JP7514457B2 - 片頭痛の予防および治療 - Google Patents
片頭痛の予防および治療 Download PDFInfo
- Publication number
- JP7514457B2 JP7514457B2 JP2019534680A JP2019534680A JP7514457B2 JP 7514457 B2 JP7514457 B2 JP 7514457B2 JP 2019534680 A JP2019534680 A JP 2019534680A JP 2019534680 A JP2019534680 A JP 2019534680A JP 7514457 B2 JP7514457 B2 JP 7514457B2
- Authority
- JP
- Japan
- Prior art keywords
- migraine
- βhb
- pharmaceutical composition
- salts
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000019695 Migraine disease Diseases 0.000 title claims description 175
- 206010027599 migraine Diseases 0.000 claims description 168
- 210000004369 blood Anatomy 0.000 claims description 61
- 239000008280 blood Substances 0.000 claims description 61
- 150000001875 compounds Chemical class 0.000 claims description 58
- 238000011282 treatment Methods 0.000 claims description 54
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 50
- 239000008194 pharmaceutical composition Substances 0.000 claims description 46
- 150000003839 salts Chemical class 0.000 claims description 45
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 43
- 208000024891 symptom Diseases 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 30
- 150000002576 ketones Chemical class 0.000 claims description 28
- 230000002265 prevention Effects 0.000 claims description 25
- 206010019233 Headaches Diseases 0.000 claims description 24
- 239000004472 Lysine Substances 0.000 claims description 23
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 claims description 22
- WDJHALXBUFZDSR-UHFFFAOYSA-M acetoacetate Chemical compound CC(=O)CC([O-])=O WDJHALXBUFZDSR-UHFFFAOYSA-M 0.000 claims description 21
- 229940024606 amino acid Drugs 0.000 claims description 15
- 235000001014 amino acid Nutrition 0.000 claims description 15
- 150000001413 amino acids Chemical class 0.000 claims description 15
- 206010028813 Nausea Diseases 0.000 claims description 13
- 230000008693 nausea Effects 0.000 claims description 13
- 159000000000 sodium salts Chemical class 0.000 claims description 11
- 230000037396 body weight Effects 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- 159000000007 calcium salts Chemical class 0.000 claims description 6
- 208000004454 Hyperalgesia Diseases 0.000 claims description 5
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 5
- 206010053552 allodynia Diseases 0.000 claims description 5
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical class NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims description 5
- 201000010099 disease Diseases 0.000 claims description 5
- 230000001953 sensory effect Effects 0.000 claims description 5
- 206010015958 Eye pain Diseases 0.000 claims description 4
- 206010016059 Facial pain Diseases 0.000 claims description 4
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 4
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 4
- 206010047700 Vomiting Diseases 0.000 claims description 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 4
- 229960000310 isoleucine Drugs 0.000 claims description 4
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 4
- 230000035945 sensitivity Effects 0.000 claims description 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 4
- 230000008673 vomiting Effects 0.000 claims description 4
- 206010061818 Disease progression Diseases 0.000 claims description 3
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical class NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 3
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical class NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims description 3
- 208000019430 Motor disease Diseases 0.000 claims description 3
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical class CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 3
- 208000020764 Sensation disease Diseases 0.000 claims description 3
- QYPPJABKJHAVHS-UHFFFAOYSA-P agmatinium(2+) Chemical class NC(=[NH2+])NCCCC[NH3+] QYPPJABKJHAVHS-UHFFFAOYSA-P 0.000 claims description 3
- 235000013361 beverage Nutrition 0.000 claims description 3
