JP2020502498A5 - - Google Patents
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- Publication number
- JP2020502498A5 JP2020502498A5 JP2019528092A JP2019528092A JP2020502498A5 JP 2020502498 A5 JP2020502498 A5 JP 2020502498A5 JP 2019528092 A JP2019528092 A JP 2019528092A JP 2019528092 A JP2019528092 A JP 2019528092A JP 2020502498 A5 JP2020502498 A5 JP 2020502498A5
- Authority
- JP
- Japan
- Prior art keywords
- protein encoded
- group
- gene selected
- tubb3
- hmga2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims 108
- 102000004169 proteins and genes Human genes 0.000 claims 52
- 108700039143 HMGA2 Proteins 0.000 claims 22
- 102100028999 High mobility group protein HMGI-C Human genes 0.000 claims 22
- 101150073387 Hmga2 gene Proteins 0.000 claims 22
- 101000713575 Homo sapiens Tubulin beta-3 chain Proteins 0.000 claims 22
- 102100036790 Tubulin beta-3 chain Human genes 0.000 claims 22
- 101000866795 Homo sapiens Non-histone chromosomal protein HMG-14 Proteins 0.000 claims 19
- 102100023541 Glutathione S-transferase omega-1 Human genes 0.000 claims 13
- 101000906386 Homo sapiens Glutathione S-transferase omega-1 Proteins 0.000 claims 13
- 102100031353 Non-histone chromosomal protein HMG-14 Human genes 0.000 claims 13
- 101000832685 Homo sapiens Small ubiquitin-related modifier 2 Proteins 0.000 claims 12
- 102100024542 Small ubiquitin-related modifier 2 Human genes 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 102100024341 10 kDa heat shock protein, mitochondrial Human genes 0.000 claims 11
- LTPSRQRIPCVMKQ-UHFFFAOYSA-N 2-amino-5-methylbenzenesulfonic acid Chemical compound CC1=CC=C(N)C(S(O)(=O)=O)=C1 LTPSRQRIPCVMKQ-UHFFFAOYSA-N 0.000 claims 11
- 102100036659 26S proteasome non-ATPase regulatory subunit 9 Human genes 0.000 claims 11
- 102100039377 28 kDa heat- and acid-stable phosphoprotein Human genes 0.000 claims 11
- 102100026357 40S ribosomal protein S13 Human genes 0.000 claims 11
- 102100025514 ATP-dependent 6-phosphofructokinase, platelet type Human genes 0.000 claims 11
- 101710106492 Acyl-CoA-binding protein Proteins 0.000 claims 11
- 101710169323 Acyl-CoA-binding protein homolog Proteins 0.000 claims 11
- 102100025580 Calmodulin-1 Human genes 0.000 claims 11
- 102100030291 Cornifin-B Human genes 0.000 claims 11
- 102100027563 Cytochrome c oxidase subunit 5A, mitochondrial Human genes 0.000 claims 11
- 102100023078 Early endosome antigen 1 Human genes 0.000 claims 11
- 102100033325 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 Human genes 0.000 claims 11
- 102100031000 Hepatoma-derived growth factor Human genes 0.000 claims 11
- 102100029009 High mobility group protein HMG-I/HMG-Y Human genes 0.000 claims 11
- 102100021639 Histone H2B type 1-K Human genes 0.000 claims 11
- 101000980303 Homo sapiens 10 kDa heat shock protein, mitochondrial Proteins 0.000 claims 11
- 101001136710 Homo sapiens 26S proteasome non-ATPase regulatory subunit 9 Proteins 0.000 claims 11
- 101001035654 Homo sapiens 28 kDa heat- and acid-stable phosphoprotein Proteins 0.000 claims 11
- 101000718313 Homo sapiens 40S ribosomal protein S13 Proteins 0.000 claims 11
- 101000693765 Homo sapiens ATP-dependent 6-phosphofructokinase, platelet type Proteins 0.000 claims 11
- 101000984164 Homo sapiens Calmodulin-1 Proteins 0.000 claims 11
- 101000702152 Homo sapiens Cornifin-B Proteins 0.000 claims 11
- 101000725076 Homo sapiens Cytochrome c oxidase subunit 5A, mitochondrial Proteins 0.000 claims 11
- 101001050162 Homo sapiens Early endosome antigen 1 Proteins 0.000 claims 11
- 101000926793 Homo sapiens Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 Proteins 0.000 claims 11
- 101000986380 Homo sapiens High mobility group protein HMG-I/HMG-Y Proteins 0.000 claims 11
