JP2020503883A5 - - Google Patents
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- JP2020503883A5 JP2020503883A5 JP2019538347A JP2019538347A JP2020503883A5 JP 2020503883 A5 JP2020503883 A5 JP 2020503883A5 JP 2019538347 A JP2019538347 A JP 2019538347A JP 2019538347 A JP2019538347 A JP 2019538347A JP 2020503883 A5 JP2020503883 A5 JP 2020503883A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 56
- 108091008874 T cell receptors Proteins 0.000 claims 46
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 46
- 210000004027 cell Anatomy 0.000 claims 35
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 150000007523 nucleic acids Chemical group 0.000 claims 14
- 239000013598 vector Substances 0.000 claims 14
- 238000003776 cleavage reaction Methods 0.000 claims 12
- 230000007017 scission Effects 0.000 claims 12
- 210000001744 T-lymphocyte Anatomy 0.000 claims 11
- 108091033319 polynucleotide Proteins 0.000 claims 11
- 239000002157 polynucleotide Substances 0.000 claims 11
- 102000040430 polynucleotide Human genes 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 9
- 239000005557 antagonist Substances 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 5
- 102000004961 Furin Human genes 0.000 claims 4
- 108090001126 Furin Proteins 0.000 claims 4
- 102000011786 HLA-A Antigens Human genes 0.000 claims 4
- 108010075704 HLA-A Antigens Proteins 0.000 claims 4
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 4
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000006337 proteolytic cleavage Effects 0.000 claims 4
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 3
- 230000000890 antigenic effect Effects 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 claims 3
- 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 210000004877 mucosa Anatomy 0.000 claims 3
- 210000000581 natural killer T-cell Anatomy 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- BCCRXDTUTZHDEU-VKHMYHEASA-N Gly-Ser Chemical compound NCC(=O)N[C@@H](CO)C(O)=O BCCRXDTUTZHDEU-VKHMYHEASA-N 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- YPBKTZBXSBLTDK-PKNBQFBNSA-N (3e)-3-[(3-bromo-4-fluoroanilino)-nitrosomethylidene]-4-[2-(sulfamoylamino)ethylamino]-1,2,5-oxadiazole Chemical compound NS(=O)(=O)NCCNC1=NON\C1=C(N=O)/NC1=CC=C(F)C(Br)=C1 YPBKTZBXSBLTDK-PKNBQFBNSA-N 0.000 claims 1
- IHWDSEPNZDYMNF-UHFFFAOYSA-N 1H-indol-2-amine Chemical compound C1=CC=C2NC(N)=CC2=C1 IHWDSEPNZDYMNF-UHFFFAOYSA-N 0.000 claims 1
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 1
- 101100451497 Dictyostelium discoideum hspB gene Proteins 0.000 claims 1
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 1
- 101150022862 HSC70 gene Proteins 0.000 claims 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101001023379 Homo sapiens Lysosome-associated membrane glycoprotein 1 Proteins 0.000 claims 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 claims 1
- 102100035133 Lysosome-associated membrane glycoprotein 1 Human genes 0.000 claims 1
- YGACXVRLDHEXKY-WXRXAMBDSA-N O[C@H](C[C@H]1c2c(cccc2F)-c2cncn12)[C@H]1CC[C@H](O)CC1 Chemical compound O[C@H](C[C@H]1c2c(cccc2F)-c2cncn12)[C@H]1CC[C@H](O)CC1 YGACXVRLDHEXKY-WXRXAMBDSA-N 0.000 claims 1