- 230000005750 disease progression Effects 0.000 claims description 3
- 159000000003 magnesium salts Chemical class 0.000 claims description 3
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical class C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 229940000425 combination drug Drugs 0.000 claims 1
- 125000000487 histidyl group Chemical class [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- 159000000001 potassium salts Chemical group 0.000 claims 1
- 230000037406 food intake Effects 0.000 description 35
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 29
- 239000008103 glucose Substances 0.000 description 29
- 230000000694 effects Effects 0.000 description 24
- 230000009467 reduction Effects 0.000 description 24
- 229960003136 leucine Drugs 0.000 description 23
- 230000002361 ketogenic effect Effects 0.000 description 22
- 239000003814 drug Substances 0.000 description 21
- 239000004395 L-leucine Substances 0.000 description 19
- 235000019454 L-leucine Nutrition 0.000 description 19
- 229940079593 drug Drugs 0.000 description 19
- 231100000869 headache Toxicity 0.000 description 19
- 230000000875 corresponding effect Effects 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- 235000019766 L-Lysine Nutrition 0.000 description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
- 239000000902 placebo Substances 0.000 description 13
- 229940068196 placebo Drugs 0.000 description 13
- 230000008859 change Effects 0.000 description 11
- 235000020887 ketogenic diet Nutrition 0.000 description 11
- 230000002503 metabolic effect Effects 0.000 description 10
- 239000002243 precursor Substances 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 10
- 235000012054 meals Nutrition 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 8
- 230000036765 blood level Effects 0.000 description 8
- 229940057917 medium chain triglycerides Drugs 0.000 description 8
- 235000019629 palatability Nutrition 0.000 description 8
- 230000003449 preventive effect Effects 0.000 description 8
- 206010027603 Migraine headaches Diseases 0.000 description 7
- 235000018977 lysine Nutrition 0.000 description 7
- 238000002483 medication Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 6
- 239000011575 calcium Substances 0.000 description 6
- 229910052791 calcium Inorganic materials 0.000 description 6
- 235000015872 dietary supplement Nutrition 0.000 description 6
- 235000003642 hunger Nutrition 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 208000007976 Ketosis Diseases 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 5
- 235000014633 carbohydrates Nutrition 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 description 5
- 230000004140 ketosis Effects 0.000 description 5
- 239000011777 magnesium Substances 0.000 description 5
- 229910052749 magnesium Inorganic materials 0.000 description 5
- 239000011707 mineral Substances 0.000 description 5
- 239000011591 potassium Substances 0.000 description 5
- 229910052700 potassium Inorganic materials 0.000 description 5
- 210000002784 stomach Anatomy 0.000 description 5
- -1 Ketone esters Chemical class 0.000 description 4
- 206010026749 Mania Diseases 0.000 description 4
- 206010027951 Mood swings Diseases 0.000 description 4
- 206010060860 Neurological symptom Diseases 0.000 description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 4
- 206010000059 abdominal discomfort Diseases 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 4
- 235000021152 breakfast Nutrition 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 230000001149 cognitive effect Effects 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 231100000673 dose–response relationship Toxicity 0.000 description 4
- 206010013781 dry mouth Diseases 0.000 description 4
- 206010016256 fatigue Diseases 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- 235000013773 glyceryl triacetate Nutrition 0.000 description 4
- 230000001771 impaired effect Effects 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 235000019645 odor Nutrition 0.000 description 4
