ES2948609T3 - Prevención y tratamiento de migraña - Google Patents

Prevención y tratamiento de migraña Download PDF

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Publication number
ES2948609T3
ES2948609T3 ES17832224T ES17832224T ES2948609T3 ES 2948609 T3 ES2948609 T3 ES 2948609T3 ES 17832224 T ES17832224 T ES 17832224T ES 17832224 T ES17832224 T ES 17832224T ES 2948609 T3 ES2948609 T3 ES 2948609T3
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ES
Spain
Prior art keywords
migraine
salt
compound
phb
symptoms
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Active
Application number
ES17832224T
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English (en)
Spanish (es)
Inventor
Elena Gross
Dirk Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kinderspital Beider Basel, University of
Universitaets Kinderspital beider Basel UKBB
Original Assignee
Kinderspital Beider Basel, University of
Universitaets Kinderspital beider Basel UKBB
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/191Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/405Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ES17832224T 2016-12-21 2017-12-20 Prevención y tratamiento de migraña Active ES2948609T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16206018 2016-12-21
EP17154258 2017-02-01
PCT/EP2017/083880 WO2018115158A1 (en) 2016-12-21 2017-12-20 Migraine prevention and treatment

Publications (1)

Publication Number Publication Date
ES2948609T3 true ES2948609T3 (es) 2023-09-14

Family

ID=61005774

Family Applications (1)

Application Number Title Priority Date Filing Date
ES17832224T Active ES2948609T3 (es) 2016-12-21 2017-12-20 Prevención y tratamiento de migraña

Country Status (17)

Country Link
US (2) US11166928B2 (https=)
EP (2) EP4245368A3 (https=)
JP (2) JP7514457B2 (https=)
KR (1) KR102610870B1 (https=)
CN (1) CN110087642B (https=)
AU (2) AU2017384625B2 (https=)
CA (1) CA3046415A1 (https=)
DK (1) DK3558280T3 (https=)
ES (1) ES2948609T3 (https=)
FI (1) FI3558280T3 (https=)
HR (1) HRP20230851T1 (https=)
HU (1) HUE062536T2 (https=)
LT (1) LT3558280T (https=)
PL (1) PL3558280T3 (https=)
RU (1) RU2753057C9 (https=)
SI (1) SI3558280T1 (https=)
WO (1) WO2018115158A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180057846A1 (en) 2016-08-30 2018-03-01 KetoneAid Inc. Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy
FI3558280T3 (fi) * 2016-12-21 2023-07-13 Univ Kinderspital Beider Basel Migreenin ennaltaehkäisy ja hoito
US20180177753A1 (en) 2016-12-23 2018-06-28 Neuroenergy Ventures, Inc. Glyceryl 3-hydroxybutyrates for migraine symptom management
US11760963B2 (en) 2017-08-23 2023-09-19 KetoneAid Inc. Ketogenic beer and alcoholic beverage mixture containing non-racemic ethyl 3-hydroxybutyrate and/or 1,3 butanediol
AU2020246928B2 (en) * 2019-03-22 2025-05-15 Société des Produits Nestlé S.A. Methods using administration of medium chain triglycerides (MCT) prior to a meal to increase ketone production from the MCTs
AU2020274805A1 (en) 2019-05-10 2021-10-28 Ketoswiss Ag Ketone bodies enclosed in microbeads
EP3956282A1 (de) * 2019-06-12 2022-02-23 IOI Oleo GmbH Verfahren zur herstellung von acylverkappten 3-hydroxycarbonsäuren sowie deren salzen und estern
CN114008014B (zh) * 2019-06-12 2024-03-22 凯托利皮克斯治疗有限责任公司 用于生产酰基封端的3-羟基羧酸的多元醇基酯的方法
US12396974B2 (en) 2020-03-27 2025-08-26 KetoneAid Ketone ester as a therapeutic treatment of Covid-19 and related viral infections
CN117677383A (zh) 2021-07-17 2024-03-08 瑞士凯托股份公司 酮体或生酮化合物与镇痛剂或抗氧化剂的组合
WO2023166069A1 (en) 2022-03-02 2023-09-07 N.V. Nutricia Fatty acids for ketosis control
CN115590963A (zh) * 2022-07-13 2023-01-13 复旦大学(Cn) 酮体、酮体诱导剂和生酮组合物中的至少一种在治疗和/或预防血小板减少症药物中的应用
KR102775899B1 (ko) 2023-12-19 2025-02-28 한림대학교 산학협력단 삽화성 편두통 및 만성 편두통 진단을 위한 정보제공 방법, 장치 및 컴퓨터 프로그램

