CN110198954A - 与ny-eso-1结合的t细胞受体和其使用方法 - Google Patents

与ny-eso-1结合的t细胞受体和其使用方法 Download PDF

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Publication number
CN110198954A
CN110198954A CN201880006628.9A CN201880006628A CN110198954A CN 110198954 A CN110198954 A CN 110198954A CN 201880006628 A CN201880006628 A CN 201880006628A CN 110198954 A CN110198954 A CN 110198954A
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seq
acid sequence
amino acid
tcr
chain
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Chinese (zh)
Inventor
M·范迪杰克
V·塞伯特
C·A·蒙特
A·A·赫维兹
M·A·埃克斯利
B·J·沃尔夫
D·利文萨尔
S·拉勒维
R·马萨卡彦
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Eiji Nath Co
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Eiji Nath Co
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A—HUMAN NECESSITIES
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    • A61K40/4269—NY-ESO
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CN201880006628.9A 2017-01-13 2018-01-12 与ny-eso-1结合的t细胞受体和其使用方法 Pending CN110198954A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762446084P 2017-01-13 2017-01-13
US62/446,084 2017-01-13
PCT/US2018/013624 WO2018132739A2 (en) 2017-01-13 2018-01-12 T cell receptors that bind to ny-eso-1 and methods of use thereof

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CN110198954A true CN110198954A (zh) 2019-09-03

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US (2) US11613764B2 (https=)
EP (1) EP3568412A2 (https=)
JP (2) JP2020503883A (https=)
KR (1) KR20190103226A (https=)
CN (1) CN110198954A (https=)
AU (1) AU2018207172B2 (https=)
BR (1) BR112019014510A2 (https=)
CA (1) CA3049016A1 (https=)
EA (1) EA201991696A1 (https=)
IL (1) IL267878A (https=)
MA (1) MA47265A (https=)
MX (1) MX2019008346A (https=)
WO (1) WO2018132739A2 (https=)

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