- 230000007115 recruitment Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 230000003867 tiredness Effects 0.000 description 4
- 208000016255 tiredness Diseases 0.000 description 4
- WHBMMWSBFZVSSR-GSVOUGTGSA-N (R)-3-hydroxybutyric acid Chemical compound C[C@@H](O)CC(O)=O WHBMMWSBFZVSSR-GSVOUGTGSA-N 0.000 description 3
- 208000013016 Hypoglycemia Diseases 0.000 description 3
- 206010027940 Mood altered Diseases 0.000 description 3
- 206010072731 White matter lesion Diseases 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 229940125681 anticonvulsant agent Drugs 0.000 description 3
- 239000001961 anticonvulsive agent Substances 0.000 description 3
- 239000000935 antidepressant agent Substances 0.000 description 3
- 229940005513 antidepressants Drugs 0.000 description 3
- 239000002876 beta blocker Substances 0.000 description 3
- 229940097320 beta blocking agent Drugs 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 235000006694 eating habits Nutrition 0.000 description 3
- 230000001667 episodic effect Effects 0.000 description 3
- 239000001087 glyceryl triacetate Substances 0.000 description 3
- 230000002218 hypoglycaemic effect Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 230000000926 neurological effect Effects 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000036542 oxidative stress Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 229960002622 triacetin Drugs 0.000 description 3
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical class C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 2
- KRQUFUKTQHISJB-YYADALCUSA-N 2-[(E)-N-[2-(4-chlorophenoxy)propoxy]-C-propylcarbonimidoyl]-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one Chemical compound CCC\C(=N/OCC(C)OC1=CC=C(Cl)C=C1)C1=C(O)CC(CC1=O)C1CCCSC1 KRQUFUKTQHISJB-YYADALCUSA-N 0.000 description 2
- QYPPJABKJHAVHS-UHFFFAOYSA-N Agmatine Natural products NCCCCNC(N)=N QYPPJABKJHAVHS-UHFFFAOYSA-N 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 2
- 208000001654 Drug Resistant Epilepsy Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
- 206010024870 Loss of libido Diseases 0.000 description 2
- WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 2
- 206010072720 Medication overuse headache Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000000060 Migraine with aura Diseases 0.000 description 2
- 208000000112 Myalgia Diseases 0.000 description 2
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 2
- 206010034912 Phobia Diseases 0.000 description 2
- 208000017143 Secondary Headache disease Diseases 0.000 description 2
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 description 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 229960002173 citrulline Drugs 0.000 description 2
- 235000013477 citrulline Nutrition 0.000 description 2
- 229960003624 creatine Drugs 0.000 description 2
- 239000006046 creatine Substances 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000081 effect on glucose Effects 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 235000012631 food intake Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 238000009533 lab test Methods 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 150000004667 medium chain fatty acids Chemical class 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- 208000013465 muscle pain Diseases 0.000 description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
- 229960003104 ornithine Drugs 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 208000019899 phobic disease Diseases 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 235000019192 riboflavin Nutrition 0.000 description 2
- 229960002477 riboflavin Drugs 0.000 description 2
- 239000002151 riboflavin Substances 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000037351 starvation Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- GIANIJCPTPUNBA-QMMMGPOBSA-N (2s)-3-(4-hydroxyphenyl)-2-nitramidopropanoic acid Chemical compound [O-][N+](=O)N[C@H](C(=O)O)CC1=CC=C(O)C=C1 GIANIJCPTPUNBA-QMMMGPOBSA-N 0.000 description 1
