KR102519771B1 - 음이온 교환제 및 칼슘 염을 포함하는 지혈 조성물 - Google Patents

음이온 교환제 및 칼슘 염을 포함하는 지혈 조성물 Download PDF

Info

Publication number
KR102519771B1
KR102519771B1 KR1020197021215A KR20197021215A KR102519771B1 KR 102519771 B1 KR102519771 B1 KR 102519771B1 KR 1020197021215 A KR1020197021215 A KR 1020197021215A KR 20197021215 A KR20197021215 A KR 20197021215A KR 102519771 B1 KR102519771 B1 KR 102519771B1
Authority
KR
South Korea
Prior art keywords
composition
matrix
hemostatic
deae
delete delete
Prior art date
Application number
KR1020197021215A
Other languages
English (en)
Korean (ko)
Other versions
KR20190099476A (ko
Inventor
타마르 아우어바흐-네보
탈리 네그레아누-길보아
하다스 알페린
이스라엘 누르
Original Assignee
옴릭스 바이오파머슈티컬스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL249725A external-priority patent/IL249725A0/en
Application filed by 옴릭스 바이오파머슈티컬스 리미티드 filed Critical 옴릭스 바이오파머슈티컬스 리미티드
Publication of KR20190099476A publication Critical patent/KR20190099476A/ko
Application granted granted Critical
Publication of KR102519771B1 publication Critical patent/KR102519771B1/ko

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/721Dextrans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/14Alkali metal chlorides; Alkaline earth metal chlorides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0004Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/208Quaternary ammonium compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/04Materials for stopping bleeding
KR1020197021215A 2016-12-22 2017-12-13 음이온 교환제 및 칼슘 염을 포함하는 지혈 조성물 KR102519771B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662437840P 2016-12-22 2016-12-22
IL249725A IL249725A0 (en) 2016-12-22 2016-12-22 A hemostatic preparation containing an anion exchanger and a calcium salt
US62/437,840 2016-12-22
IL249725 2016-12-22
PCT/IL2017/000009 WO2018116287A1 (en) 2016-12-22 2017-12-13 Hemostatic composition comprising an anion exchanger and a calcium salt

Publications (2)

Publication Number Publication Date
KR20190099476A KR20190099476A (ko) 2019-08-27
KR102519771B1 true KR102519771B1 (ko) 2023-04-10

Family

ID=61024813

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197021215A KR102519771B1 (ko) 2016-12-22 2017-12-13 음이온 교환제 및 칼슘 염을 포함하는 지혈 조성물

Country Status (9)

Country Link
EP (1) EP3558326A1 (pt)
JP (2) JP2020502241A (pt)
KR (1) KR102519771B1 (pt)
CN (1) CN110121350A (pt)
AU (1) AU2017383546A1 (pt)
BR (1) BR112019012531A2 (pt)
CA (1) CA3047529A1 (pt)
CO (1) CO2019006822A2 (pt)
IL (1) IL267432B1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112675356A (zh) * 2020-12-23 2021-04-20 湖南工业大学 长期保存的止血组合物及其制备方法和长期保存的抗菌止血混合物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532134A (en) * 1981-04-06 1985-07-30 Malette William Graham Method of achieving hemostasis, inhibiting fibroplasia, and promoting tissue regeneration in a tissue wound
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5502042A (en) * 1994-07-22 1996-03-26 United States Surgical Corporation Methods and compositions for treating wounds
US6056970A (en) * 1998-05-07 2000-05-02 Genzyme Corporation Compositions comprising hemostatic compounds and bioabsorbable polymers
JP4159682B2 (ja) * 1998-12-22 2008-10-01 株式会社クラレ 止血材
US7371403B2 (en) * 2002-06-14 2008-05-13 Providence Health System-Oregon Wound dressing and method for controlling severe, life-threatening bleeding
US20080145455A1 (en) * 2006-12-13 2008-06-19 Bedard Robert L Combination of Inorganic Hemostatic Agents with Other Hemostatic Agents
US8110208B1 (en) * 2009-03-30 2012-02-07 Biolife, L.L.C. Hemostatic compositions for arresting blood flow from an open wound or surgical site
GB201004072D0 (en) * 2010-03-11 2010-04-28 Turzi Antoine Process, tube and device for the preparation of wound healant composition
EP2575906B1 (en) * 2010-05-24 2014-12-10 University of Utah Research Foundation Reinforced adhesive complex coacervates and methods of making and using thereof
EP2776068A4 (en) * 2011-11-13 2015-05-20 Suneris Inc IN SITU CROSSLINKABLE POLYMER COMPOSITIONS AND RELATED METHODS

Also Published As

Publication number Publication date
IL267432B1 (en) 2024-03-01
JP2022166257A (ja) 2022-11-01
IL267432A (en) 2019-08-29
CN110121350A (zh) 2019-08-13
AU2017383546A1 (en) 2019-06-20
EP3558326A1 (en) 2019-10-30
KR20190099476A (ko) 2019-08-27
CO2019006822A2 (es) 2019-07-10
AU2017383546A9 (en) 2019-07-11
CA3047529A1 (en) 2018-06-28
BR112019012531A2 (pt) 2019-11-19
JP2020502241A (ja) 2020-01-23

Similar Documents

Publication Publication Date Title
CA2851332C (en) Hemostatic compositions
US9808553B2 (en) Haemostatic wound dressing
AU2011204558B2 (en) Dry powder fibrin sealant
Seyednejad et al. Topical haemostatic agents
Li et al. Preparation and the hemostatic property study of porous gelatin microspheres both in vitro and in vivo
CA2851321A1 (en) Hemostatic compositions
JP2012506903A (ja) スプレー可能なカプセル化された機能性微粒子組成物及びその製造方法
US20130096082A1 (en) Hemostatic compositions
Hong et al. A review of treatments for non-compressible torso hemorrhage (NCTH) and internal bleeding
Hu et al. Topical hemostatic materials for coagulopathy
JP2015535192A (ja) 圧迫不可能な出血時に用いる組織シーラントの改良
JP2022166257A (ja) アニオン交換体及びカルシウム塩を含む止血用組成物
JP6461957B2 (ja) トロンビンとペクチンとを含む乾燥パッド
US11857564B2 (en) Hemostatic composition comprising an anion exchanger and a calcium salt
US11903961B2 (en) Hemostatic agent and method of production thereof

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant