | Verfahren zur herstellung von acylverkappten 3-hydroxycarbonsäuren sowie deren salzen und estern |
| CN114008014B (zh) * | 2019-06-12 | 2024-03-22 | 凯托利皮克斯治疗有限责任公司 | 用于生产酰基封端的3-羟基羧酸的多元醇基酯的方法 |
| US12396974B2 (en) | 2020-03-27 | 2025-08-26 | KetoneAid | Ketone ester as a therapeutic treatment of Covid-19 and related viral infections |
| CN117677383A (zh) | 2021-07-17 | 2024-03-08 | 瑞士凯托股份公司 | 酮体或生酮化合物与镇痛剂或抗氧化剂的组合 |
| WO2023166069A1 (en) | 2022-03-02 | 2023-09-07 | N.V. Nutricia | Fatty acids for ketosis control |
| CN115590963A (zh) * | 2022-07-13 | 2023-01-13 | 复旦大学（Cn） | 酮体、酮体诱导剂和生酮组合物中的至少一种在治疗和/或预防血小板减少症药物中的应用 |
| KR102775899B1 (ko) | 2023-12-19 | 2025-02-28 | 한림대학교 산학협력단 | 삽화성 편두통 및 만성 편두통 진단을 위한 정보제공 방법, 장치 및 컴퓨터 프로그램 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0174979A4 (en) * | 1984-03-01 | 1987-11-23 | Vernon Erk | METHOD FOR LOWERING THE BLOOD GLUCOSE LEVEL IN VERBELTIES. |
| JPH0665458A (ja) | 1992-08-21 | 1994-03-08 | Nippon Oil & Fats Co Ltd | 塩素含有樹脂組成物 |
| US5420335A (en) * | 1993-09-30 | 1995-05-30 | Birkhahn; Ronald H. | Parenteral nutrients based on watersoluble glycerol bisacetoacetates |
| CN1315473C (zh) * | 1997-03-17 | 2007-05-16 | 英国技术集团国际有限公司 | 治疗组合物 |
| DK1123094T3 (da) | 1998-09-15 | 2007-08-20 | Btg Int Ltd | Terapeutiske præparater (II) |
| US20050129783A1 (en) * | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
| US7807718B2 (en) * | 2006-06-30 | 2010-10-05 | Sami A. Hashim | Glyceride esters for the treatment of diseases associated with reduced neuronal metabolism of glucose |
| US20120034193A1 (en) | 2009-01-24 | 2012-02-09 | Daryl Rees | Treatment of neurotrophic factor mediated disorders |
| GB201206192D0 (en) | 2012-04-05 | 2012-05-23 | Tdeltas Ltd | Ketone bodies and ketone body esters and for maintaining or improving muscle power output |
| CN103877118A (zh) | 2014-03-11 | 2014-06-25 | 天津金耀集团有限公司 | 一种由醋丙甲泼尼龙、氧化锌组成的药物组合物 |
| US20160078782A1 (en) * | 2014-09-17 | 2016-03-17 | The Trustees Of Boston College | Glucose Ketone Index for MetabolicTherapy |
| US20180200220A1 (en) * | 2015-07-10 | 2018-07-19 | Cognate Nutritionals, Inc. | Prophylaxis and mitigation of migraine headaches using ketogenic medium chain triglycerides, ketone esters, and other ketogenic sources |
| FI3558280T3 (fi) * | 2016-12-21 | 2023-07-13 | Univ Kinderspital Beider Basel | Migreenin ennaltaehkäisy ja hoito |
| US20180177753A1 (en) | 2016-12-23 | 2018-06-28 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for migraine symptom management |
| US10500182B2 (en) | 2018-01-10 | 2019-12-10 | Robert Firger | Compositions of ketogenic sources, micronutrients and phytochemicals for prophylaxis and mitigation of migraine headache |
-
2017
- 2017-12-20 FI FIEP17832224.4T patent/FI3558280T3/fi active
- 2017-12-20 SI SI201731394T patent/SI3558280T1/sl unknown
- 2017-12-20 JP JP2019534680A patent/JP7514457B2/ja active Active
- 2017-12-20 DK DK17832224.4T patent/DK3558280T3/da active
- 2017-12-20 ES ES17832224T patent/ES2948609T3/es active Active
- 2017-12-20 HU HUE17832224A patent/HUE062536T2/hu unknown
- 2017-12-20 RU RU2019122562A patent/RU2753057C9/ru active
- 2017-12-20 CA CA3046415A patent/CA3046415A1/en active Pending
- 2017-12-20 EP EP23176972.0A patent/EP4245368A3/en active Pending
- 2017-12-20 AU AU2017384625A patent/AU2017384625B2/en active Active
- 2017-12-20 EP EP17832224.4A patent/EP3558280B1/en active Active
- 2017-12-20 HR HRP20230851TT patent/HRP20230851T1/hr unknown
- 2017-12-20 PL PL17832224.4T patent/PL3558280T3/pl unknown
- 2017-12-20 US US16/472,309 patent/US11166928B2/en active Active
- 2017-12-20 CN CN201780079158.4A patent/CN110087642B/zh active Active
- 2017-12-20 LT LTEPPCT/EP2017/083880T patent/LT3558280T/lt unknown
- 2017-12-20 KR KR1020197021346A patent/KR102610870B1/ko active Active
- 2017-12-20 WO PCT/EP2017/083880 patent/WO2018115158A1/en not_active Ceased
-
2021
- 2021-06-01 US US17/335,319 patent/US11890264B2/en active Active
-
2022
- 2022-03-07 AU AU2022201565A patent/AU2022201565B2/en active Active
- 2022-08-18 JP JP2022130419A patent/JP2022166218A/ja active Pending
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