JP2020504112A5 - - Google Patents
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- JP2020504112A5 JP2020504112A5 JP2019533594A JP2019533594A JP2020504112A5 JP 2020504112 A5 JP2020504112 A5 JP 2020504112A5 JP 2019533594 A JP2019533594 A JP 2019533594A JP 2019533594 A JP2019533594 A JP 2019533594A JP 2020504112 A5 JP2020504112 A5 JP 2020504112A5
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- JP
- Japan
- Prior art keywords
- seq
- fab
- variable region
- heavy chain
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- Prior art date
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022167563A JP7622017B2 (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437622P | 2016-12-21 | 2016-12-21 | |
| US62/437,622 | 2016-12-21 | ||
| US201762520854P | 2017-06-16 | 2017-06-16 | |
| US62/520,854 | 2017-06-16 | ||
| PCT/IB2017/058159 WO2018116178A1 (en) | 2016-12-21 | 2017-12-19 | Antibody drug conjugates for ablating hematopoietic stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022167563A Division JP7622017B2 (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504112A JP2020504112A (ja) | 2020-02-06 |
| JP2020504112A5 true JP2020504112A5 (enExample) | 2021-02-04 |
| JP7181203B2 JP7181203B2 (ja) | 2022-11-30 |
Family
ID=60957364
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533594A Expired - Fee Related JP7181203B2 (ja) | 2016-12-21 | 2017-12-19 | 造血幹細胞を除去するための抗体薬物結合体 |
| JP2022167563A Active JP7622017B2 (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022167563A Active JP7622017B2 (ja) | 2016-12-21 | 2022-10-19 | 造血幹細胞を除去するための抗体薬物結合体 |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US11357864B2 (enExample) |
| EP (1) | EP3558389A1 (enExample) |
| JP (2) | JP7181203B2 (enExample) |
| KR (2) | KR20240093751A (enExample) |
| CN (2) | CN117653740A (enExample) |
| AU (1) | AU2017383458C1 (enExample) |
| BR (1) | BR112019012483A2 (enExample) |
| CA (1) | CA3045592A1 (enExample) |
| CL (1) | CL2019001745A1 (enExample) |
| CO (1) | CO2019006455A2 (enExample) |
| CR (1) | CR20190296A (enExample) |
| CU (1) | CU24644B1 (enExample) |
| EA (1) | EA201991526A1 (enExample) |
| EC (1) | ECSP19044625A (enExample) |
| IL (2) | IL300567A (enExample) |
| JO (1) | JOP20190155B1 (enExample) |
| MA (1) | MA47231A (enExample) |
| MX (1) | MX2019007582A (enExample) |
| MY (1) | MY193985A (enExample) |
| PE (1) | PE20191539A1 (enExample) |
| PH (1) | PH12019501330A1 (enExample) |
| SA (1) | SA519402188B1 (enExample) |
| TW (2) | TWI852077B (enExample) |
| WO (1) | WO2018116178A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201591465A1 (ru) * | 2013-02-08 | 2015-12-30 | АйАрЭм ЭлЭлСи | Специфичные участки для модификации антител для получения иммуноконъюгатов |
| US10464969B2 (en) * | 2016-05-05 | 2019-11-05 | Novartis Ag | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase |
| US10111966B2 (en) * | 2016-06-17 | 2018-10-30 | Magenta Therapeutics, Inc. | Methods for the depletion of CD117+ cells |
| JP2021526525A (ja) * | 2018-06-07 | 2021-10-07 | マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 抗体薬物コンジュゲート（ａｄｃｓ）を用いた治療方法 |
| UY38265A (es) * | 2018-06-20 | 2020-01-31 | Novartis Ag | Conjugados anticuerpo droga para ablación de células madre hematopoyéticas |
| JP7598312B2 (ja) * | 2018-07-23 | 2024-12-11 | ハイデルベルク ファーマ リサーチ ゲーエムベーハー | 同種異系の細胞療法における抗－ｃｄ１３７抗体薬物コンジュゲート（ａｄｃ）の使用 |
| EP3826625A4 (en) * | 2018-07-23 | 2022-08-24 | Magenta Therapeutics, Inc. | USE OF ANTI-CD5 ANTIBODY DRUG CONJUGATE (ADC) IN ALLOGENE CELL THERAPY |
