JP2020502230A5 - - Google Patents

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Publication number
JP2020502230A5
JP2020502230A5 JP2019534197A JP2019534197A JP2020502230A5 JP 2020502230 A5 JP2020502230 A5 JP 2020502230A5 JP 2019534197 A JP2019534197 A JP 2019534197A JP 2019534197 A JP2019534197 A JP 2019534197A JP 2020502230 A5 JP2020502230 A5 JP 2020502230A5
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JP
Japan
Prior art keywords
methyl
pyridyl
amine
isopropyl
ethoxy
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Application number
JP2019534197A
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English (en)
Japanese (ja)
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JP7074758B2 (ja
JP2020502230A (ja
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Priority claimed from PCT/EP2017/083721 external-priority patent/WO2018115067A1/en
Publication of JP2020502230A publication Critical patent/JP2020502230A/ja
Publication of JP2020502230A5 publication Critical patent/JP2020502230A5/ja
Application granted granted Critical
Publication of JP7074758B2 publication Critical patent/JP7074758B2/ja
Expired - Fee Related legal-status Critical Current
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JP2019534197A 2016-12-22 2017-12-20 ＰＤＥ１阻害剤としてのピラゾロ［３，４－ｂ］ピリジン及びイミダゾ［１，５－ｂ］ピリダジン Expired - Fee Related JP7074758B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201600784 2016-12-22
DKPA201600784 2016-12-22
DKPA201700404 2017-07-06
DKPA201700404 2017-07-06
PCT/EP2017/083721 WO2018115067A1 (en) 2016-12-22 2017-12-20 Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors

Publications (3)

Publication Number Publication Date
JP2020502230A JP2020502230A (ja) 2020-01-23
JP2020502230A5 true JP2020502230A5 (https=) 2021-01-28
JP7074758B2 JP7074758B2 (ja) 2022-05-24

Family

ID=60812077

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019534197A Expired - Fee Related JP7074758B2 (ja) 2016-12-22 2017-12-20 ＰＤＥ１阻害剤としてのピラゾロ［３，４－ｂ］ピリジン及びイミダゾ［１，５－ｂ］ピリダジン

Country Status (23)

Country Link
US (2) US10351561B2 (https=)
EP (1) EP3558988B1 (https=)
JP (1) JP7074758B2 (https=)
KR (1) KR20190095301A (https=)
CN (1) CN110099901B (https=)
AU (1) AU2017384481A1 (https=)
BR (1) BR112018017067A2 (https=)
CA (1) CA3046588A1 (https=)
CL (1) CL2019001669A1 (https=)
CO (1) CO2019005538A2 (https=)
CR (1) CR20190302A (https=)
DO (1) DOP2019000169A (https=)
EC (1) ECSP19043790A (https=)
ES (1) ES2882335T3 (https=)
IL (1) IL267561A (https=)
JO (1) JOP20190126A1 (https=)
MX (1) MX2019007509A (https=)
PE (1) PE20191323A1 (https=)
PH (1) PH12019501324A1 (https=)
RU (1) RU2019116251A (https=)
TW (1) TW201829405A (https=)
WO (1) WO2018115067A1 (https=)
ZA (1) ZA201904236B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
JOP20190126A1 (ar) 2016-12-22 2019-05-28 H Lundbeck As بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
EP3723807B1 (en) 2017-12-14 2021-10-20 H. Lundbeck A/S Combination treatments comprising administration of 1h-pyrazolo[4,3-b]pyridines
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
WO2019121840A1 (en) 2017-12-20 2019-06-27 H. Lundbeck A/S Pyrazolo[3,4-b]pyridines and imidazo[1,5-b]pyridazines as pde1 inhibitors
US10766893B2 (en) 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
TW201927784A (zh) 2017-12-20 2019-07-16 丹麥商Ｈ 朗德貝克公司 作為pde1抑制劑之大環
US20230121698A1 (en) * 2019-12-23 2023-04-20 Sanford Burnham Prebys Medical Discovery Institute Ectonucleotide pyrophosphatase/phosphodiesterase 1 (enpp1) modulators and uses thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326379B1 (en) * 1998-09-16 2001-12-04 Bristol-Myers Squibb Co. Fused pyridine inhibitors of cGMP phosphodiesterase
DE602005011286D1 (en) * 2004-07-05 2009-01-08 Astellas Pharma Inc Pyrazolopyridinderivate
US7652035B2 (en) 2004-10-19 2010-01-26 Neurocrine Bioscience, Inc. CRF receptor antagonists and methods relating thereto
WO2008070095A1 (en) 2006-12-05 2008-06-12 Intra-Cellular Therapies, Inc. Novel uses
NZ579645A (en) 2007-03-14 2012-01-12 Ranbaxy Lab Ltd Pyrazolo (3, 4-b) pyridine derivatives as phosphodiesterase inhibitors
WO2009067607A2 (en) * 2007-11-20 2009-05-28 Memory Pharmaceuticals Corporation Combinations of pde4 inhibitors and antipsychotics for the treatment of psychotic disorders
EP2367431B1 (en) * 2008-12-06 2015-08-05 Intra-Cellular Therapies, Inc. Organic compounds
EP2828253A1 (en) 2012-03-19 2015-01-28 Abide Therapeutics, Inc. Carbamate compounds and of making and using same
TW201533043A (zh) * 2013-04-18 2015-09-01 Lundbeck & Co As H 作爲ｌｒｒｋ２抑制劑的芳基吡咯并吡啶衍生化合物
WO2016042775A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic derivative
US20160083400A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic guanidine derivative
US20160083391A1 (en) 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic piperazine derivative
TW201629064A (zh) 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
TW201639851A (zh) 2015-03-16 2016-11-16 大日本住友製藥股份有限公司 雙環咪唑衍生物
TW201643167A (zh) * 2015-04-22 2016-12-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之咪唑並三酮
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
JOP20190126A1 (ar) 2016-12-22 2019-05-28 H Lundbeck As بيرازولو [3، 4-b] بيريدينات وإيميدازو [1، 5-b] بيريدازينات على هيئة مثبطات PDE1
TW201927784A (zh) 2017-12-20 2019-07-16 丹麥商Ｈ 朗德貝克公司 作為pde1抑制劑之大環
US10766893B2 (en) 2017-12-20 2020-09-08 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors

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