- 229940126547 T-cell immunoglobulin mucin-3 Drugs 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000034994 death Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229950006370 epacadostat Drugs 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 244000144980 herd Species 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- KRTIYQIPSAGSBP-KLAILNCOSA-N linrodostat Chemical compound C1(CCC(CC1)C1=C2C=C(F)C=CC2=NC=C1)[C@@H](C)C(=O)NC1=CC=C(Cl)C=C1 KRTIYQIPSAGSBP-KLAILNCOSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960003301 nivolumab Drugs 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 229960002621 pembrolizumab Drugs 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023000639A JP2023029503A (ja) | 2017-01-13 | 2023-01-05 | Ｎｙ－ｅｓｏ－１に結合するｔ細胞受容体およびその使用方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762446084P | 2017-01-13 | 2017-01-13 | |
| US62/446,084 | 2017-01-13 | ||
| PCT/US2018/013624 WO2018132739A2 (en) | 2017-01-13 | 2018-01-12 | T cell receptors that bind to ny-eso-1 and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023000639A Division JP2023029503A (ja) | 2017-01-13 | 2023-01-05 | Ｎｙ－ｅｓｏ－１に結合するｔ細胞受容体およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020503883A JP2020503883A (ja) | 2020-02-06 |
| JP2020503883A5 true JP2020503883A5 (https=) | 2021-02-25 |
Family
ID=61656335
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019538347A Ceased JP2020503883A (ja) | 2017-01-13 | 2018-01-12 | Ｎｙ−ｅｓｏ−１に結合するｔ細胞受容体およびその使用方法 |
| JP2023000639A Pending JP2023029503A (ja) | 2017-01-13 | 2023-01-05 | Ｎｙ－ｅｓｏ－１に結合するｔ細胞受容体およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023000639A Pending JP2023029503A (ja) | 2017-01-13 | 2023-01-05 | Ｎｙ－ｅｓｏ－１に結合するｔ細胞受容体およびその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11613764B2 (https=) |
| EP (1) | EP3568412A2 (https=) |
| JP (2) | JP2020503883A (https=) |
| KR (1) | KR20190103226A (https=) |
| CN (1) | CN110198954A (https=) |
| AU (1) | AU2018207172B2 (https=) |
| BR (1) | BR112019014510A2 (https=) |
| CA (1) | CA3049016A1 (https=) |
| EA (1) | EA201991696A1 (https=) |
| IL (1) | IL267878A (https=) |
| MA (1) | MA47265A (https=) |
| MX (1) | MX2019008346A (https=) |
| WO (1) | WO2018132739A2 (https=) |
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| CN116298309B (zh) | 2018-08-13 | 2024-04-02 | 根路径基因组学公司 | 成对的二分免疫受体多核苷酸的高通量克隆及其应用 |
| CA3111381A1 (en) * | 2018-09-05 | 2020-04-30 | The Regents Of The University Of California | Composition of ny-eso-1-specific t cell receptors restricted on multiple major histocompatibility complex molecules |
| WO2020086647A1 (en) * | 2018-10-23 | 2020-04-30 | Regeneron Pharmaceuticals, Inc. | Ny-eso-1 t cell receptors and methods of use thereof |
| WO2020206238A2 (en) * | 2019-04-05 | 2020-10-08 | Rootpath Genomics, Inc. | Compositions and methods for t-cell receptor gene assembly |
| WO2020263830A1 (en) | 2019-06-25 | 2020-12-30 | Gilead Sciences, Inc. | Flt3l-fc fusion proteins and methods of use |
| JP7674278B2 (ja) * | 2019-07-03 | 2025-05-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗ニューヨーク食道扁平上皮がん１（ｎｙ－ｅｓｏ－１）抗原結合タンパク質およびその使用方法 |
| AU2020358975A1 (en) * | 2019-10-03 | 2022-04-21 | Regeneron Pharmaceuticals, Inc. | High-throughput method to screen cognate T cell and epitope reactivities in primary human cells |