| CN113330026A (zh) * | 2018-10-23 | 2021-08-31 | 美真达治疗公司 | Fc沉默的抗体药物缀合物(ADC)及其用途 |
| EP3873532A1 (en) * | 2018-10-31 | 2021-09-08 | Novartis AG | Dc-sign antibody drug conjugates |
| UA128431C2 (uk) * | 2018-11-26 | 2024-07-10 | Форті Севен, Інк. | ГУМАНІЗОВАНЕ АНТИТІЛО ДО c-Kit |
| US11702446B2 (en) | 2018-12-12 | 2023-07-18 | Levim Biotech Llp | Acylation process for preparation of N-substituted peptide |
| AU2020289360A1 (en) | 2019-06-04 | 2022-01-20 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for treating autoimmune diseases |
| KR102793948B1 (ko) | 2019-08-07 | 2025-04-11 | 맙플렉스 인터내셔널 컴퍼니 리미티드 | 항체-약물 접합체 및 이의 용도 |
| CN116183899B (zh) * | 2023-04-28 | 2023-06-30 | 天津市协和医药科技集团有限公司 | 一种吖啶酯标记抗体保存液的制备方法 |
| TW202513593A (zh) * | 2023-09-08 | 2025-04-01 | 大陸商信達生物製藥（蘇州）有限公司 | 半胱胺酸改造的抗體和免疫綴合物 |
| KR20260105725A (ko) | 2023-10-12 | 2026-07-07 | 메모리얼 슬로안 케터링 캔서 센터 | 백혈병 치료를 위한 clk/dyrk 억제제 및 bcl2 억제제의 병용 요법 |
Family Cites Families (37)
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|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4880078A (en) | 1987-06-29 | 1989-11-14 | Honda Giken Kogyo Kabushiki Kaisha | Exhaust muffler |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| JPH06507404A (ja) | 1991-05-01 | 1994-08-25 | ヘンリー エム．ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン | 感染性の呼吸性疾患の治療方法 |
| US5934272A (en) | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
| US6132764A (en) | 1994-08-05 | 2000-10-17 | Targesome, Inc. | Targeted polymerized liposome diagnostic and treatment agents |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6019968A (en) | 1995-04-14 | 2000-02-01 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
| US5985320A (en) | 1996-03-04 | 1999-11-16 | The Penn State Research Foundation | Materials and methods for enhancing cellular internalization |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| DE69732306T2 (de) | 1997-01-16 | 2006-01-12 | Massachusetts Institute Of Technology, Cambridge | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| JP3614866B2 (ja) | 1997-06-12 | 2005-01-26 | リサーチ コーポレイション テクノロジーズ，インコーポレイティド | 人工抗体ポリペプチド |
| ES2198922T3 (es) | 1998-06-24 | 2004-02-01 | Advanced Inhalation Research, Inc. | Particulas porosas grandes emitadas por un inhalador. |
| US7771951B2 (en) | 2001-12-03 | 2010-08-10 | Amgen Fremont Inc. | Antibody categorization based on binding characteristics |
| CA2476166C (en) | 2002-02-14 | 2011-11-15 | Immunomedics, Inc. | Anti-cd20 antibodies and fusion proteins thereof and methods of use |
| AU2003245752A1 (en) | 2002-06-28 | 2004-01-19 | Bio Transplant, Inc. | Process for promoting graft acceptance by depletion of hematopoietic stem cells |
| DE602004028347D1 (de) | 2003-03-24 | 2010-09-09 | Zymogenetics Inc | Anti-il-22ra antikörper und bindungspartner und verwendungsmethoden bei entzündung |
| TWI395754B (zh) | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之ｃ-ｋｉｔ抗體 |
| EP3255061B1 (en) | 2006-11-03 | 2021-06-16 | The Board of Trustees of the Leland Stanford Junior University | Selective immunodepletion of endogenous stem cell niche for engraftment |
| US8540517B2 (en) | 2006-11-27 | 2013-09-24 | Pharos Innovations, Llc | Calculating a behavioral path based on a statistical profile |
| BRPI1015234A2 (en) | 2009-06-22 | 2018-02-20 | Medimmune Llc | fc regions designed for site specific conjugation. |
| US20120189633A1 (en) | 2011-01-26 | 2012-07-26 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