- JUGDUPKFVWGEKF-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl 3-oxobutanoate Chemical compound CC(=O)CC(=O)OC(CO)CO JUGDUPKFVWGEKF-UHFFFAOYSA-N 0.000 description 1
- BCFBCLJFXYLWCI-UHFFFAOYSA-N 2,3-bis(3-oxobutanoyloxy)propyl 3-oxobutanoate Chemical compound CC(=O)CC(=O)OCC(OC(=O)CC(C)=O)COC(=O)CC(C)=O BCFBCLJFXYLWCI-UHFFFAOYSA-N 0.000 description 1
- BJXWCJCOADTGSW-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-oxobutanoate Chemical compound CC(=O)CC(=O)OCC(O)CO BJXWCJCOADTGSW-UHFFFAOYSA-N 0.000 description 1
- 108010030844 2-methylcitrate synthase Proteins 0.000 description 1
- RILHUWWTCSDPAN-UHFFFAOYSA-N 3-(3-hydroxybutanoyloxy)butanoic acid Chemical compound CC(O)CC(=O)OC(C)CC(O)=O RILHUWWTCSDPAN-UHFFFAOYSA-N 0.000 description 1
- FOGULOSPKZUOPL-UHFFFAOYSA-N 3-(3-hydroxybutanoyloxy)butyl 3-hydroxybutanoate Chemical compound CC(O)CC(=O)OCCC(C)OC(=O)CC(C)O FOGULOSPKZUOPL-UHFFFAOYSA-N 0.000 description 1
- HPSXWFLUQVYJDN-UHFFFAOYSA-N 3-(3-oxobutanoyloxy)butanoic acid Chemical compound OC(=O)CC(C)OC(=O)CC(C)=O HPSXWFLUQVYJDN-UHFFFAOYSA-N 0.000 description 1
- MDOKNTXSIGQKCJ-UHFFFAOYSA-N 3-(3-oxobutanoyloxy)butyl 3-oxobutanoate Chemical compound CC(=O)CC(=O)OC(C)CCOC(=O)CC(C)=O MDOKNTXSIGQKCJ-UHFFFAOYSA-N 0.000 description 1
- AOWPVIWVMWUSBD-UHFFFAOYSA-N 3-hydroxybutyl 3-hydroxybutanoate Chemical compound CC(O)CCOC(=O)CC(C)O AOWPVIWVMWUSBD-UHFFFAOYSA-N 0.000 description 1
- VBCGHHOILKAEHQ-UHFFFAOYSA-N 3-hydroxybutyl 3-oxobutanoate Chemical compound CC(O)CCOC(=O)CC(C)=O VBCGHHOILKAEHQ-UHFFFAOYSA-N 0.000 description 1
- QYYWATKDAYJXOR-UHFFFAOYSA-N 4-hydroxybutan-2-yl 3-hydroxybutanoate Chemical compound CC(O)CC(=O)OC(C)CCO QYYWATKDAYJXOR-UHFFFAOYSA-N 0.000 description 1
- HVPUQXLHAFCJAX-UHFFFAOYSA-N 4-hydroxybutan-2-yl 3-oxobutanoate Chemical compound OCCC(C)OC(=O)CC(C)=O HVPUQXLHAFCJAX-UHFFFAOYSA-N 0.000 description 1
- 208000010444 Acidosis Diseases 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 206010003805 Autism Diseases 0.000 description 1
- 208000020706 Autistic disease Diseases 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010074051 C-Reactive Protein Proteins 0.000 description 1
- 102100032752 C-reactive protein Human genes 0.000 description 1
- 108010071536 Citrate (Si)-synthase Proteins 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 102100030878 Cytochrome c oxidase subunit 1 Human genes 0.000 description 1
- 101710091265 Cytochrome c oxidase subunit 1 Proteins 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 125000003440 L-leucyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H] 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- 244000228451 Stevia rebaudiana Species 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 208000024799 Thyroid disease Diseases 0.000 description 1
- 108010057266 Type A Botulinum Toxins Proteins 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- HFMLYEAYFMPTFV-UHFFFAOYSA-N [2-hydroxy-3-(3-oxobutanoyloxy)propyl] 3-oxobutanoate Chemical compound CC(=O)CC(=O)OCC(O)COC(=O)CC(C)=O HFMLYEAYFMPTFV-UHFFFAOYSA-N 0.000 description 1
- WSFAZJAGWNHOCC-UHFFFAOYSA-N [3-hydroxy-2-(3-oxobutanoyloxy)propyl] 3-oxobutanoate Chemical compound CC(=O)CC(=O)OCC(CO)OC(=O)CC(C)=O WSFAZJAGWNHOCC-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 description 1
- 229960005164 acesulfame Drugs 0.000 description 1
- WDJHALXBUFZDSR-UHFFFAOYSA-N acetoacetic acid Chemical compound CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 description 1
- 125000002339 acetoacetyl group Chemical group O=C([*])C([H])([H])C(=O)C([H])([H])[H] 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000002460 anti-migrenic effect Effects 0.000 description 1
- 239000008122 artificial sweetener Substances 0.000 description 1
- 235000021311 artificial sweeteners Nutrition 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 229940089093 botox Drugs 0.000 description 1
- 235000020827 calorie restriction Nutrition 0.000 description 1
- 108091006003 carbonylated proteins Proteins 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- 230000003087 glucogenic effect Effects 0.000 description 1
