CN109415371A - 一种新型2-酰氨基噻唑衍生物及其制备方法与用途 - Google Patents

一种新型2-酰氨基噻唑衍生物及其制备方法与用途 Download PDF

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Publication number
CN109415371A
CN109415371A CN201780042550.1A CN201780042550A CN109415371A CN 109415371 A CN109415371 A CN 109415371A CN 201780042550 A CN201780042550 A CN 201780042550A CN 109415371 A CN109415371 A CN 109415371A
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China
Prior art keywords
base
chloro
chlorothiophene
thiazole
pyrroles
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CN201780042550.1A
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CN109415371B (zh
Inventor
蔡家强
郁楠
曾宏
宋宏梅
卿燕
宋帅
邓汉文
唐祖建
段小凡
黄海涛
叶红
刘钢
王利春
王晶翼
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Abstract

本发明涉及一种新型2‑酰氨基噻唑衍生物。本发明还涉及这些新型2‑酰氨基噻唑衍生物及其中间体的制备方法以及包含这些化合物的药物组合物。此外，本发明还涉及这些新型2‑酰氨基噻唑衍生物以及包含其的药物组合物在治疗和/或预防血小板生成素受体介导的疾病中的用途。

Description

PCT国内申请，说明书已公开。

Claims (30)

  1. PCT国内申请，权利要求书已公开。
CN201780042550.1A 2016-09-08 2017-08-31 一种2-酰氨基噻唑衍生物及其制备方法与用途 Active CN109415371B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016108106569 2016-09-08
CN201610810656 2016-09-08
PCT/CN2017/099945 WO2018045907A1 (zh) 2016-09-08 2017-08-31 一种新型2-酰氨基噻唑衍生物及其制备方法与用途

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CN109415371A true CN109415371A (zh) 2019-03-01
CN109415371B CN109415371B (zh) 2021-07-09

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Country Link
US (1) US20190315771A1 (zh)
EP (1) EP3511332A4 (zh)
JP (1) JP2019529342A (zh)
CN (1) CN109415371B (zh)
WO (1) WO2018045907A1 (zh)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1357116A1 (en) * 2001-02-02 2003-10-29 Yamanouchi Pharmaceutical Co. Ltd. 2-acylaminothiazole derivative or its salt
EP1466912A1 (en) * 2002-01-18 2004-10-13 Yamanouchi Pharmaceutical Co. Ltd. 2-acylaminothiazole derivative or salt thereof
WO2007004038A1 (en) * 2005-07-05 2007-01-11 Pfizer Products Inc. Aminothiazole derivatives as agonists of the thrombopoietin receptor
WO2007054783A2 (en) * 2005-11-08 2007-05-18 Astellas Pharma Inc. Compositions and methods for treating thrombocytopenia
CN101809008A (zh) * 2007-07-31 2010-08-18 盐野义制药株式会社 含有具血小板生成素受体激动作用的光学活性化合物的药物组合物及其中间体
US8049016B2 (en) * 2008-02-20 2011-11-01 Novartis Ag Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004263442B2 (en) 2003-08-12 2008-05-29 Shionogi & Co., Ltd. Compounds having thrombopoietin receptor agonism

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1357116A1 (en) * 2001-02-02 2003-10-29 Yamanouchi Pharmaceutical Co. Ltd. 2-acylaminothiazole derivative or its salt
EP1466912A1 (en) * 2002-01-18 2004-10-13 Yamanouchi Pharmaceutical Co. Ltd. 2-acylaminothiazole derivative or salt thereof
WO2007004038A1 (en) * 2005-07-05 2007-01-11 Pfizer Products Inc. Aminothiazole derivatives as agonists of the thrombopoietin receptor
WO2007054783A2 (en) * 2005-11-08 2007-05-18 Astellas Pharma Inc. Compositions and methods for treating thrombocytopenia
CN101809008A (zh) * 2007-07-31 2010-08-18 盐野义制药株式会社 含有具血小板生成素受体激动作用的光学活性化合物的药物组合物及其中间体
US8049016B2 (en) * 2008-02-20 2011-11-01 Novartis Ag Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes

Also Published As

Publication number Publication date
CN109415371B (zh) 2021-07-09
US20190315771A1 (en) 2019-10-17
JP2019529342A (ja) 2019-10-17
EP3511332A4 (en) 2020-03-25
EP3511332A1 (en) 2019-07-17
WO2018045907A1 (zh) 2018-03-15

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