- 101000898898 Homo sapiens Histone H2B type 1-K Proteins 0.000 claims 11
- 101001076613 Homo sapiens Immortalization up-regulated protein Proteins 0.000 claims 11
- 101001042036 Homo sapiens Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Proteins 0.000 claims 11
- 101000942713 Homo sapiens Liprin-alpha-2 Proteins 0.000 claims 11
- 101001027945 Homo sapiens Metallothionein-1E Proteins 0.000 claims 11
- 101001027938 Homo sapiens Metallothionein-1G Proteins 0.000 claims 11
- 101000866805 Homo sapiens Non-histone chromosomal protein HMG-17 Proteins 0.000 claims 11
- 101001082207 Homo sapiens Parathymosin Proteins 0.000 claims 11
- 101001133656 Homo sapiens Plasminogen activator inhibitor 1 RNA-binding protein Proteins 0.000 claims 11
- 101000980965 Homo sapiens Protein CDV3 homolog Proteins 0.000 claims 11
- 101001098824 Homo sapiens Protein disulfide-isomerase A4 Proteins 0.000 claims 11
- 101000738322 Homo sapiens Prothymosin alpha Proteins 0.000 claims 11
- 101000700735 Homo sapiens Serine/arginine-rich splicing factor 7 Proteins 0.000 claims 11
- 101001090050 Homo sapiens Thioredoxin-dependent peroxide reductase, mitochondrial Proteins 0.000 claims 11
- 101000658138 Homo sapiens Thymosin beta-10 Proteins 0.000 claims 11
- 101000795292 Homo sapiens Tripartite motif-containing protein 6 Proteins 0.000 claims 11
- 101000830781 Homo sapiens Tropomyosin alpha-4 chain Proteins 0.000 claims 11
- 101000806601 Homo sapiens V-type proton ATPase catalytic subunit A Proteins 0.000 claims 11
- 101000788845 Homo sapiens Zinc finger CCCH domain-containing protein 11A Proteins 0.000 claims 11
- 102100025886 Immortalization up-regulated protein Human genes 0.000 claims 11
- 102100021332 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Human genes 0.000 claims 11
- 102100032894 Liprin-alpha-2 Human genes 0.000 claims 11
- 102100037510 Metallothionein-1E Human genes 0.000 claims 11
- 102100037512 Metallothionein-1G Human genes 0.000 claims 11
- -1 NEB Proteins 0.000 claims 11
- 102100031346 Non-histone chromosomal protein HMG-17 Human genes 0.000 claims 11
- 102100027370 Parathymosin Human genes 0.000 claims 11
- 102100034055 Plasminogen activator inhibitor 1 RNA-binding protein Human genes 0.000 claims 11
- 102100024449 Protein CDV3 homolog Human genes 0.000 claims 11
- 102100037089 Protein disulfide-isomerase A4 Human genes 0.000 claims 11
- 102100037925 Prothymosin alpha Human genes 0.000 claims 11
- 102100031269 Putative peripheral benzodiazepine receptor-related protein Human genes 0.000 claims 11
- 102100029287 Serine/arginine-rich splicing factor 7 Human genes 0.000 claims 11
- 102100034769 Thioredoxin-dependent peroxide reductase, mitochondrial Human genes 0.000 claims 11
- 102100034998 Thymosin beta-10 Human genes 0.000 claims 11
- OKKRPWIIYQTPQF-UHFFFAOYSA-N Trimethylolpropane trimethacrylate Chemical compound CC(=C)C(=O)OCC(CC)(COC(=O)C(C)=C)COC(=O)C(C)=C OKKRPWIIYQTPQF-UHFFFAOYSA-N 0.000 claims 11
- 102100029673 Tripartite motif-containing protein 6 Human genes 0.000 claims 11
- 102100024944 Tropomyosin alpha-4 chain Human genes 0.000 claims 11
- 102100037466 V-type proton ATPase catalytic subunit A Human genes 0.000 claims 11
- 102100025402 Zinc finger CCCH domain-containing protein 11A Human genes 0.000 claims 11
- 108010052188 hepatoma-derived growth factor Proteins 0.000 claims 11
- 102100024442 60S ribosomal protein L13 Human genes 0.000 claims 10
- 101000691550 Homo sapiens 39S ribosomal protein L13, mitochondrial Proteins 0.000 claims 10
- 101001118201 Homo sapiens 60S ribosomal protein L13 Proteins 0.000 claims 10
- 101001000104 Homo sapiens Myosin-11 Proteins 0.000 claims 10
- 101000587717 Homo sapiens Sulfide:quinone oxidoreductase, mitochondrial Proteins 0.000 claims 10