| AR086044A1 (es) | 2011-05-12 | 2013-11-13 | Imclone Llc | Anticuerpos que se unen especificamente a un dominio extracelular de c-kit y usos de los mismos |
| EP4063391A1 (en) | 2012-07-25 | 2022-09-28 | Celldex Therapeutics, Inc. | Anti-kit antibodies and uses thereof |
| EA201591465A1 (ru) | 2013-02-08 | 2015-12-30 | АйАрЭм ЭлЭлСи | Специфичные участки для модификации антител для получения иммуноконъюгатов |
| MX366978B (es) * | 2013-03-15 | 2019-08-01 | Novartis Ag | Conjugados de anticuerpo - farmaco. |
| BR112016020065A2 (pt) * | 2014-03-12 | 2018-02-20 | Novartis Ag | sítios específicos para modificar anticorpos para fazer imunoconjugados |
| US9884817B2 (en) | 2014-06-13 | 2018-02-06 | Novartis Ag | Auristatin derivatives and conjugates thereof |
| WO2016020791A1 (en) | 2014-08-05 | 2016-02-11 | Novartis Ag | Ckit antibody drug conjugates |
| EP3215519A1 (en) * | 2014-11-06 | 2017-09-13 | Novartis AG | Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase |
| HK1256681A1 (zh) * | 2015-04-06 | 2019-10-04 | President And Fellows Of Harvard College | 用於非清髓性预处理的组合物和方法 |
| US20190194315A1 (en) * | 2015-06-17 | 2019-06-27 | Novartis Ag | Antibody drug conjugates |
| US10111966B2 (en) * | 2016-06-17 | 2018-10-30 | Magenta Therapeutics, Inc. | Methods for the depletion of CD117+ cells |
-
2017
- 2017-12-19 CN CN202311642832.9A patent/CN117653740A/zh active Pending
- 2017-12-19 US US16/470,897 patent/US11357864B2/en active Active
- 2017-12-19 CU CU2019000061A patent/CU24644B1/es unknown
- 2017-12-19 AU AU2017383458A patent/AU2017383458C1/en not_active Ceased
- 2017-12-19 CN CN201780079504.9A patent/CN110099697B/zh active Active
- 2017-12-19 KR KR1020247016376A patent/KR20240093751A/ko not_active Ceased
- 2017-12-19 JP JP2019533594A patent/JP7181203B2/ja not_active Expired - Fee Related
- 2017-12-19 KR KR1020197020530A patent/KR20190099238A/ko not_active Ceased
- 2017-12-19 TW TW111133640A patent/TWI852077B/zh not_active IP Right Cessation
- 2017-12-19 IL IL300567A patent/IL300567A/en unknown
- 2017-12-19 MX MX2019007582A patent/MX2019007582A/es unknown
- 2017-12-19 BR BR112019012483-7A patent/BR112019012483A2/pt unknown
- 2017-12-19 EA EA201991526A patent/EA201991526A1/ru unknown
- 2017-12-19 MY MYPI2019003457A patent/MY193985A/en unknown
- 2017-12-19 TW TW106144615A patent/TWI778994B/zh not_active IP Right Cessation
- 2017-12-19 MA MA047231A patent/MA47231A/fr unknown
- 2017-12-19 PE PE2019001291A patent/PE20191539A1/es unknown
- 2017-12-19 EP EP17829033.4A patent/EP3558389A1/en active Pending
- 2017-12-19 WO PCT/IB2017/058159 patent/WO2018116178A1/en not_active Ceased
- 2017-12-19 CA CA3045592A patent/CA3045592A1/en active Pending
- 2017-12-19 CR CR20190296A patent/CR20190296A/es unknown
- 2017-12-19 JO JOJO/P/2019/0155A patent/JOP20190155B1/ar active
-
2019
- 2019-06-13 PH PH12019501330A patent/PH12019501330A1/en unknown
- 2019-06-18 IL IL267478A patent/IL267478B2/en unknown
- 2019-06-19 CO CONC2019/0006455A patent/CO2019006455A2/es unknown
- 2019-06-20 SA SA519402188A patent/SA519402188B1/ar unknown
- 2019-06-20 CL CL2019001745A patent/CL2019001745A1/es unknown
- 2019-06-21 EC ECSENADI201944625A patent/ECSP19044625A/es unknown
-
2022
- 2022-06-06 US US17/833,077 patent/US12171839B2/en active Active
- 2022-10-19 JP JP2022167563A patent/JP7622017B2/ja active Active
-
2024
- 2024-11-05 US US18/937,914 patent/US20250064964A1/en active Pending
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