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0174979A4 (en) * 1984-03-01 1987-11-23 Vernon Erk METHOD FOR LOWERING THE BLOOD GLUCOSE LEVEL IN VERBELTIES.
JPH0665458A (ja) 1992-08-21 1994-03-08 Nippon Oil & Fats Co Ltd 塩素含有樹脂組成物
US5420335A (en) * 1993-09-30 1995-05-30 Birkhahn; Ronald H. Parenteral nutrients based on watersoluble glycerol bisacetoacetates
CN1315473C (zh) * 1997-03-17 2007-05-16 英国技术集团国际有限公司 治疗组合物
DK1123094T3 (da) 1998-09-15 2007-08-20 Btg Int Ltd Terapeutiske præparater (II)
US20050129783A1 (en) * 2001-04-19 2005-06-16 Mccleary Edward L. Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health
US7807718B2 (en) * 2006-06-30 2010-10-05 Sami A. Hashim Glyceride esters for the treatment of diseases associated with reduced neuronal metabolism of glucose
US20120034193A1 (en) 2009-01-24 2012-02-09 Daryl Rees Treatment of neurotrophic factor mediated disorders
GB201206192D0 (en) 2012-04-05 2012-05-23 Tdeltas Ltd Ketone bodies and ketone body esters and for maintaining or improving muscle power output
CN103877118A (zh) 2014-03-11 2014-06-25 天津金耀集团有限公司 一种由醋丙甲泼尼龙、氧化锌组成的药物组合物
US20160078782A1 (en) * 2014-09-17 2016-03-17 The Trustees Of Boston College Glucose Ketone Index for MetabolicTherapy
US20180200220A1 (en) * 2015-07-10 2018-07-19 Cognate Nutritionals, Inc. Prophylaxis and mitigation of migraine headaches using ketogenic medium chain triglycerides, ketone esters, and other ketogenic sources
FI3558280T3 (fi) * 2016-12-21 2023-07-13 Univ Kinderspital Beider Basel Migreenin ennaltaehkäisy ja hoito
US20180177753A1 (en) 2016-12-23 2018-06-28 Neuroenergy Ventures, Inc. Glyceryl 3-hydroxybutyrates for migraine symptom management
US10500182B2 (en) 2018-01-10 2019-12-10 Robert Firger Compositions of ketogenic sources, micronutrients and phytochemicals for prophylaxis and mitigation of migraine headache

Also Published As

Publication number Publication date
AU2022201565A1 (en) 2022-03-31
RU2753057C9 (ru) 2021-09-10
RU2019122562A3 (https=) 2021-01-27
RU2019122562A (ru) 2021-01-27
HUE062536T2 (hu) 2023-11-28
FI3558280T3 (fi) 2023-07-13
KR20190099486A (ko) 2019-08-27
KR102610870B1 (ko) 2023-12-06
CA3046415A1 (en) 2018-06-28
CN110087642B (zh) 2022-12-27
EP4245368A3 (en) 2024-01-03
US11890264B2 (en) 2024-02-06
AU2022201565B2 (en) 2023-07-06
CN110087642A (zh) 2019-08-02
HRP20230851T1 (hr) 2023-11-10
EP3558280A1 (en) 2019-10-30
US20190374490A1 (en) 2019-12-12
JP2020504746A (ja) 2020-02-13
WO2018115158A1 (en) 2018-06-28
DK3558280T3 (da) 2023-08-21
JP7514457B2 (ja) 2024-07-11
RU2753057C2 (ru) 2021-08-11
EP4245368A2 (en) 2023-09-20
AU2017384625B2 (en) 2021-12-16
JP2022166218A (ja) 2022-11-01
US11166928B2 (en) 2021-11-09
LT3558280T (lt) 2023-10-10
AU2017384625A1 (en) 2019-06-13
US20210338618A1 (en) 2021-11-04
PL3558280T3 (pl) 2023-10-16
EP3558280B1 (en) 2023-06-07
SI3558280T1 (sl) 2023-10-30

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