- 102100036639 Myosin-11 Human genes 0.000 claims 10
- 102100031138 Sulfide:quinone oxidoreductase, mitochondrial Human genes 0.000 claims 10
- 102100030943 Glutathione S-transferase P Human genes 0.000 claims 9
- 101001010139 Homo sapiens Glutathione S-transferase P Proteins 0.000 claims 9
- 102000003741 Actin-related protein 3 Human genes 0.000 claims 8
- 108090000104 Actin-related protein 3 Proteins 0.000 claims 8
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 claims 8
- 108700010013 HMGB1 Proteins 0.000 claims 8
- 101150021904 HMGB1 gene Proteins 0.000 claims 8
- 102100037907 High mobility group protein B1 Human genes 0.000 claims 8
- 101000961149 Homo sapiens Immunoglobulin heavy constant gamma 4 Proteins 0.000 claims 8
- 102100039347 Immunoglobulin heavy constant gamma 4 Human genes 0.000 claims 8
- 230000009759 skin aging Effects 0.000 claims 8
- 102100032303 26S proteasome non-ATPase regulatory subunit 2 Human genes 0.000 claims 7
- 102100032559 Clathrin light chain B Human genes 0.000 claims 7
- 102000058063 Glucose Transporter Type 1 Human genes 0.000 claims 7
- 101000590272 Homo sapiens 26S proteasome non-ATPase regulatory subunit 2 Proteins 0.000 claims 7
- 101000942271 Homo sapiens Clathrin light chain B Proteins 0.000 claims 7
- 101000596119 Homo sapiens Plastin-3 Proteins 0.000 claims 7
- 101000611053 Homo sapiens Proteasome subunit beta type-2 Proteins 0.000 claims 7
- 101000837067 Homo sapiens SH3 domain-binding glutamic acid-rich-like protein 3 Proteins 0.000 claims 7
- 101000658157 Homo sapiens Thymosin beta-4 Proteins 0.000 claims 7
- 102100035220 Plastin-3 Human genes 0.000 claims 7
- 102100040400 Proteasome subunit beta type-2 Human genes 0.000 claims 7
- 102100028643 SH3 domain-binding glutamic acid-rich-like protein 3 Human genes 0.000 claims 7
- 108091006296 SLC2A1 Proteins 0.000 claims 7
- 102100035000 Thymosin beta-4 Human genes 0.000 claims 7
- 101001116674 Homo sapiens Prefoldin subunit 2 Proteins 0.000 claims 6
- 101000730802 Homo sapiens Prefoldin subunit 6 Proteins 0.000 claims 6
- 101000653663 Homo sapiens T-complex protein 1 subunit epsilon Proteins 0.000 claims 6
- 102100024920 Prefoldin subunit 2 Human genes 0.000 claims 6
- 102100032926 Prefoldin subunit 6 Human genes 0.000 claims 6
- 102100029886 T-complex protein 1 subunit epsilon Human genes 0.000 claims 6
- 102100023679 40S ribosomal protein S28 Human genes 0.000 claims 5
- 101000623076 Homo sapiens 40S ribosomal protein S28 Proteins 0.000 claims 5
- 101000831940 Homo sapiens Stathmin Proteins 0.000 claims 5
- 102100024237 Stathmin Human genes 0.000 claims 5
- 108010075843 alpha-2-HS-Glycoprotein Proteins 0.000 claims 5
- 102000012005 alpha-2-HS-Glycoprotein Human genes 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 230000032683 aging Effects 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 102100036816 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Human genes 0.000 claims 1
- 101000906005 Fasciola hepatica Glutathione S-transferase class-mu 26 kDa isozyme 1 Proteins 0.000 claims 1
- 101000851788 Homo sapiens Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Proteins 0.000 claims 1
- 101001071694 Homo sapiens Glutathione S-transferase Mu 1 Proteins 0.000 claims 1
- 101000632561 Homo sapiens SH3 domain-binding glutamic acid-rich protein Proteins 0.000 claims 1
- 101000875296 Homo sapiens Serine/threonine-protein phosphatase CPPED1 Proteins 0.000 claims 1
- 102100028400 SH3 domain-binding glutamic acid-rich protein Human genes 0.000 claims 1
- 102100036209 Serine/threonine-protein phosphatase CPPED1 Human genes 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16306561 | 2016-11-25 | ||
| EP16306561.8 | 2016-11-25 | ||
| PCT/EP2017/080414 WO2018096117A1 (en) | 2016-11-25 | 2017-11-24 | New biomarkers of human skin aging |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502498A JP2020502498A (ja) | 2020-01-23 |
| JP2020502498A5 true JP2020502498A5 (cg-RX-API-DMAC7.html) | 2021-01-14 |
| JP7115756B2 JP7115756B2 (ja) | 2022-08-09 |
Family
ID=57517827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019528092A Active JP7115756B2 (ja) | 2016-11-25 | 2017-11-24 | ヒトの皮膚の老化の新規バイオマーカー |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20210109111A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3545301A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7115756B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN110268263B (cg-RX-API-DMAC7.html) |
| CA (1) | CA3041959A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2019116069A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018096117A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019236632A1 (en) * | 2018-06-04 | 2019-12-12 | Avon Products. Inc. | Protein biomarkers for identifying and treating aging skin and skin conditions |
| JP7633003B2 (ja) * | 2019-11-29 | 2025-02-19 | ポーラ化成工業株式会社 | 抗老化成分のスクリーニング方法 |
| WO2023090901A1 (ko) * | 2021-11-18 | 2023-05-25 | 의료법인 성광의료재단 | 기계 학습을 이용한 세포 노화의 마커를 선별하는 방법, 세포 노화 바이오 마커, 및 이를 이용한 세놀리틱 제제를 스크리닝 하는 방법 |
| TW202333717A (zh) * | 2022-01-07 | 2023-09-01 | 美商蕾瑞拉股份有限公司 | 用於皮膚治療的組合物、調配物及方法 |
| JP2023130972A (ja) * | 2022-03-08 | 2023-09-21 | 株式会社 資生堂 | 黄ぐすみ抑制方法、黄ぐすみ抑制剤のスクリーニング方法、及び黄ぐすみ感受性の評価方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001249098A1 (en) * | 2000-03-10 | 2001-09-24 | Lifespan Biosciences, Inc. | Nucleic acid sequences associated with aging, particularly skin aging |
| DE10100121A1 (de) * | 2001-01-03 | 2002-08-01 | Henkel Kgaa | Verfahren zur Bestimmung des Hautstreß oder der Hautalterung in vitro |
| EP1579221A2 (de) * | 2003-01-03 | 2005-09-28 | Alcedo Biotech GmbH | Verwendungen von hmgb, hmgn, hmga proteinen |
| WO2004083398A2 (en) * | 2003-03-17 | 2004-09-30 | The Government Of The United States Of America As Represented By The Secretary Of Department Of Health And Human Services | Therapeutic uses of hmgn1 and hmgn2 |
| US7972788B2 (en) * | 2005-08-23 | 2011-07-05 | Fancl Corporation | Skin aging marker and technique for use thereof |
| US8859021B2 (en) * | 2007-05-14 | 2014-10-14 | Sytheon | Skin appearance through gene manipulation |
| KR100999261B1 (ko) * | 2007-10-09 | 2010-12-07 | (주)아모레퍼시픽 | 여성호르몬 결핍으로 초래되는 여성 피부의 노화 억제제 스크리닝 방법 |
| FR2925313A1 (fr) * | 2007-12-19 | 2009-06-26 | Oreal | Utilisation cosmetique de proteines de type plakoglobine |
| US20120034613A1 (en) * | 2010-08-03 | 2012-02-09 | Nse Products, Inc. | Apparatus and Method for Testing Relationships Between Gene Expression and Physical Appearance of Skin |
| EP2704728A4 (en) * | 2011-05-03 | 2015-04-22 | Dermachip Inc | EXPRESSION SIGNATURES OF AGENTS ASSOCIATED WITH SKIN AGING AND GEN NETWORKS |
| MX2015012298A (es) * | 2013-03-15 | 2015-12-16 | Procter & Gamble | Un metodo no invasivo para medir peptidos antimicrobianos de la piel como una medicion objetica de proteccion natural de los microbios. |
-
2017
- 2017-11-24 WO PCT/EP2017/080414 patent/WO2018096117A1/en not_active Ceased
- 2017-11-24 US US16/464,517 patent/US20210109111A1/en not_active Abandoned
- 2017-11-24 CN CN201780072821.8A patent/CN110268263B/zh not_active Expired - Fee Related
- 2017-11-24 CA CA3041959A patent/CA3041959A1/en active Pending
- 2017-11-24 JP JP2019528092A patent/JP7115756B2/ja active Active
- 2017-11-24 EP EP17801484.1A patent/EP3545301A1/en not_active Withdrawn
- 2017-11-24 RU RU2019116069A patent/RU2019116069A/ru not_active Application Discontinuation
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