JP2020503051A5 - - Google Patents
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- Publication number
- JP2020503051A5 JP2020503051A5 JP2019535916A JP2019535916A JP2020503051A5 JP 2020503051 A5 JP2020503051 A5 JP 2020503051A5 JP 2019535916 A JP2019535916 A JP 2019535916A JP 2019535916 A JP2019535916 A JP 2019535916A JP 2020503051 A5 JP2020503051 A5 JP 2020503051A5
- Authority
- JP
- Japan
- Prior art keywords
- mutant
- algae
- control
- microorganism
- compared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 241000195493 Cryptophyta Species 0.000 claims description 81
- 244000005700 microbiome Species 0.000 claims description 67
- 238000000034 method Methods 0.000 claims description 48
- 230000000243 photosynthetic effect Effects 0.000 claims description 33
- 108010060806 Photosystem II Protein Complex Proteins 0.000 claims description 17
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 claims description 12
- 229930002875 chlorophyll Natural products 0.000 claims description 11
- 235000019804 chlorophyll Nutrition 0.000 claims description 11
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 241000418569 Marinichlorella Species 0.000 claims description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 239000002028 Biomass Substances 0.000 claims description 6
- 241000195628 Chlorophyta Species 0.000 claims description 6
- 108010003581 Ribulose-bisphosphate carboxylase Proteins 0.000 claims description 6
- 101100204457 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SVF1 gene Proteins 0.000 claims description 6
- 230000035772 mutation Effects 0.000 claims description 6
- 229920001184 polypeptide Polymers 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 241000894007 species Species 0.000 claims description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 241000195649 Chlorella <Chlorellales> Species 0.000 claims description 4
- 241000457035 Heveochlorella Species 0.000 claims description 4
- 241000196305 Nannochloris Species 0.000 claims description 4
- 241000894422 Pseudochlorella Species 0.000 claims description 4
- 241000513961 Tetrachlorella Species 0.000 claims description 4
- 239000012190 activator Substances 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 150000002632 lipids Chemical class 0.000 claims description 4
- 241001036353 Parachlorella Species 0.000 claims description 3
- 241001293481 Trebouxiophyceae Species 0.000 claims description 3
- 229930002869 chlorophyll b Natural products 0.000 claims description 3
- NSMUHPMZFPKNMZ-VBYMZDBQSA-M chlorophyll b Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C=O)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 NSMUHPMZFPKNMZ-VBYMZDBQSA-M 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 241001425589 Auxenochlorella Species 0.000 claims description 2
- 241001536324 Botryococcus Species 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 241000196315 Prasinocladus Species 0.000 claims description 2
- 241000196321 Tetraselmis Species 0.000 claims description 2
- 241001411205 Viridiella Species 0.000 claims description 2
- 230000003213 activating effect Effects 0.000 claims description 2
- 229930002868 chlorophyll a Natural products 0.000 claims description 2
- 230000002950 deficient Effects 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 150000003626 triacylglycerols Chemical group 0.000 claims description 2
- 230000004568 DNA-binding Effects 0.000 claims 1
- 206010064571 Gene mutation Diseases 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 241000508318 Chlorogonium Species 0.000 description 6
- 238000012163 sequencing technique Methods 0.000 description 4
- 241000196307 prasinophytes Species 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 241001195790 Charales Species 0.000 description 2
- 241000195585 Chlamydomonas Species 0.000 description 2
- 230000001651 autotrophic effect Effects 0.000 description 2
- 238000002703 mutagenesis Methods 0.000 description 2
- 231100000350 mutagenesis Toxicity 0.000 description 2
- 241000590031 Alteromonas Species 0.000 description 1
- 241000196169 Ankistrodesmus Species 0.000 description 1
- 241000218459 Carteria Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 241000195634 Dunaliella Species 0.000 description 1
- 241000168525 Haematococcus Species 0.000 description 1
- 241000195644 Neochloris Species 0.000 description 1