| TWI890283B (zh) | 2020-02-14 | 2025-07-11 | 美商基利科學股份有限公司 | 結合ccr8之抗體及融合蛋白及其用途 |
| TW202406932A (zh) | 2020-10-22 | 2024-02-16 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| US20240366741A1 (en) * | 2021-03-12 | 2024-11-07 | Purdue Research Foundation | Novel vaccine formulations for mycobacterium tuberculosis and use of thereof |
| WO2022245671A1 (en) | 2021-05-18 | 2022-11-24 | Gilead Sciences, Inc. | Methods of using flt3l-fc fusion proteins |
| AU2022375782B2 (en) | 2021-10-28 | 2026-02-26 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
| WO2023077028A1 (en) * | 2021-10-28 | 2023-05-04 | Lyell Immunopharma, Inc. | Enhanced t cell therapy targeting ny-eso-1 |
| JP7787991B2 (ja) | 2021-10-29 | 2025-12-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｃｄ７３化合物 |
| KR20240123836A (ko) | 2021-12-22 | 2024-08-14 | 길리애드 사이언시즈, 인코포레이티드 | 이카로스 아연 핑거 패밀리 분해제 및 이의 용도 |
| US12122764B2 (en) | 2021-12-22 | 2024-10-22 | Gilead Sciences, Inc. | IKAROS zinc finger family degraders and uses thereof |
| TW202340168A (zh) | 2022-01-28 | 2023-10-16 | 美商基利科學股份有限公司 | Ｐａｒｐ７抑制劑 |
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| CR20240451A (es) | 2022-04-21 | 2024-12-04 | Gilead Sciences Inc | Compuestos de modulación de kras g12d |
| KR20250028371A (ko) | 2022-07-01 | 2025-02-28 | 길리애드 사이언시즈, 인코포레이티드 | Cd73 화합물 |
| AU2023409398A1 (en) | 2022-12-22 | 2025-06-05 | Gilead Sciences, Inc. | Prmt5 inhibitors and uses thereof |
| AU2024252725A1 (en) | 2023-04-11 | 2025-11-06 | Gilead Sciences, Inc. | Kras modulating compounds |
| CR20250446A (es) | 2023-04-21 | 2025-12-02 | Gilead Sciences Inc | Inhibidores de prmt5 y usos de los mismos |
| CN121443326A (zh) * | 2023-06-30 | 2026-01-30 | 森迪生物科学公司 | 改进的多顺反子系统及其用途 |
| AU2024306338A1 (en) | 2023-06-30 | 2026-01-08 | Gilead Sciences, Inc. | Kras modulating compounds |
| CN121620513A (zh) | 2023-07-26 | 2026-03-06 | 吉利德科学公司 | Parp7抑制剂 |
| KR20260046403A (ko) | 2023-07-26 | 2026-04-07 | 길리애드 사이언시즈, 인코포레이티드 | Parp7 저해제 |
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-
2018
- 2018-01-12 JP JP2019538347A patent/JP2020503883A/ja not_active Ceased
- 2018-01-12 WO PCT/US2018/013624 patent/WO2018132739A2/en not_active Ceased
- 2018-01-12 EA EA201991696A patent/EA201991696A1/ru unknown
- 2018-01-12 CN CN201880006628.9A patent/CN110198954A/zh active Pending
- 2018-01-12 KR KR1020197021319A patent/KR20190103226A/ko not_active Ceased
- 2018-01-12 BR BR112019014510-9A patent/BR112019014510A2/pt not_active IP Right Cessation
- 2018-01-12 AU AU2018207172A patent/AU2018207172B2/en not_active Ceased
- 2018-01-12 MA MA047265A patent/MA47265A/fr unknown
- 2018-01-12 MX MX2019008346A patent/MX2019008346A/es unknown
- 2018-01-12 EP EP18711429.3A patent/EP3568412A2/en active Pending
- 2018-01-12 CA CA3049016A patent/CA3049016A1/en active Pending
-
2019
- 2019-07-07 IL IL267878A patent/IL267878A/en unknown
- 2019-07-15 US US16/512,031 patent/US11613764B2/en active Active
-
2023
- 2023-01-05 JP JP2023000639A patent/JP2023029503A/ja active Pending
- 2023-03-27 US US18/190,954 patent/US20240102044A1/en not_active Abandoned
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