- 230000007946 glucose deprivation Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 238000009863 impact test Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000007449 liver function test Methods 0.000 description 1
- 229940118019 malondialdehyde Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 206010052787 migraine without aura Diseases 0.000 description 1
- 208000012268 mitochondrial disease Diseases 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 201000003631 narcolepsy Diseases 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000003961 neuronal insult Effects 0.000 description 1
- 230000000324 neuroprotective effect Effects 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 230000008599 nitrosative stress Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008289 pathophysiological mechanism Effects 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 235000021075 protein intake Nutrition 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 238000010206 sensitivity analysis Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000013179 statistical model Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 208000021510 thyroid gland disease Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022130419A JP2022166218A (ja) | 2016-12-21 | 2022-08-18 | 片頭痛の予防および治療 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16206018 | 2016-12-21 | ||
| EP16206018.0 | 2016-12-21 | ||
| EP17154258 | 2017-02-01 | ||
| EP17154258.2 | 2017-02-01 | ||
| PCT/EP2017/083880 WO2018115158A1 (en) | 2016-12-21 | 2017-12-20 | Migraine prevention and treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022130419A Division JP2022166218A (ja) | 2016-12-21 | 2022-08-18 | 片頭痛の予防および治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504746A JP2020504746A (ja) | 2020-02-13 |
| JP2020504746A5 JP2020504746A5 (https=) | 2021-02-04 |
| JP7514457B2 true JP7514457B2 (ja) | 2024-07-11 |
Family
ID=61005774
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019534680A Active JP7514457B2 (ja) | 2016-12-21 | 2017-12-20 | 片頭痛の予防および治療 |
| JP2022130419A Pending JP2022166218A (ja) | 2016-12-21 | 2022-08-18 | 片頭痛の予防および治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022130419A Pending JP2022166218A (ja) | 2016-12-21 | 2022-08-18 | 片頭痛の予防および治療 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11166928B2 (https=) |
| EP (2) | EP4245368A3 (https=) |
| JP (2) | JP7514457B2 (https=) |
| KR (1) | KR102610870B1 (https=) |
| CN (1) | CN110087642B (https=) |
| AU (2) | AU2017384625B2 (https=) |
| CA (1) | CA3046415A1 (https=) |
| DK (1) | DK3558280T3 (https=) |
| ES (1) | ES2948609T3 (https=) |
| FI (1) | FI3558280T3 (https=) |
| HR (1) | HRP20230851T1 (https=) |
| HU (1) | HUE062536T2 (https=) |
| LT (1) | LT3558280T (https=) |
| PL (1) | PL3558280T3 (https=) |
| RU (1) | RU2753057C9 (https=) |
| SI (1) | SI3558280T1 (https=) |
| WO (1) | WO2018115158A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180057846A1 (en) | 2016-08-30 | 2018-03-01 | KetoneAid Inc. | Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy |
| FI3558280T3 (fi) * | 2016-12-21 | 2023-07-13 | Univ Kinderspital Beider Basel | Migreenin ennaltaehkäisy ja hoito |
| US20180177753A1 (en) | 2016-12-23 | 2018-06-28 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for migraine symptom management |
| US11760963B2 (en) | 2017-08-23 | 2023-09-19 | KetoneAid Inc. | Ketogenic beer and alcoholic beverage mixture containing non-racemic ethyl 3-hydroxybutyrate and/or 1,3 butanediol |
| AU2020246928B2 (en) * | 2019-03-22 | 2025-05-15 | Société des Produits Nestlé S.A. | Methods using administration of medium chain triglycerides (MCT) prior to a meal to increase ketone production from the MCTs |
| AU2020274805A1 (en) | 2019-05-10 | 2021-10-28 | Ketoswiss Ag | Ketone bodies enclosed in microbeads |
| EP3956282A1 (de) * | 2019-06-12 | 2022-02-23 | IOI Oleo GmbH | Verfahren zur herstellung von acylverkappten 3-hydroxycarbonsäuren sowie deren salzen und estern |
| CN114008014B (zh) * | 2019-06-12 | 2024-03-22 | 凯托利皮克斯治疗有限责任公司 | 用于生产酰基封端的3-羟基羧酸的多元醇基酯的方法 |
