JP2020502241A - アニオン交換体及びカルシウム塩を含む止血用組成物 - Google Patents

アニオン交換体及びカルシウム塩を含む止血用組成物 Download PDF

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Publication number
JP2020502241A
JP2020502241A JP2019534316A JP2019534316A JP2020502241A JP 2020502241 A JP2020502241 A JP 2020502241A JP 2019534316 A JP2019534316 A JP 2019534316A JP 2019534316 A JP2019534316 A JP 2019534316A JP 2020502241 A JP2020502241 A JP 2020502241A
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Prior art keywords
composition
group
hemostatic
matrix
composition according
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JP2019534316A
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English (en)
Japanese (ja)
Inventor
アウアーバッハ−ニーボー・タマル
ネグラヌ−ギルボア・タリ
アルペリン・ハダス
ヌル・イスラエル
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Omrix Biopharmaceuticals Ltd
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Omrix Biopharmaceuticals Ltd
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Publication date
Priority claimed from IL249725A external-priority patent/IL249725A0/en
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Publication of JP2020502241A publication Critical patent/JP2020502241A/ja
Priority to JP2022131617A priority Critical patent/JP2022166257A/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/721Dextrans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/14Alkali metal chlorides; Alkaline earth metal chlorides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0004Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/208Quaternary ammonium compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/04Materials for stopping bleeding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019534316A 2016-12-22 2017-12-13 アニオン交換体及びカルシウム塩を含む止血用組成物 Pending JP2020502241A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022131617A JP2022166257A (ja) 2016-12-22 2022-08-22 アニオン交換体及びカルシウム塩を含む止血用組成物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662437840P 2016-12-22 2016-12-22
IL249725A IL249725A0 (en) 2016-12-22 2016-12-22 A hemostatic preparation containing an anion exchanger and a calcium salt
US62/437,840 2016-12-22
IL249725 2016-12-22
PCT/IL2017/000009 WO2018116287A1 (en) 2016-12-22 2017-12-13 Hemostatic composition comprising an anion exchanger and a calcium salt

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022131617A Division JP2022166257A (ja) 2016-12-22 2022-08-22 アニオン交換体及びカルシウム塩を含む止血用組成物

Publications (1)

Publication Number Publication Date
JP2020502241A true JP2020502241A (ja) 2020-01-23

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JP2019534316A Pending JP2020502241A (ja) 2016-12-22 2017-12-13 アニオン交換体及びカルシウム塩を含む止血用組成物
JP2022131617A Pending JP2022166257A (ja) 2016-12-22 2022-08-22 アニオン交換体及びカルシウム塩を含む止血用組成物

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Country Status (9)

Country Link
EP (1) EP3558326A1 (pt)
JP (2) JP2020502241A (pt)
KR (1) KR102519771B1 (pt)
CN (1) CN110121350A (pt)
AU (1) AU2017383546A1 (pt)
BR (1) BR112019012531A2 (pt)
CA (1) CA3047529A1 (pt)
CO (1) CO2019006822A2 (pt)
IL (1) IL267432B1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112675356A (zh) * 2020-12-23 2021-04-20 湖南工业大学 长期保存的止血组合物及其制备方法和长期保存的抗菌止血混合物的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5988424A (ja) * 1982-11-08 1984-05-22 ウイリアム・グラハム・マレツト 医薬組成物
JP2000186048A (ja) * 1998-12-22 2000-07-04 Kuraray Co Ltd 止血材
JP2002513645A (ja) * 1998-05-07 2002-05-14 ジェンザイム・コーポレーション 止血化合物および生体吸収性ポリマーを含む組成物
JP2007526026A (ja) * 2003-12-23 2007-09-13 ヘムコン, インコーポレイテッド 創傷被覆材および生命を脅かす重篤な出血を抑制するための方法
JP2014533181A (ja) * 2011-11-13 2014-12-11 スネリス・インコーポレイテッド インサイチュー架橋性ポリマー組成物およびその方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5502042A (en) * 1994-07-22 1996-03-26 United States Surgical Corporation Methods and compositions for treating wounds
US20080145455A1 (en) * 2006-12-13 2008-06-19 Bedard Robert L Combination of Inorganic Hemostatic Agents with Other Hemostatic Agents
US8110208B1 (en) * 2009-03-30 2012-02-07 Biolife, L.L.C. Hemostatic compositions for arresting blood flow from an open wound or surgical site
GB201004072D0 (en) * 2010-03-11 2010-04-28 Turzi Antoine Process, tube and device for the preparation of wound healant composition
EP2575906B1 (en) * 2010-05-24 2014-12-10 University of Utah Research Foundation Reinforced adhesive complex coacervates and methods of making and using thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5988424A (ja) * 1982-11-08 1984-05-22 ウイリアム・グラハム・マレツト 医薬組成物
JP2002513645A (ja) * 1998-05-07 2002-05-14 ジェンザイム・コーポレーション 止血化合物および生体吸収性ポリマーを含む組成物
JP2000186048A (ja) * 1998-12-22 2000-07-04 Kuraray Co Ltd 止血材
JP2007526026A (ja) * 2003-12-23 2007-09-13 ヘムコン, インコーポレイテッド 創傷被覆材および生命を脅かす重篤な出血を抑制するための方法
JP2014533181A (ja) * 2011-11-13 2014-12-11 スネリス・インコーポレイテッド インサイチュー架橋性ポリマー組成物およびその方法

Also Published As

Publication number Publication date
IL267432B1 (en) 2024-03-01
KR102519771B1 (ko) 2023-04-10
JP2022166257A (ja) 2022-11-01
IL267432A (en) 2019-08-29
CN110121350A (zh) 2019-08-13
AU2017383546A1 (en) 2019-06-20
EP3558326A1 (en) 2019-10-30
KR20190099476A (ko) 2019-08-27
CO2019006822A2 (es) 2019-07-10
AU2017383546A9 (en) 2019-07-11
CA3047529A1 (en) 2018-06-28
BR112019012531A2 (pt) 2019-11-19

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