- 241000546131 Oedogonium Species 0.000 description 1
- 241001221669 Ostreococcus Species 0.000 description 1
- 241000122116 Parvimonas Species 0.000 description 1
- 241001494897 Pelagomonas Species 0.000 description 1
- 241000195615 Volvox Species 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000010362 genome editing Methods 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000002743 insertional mutagenesis Methods 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229930001119 polyketide Natural products 0.000 description 1
- 125000000830 polyketide group Chemical group 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662441002P | 2016-12-30 | 2016-12-30 | |
| US62/441,002 | 2016-12-30 | ||
| PCT/US2017/069073 WO2018126201A1 (en) | 2016-12-30 | 2017-12-29 | High productivity algal mutants having reduced photosynthetic antenna |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020503051A JP2020503051A (ja) | 2020-01-30 |
| JP2020503051A5 true JP2020503051A5 (enExample) | 2021-01-28 |
| JP7057786B2 JP7057786B2 (ja) | 2022-04-20 |
Family
ID=62708892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019535916A Active JP7057786B2 (ja) | 2016-12-30 | 2017-12-29 | 光合成アンテナの減少を有する高生産性藻類突然変異体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10968259B2 (enExample) |
| EP (1) | EP3562833A4 (enExample) |
| JP (1) | JP7057786B2 (enExample) |
| AU (1) | AU2017388870B2 (enExample) |
| BR (1) | BR112019013193A2 (enExample) |
| CA (1) | CA3047811A1 (enExample) |
| MX (1) | MX389720B (enExample) |
| SA (1) | SA519401668B1 (enExample) |
| WO (1) | WO2018126201A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220348946A1 (en) * | 2021-04-23 | 2022-11-03 | Viridos, Inc. | Chlorophyte algae having improved productivity |
| CA2972454C (en) * | 2014-12-31 | 2024-09-10 | Synthetic Genomics Inc | Compositions and methods for high efficiency in vivo genome editing |
| AU2018395264B2 (en) * | 2017-12-29 | 2023-06-22 | Synthetic Genomics, Inc. | Genetic modulation of photosynthetic organisms for improved growth |
| AU2019310022A1 (en) * | 2018-07-23 | 2021-02-04 | Synthetic Genomics, Inc. | Microorganisms having increased lipid production, and compositions and methods of making and using the same |
| US20220010321A1 (en) * | 2018-11-01 | 2022-01-13 | Keygene N.V. | Dual guide rna for crispr/cas genome editing in plants cells |
| JP7397437B2 (ja) * | 2018-11-07 | 2023-12-13 | 学校法人 中央大学 | クロロフィル含有率が減少し、且つ油脂生産性が増加した緑藻変異体及びその利用 |
| JP7416383B2 (ja) * | 2018-11-26 | 2024-01-17 | 株式会社カネカ | ゲノム編集方法 |
| WO2020111029A1 (ja) * | 2018-11-26 | 2020-06-04 | 株式会社カネカ | ゲノム編集方法 |
| CN110033825B (zh) * | 2019-04-26 | 2021-08-13 | 扬州大学 | 一种箭筈豌豆种质资源筛选方法 |
| IL293882A (en) * | 2019-12-17 | 2022-08-01 | Viridos Inc | Recombinant algae with high lipid productivity |
| IL301125A (en) * | 2020-09-11 | 2023-05-01 | Viridos Inc | Recombinant algae having high lipid productivity |
| WO2022080234A1 (ja) * | 2020-10-12 | 2022-04-21 | Dic株式会社 | ガルデリア属に属する藻類のゲノム改変方法 |
| EP4654981A1 (en) * | 2023-01-27 | 2025-12-03 | Gentibio, Inc. | Engineered repair regulatory t cells |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002312390A1 (en) * | 2001-06-06 | 2002-12-16 | The General Hospital Corporation | Cytokinin response regulators and uses thereof |
| EP3401388B1 (en) * | 2012-12-06 | 2019-07-10 | Synthetic Genomics, Inc. | Algal mutants having a locked-in high light acclimated phenotype |
| WO2016168756A1 (en) * | 2015-04-15 | 2016-10-20 | Synthetic Genomics, Inc. | Algal chloroplastic srp54 mutants |
-
2017
- 2017-12-29 EP EP17887143.0A patent/EP3562833A4/en active Pending
- 2017-12-29 JP JP2019535916A patent/JP7057786B2/ja active Active
- 2017-12-29 WO PCT/US2017/069073 patent/WO2018126201A1/en not_active Ceased
- 2017-12-29 US US15/859,094 patent/US10968259B2/en active Active
- 2017-12-29 MX MX2019007765A patent/MX389720B/es unknown
- 2017-12-29 BR BR112019013193A patent/BR112019013193A2/pt active Search and Examination
- 2017-12-29 CA CA3047811A patent/CA3047811A1/en active Pending
- 2017-12-29 AU AU2017388870A patent/AU2017388870B2/en active Active
-
2019
- 2019-04-28 SA SA519401668A patent/SA519401668B1/ar unknown
-
2021
- 2021-02-17 US US17/178,179 patent/US11787843B2/en active Active
-
2023
- 2023-09-27 US US18/475,792 patent/US20240052001A1/en active Pending
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