| US12396974B2 (en) | 2020-03-27 | 2025-08-26 | KetoneAid | Ketone ester as a therapeutic treatment of Covid-19 and related viral infections |
| CN117677383A (zh) | 2021-07-17 | 2024-03-08 | 瑞士凯托股份公司 | 酮体或生酮化合物与镇痛剂或抗氧化剂的组合 |
| WO2023166069A1 (en) | 2022-03-02 | 2023-09-07 | N.V. Nutricia | Fatty acids for ketosis control |
| CN115590963A (zh) * | 2022-07-13 | 2023-01-13 | 复旦大学（Cn） | 酮体、酮体诱导剂和生酮组合物中的至少一种在治疗和/或预防血小板减少症药物中的应用 |
| KR102775899B1 (ko) | 2023-12-19 | 2025-02-28 | 한림대학교 산학협력단 | 삽화성 편두통 및 만성 편두통 진단을 위한 정보제공 방법, 장치 및 컴퓨터 프로그램 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001515510A (ja) | 1997-03-17 | 2001-09-18 | ビーティージー・インターナショナル・リミテッド | 治療用組成物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0174979A4 (en) * | 1984-03-01 | 1987-11-23 | Vernon Erk | METHOD FOR LOWERING THE BLOOD GLUCOSE LEVEL IN VERBELTIES. |
| JPH0665458A (ja) | 1992-08-21 | 1994-03-08 | Nippon Oil & Fats Co Ltd | 塩素含有樹脂組成物 |
| US5420335A (en) * | 1993-09-30 | 1995-05-30 | Birkhahn; Ronald H. | Parenteral nutrients based on watersoluble glycerol bisacetoacetates |
| DK1123094T3 (da) | 1998-09-15 | 2007-08-20 | Btg Int Ltd | Terapeutiske præparater (II) |
| US20050129783A1 (en) * | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
| US7807718B2 (en) * | 2006-06-30 | 2010-10-05 | Sami A. Hashim | Glyceride esters for the treatment of diseases associated with reduced neuronal metabolism of glucose |
| US20120034193A1 (en) | 2009-01-24 | 2012-02-09 | Daryl Rees | Treatment of neurotrophic factor mediated disorders |
| GB201206192D0 (en) | 2012-04-05 | 2012-05-23 | Tdeltas Ltd | Ketone bodies and ketone body esters and for maintaining or improving muscle power output |
| CN103877118A (zh) | 2014-03-11 | 2014-06-25 | 天津金耀集团有限公司 | 一种由醋丙甲泼尼龙、氧化锌组成的药物组合物 |
| US20160078782A1 (en) * | 2014-09-17 | 2016-03-17 | The Trustees Of Boston College | Glucose Ketone Index for MetabolicTherapy |
| US20180200220A1 (en) * | 2015-07-10 | 2018-07-19 | Cognate Nutritionals, Inc. | Prophylaxis and mitigation of migraine headaches using ketogenic medium chain triglycerides, ketone esters, and other ketogenic sources |
| FI3558280T3 (fi) * | 2016-12-21 | 2023-07-13 | Univ Kinderspital Beider Basel | Migreenin ennaltaehkäisy ja hoito |
| US20180177753A1 (en) | 2016-12-23 | 2018-06-28 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for migraine symptom management |
| US10500182B2 (en) | 2018-01-10 | 2019-12-10 | Robert Firger | Compositions of ketogenic sources, micronutrients and phytochemicals for prophylaxis and mitigation of migraine headache |
-
2017
- 2017-12-20 FI FIEP17832224.4T patent/FI3558280T3/fi active
- 2017-12-20 SI SI201731394T patent/SI3558280T1/sl unknown
- 2017-12-20 JP JP2019534680A patent/JP7514457B2/ja active Active
- 2017-12-20 DK DK17832224.4T patent/DK3558280T3/da active
- 2017-12-20 ES ES17832224T patent/ES2948609T3/es active Active
- 2017-12-20 HU HUE17832224A patent/HUE062536T2/hu unknown
- 2017-12-20 RU RU2019122562A patent/RU2753057C9/ru active
- 2017-12-20 CA CA3046415A patent/CA3046415A1/en active Pending
- 2017-12-20 EP EP23176972.0A patent/EP4245368A3/en active Pending
- 2017-12-20 AU AU2017384625A patent/AU2017384625B2/en active Active
- 2017-12-20 EP EP17832224.4A patent/EP3558280B1/en active Active
- 2017-12-20 HR HRP20230851TT patent/HRP20230851T1/hr unknown
- 2017-12-20 PL PL17832224.4T patent/PL3558280T3/pl unknown
- 2017-12-20 US US16/472,309 patent/US11166928B2/en active Active
- 2017-12-20 CN CN201780079158.4A patent/CN110087642B/zh active Active
- 2017-12-20 LT LTEPPCT/EP2017/083880T patent/LT3558280T/lt unknown
- 2017-12-20 KR KR1020197021346A patent/KR102610870B1/ko active Active
- 2017-12-20 WO PCT/EP2017/083880 patent/WO2018115158A1/en not_active Ceased
-
2021
- 2021-06-01 US US17/335,319 patent/US11890264B2/en active Active
-
2022
- 2022-03-07 AU AU2022201565A patent/AU2022201565B2/en active Active
- 2022-08-18 JP JP2022130419A patent/JP2022166218A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001515510A (ja) | 1997-03-17 | 2001-09-18 | ビーティージー・インターナショナル・リミテッド | 治療用組成物 |
Non-Patent Citations (3)
| Title |
|---|
| Ｅｐｉｌｅｐｓｉａ ４２（Ｓｕｐｐｌ．３）（２００１），８－１２ |
| Ｅｕｒｏｐｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｌｏｇｙ ２２（２０１５），１７０－１７７ |
| 臨床神経学 ５４（１２）（２０１４），１００３－１００５ |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022201565A1 (en) | 2022-03-31 |
| RU2753057C9 (ru) | 2021-09-10 |
| ES2948609T3 (es) | 2023-09-14 |
| RU2019122562A3 (https=) | 2021-01-27 |
| RU2019122562A (ru) | 2021-01-27 |
| HUE062536T2 (hu) | 2023-11-28 |
| FI3558280T3 (fi) | 2023-07-13 |
| KR20190099486A (ko) | 2019-08-27 |
| KR102610870B1 (ko) | 2023-12-06 |
| CA3046415A1 (en) | 2018-06-28 |
| CN110087642B (zh) | 2022-12-27 |
| EP4245368A3 (en) | 2024-01-03 |
| US11890264B2 (en) | 2024-02-06 |
| AU2022201565B2 (en) | 2023-07-06 |
| CN110087642A (zh) | 2019-08-02 |
| HRP20230851T1 (hr) | 2023-11-10 |
| EP3558280A1 (en) | 2019-10-30 |
| US20190374490A1 (en) | 2019-12-12 |
| JP2020504746A (ja) | 2020-02-13 |
| WO2018115158A1 (en) | 2018-06-28 |
| DK3558280T3 (da) | 2023-08-21 |
| RU2753057C2 (ru) | 2021-08-11 |
| EP4245368A2 (en) | 2023-09-20 |
| AU2017384625B2 (en) | 2021-12-16 |
| JP2022166218A (ja) | 2022-11-01 |
| US11166928B2 (en) | 2021-11-09 |
| LT3558280T (lt) | 2023-10-10 |
| AU2017384625A1 (en) | 2019-06-13 |
| US20210338618A1 (en) | 2021-11-04 |
| PL3558280T3 (pl) | 2023-10-16 |
| EP3558280B1 (en) | 2023-06-07 |
| SI3558280T1 (sl) | 2023-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7514457B2 (ja) | 片頭痛の予防および治療 | |
| US11773051B2 (en) | S-enantiomers of beta-hydroxybutyrate and butanediol and methods for using same | |
| US6835750B1 (en) | Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II | |
| Pezzoli et al. | Levodopa in Parkinson's disease: from the past to the future | |
| US20070179197A1 (en) | Compositions and methods for improving or preserving brain function | |
| US20150057306A1 (en) | Compositions comprising scopolamine and ketamine in the treatment of depression | |
| Lal et al. | A randomized, double-blind, placebo-controlled, dose-response study to assess the pharmacokinetics, efficacy, and safety of gabapentin enacarbil in subjects with restless legs syndrome | |
| JP2018131470A (ja) | グルコーストランスポータ１欠乏の治療のためのトリヘプタノイン | |
| CN107835695A (zh) | 用于治疗自闭症的组合物和方法 | |
| Jost et al. | Inhaled levodopa for threatening impending OFF episodes in managing Parkinson’s disease | |
| Włodarek | The possibility of use of the ketogenic diet and medium chain triglycerides supplementation in the support therapy of Alzheimer disease | |
| Bourque et al. | The plasmalogen precursor analog PPI-1011 reduces the development of L-DOPA-induced dyskinesias in de novo MPTP monkeys | |
| White et al. | Systematic review of the use of ketones in the management of acute and chronic neurological disorders | |
| US20180147175A1 (en) | Compositions and methods for treatment of movement disorders | |
| Fargahi et al. | Impact of Adjuvant Anticonvulsant Medications on Benzodiazepine Use and Delirium in Alcohol Withdrawal Syndrome | |
| White et al. | Novel Metabolic Substrates for Feeding the Injured Brain |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201218 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20201218 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20210916 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20211005 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20211227 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220404 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20220419 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20220818 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20220818 |
|
| C116 | Written invitation by the chief administrative judge to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C116 Effective date: 20220913 |
|
| C22 | Notice of designation (change) of administrative judge |
Free format text: JAPANESE INTERMEDIATE CODE: C22 Effective date: 20220913 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240329 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20240619 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7514457 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |