JP2020502252A5 - - Google Patents
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- Publication number
- JP2020502252A5 JP2020502252A5 JP2019534721A JP2019534721A JP2020502252A5 JP 2020502252 A5 JP2020502252 A5 JP 2020502252A5 JP 2019534721 A JP2019534721 A JP 2019534721A JP 2019534721 A JP2019534721 A JP 2019534721A JP 2020502252 A5 JP2020502252 A5 JP 2020502252A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolo
- pyridine
- pyridin
- quinoline
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022133200A JP2022166286A (ja) | 2016-12-23 | 2022-08-24 | Ｄｙｒｋ１ａおよび／またはｄｙｒｋ１ｂキナーゼの阻害剤としてのキノリンの誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16460096 | 2016-12-23 | ||
| EP16460096.7 | 2016-12-23 | ||
| PCT/US2017/067527 WO2018119039A1 (en) | 2016-12-23 | 2017-12-20 | Derivatives of quinolines as inhibitors of dyrk1a and/or dyrk1b kinases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022133200A Division JP2022166286A (ja) | 2016-12-23 | 2022-08-24 | Ｄｙｒｋ１ａおよび／またはｄｙｒｋ１ｂキナーゼの阻害剤としてのキノリンの誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502252A JP2020502252A (ja) | 2020-01-23 |
| JP2020502252A5 true JP2020502252A5 (cg-RX-API-DMAC10.html) | 2021-01-28 |
| JP7134973B2 JP7134973B2 (ja) | 2022-09-12 |
Family
ID=57777491
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019534721A Expired - Fee Related JP7134973B2 (ja) | 2016-12-23 | 2017-12-20 | Ｄｙｒｋ１ａおよび／またはｄｙｒｋ１ｂキナーゼの阻害剤としてのキノリンの誘導体 |
| JP2022133200A Pending JP2022166286A (ja) | 2016-12-23 | 2022-08-24 | Ｄｙｒｋ１ａおよび／またはｄｙｒｋ１ｂキナーゼの阻害剤としてのキノリンの誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022133200A Pending JP2022166286A (ja) | 2016-12-23 | 2022-08-24 | Ｄｙｒｋ１ａおよび／またはｄｙｒｋ１ｂキナーゼの阻害剤としてのキノリンの誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10577365B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP3558321B1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP7134973B2 (cg-RX-API-DMAC10.html) |
| LT (1) | LT3558321T (cg-RX-API-DMAC10.html) |
| PL (1) | PL3558321T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2018119039A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3558321T3 (pl) * | 2016-12-23 | 2023-10-23 | Felicitex Therapeutics, Inc. | Pochodne chinolin jako inhibitory kinaz dyrk1a i/lub dyrk1b |
| CN110483508B (zh) * | 2019-08-29 | 2020-05-08 | 山东大学 | 化合物、制备方法及在制备GSK-3β抑制剂中的应用 |
| US12590298B2 (en) | 2019-10-18 | 2026-03-31 | The Regents Of The University Of California | Ex vivo tumor angiogenesis model |
| US11884647B2 (en) | 2019-10-18 | 2024-01-30 | The Regents Of The University Of California | Compounds and methods for targeting pathogenic blood vessels |
| KR20230003981A (ko) * | 2021-06-30 | 2023-01-06 | 한국화학연구원 | DYRK1 억제제인 피롤로[3,2-c]피리딘 유도체 및 이의 용도 |
| WO2023064349A1 (en) * | 2021-10-12 | 2023-04-20 | Biosplice Therapeutics, Inc. | 1h-pyrrolo[2,3-b]pyridines as dyrk1a inhibitors |
| WO2023250082A2 (en) * | 2022-06-22 | 2023-12-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of dyrk/clk and uses thereof |
| IL327381A (en) | 2023-09-28 | 2026-05-01 | Graviton Pharmaceuticals B V | Treatment for type 1 diabetes using ROCK2 and DYRK1 inhibitors |
| CN120904163B (zh) * | 2025-10-09 | 2026-01-30 | 北京大学第一医院(北京大学第一临床医学院) | 一种喹啉类化合物或其药学上可接受的盐及其制备方法和用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040111445A (ko) | 2002-03-28 | 2004-12-31 | 에자이 가부시키가이샤 | 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌 |
| US20070066641A1 (en) | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
| GB0405055D0 (en) | 2004-03-05 | 2004-04-07 | Eisai London Res Lab Ltd | JNK inhibitors |
| ES2364340T3 (es) | 2004-03-30 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | Azaindoles útiles como inhibidores de jak y otras proteína quinasas. |
| EP1828180A4 (en) | 2004-12-08 | 2010-09-15 | Glaxosmithkline Llc | 1H-pyrrolo [2,3-BETA] PYRIDINE |
| ES2431466T3 (es) * | 2006-06-30 | 2013-11-26 | Sunesis Pharmaceuticals, Inc. | Inhibidores de piridinonil pdk1 |
| AU2009322656A1 (en) * | 2008-12-05 | 2010-06-10 | Merck Sharp & Dohme Corp. | Inhibitors of phosphoinositide dependent kinase 1 (PDK1) |
| EP2576549A4 (en) | 2010-05-24 | 2013-12-18 | Univ Rochester | Bicyclic Heteroarylkinase Inhibitors and Methods of Use |
| US9120749B2 (en) | 2010-07-30 | 2015-09-01 | Oncotherapy Science, Inc. | Quinoline derivatives and MELK inhibitors containing the same |
| US8362023B2 (en) | 2011-01-19 | 2013-01-29 | Hoffmann-La Roche Inc. | Pyrazolo pyrimidines |
| WO2012129338A1 (en) | 2011-03-22 | 2012-09-27 | Amgen Inc. | Azole compounds as pim inhibitors |
| PL3141548T3 (pl) | 2011-07-05 | 2020-09-07 | Vertex Pharmaceuticals Incorporated | Sposoby i związki pośrednie do wytwarzania azaindoli |
| KR102006749B1 (ko) | 2011-08-19 | 2019-08-02 | 디악쏘니 | Dyrk1 억제제 및 이의 용도 |
| US10485800B2 (en) * | 2012-11-30 | 2019-11-26 | The University Of Rochester | Mixed lineage kinase inhibitors for HIV/AIDS therapies |
| CN105777756B (zh) | 2014-07-02 | 2019-03-01 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
| PL3558321T3 (pl) * | 2016-12-23 | 2023-10-23 | Felicitex Therapeutics, Inc. | Pochodne chinolin jako inhibitory kinaz dyrk1a i/lub dyrk1b |
-
2017
- 2017-12-20 PL PL17883520.3T patent/PL3558321T3/pl unknown
- 2017-12-20 LT LTEPPCT/US2017/067527T patent/LT3558321T/lt unknown
- 2017-12-20 WO PCT/US2017/067527 patent/WO2018119039A1/en not_active Ceased
- 2017-12-20 EP EP17883520.3A patent/EP3558321B1/en active Active
- 2017-12-20 EP EP22214338.0A patent/EP4183786A1/en not_active Withdrawn
- 2017-12-20 US US15/848,786 patent/US10577365B2/en active Active
- 2017-12-20 JP JP2019534721A patent/JP7134973B2/ja not_active Expired - Fee Related
-
2022
- 2022-08-24 JP JP2022133200A patent/JP2022166286A/ja active Pending
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